Effects of a new modified, balanced hydroxyethyl starch preparation (Hextend®) on measures of coagulation

British Journal of Anaesthesia

Volumn 89, Issue 5, 2002, Pages 722-728

  Boldt, J ^a   Haisch, G ^a   Suttner, S ^a   Kumle, B ^a   Schellhaass, A ^a  

^a KLINIKUM LUDWIGSHAFEN   (Germany)

Author keywords

Blood, coagulation; Blood, volume replacement; Surgery, abdominal

Indexed keywords

ADRENALIN; APROTININ; DESFLURANE; DOPAMINE; FENTANYL; HETASTARCH; MIDAZOLAM; NORADRENALIN; RINGER LACTATE SOLUTION; THIOPENTAL; VECURONIUM;

ABDOMINAL SURGERY; ADULT; AGED; ANESTHESIA INDUCTION; ARTICLE; BLEEDING; BLOOD CLOTTING; BLOOD CLOTTING DISORDER; BLOOD CLOTTING TIME; BLOOD TRANSFUSION; CENTRAL VENOUS PRESSURE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG INFUSION; FEMALE; FIBRINOLYSIS; HUMAN; HYPERCOAGULABILITY; HYPOVOLEMIA; MAJOR CLINICAL STUDY; MALE; MOLECULAR WEIGHT; POSTOPERATIVE PERIOD; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; REACTION TIME; THROMBOELASTOGRAPHY;

EID: 0036841594     PISSN: 00070912     EISSN: None     Source Type: Journal    
DOI: 10.1093/bja/aef242     Document Type: Article

References (32)

