Inhibition of tumor cell proliferation by σ ligands is associated with K+ channel inhibition and p27kip1 accumulation

Journal of Pharmacology and Experimental Therapeutics

Volumn 311, Issue 3, 2004, Pages 1105-1114

  Renaudo, Adrien ^a   Watry, Vanina ^a   Chassot, Anne Amandine ^b   Ponzio, Gilles ^d   Ehrenfeld, Jordi ^a   Soriani, Olivier ^a,c  

^a CNRS   (France)

^b UNIVERSITÉ CÔTE D'AZUR   (France)

^c UNSA Ctr Natl Rech Sci UMR 6078   (France)

^d NONE

Author keywords

[No Author keywords available]

Indexed keywords

1,3 BIS(2 METHYLPHENYL)GUANIDINE; 4 AMINOPYRIDINE; CASPASE 3; CYCLIN A; CYCLIN DEPENDENT KINASE INHIBITOR; DNA; IGMESINE; LIGAND; PENTAZOCINE; POTASSIUM CHANNEL; POTASSIUM CHANNEL BLOCKING AGENT; PROTEIN P27; SIGMA OPIATE RECEPTOR; TETRYLAMMONIUM; VOLTAGE GATED POTASSIUM CHANNEL;

ARTICLE; CANCER CELL CULTURE; CELL CYCLE; CELL CYCLE G1 PHASE; CELL PROLIFERATION; CONTROLLED STUDY; CULTURE MEDIUM; DNA STRUCTURE; ENZYME ACTIVITY; GROWTH INHIBITION; HUMAN; HUMAN CELL; LEUKEMIA; LEUKEMIA CELL LINE; LUNG SMALL CELL CANCER; PATCH CLAMP; POTASSIUM CURRENT; PRIORITY JOURNAL; PROTEIN EXPRESSION; TUMOR CELL; WESTERN BLOTTING;

ANILIDES; APOPTOSIS; BLOTTING, WESTERN; CASPASES; CELL CYCLE PROTEINS; CELL LINE, TUMOR; CELL PROLIFERATION; CYCLIN A; CYCLIN-DEPENDENT KINASE INHIBITOR P21; CYCLIN-DEPENDENT KINASE INHIBITOR P27; DNA FRAGMENTATION; DOWN-REGULATION; ELECTROPHYSIOLOGY; G1 PHASE; HUMANS; JURKAT CELLS; KINETICS; MEMBRANE POTENTIALS; OLIGOPEPTIDES; PATCH-CLAMP TECHNIQUES; POTASSIUM CHANNEL BLOCKERS; RECEPTORS, SIGMA; TUMOR SUPPRESSOR PROTEINS;

EID: 10044270856     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: 10.1124/jpet.104.072413     Document Type: Article

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