Radiographic osteoarthritis at three joint sites and FRZB, LRP5, and LRP6 polymorphisms in two population-based cohorts

Osteoarthritis and Cartilage

Volumn 16, Issue 10, 2008, Pages 1141-1149

  Kerkhof, J M ^a   Uitterlinden, A G ^a   Valdes, A M ^b   Hart, D J ^b   Rivadeneira, F ^a   Jhamai, M ^a   Hofman, A ^a   Pols, H A P ^a   Bierma Zeinstra, S M A ^a   Spector, T D ^b   van Meurs, J B ^a  

^a ERASMUS MEDICAL CENTER   (Netherlands)

^b ST THOMAS HOSPITAL   (United Kingdom)

Author keywords

FRZB; LRP5; LRP6; Osteoarthritis; Polymorphism; Wnt

Indexed keywords

ALANINE; ARGININE; CARBOXY TERMINAL TELOPEPTIDE; COLLAGEN TYPE 2; CREATININE; GLYCINE; ISOLEUCINE; LOW DENSITY LIPOPROTEIN RECEPTOR RELATED PROTEIN 5; LOW DENSITY LIPOPROTEIN RECEPTOR RELATED PROTEIN 6; REGULATOR PROTEIN; SECRETED FRIZZLED RELATED PROTEIN; TRYPTOPHAN; VALINE; WNT PROTEIN;

ADULT; AGED; ALLELE; ARTICLE; CARPAL JOINT; CARPOMETACARPAL JOINT; COHORT ANALYSIS; CONTROLLED STUDY; CREATININE URINE LEVEL; DISTAL INTERPHALANGEAL JOINT; FEMALE; GENDER BIAS; GENETIC ASSOCIATION; GENETIC HETEROGENEITY; GENETIC POLYMORPHISM; GENETIC RISK; GENETIC VARIABILITY; HAND DISEASE; HAND RADIOGRAPHY; HIP OSTEOARTHRITIS; HIP RADIOGRAPHY; HUMAN; INTERPHALANGEAL JOINT; KNEE OSTEOARTHRITIS; KNEE RADIOGRAPHY; MAJOR CLINICAL STUDY; MALE; PHENOTYPIC VARIATION; POPULATION RESEARCH; PRIORITY JOURNAL; PROTEIN URINE LEVEL; PROXIMAL INTERPHALANGEAL JOINT; SCAPHOID BONE; SCORING SYSTEM; SIGNAL TRANSDUCTION; STANDARDIZATION; TOTAL HIP PROSTHESIS; TRAPEZOID BONE;

AGED; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GLYCOPROTEINS; GREAT BRITAIN; HUMANS; JOINTS; LDL-RECEPTOR RELATED PROTEINS; MALE; MIDDLE AGED; NETHERLANDS; OSTEOARTHRITIS; POLYMORPHISM, GENETIC; RECEPTORS, LDL; SIGNAL TRANSDUCTION;

EID: 48349084103     PISSN: 10634584     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.joca.2008.02.007     Document Type: Article

References (54)