1. Mythen MG, Webb AR. Intra-operative gut mucosal hypoperfusion is associated with increased post-operative complications and costs. Intensive Care Med 1994; 20: 99-104
2. Warren BB, Durieux ME. Hydroxyethylstarch: safe or not? Anesth Analg 1997; 84: 206-12
3. Cope JT, Banks D, Mauney MC, et al. Intraoperative hetastarch infusion impairs hemostasis after cardiac surgery operations. Ann Thorac Surg 1997; 63: 78-82
4. Baldassare S, Vincent JL. Coagulopathy induced by hydroxyethyl starch. Anesth Analg 1997; 84: 451-3
5. Traylor RJ, Pearl RG. Crystalloid versus colloid versus colloid: all colloids are not created equal. Anesth Analg 1996; 83: 209-12
6. Strauss RG. Volume replacement and coagulation: a comparative review. J Cardiothorac Anesth 1988; 2 (Suppl 1): 24-32
7. Boldt J, Müller M, Heesen M, Heyn O, Hempelmann G. Influence of different volume therapies on platelet function in the critically ill. Intensive Care Med 1996; 22: 1075-81
8. deJonge E, Levi M. Effects of different plasma substitutes on blood coagulation: a comparative review. Crit Care Med 2001; 29: 1261-7
9. Huet RCGG, Siemons AW, Baus D, et al. A novel hydroxyethyl starch (Voluven®) for effective perioperative plasma volume substitution in cardiac surgery. Can J Anesth 2000; 47: 1207-15
10. Langeron O, Doelberg M, Ang ET, Bonnet F, Capdevila X, Coriat P. Voluven®, a lower substituted novel hydroxyethyl starch (HES 130/0.4), causes fewer effects on coagulation in major orthopedic surgery than HES 200/0.5. Anesth Analg 2001; 92: 855-62
11. Gan TJ, Bennett-Guerrero E. Phillips-Bute B. et al. Hextende®®, a physiologically balanced plasma expander for large volume use in major surgery: a randomized phase Ill clinical trial. Anesth Analg 1999; 88: 992-8
12. Bick RL. Evaluation of a new hydroxyethyl starch preparation (Hextend®) on selected coagulation parameters. Clin Appl Thrombosis/Hemostasis 1995; 1: 215-29
13. Mahla E, Lag T, Vicenzi M, et al. Thrombelastography for monitoring prolonged hypercoagulability after major abdominal surgery. Anesth Analg 2001; 92: 572-7
14. Calatzis A, Haas S, Gödje O. Thrombelastographic coagulation monitoring during cardiovascular surgery with the RoTEG coagulation analyzer. In: Pifarré R, ed. Management of Bleeding in Cardiovascular Surgery. Philadelphia: Hanley & Belfus, 2000; 215-26
15. Jamnicki M, Zollinger A, Seifert B, et al. Compromised blood coagulation: An in vitro comparison of hydroxyethyl starch 130/0.4 and hydroxyethyl starch 200/0.5 using thrombelastography. Anesth Analg 1998; 87: 989-93
16. Treib J, Haass A, Pindur G, et al. All medium starches are not the same: influence of hydroxyethyl substitution of hydroxyethyl starch on plasma volume, hemorrheologic conditions, and coagulation. Transfusion 1996; 36: 450-5
17. Spiess BD. Maintenance of homeostasis in coagulation during cardiopulmonary bypass. J Cardiothorac Vasc Anesth 1999; 13: 2-5
18. Pivalizza EG. Thrombelastography: another point of view. Anesth Analg 2001; 93: 517-8
19. Entholzner EK, Mielke LL, Calatzis AN, Feyh J, Hipp R, Hargasser SR. Coagulation effects of a recently developed hydroxy-ethyl starch (HES 130/0.4) compared to hydroxyethyl starches with higher molecular weight. Acta Anaesthesiol Scand 2000; 44: 1116-21
20. Dietrich GV, Schueck R, Menges T, Kiesenbauer NP, Fruehauf AC, Marquardt I. Comparison of four methods for the determination of platelet function in whole blood in cardiac surgery. Thromb Res 1998; 89: 295-301
21. Shore-Lesserson L, Manspeizer HE, DePerio M, Francis S, VelaCantos F, Ergin A. Thrombelastography-guided transfusion algorithm reduces transfusions in complex cardiac surgery. Anesth Analg 1999; 88: 312-9
22. Miller BE, Guzzetta NA, Tosone SR, Levy JH. Rapid evaluation of coagulopathies after cardiopulmonary bypass in children using modified thrombelastography. Anesth Analg 2000; 90: 1324-30
23. Tuman KJ, McCarthy RJ, Djuric M, et al. Evaluation of coagulation during cardiopulmonary bypass with a heparinase-modified thrombelastography assay. J Cardiothorac Vasc Anesth 1994; 8: 144-9
24. Payen JF, Baruch M, Horvilleur E, et al. Changes in specific markers of haemostasis during reduction mammoplasty. Br J Anaesth 1998; 80: 464-6
25. Ruttmann TG, James MFM, Viljoen JF. Haemodilution induces a hypercoagulable state. Br J Anaesth 1996; 76: 412-4
26. Ruttmann TG, James MFM, Aronson I. In vivo investigation into the effects of haemodilution with hydroxyethyl starch (200/0.5) and normal saline on coagulation. Br J Anaesth 1998; 80: 612-6
27. Petroianu GA, Liu J, Maleck WH, Mattinger C, Bergler WF. The effect on in vitro hemodilution with gelatin, dextran, hydroxy-ethylstarch, or Ringer's solution on thrombelastograph. Anesth Analg 2000; 90: 795-800
28. Ng KFJ, Lo JWR. The development of hypercoagulability state, as measured by thrombelastography, associated with intracoperative surgical blood. Anaesth Intens Care 1996; 24: 20-5
29. Monkhouse FC. Relationship between antithrombin and thrombin levels in plasma and serum. Am J Physiol 1959; 197: 984-8
30. Janvrin SB, Davies G, Greenhalgh RM. Postoperative deep vein thrombosis caused by intravenous fluids during surgery. Br J Surg 1980; 67: 690-3
31. Waitzinger J, Bepperling F, Pabst G, Cipitz J, Müller M, Baron JF. Pharmacokinetics and tolerability of a new hydroxyethylstarch (HES) specification (HES 130/0.4) after single-dose infusion of 6% or 10% solution in healthy volunteers. Clin Drug Invest 1998; 16: 151-60
32. Konrad CH, Marki T, Schuepfer G, Gerber H, Tschopp M. In vitro effects of different medium molecular hydroxyethylstarch solutions and lactated Ringer's solution on coagulation using SONOCLOT. Anesth Analg 2000; 90: 274-9