Hydroxyethylstarch and gelatin solutions impair blood coagulation after cardiac surgery: A prospective randomized trial

British Journal of Anaesthesia

Volumn 104, Issue 6, 2010, Pages 691-697

  Schramko, A ^a   Suojaranta Ylinen, R ^a   Kuitunen, A ^a   Raivio, P ^a   Kukkonen, S ^a   Niemi, T ^a  

^a HELSINKI UNIVERSITY CENTRAL HOSPITAL   (Finland)

Author keywords

Blood, coagulation; Blood, loss; Fluids, i.v; Surgery, cardiovascular

Indexed keywords

FRESH FROZEN PLASMA; GELATIN SUCCINATE; HETASTARCH; RINGER ACETATE; THROMBOCYTE CONCENTRATE;

ADULT; AGED; ARTICLE; BLOOD CLOTTING; BLOOD CLOTTING TIME; CLINICAL ARTICLE; CLINICAL TRIAL; COLLOID; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOSE RESPONSE; ERYTHROCYTE TRANSFUSION; FEMALE; FIBRINOLYSIS; HEART SURGERY; HUMAN; HYPOVOLEMIA; MALE; MEASUREMENT; POSTOPERATIVE PERIOD; PRIORITY JOURNAL; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL; SINGLE BLIND PROCEDURE; THORAX DRAINAGE; THROMBOELASTOMETRY;

EID: 77952483666     PISSN: 00070912     EISSN: 14716771     Source Type: Journal    
DOI: 10.1093/bja/aeq084     Document Type: Article

References (37)