1. Dieppe P.A., and Lohmander L.S. Pathogenesis and management of pain in osteoarthritis. Lancet 365 9463 (2005) 965-973
2. Spector T.D., and MacGregor A.J. Risk factors for osteoarthritis: genetics. Osteoarthritis Cartilage 12 Suppl A (2004) S39-S44
3. Church V., Nohno T., Linker C., Marcelle C., and Francis-West P. Wnt regulation of chondrocyte differentiation. J Cell Sci 115 Pt 24 (2002) 4809-4818
4. Enomoto-Iwamoto M., Kitagaki J., Koyama E., Tamamura Y., Wu C., Kanatani N., et al. The Wnt antagonist Frzb-1 regulates chondrocyte maturation and long bone development during limb skeletogenesis. Dev Biol 251 1 (2002) 142-156
5. Hill T.P., Spater D., Taketo M.M., Birchmeier W., and Hartmann C. Canonical Wnt/beta-catenin signaling prevents osteoblasts from differentiating into chondrocytes. Dev Cell 8 5 (2005) 727-738
6. Loughlin J., Dowling B., Chapman K., Marcelline L., Mustafa Z., Southam L., et al. Functional variants within the secreted frizzled-related protein 3 gene are associated with hip osteoarthritis in females. Proc Natl Acad Sci U S A 101 26 (2004) 9757-9762
7. Min J.L., Meulenbelt I., Riyazi N., Kloppenburg M., Houwing-Duistermaat J.J., Seymour A.B., et al. Association of the Frizzled-related protein gene with symptomatic osteoarthritis at multiple sites. Arthritis Rheum 52 4 (2005) 1077-1080
8. Nakamura Y., Nawata M., and Wakitani S. Expression profiles and functional analyses of Wnt-related genes in human joint disorders. Am J Pathol 167 1 (2005) 97-105
9. Ryu J.H., Kim S.J., Kim S.H., Oh C.D., Hwang S.G., Chun C.H., et al. Regulation of the chondrocyte phenotype by beta-catenin. Development 129 23 (2002) 5541-5550
10. Yates K.E., Shortkroff S., and Reish R.G. Wnt influence on chondrocyte differentiation and cartilage function. DNA Cell Biol 24 7 (2005) 446-457
11. Lane N.E., Lian K., Nevitt M.C., Zmuda J.M., Lui L., Li J., et al. Frizzled-related protein variants are risk factors for hip osteoarthritis. Arthritis Rheum 54 4 (2006) 1246-1254
12. Lin K., Wang S., Julius M.A., Kitajewski J., Moos Jr. M., and Luyten F.P. The cysteine-rich frizzled domain of Frzb-1 is required and sufficient for modulation of Wnt signaling. Proc Natl Acad Sci U S A 94 21 (1997) 11196-11200
13. Valdes A.M., Loughlin J., Oene M.V., Chapman K., Surdulescu G.L., Doherty M., et al. Sex and ethnic differences in the association of ASPN, CALM1, COL2A1, COMP, and FRZB with genetic susceptibility to osteoarthritis of the knee. Arthritis Rheum 56 1 (2006) 137-146
14. Lories R.J., Boonen S., Peeters J., de Vlam K., and Luyten F.P. Evidence for a differential association of the Arg200Trp single-nucleotide polymorphism in FRZB with hip osteoarthritis and osteoporosis. Rheumatology (Oxford) 45 1 (2006) 113-114
15. Rodriguez-Lopez J., Pombo-Suarez M., Liz M., Gomez-Reino J.J., and Gonzalez A. Further evidence of the role of frizzled-related protein gene polymorphisms in osteoarthritis. Ann Rheum Dis 66 8 (2007) 1052-1055
16. Gordon A., Southam L., Loughlin J., Wilson A.G., Stockley I., Hamer A.J., et al. Variation in the secreted frizzled-related protein-3 gene and risk of osteolysis and heterotopic ossification after total hip arthroplasty. J Orthop Res (2007)
17. Tamai K., Semenov M., Kato Y., Spokony R., Liu C., Katsuyama Y., et al. LDL-receptor-related proteins in Wnt signal transduction. Nature 407 6803 (2000) 530-535
18. Westendorf J.J., Kahler R.A., and Schroeder T.M. Wnt signaling in osteoblasts and bone diseases. Gene 341 (2004) 19-39
19. Boyden L.M., Mao J., Belsky J., Mitzner L., Farhi A., Mitnick M.A., et al. High bone density due to a mutation in LDL-receptor-related protein 5. N Engl J Med 346 20 (2002) 1513-1521
