Increased expression of SVCT2 in a new mouse model raises ascorbic acid in tissues and protects against paraquat-induced oxidative damage in lung

PLoS ONE

Volumn 7, Issue 4, 2012, Pages

  Harrison, Fiona Edith ^a   Best, Jennifer Lee ^a   Meredith, Martha Elizabeth ^a   Gamlin, Clare Ruth ^a   Borza, Dorin Bogdan ^b   May, James Michael ^a  

^a VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

^b VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALBUMIN; ASCORBIC ACID; CREATININE; ISOPROSTANE DERIVATIVE; MALONALDEHYDE; MESSENGER RNA; PARAQUAT; SODIUM ASCORBIC ACID COTRANSPORTER; SODIUM ASCORBIC ACID COTRANSPORTER 2; THIOBARBITURIC ACID REACTIVE SUBSTANCE; UNCLASSIFIED DRUG; ALBUMINOID; SLC23A2 PROTEIN, MOUSE;

AMINO ACID SEQUENCE; ANIMAL BEHAVIOR; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANXIETY; ARTICLE; COGNITION; CONTROLLED STUDY; FEMALE; FLUORESCENCE IN SITU HYBRIDIZATION; GENOTYPE; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; KIDNEY; KIDNEY FUNCTION; LIVER; LOCOMOTION; LUNG; LUNG INJURY; MALE; NONHUMAN; OXIDATIVE STRESS; PHENOTYPE; POSTNATAL DEVELOPMENT; PROTEIN EXPRESSION; SENSORIMOTOR FUNCTION; SIGNAL TRANSDUCTION; TRANSGENE; ANIMAL; ANTIBODY SPECIFICITY; BIOSYNTHESIS; DRUG EFFECT; FOUNDER EFFECT; GENETICS; METABOLISM; MOTOR ACTIVITY; MOUSE; PHYSIOLOGY; TRANSGENIC MOUSE; UPREGULATION;

MUS; MUS MUSCULUS;

ALBUMINS; ANIMALS; ANXIETY; ASCORBIC ACID; COGNITION; F2-ISOPROSTANES; FOUNDER EFFECT; KIDNEY; LIVER; LUNG; MICE; MICE, TRANSGENIC; MODELS, ANIMAL; MOTOR ACTIVITY; ORGAN SPECIFICITY; OXIDATIVE STRESS; PARAQUAT; RNA, MESSENGER; SODIUM-COUPLED VITAMIN C TRANSPORTERS; UP-REGULATION;

EID: 84860485494     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0035623     Document Type: Article

References (30)