1. Gallandat Huet RC, Siemons AW, Baus D, et al. A novel hydroxyethyl starch (Voluven) for effective perioperative plasma volume substitution in cardiac surgery. Can J Anaesth 2000;47:1207-15
2. Karanko MS, Klossner JA, Laaksonen VO. Restoration of volume by crystalloid versus colloid after coronary artery bypass: hemodynamics, lung water, oxygenation, and outcome. Crit Care Med 1987;15:559-66
3. Verheij J, van Lingen A, Beishuizen A, et al. Cardiac response is greater for colloid than saline fluid loading after cardiac or vascular surgery. Intensive Care Med 2006;32:1030-8
4. Niemi TT, Kuitunen AH. Hydroxyethyl starch impairs in vitro coagulation. Acta Anaesthesiol Scand 1998;42:1104-9
5. Schramko AA, Suojaranta-Ylinen RT, Kuitunen AH, Kukkonen SI, Niemi TT. Rapidly degradable hydroxyethyl starch solutions impair blood coagulation after cardiac surgery: a prospective randomized trial. Anesth Analg 2009;108:30-6
6. deJonge E, Levi M. Effects of different plasma substitutes on blood coagulation: a comparative review. Crit Care Med 2001;29:1261-7
7. Felfernig M, Franz A, Bräunlich P, Fohringer C, Kozek-Langenecker SA. The effects of hydroxyethyl starch solutions on thromboelastography in preoperative male patients. Acta Anaesthesiol Scand 2003;47:70-3
8. Vogt NH, Bothner U, Lerch G, Lindner KH, Georgieff M. Large-dose administration of 6% hydroxyethyl starch 200/0.5 total hip arthroplasty: plasma homeostasis, hemostasis, and renal function compared to use of 5% human albumin. Anesth Analg 1996;83:262-8
9. Boldt J, Suttner S, Brosch C, Lehmann A, Mengistu A. Influence on coagulation of a potato-derived hydroxethylstarch (HES 130/0.42) and a maize-derived hydroxethylstarch (HES 130/0.4) in patients undergoing cardiac surgery. Br J Anaesth 2009;102:191-7
10. Van der Linden PJ, De Hert SG, Daper A, et al. 3.5% urea-linked gelatin is as effective as 6% HES 200/0.5 for volume management in cardiac surgery patients. Can J Anaesth 2004;51:236-41
11. Boldt J, Brosch Ch, Röhm K, Papsdorf M, Mengistu A. Comparison of the effects of gelatin and a modern hydroxyethyl starch solution on renal function and inflammatory response in elderly cardiac surgery patients. Br J Anaesth 2008;100:457-64
12. Schramko AA, Kuitunen AH, Suojaranta-Ylinen RT, Niemi TT. Role of fibrinogen-, factor VIII- and XIII-mediated clot propagation in gelatin haemodilution. An in vitro study using thromboelastometry. Acta Anaesthesiol Scand 2009;53:731-5
13. Boldt J, Knothe C, Zickmann B, Andres P, Dapper F, Hempelmann G. Influence of different volume therapies on platelet function in patients undergoing cardiopulmonary bypass. Anesth Analg 1993;76:1185-90
14. Saxena N, Chauhan S, Ramesh GS. A comparison of hetastarch, albumin and Ringer lactate for volume replacement in coronary artery bypass surgery. J Anaesth Clin Pharmacol 1997;13:117-20
15. Perel P, Roberts I. Colloids versus crystalloids for fluid resuscitation in critically ill patients. Cochrane Database Syst Rev 2007;17: CD000567
16. Despotis G, Avidan MS, Hogue CW. Mechanisms and attenuation of hemostatic activation during extracorporeal circulation. Ann Thorac Surg 2001;72:1821-31
17. Wilkes MM, Navickis RJ, Sibbald WJ. Albumin versus hydroxyethyl starch in cardiopulmonary bypass surgery: a meta-analysis for postoperative bleeding. Ann Thorac Surg 2001;72:527-33
18. Rahe-Meyer N, Solomon C, Vorweg M, et al. Multicentric comparison of single portion reagents and liquid reagents for thromboelastometry. Blood Coagul Fibrinolysis 2009;20:218-22
19. Rugeri L, Levrat A, David JS, et al. Diagnosis of early coagulation abnormalities in trauma patients by rotation thrombelastography. J Thromb Haemost 2007;5:289-95
20. Niemi TT, Suojaranta-Ylinen RT, Kukkonen SI, Kuitunen AH. Gelatin and hydroxyethyl starch, but not albumin, impair hemostasis after cardiac surgery. Anesth Analg 2006;102:998-1006
21. Welsby IJ, Jiao K, Ortel TL, et al. The kaolin-activated Thrombelastograph predicts bleeding after cardiac surgery. J Cardiothorac Vasc Anesth 2006;20:531-5
22. Boldt J, Haisch G, Suttner S, Kumle B, Schellhaass A. Effects of a new modified, balanced hydroxyethyl starch preparation (Hextend) on measures of coagulation. Br J Anaesth 2002;89:722-8
23. Nielsen VG. Effects of Hextend hemodilution on plasma coagulation kinetics in the rabbit: role of factor XIII-mediated fibrin polymer crosslinking. J Surg Res 2006;132:17-22
24. Niemi TT, Kuitunen AH. Artificial colloids impair haemostasis. An in vitro study using thromboelastometry coagulation analysis. Acta Anaesthesiol Scand 2005;49:373-8
25. Boldt J, Wolf M, Mengistu A. A new plasma-adapted hydroxyethylstarch preparation: in vitro coagulation studies using thrombelastography and whole blood aggregometry. Anesth Analg 2007;104:425-30
26. Schols SE, Lance MD, Feijge MA. Impaired thrombin generation and fibrin clot formation in patients with dilutional coagulopathy during major surgery. Thromb Haemost 2010;103:318-28
27. Mittermayr M, Streif W, Haas T, et al. Hemostatic changes after crystalloid or colloid fluid administration during major orthopedic surgery: the role of fibrinogen administration. Anesth Analg 2007;105:905-17
28. Van der Linden P, Ickx BE. The effects of colloid solutions on hemostasis. Can J Anaesth 2006;53:30-9
29. Singbartl K, Innerhofer P, Radvan J, et al. Hemostasis and hemodilution: a quantitative mathematical guide for clinical practice. Anesth Analg 2003;96:929-35
30. Lang T, Johanning K, Metzler H, et al. The effects of fibrinogen levels on thromboelastometric variables in the presence of thrombocytopenia. Anesth Analg 2009;108:751-8
31. Omar MN, Shouk TA, Khaleq MA. Activity of blood coagulation and fibrinolysis during and after hydroxyethyl starch (HES) colloidal volume replacement. Clin Biochem 1999;32:269-74
32. Ruttmann TG, James MF, Finlayson J. Effects on coagulation of intravenous crystalloid or colloid in patients undergoing peripheral vascular surgery. Br J Anaesth 2002;89:226-30
33. Boldt J, Suttner S. Plasma substitutes. Review. Minerva Anestesiol 2005;71:741-58
34. Kuitunen AH, Heikkila LJ, Salmenpera MT. Cardiopulmonary bypass with heparin-coated circuits and reduced systemic anticoagulation. Ann Thorac Surg 1997;63:438-44
35. Niemi TT, Svartling N, Syrjälä M, Asko-Seljavaara S, Rosenberg P. Haemostatic disturbances in burned patients during early excision and skin grafting. Blood Coagul Fibrinolysis 1998;9:19-28
36. Nielsen VG. Hemodilution modulates the time of onset and rate of fibrinolysis in human and rabbit plasma. J Heart Lung Transplant 2006;25:1344-52
37. Kozek-Langenecker SA, Jungheinrich C, Sauermann W, Van der Linden P. The effects of hydroxyethyl starch 130/0.4 (6%) on blood loss and use of blood products in major surgery: a pooled analysis of randomized clinical trials. Anesth Analg 2008;107:382-90