메뉴 건너뛰기




Volumn 7, Issue 5, 2012, Pages

The secreted lipoprotein, MPT83, of Mycobacterium tuberculosis is recognized during human tuberculosis and stimulates protective immunity in mice

Author keywords

[No Author keywords available]

Indexed keywords

BCG VACCINE; DNA VACCINE; EPITOPE; GAMMA INTERFERON; LIPOPROTEIN; LIVE VACCINE; MPT83 LIPOPROTEIN; UNCLASSIFIED DRUG; BACTERIAL ANTIGEN; BACTERIAL PROTEIN; IMMUNOLOGICAL ADJUVANT; MEMBRANE PROTEIN; MPB83 PROTEIN, MYCOBACTERIUM;

EID: 84860464162     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0034991     Document Type: Article
Times cited : (33)

References (49)
  • 1
    • 79955103273 scopus 로고    scopus 로고
    • World Health Organization, Geneva, World Health Organization
    • World Health Organization (2011) Global tuberculosis control: WHO report 2011. Geneva World Health Organization. viii, 246 p.
    • (2011) Global tuberculosis control: WHO report 2011
  • 2
    • 0028872014 scopus 로고
    • Variation in protection by BCG: implications of and for heterologous immunity
    • Fine PE, (1995) Variation in protection by BCG: implications of and for heterologous immunity. Lancet 346: 1339-1345.
    • (1995) Lancet , vol.346 , pp. 1339-1345
    • Fine, P.E.1
  • 3
    • 22344433382 scopus 로고    scopus 로고
    • Increased vaccine efficacy against tuberculosis of recombinant Mycobacterium bovis bacille Calmette-Guerin mutants that secrete listeriolysin
    • Grode L, Seiler P, Baumann S, Hess J, Brinkmann V, et al. (2005) Increased vaccine efficacy against tuberculosis of recombinant Mycobacterium bovis bacille Calmette-Guerin mutants that secrete listeriolysin. J Clin Invest 115: 2472-2479.
    • (2005) J Clin Invest , vol.115 , pp. 2472-2479
    • Grode, L.1    Seiler, P.2    Baumann, S.3    Hess, J.4    Brinkmann, V.5
  • 4
    • 54949108635 scopus 로고    scopus 로고
    • A new recombinant bacille Calmette-Guerin vaccine safely induces significantly enhanced tuberculosis-specific immunity in human volunteers
    • Hoft DF, Blazevic A, Abate G, Hanekom WA, Kaplan G, et al. (2008) A new recombinant bacille Calmette-Guerin vaccine safely induces significantly enhanced tuberculosis-specific immunity in human volunteers. J Infect Dis 198: 1491-1501.
    • (2008) J Infect Dis , vol.198 , pp. 1491-1501
    • Hoft, D.F.1    Blazevic, A.2    Abate, G.3    Hanekom, W.A.4    Kaplan, G.5
  • 5
    • 80051716214 scopus 로고    scopus 로고
    • A booster vaccine expressing a latency-associated antigen augments BCG induced immunity and confers enhanced protection against tuberculosis
    • Dey B, Jain R, Gupta UD, Katoch VM, Ramanathan VD, et al. (2011) A booster vaccine expressing a latency-associated antigen augments BCG induced immunity and confers enhanced protection against tuberculosis. PLoS One 6: e23360.
    • (2011) PLoS One , vol.6
    • Dey, B.1    Jain, R.2    Gupta, U.D.3    Katoch, V.M.4    Ramanathan, V.D.5
  • 6
    • 20144362100 scopus 로고    scopus 로고
    • Protection of macaques against Mycobacterium tuberculosis infection by a subunit vaccine based on a fusion protein of antigen 85B and ESAT-6
    • Langermans JA, Doherty TM, Vervenne RA, van der Laan T, Lyashchenko K, et al. (2005) Protection of macaques against Mycobacterium tuberculosis infection by a subunit vaccine based on a fusion protein of antigen 85B and ESAT-6. Vaccine 23: 2740-2750.