20. Ferrari S.L., Deutsch S., Choudhury U., Chevalley T., Bonjour J.P., Dermitzakis E.T., et al. Polymorphisms in the low-density lipoprotein receptor-related protein 5 (LRP5) gene are associated with variation in vertebral bone mass, vertebral bone size, and stature in whites. Am J Hum Genet 74 5 (2004) 866-875
21. Gong Y., Slee R.B., Fukai N., Rawadi G., Roman-Roman S., Reginato A.M., et al. LDL receptor-related protein 5 (LRP5) affects bone accrual and eye development. Cell 107 4 (2001) 513-523
22. Koay M.A., Woon P.Y., Zhang Y., Miles L.J., Duncan E.L., Ralston S.H., et al. Influence of LRP5 polymorphisms on normal variation in BMD. J Bone Miner Res 19 10 (2004) 1619-1627
23. Little R.D., Carulli J.P., Del Mastro R.G., Dupuis J., Osborne M., Folz C., et al. A mutation in the LDL receptor-related protein 5 gene results in the autosomal dominant high-bone-mass trait. Am J Hum Genet 70 1 (2002) 11-19
24. Mizuguchi T., Furuta I., Watanabe Y., Tsukamoto K., Tomita H., Tsujihata M., et al. LRP5, low-density-lipoprotein-receptor-related protein 5, is a determinant for bone mineral density. J Hum Genet 49 2 (2004) 80-86
25. Patel M.S., and Karsenty G. Regulation of bone formation and vision by LRP5. N Engl J Med 346 20 (2002) 1572-1574
26. van Meurs J.B., Rivadeneira F., Jhamai M., Hugens W., Hofman A., van Leeuwen J.P., et al. Common genetic variation of the low-density lipoprotein receptor-related protein 5 and 6 genes determines fracture risk in elderly white men. J Bone Miner Res 21 1 (2006) 141-150
27. Smith A.J., Gidley J., Sandy J.R., Perry M.J., Elson C.J., Kirwan J.R., et al. Haplotypes of the low-density lipoprotein receptor-related protein 5 (LRP5) gene: are they a risk factor in osteoarthritis?. Osteoarthritis Cartilage 13 7 (2005) 608-613
28. Hofman A., Breteler M.M., vanDuijn C.M., Krestin G.P., Pols H.A., Stricker B.H., et al. The Rotterdam Study: objectives and design update. Eur J Epidemiol 22 11 (2007) 819-829
29. Reijman M., Hazes J.M., Bierma-Zeinstra S.M., Koes B.W., Christgau S., Christiansen C., et al. A new marker for osteoarthritis: cross-sectional and longitudinal approach. Arthritis Rheum 50 8 (2004) 2471-2478
30. Dahaghin S., Bierma-Zeinstra S.M., Ginai A.Z., Pols H.A., Hazes J.M., and Koes B.W. Prevalence and pattern of radiographic hand osteoarthritis and association with pain and disability (the Rotterdam study). Ann Rheum Dis 64 5 (2005) 682-687
31. Mattace-Raso F.U., van der Cammen T.J., Hofman A., van Popele N.M., Bos M.L., Schalekamp M.A., et al. Arterial stiffness and risk of coronary heart disease and stroke: the Rotterdam Study. Circulation 113 5 (2006) 657-663
32. de Voogd S., Ikram M.K., Wolfs R.C., Jansonius N.M., Witteman J.C., Hofman A., et al. Is diabetes mellitus a risk factor for open-angle glaucoma? The Rotterdam Study. Ophthalmology 113 10 (2006) 1827-1831
33. Odding E., Valkenburg H.A., Algra D., Vandenouweland F.A., Grobbee D.E., and Hofman A. Associations of radiological osteoarthritis of the hip and knee with locomotor disability in the Rotterdam Study. Ann Rheum Dis 57 4 (1998) 203-208
34. Rosenbaum S., Skinner R.K., Knight I.B., and Garrow J.S. A survey of heights and weights of adults in Great Britain, 1980. Ann Hum Biol 12 2 (1985) 115-127
35. Hart D.J., Mootoosamy I., Doyle D.V., and Spector T.D. The relationship between osteoarthritis and osteoporosis in the general population: the Chingford Study. Ann Rheum Dis 53 3 (1994) 158-162
36. Hart D.J., and Spector T.D. The relationship of obesity, fat distribution and osteoarthritis in women in the general population: the Chingford Study. J Rheumatol 20 2 (1993) 331-335
37. Hart D.J., and Spector T.D. Cigarette smoking and risk of osteoarthritis in women in the general population: the Chingford study. Ann Rheum Dis 52 2 (1993) 93-96
38. Kellgren J. Atlas of Standard Radiographs of Arthritis (1963), Blackwell Scientific, Oxford p. 19