1. Savini I, Rossi A, Pierro C, Avigliano L, Catani MV, (2007) SVCT1 and SVCT2: key proteins for vitamin C uptake. Amino Acids 34 (3): 347-355.
2. Harrison FE, May JM, (2009) Vitamin C function in the brain: vital role of the ascorbate transporter SVCT2. Free Radic Biol Med 46: 719-730.
3. Tsukaguchi H, Tokui T, Mackenzie B, Berger UV, Chen XZ, et al. (1999) A family of mammalian Na+-dependent L-ascorbic acid transporters. Nature 399: 70-75.
4. Maeda N, Hagihara H, Nakata Y, Hiller S, Wilder J, et al. (2000) Aortic wall damage in mice unable to synthesize ascorbic acid. Proc Natl Acad Sci U S A 97: 841-846.
5. Sotiriou S, Gispert S, Cheng J, Wang Y, Chen A, et al. (2002) Ascorbic-acid transporter Slc23a1 is essential for vitamin C transport into the brain and for perinatal survival. Nat Med 8: 514-517.
6. Corpe CP, Tu H, Eck P, Wang J, Faulhaber-Walter R, et al. (2010) Vitamin C transporter Slc23a1 links renal reabsorption, vitamin C tissue accumulation, and perinatal survival in mice. J Clin Invest 120: 1069-1083.
7. Harrison FE, Dawes SM, Meredith ME, Babaev VR, Li L, et al. (2010) Low vitamin C and increased oxidative stress cell death in mice that lack the sodium-dependent vitamin C transporter SVCT2. Free Radic Biol Med 49: 821-829.
8. Harrison FE, Allard J, Bixler R, Usoh C, Li L, et al. (2009) Antioxidants and cognitive training interact to affect oxidative stress and memory in APP/PSEN1 mice. Nutritional Neuroscience 12: 203-218.
9. Harrison FE, Hosseini AH, McDonald MP, May JM, (2009) Vitamin C reduces spatial learning deficits in middle-aged and very old APP/PSEN1 transgenic and wild-type mice. Pharmacol Biochem Behav 93: 443-450.
10. Meredith ME, Harrison FE, May JM, (2011) Differential regulation of the ascorbic acid transporter SVCT2 during development and in response to ascorbic acid depletion. Biochem Biophys Res Commun 414: 737-742.
11. Amano A, Aigaki T, Maruyama N, Ishigami A, (2010) Ascorbic acid depletion enhances expression of the sodium-dependent vitamin C transporters, SVCT1 and SVCT2, and uptake of ascorbic acid in livers of SMP30/GNL knockout mice. Arch Biochem Biophys 496 (1): 38-44.
12. Fan X, Reneker LW, Obrenovich ME, Strauch C, Cheng R, et al. (2006) Vitamin C mediates chemical aging of lens crystallins by the Maillard reaction in a humanized mouse model. Proc Natl Acad Sci U S A 103: 16912-16917.
13. May JM, Qu ZC, Mendiratta S, (1998) Protection and recycling of alpha-tocopherol in human erythrocytes by intracellular ascorbic acid. Arch Biochem Biophys 349: 281-289.
14. Pachla LA, Kissinger PT, (1979) Analysis of ascorbic acid by liquid chromatography with amperometric detection. Methods Enzymol 62: 15-24.
15. Harrison FE, Hosseini AH, Dawes SM, Weaver S, May JM, (2009) Ascorbic acid attenuates scopolamine-induced spatial learning deficits in the water maze. Behav Brain Res 205: 550-558.
16. Milne GL, Sanchez SC, Musiek ES, Morrow JD, (2007) Quantification of F2-isoprostanes as a biomarker of oxidative stress. Nat Protoc 2: 221-226.
17. Awadalla EA, (2010) Efficacy of vitamin C against liver and kidney damage induced by paraquat toxicity. Experimental and toxicologic pathology official journal of the Gesellschaft fur Toxikologische Pathologie doi:10.1016/j.etp.2010.10.009.
18. Prasad K, Tarasewicz E, Mathew J, Strickland PA, Buckley B, et al. (2009) Toxicokinetics and toxicodynamics of paraquat accumulation in mouse brain. Exp Neurol 215: 358-367.
19. Mun GH, Kim MJ, Lee JH, Kim HJ, Chung YH, et al. (2006) Immunohistochemical study of the distribution of sodium-dependent vitamin C transporters in adult rat brain. J Neurosci Res 83: 919-928.
20. May JM, Qu ZC, Qiao H, (2009) Transfer of ascorbic acid across the vascular endothelium: mechanism and self-regulation. American journal of physiology Cell physiology 297: C169-178.
21. Boyer JC, Campbell CE, Sigurdson WJ, Kuo SM, (2005) Polarized localization of vitamin C transporters, SVCT1 and SVCT2, in epithelial cells. Biochem Biophys Res Commun 334: 150-156.
22. Craven PA, DeRubertis FR, Kagan VE, Melhem M, Studer RK, (1997) Effects of supplementation with vitamin C or E on albuminuria, glomerular TGF-beta, and glomerular size in diabetes. Journal of the American Society of Nephrology: JASN 8: 1405-1414.
23. Gess B, Rohr D, Fledrich R, Sereda MW, Kleffner I, et al. (2011) Sodium-dependent vitamin C transporter 2 deficiency causes hypomyelination and extracellular matrix defects in the peripheral nervous system. The Journal of neuroscience: the official journal of the Society for Neuroscience 31: 17180-17192.
24. Harrison FE, Yu SS, Van Den Bossche KL, Li L, May JM, et al. (2008) Elevated oxidative stress and sensorimotor deficits but normal cognition in mice that cannot synthesize ascorbic acid. J Neurochem 106: 1198-1208.
25. Moon JM, Chun BJ, (2011) The efficacy of high doses of vitamin C in patients with paraquat poisoning. Hum Exp Toxicol 30: 844-850.
26. Ma LJ, Fogo AB, (2003) Model of robust induction of glomerulosclerosis in mice: importance of genetic background. Kidney international 64: 350-355.
27. Dinis-Oliveira RJ, Duarte JA, Sanchez-Navarro A, Remiao F, Bastos ML, et al. (2008) Paraquat poisonings: mechanisms of lung toxicity, clinical features, and treatment. Critical reviews in toxicology 38: 13-71.
28. Qiao H, May JM, (2008) Development of ascorbate transporters in brain cortical capillary endothelial cells in culture. Brain Res 1208: 79-86.
29. Savini I, Rossi A, Catani MV, Ceci R, Avigliano L, (2007) Redox regulation of vitamin C transporter SVCT2 in C2C12 myotubes. Biochem Biophys Res Commun 361: 385-390.
30. Dixon SJ, Wilson JX, (1992) Adaptive regulation of ascorbate transport in osteoblastic cells. J Bone Miner Res 7: 675-681.