    • (2005) Vaccine , vol.23 , pp. 2740-2750
    • Langermans, J.A.1    Doherty, T.M.2    Vervenne, R.A.3    van der Laan, T.4    Lyashchenko, K.5
  • 7
    • 73949150251 scopus 로고    scopus 로고
    • Non-clinical efficacy and safety of HyVac4:IC31 vaccine administered in a BCG prime-boost regimen
    • Skeiky YA, Dietrich J, Lasco TM, Stagliano K, Dheenadhayalan V, et al. (2010) Non-clinical efficacy and safety of HyVac4:IC31 vaccine administered in a BCG prime-boost regimen. Vaccine 28: 1084-1093.
    • (2010) Vaccine , vol.28 , pp. 1084-1093
    • Skeiky, Y.A.1    Dietrich, J.2    Lasco, T.M.3    Stagliano, K.4    Dheenadhayalan, V.5
  • 8
    • 70349551599 scopus 로고    scopus 로고
    • The candidate tuberculosis vaccine Mtb72F/AS02A: Tolerability and immunogenicity in humans
    • Von Eschen K, Morrison R, Braun M, Ofori-Anyinam O, De Kock E, et al. (2009) The candidate tuberculosis vaccine Mtb72F/AS02A: Tolerability and immunogenicity in humans. Hum Vaccin 5: 475-482.
    • (2009) Hum Vaccin , vol.5 , pp. 475-482
    • Von Eschen, K.1    Morrison, R.2    Braun, M.3    Ofori-Anyinam, O.4    De Kock, E.5
  • 9
    • 9144267735 scopus 로고    scopus 로고
    • Recombinant modified vaccinia virus Ankara expressing antigen 85A boosts BCG-primed and naturally acquired antimycobacterial immunity in humans
    • McShane H, Pathan AA, Sander CR, Keating SM, Gilbert SC, et al. (2004) Recombinant modified vaccinia virus Ankara expressing antigen 85A boosts BCG-primed and naturally acquired antimycobacterial immunity in humans. Nature Medicine 10: 1240-1244.
    • (2004) Nature Medicine , vol.10 , pp. 1240-1244
    • McShane, H.1    Pathan, A.A.2    Sander, C.R.3    Keating, S.M.4    Gilbert, S.C.5
  • 10
    • 20444503715 scopus 로고    scopus 로고
    • Tuberculosis vaccine development; from mouse to man
    • Reed S, Lobet Y, (2005) Tuberculosis vaccine development; from mouse to man. Microbes Infect 7: 922-931.
    • (2005) Microbes Infect , vol.7 , pp. 922-931
    • Reed, S.1    Lobet, Y.2
  • 11
    • 0029974805 scopus 로고    scopus 로고
    • Molecular characterization of MPT83: a seroreactive antigen of Mycobacterium tuberculosis with homology to MPT70
    • Hewinson RG, Michell SL, Russell WP, McAdam RA, Jacobs WR Jr, (1996) Molecular characterization of MPT83: a seroreactive antigen of Mycobacterium tuberculosis with homology to MPT70. Scand J Immunol 43: 490-499.
    • (1996) Scand J Immunol , vol.43 , pp. 490-499
    • Hewinson, R.G.1    Michell, S.L.2    Russell, W.P.3    McAdam, R.A.4    Jacobs Jr., W.R.5
  • 12
    • 0032036389 scopus 로고    scopus 로고
    • Immunochemical characterization of the MPB70/80 and MPB83 proteins of Mycobacterium bovis
    • Wiker HG, Lyashchenko KP, Aksoy AM, Lightbody KA, Pollock JM, et al. (1998) Immunochemical characterization of the MPB70/80 and MPB83 proteins of Mycobacterium bovis. Infect Immun 66: 1445-1452.
    • (1998) Infect Immun , vol.66 , pp. 1445-1452
    • Wiker, H.G.1    Lyashchenko, K.P.2    Aksoy, A.M.3    Lightbody, K.A.4    Pollock, J.M.5
  • 13
    • 39649092927 scopus 로고    scopus 로고
    • Antigen specific immunological responses of badgers (Meles meles) experimentally infected with Mycobacterium bovis