39. Bergink A.P., van der Klift M., Hofman A., Verhaar J.A., van Leeuwen J.P., Uitterlinden A.G., et al. Osteoarthritis of the knee is associated with vertebral and nonvertebral fractures in the elderly: the Rotterdam Study. Arthritis Rheum 49 5 (2003) 648-657
40. Christgau S., Garnero P., Fledelius C., Moniz C., Ensig M., Gineyts E., et al. Collagen type II C-telopeptide fragments as an index of cartilage degradation. Bone 29 3 (2001) 209-215
41. van Meurs J.B., Dhonukshe-Rutten R.A., Pluijm S.M., van der Klift M., de Jonge R., Lindemans J., et al. Homocysteine levels and the risk of osteoporotic fracture. N Engl J Med 350 20 (2004) 2033-2041
42. Rivadeneira F., van Meurs J.B., Kant J., Zillikens M.C., Stolk L., Beck T.J., et al. Estrogen receptor beta (ESR2) polymorphisms in interaction with estrogen receptor alpha (ESR1) and insulin-like growth factor I (IGF1) variants influence the risk of fracture in postmenopausal women. J Bone Miner Res 21 9 (2006) 1443-1456
43. RevMan analyses [Computer program]. Version 1.0 for Windows. Review Manager (RevMan) 4.3 (2006), The Nordic Cochrane Centre, The Cochrane Collaboration, Copenhagen
44. Spector T.D., Ahmadi K.R., and Valdes A.M. When is a replication not a replication? Or how to spot a good genetic association study. Arthritis Rheum 54 4 (2006) 1051-1054
45. Ioannidis J.P., Gwinn M., Little J., Higgins J.P., Bernstein J.L., Boffetta P., et al. A road map for efficient and reliable human genome epidemiology. Nat Genet 38 1 (2006) 3-5
46. Ioannidis J.P., Boffetta P., Little J., O'brien T.R., Uitterlinden A.G., Vineis P., et al. Assessment of cumulative evidence on genetic associations: interim guidelines. Int J Epidemiol (2007 Sep 26) [Epub ahead of print]
47. NCI-NHGRI Working Group on Replication in Association Studies, Chanock S.J., Manolio T., Boehnke M., Boerwinkle E., Hunter D.J., Thomas G., et al. Replicating genotype-phenotype associations. Nature 447 7145 (2007) 655-660
48. Kellgren J.H., and Lawrence J.S. Radiological assessment of osteo-arthrosis. Ann Rheum Dis 16 4 (1957) 494-502
49. Garnero P., Piperno M., Gineyts E., Christgau S., Delmas P.D., and Vignon E. Cross sectional evaluation of biochemical markers of bone, cartilage, and synovial tissue metabolism in patients with knee osteoarthritis: relations with disease activity and joint damage. Ann Rheum Dis 60 6 (2001) 619-626
50. Garnero P., Ayral X., Rousseau J.C., Christgau S., Sandell L.J., Dougados M., et al. Uncoupling of type II collagen synthesis and degradation predicts progression of joint damage in patients with knee osteoarthritis. Arthritis Rheum 46 10 (2002) 2613-2624
51. Vignon E., Garnero P., Delmas P., Avouac B., Bettica P., Boers M., et al. Recommendations for the registration of drugs used in the treatment of osteoarthritis: an update on biochemical markers. Osteoarthritis Cartilage 9 4 (2001) 289-293
52. Garnero P., Gineyts E., Christgau S., Finck B., and Delmas P.D. Association of baseline levels of urinary glucosyl-galactosyl-pyridinoline and type II collagen C-telopeptide with progression of joint destruction in patients with early rheumatoid arthritis. Arthritis Rheum 46 1 (2002) 21-30
53. Kiel D.P., Ferrari S.L., Cupples L.A., Karasik D., Manen D., Imamovic A., et al. Genetic variation at the low-density lipoprotein receptor-related protein 5 (LRP5) locus modulates Wnt signaling and the relationship of physical activity with bone mineral density in men. Bone 40 3 (2007 Mar) 587-596
54. De Ferrari G.V., Papassotiropoulos A., Biechele T., Wavrant De-Vrieze F., Avila M.E., Major M.B., et al. Common genetic variation within the low-density lipoprotein receptor-related protein 6 and late-onset Alzheimer's disease. Proc Natl Acad Sci U S A 104 22 (2007 May 29) 9434-9439