    • Lesellier S, Corner L, Costello E, Sleeman P, Lyashchenko K, et al. (2008) Antigen specific immunological responses of badgers (Meles meles) experimentally infected with Mycobacterium bovis. Vet Immunol Immunopathol 122: 35-45.
    • (2008) Vet Immunol Immunopathol , vol.122 , pp. 35-45
    • Lesellier, S.1    Corner, L.2    Costello, E.3    Sleeman, P.4    Lyashchenko, K.5
  • 14
    • 19444367666 scopus 로고    scopus 로고
    • Combined DNA vaccines formulated either in DDA or in saline protect cattle from Mycobacterium bovis infection
    • Cai H, Tian X, Hu XD, Li SX, Yu DH, et al. (2005) Combined DNA vaccines formulated either in DDA or in saline protect cattle from Mycobacterium bovis infection. Vaccine 23: 3887-3895.
    • (2005) Vaccine , vol.23 , pp. 3887-3895
    • Cai, H.1    Tian, X.2    Hu, X.D.3    Li, S.X.4    Yu, D.H.5
  • 15
    • 0034463154 scopus 로고    scopus 로고
    • Vaccination of mice and cattle with plasmid DNA encoding the Mycobacterium bovis antigen MPB83
    • Chambers MA, Vordermeier H, Whelan A, Commander N, Tascon R, et al. (2000) Vaccination of mice and cattle with plasmid DNA encoding the Mycobacterium bovis antigen MPB83. Clin Infect Dis 30 (Suppl 3): S283-287.
    • (2000) Clin Infect Dis , vol.30 , Issue.SUPPL. 3
    • Chambers, M.A.1    Vordermeier, H.2    Whelan, A.3    Commander, N.4    Tascon, R.5
  • 16
    • 0034623976 scopus 로고    scopus 로고
    • Effective DNA vaccination of cattle with the mycobacterial antigens MPB83 and MPB70 does not compromise the specificity of the comparative intradermal tuberculin skin test
    • Vordermeier HM, Cockle PJ, Whelan AO, Rhodes S, Chambers MA, et al. (2000) Effective DNA vaccination of cattle with the mycobacterial antigens MPB83 and MPB70 does not compromise the specificity of the comparative intradermal tuberculin skin test. Vaccine 19: 1246-1255.
    • (2000) Vaccine , vol.19 , pp. 1246-1255
    • Vordermeier, H.M.1    Cockle, P.J.2    Whelan, A.O.3    Rhodes, S.4    Chambers, M.A.5
  • 17
    • 2442577262 scopus 로고    scopus 로고
    • Antibody bound to the surface antigen MPB83 of Mycobacterium bovis enhances survival against high dose and low dose challenge
    • Chambers MA, Gavier-Widen D, Hewinson RG, (2004) Antibody bound to the surface antigen MPB83 of Mycobacterium bovis enhances survival against high dose and low dose challenge. FEMS Immunol Med Microbiol 41: 93-100.
    • (2004) FEMS Immunol Med Microbiol , vol.41 , pp. 93-100
    • Chambers, M.A.1    Gavier-Widen, D.2    Hewinson, R.G.3
  • 18
    • 19944421087 scopus 로고    scopus 로고
    • Reduced expression of antigenic proteins MPB70 and MPB83 in Mycobacterium bovis BCG strains due to a start codon mutation in sigK
    • Charlet D, Mostowy S, Alexander D, Sit L, Wiker HG, et al. (2005) Reduced expression of antigenic proteins MPB70 and MPB83 in Mycobacterium bovis BCG strains due to a start codon mutation in sigK. Mol Microbiol 56: 1302-1313.
    • (2005) Mol Microbiol , vol.56 , pp. 1302-1313
    • Charlet, D.1    Mostowy, S.2    Alexander, D.3    Sit, L.4    Wiker, H.G.5
  • 19
  • 21
    • 77950690752 scopus 로고    scopus 로고
    • Ag85B-ESAT-6 adjuvanted with IC31 promotes strong and long-lived Mycobacterium tuberculosis specific T cell responses in naive human volunteers
    • van Dissel JT, Arend SM, Prins C, Bang P, Tingskov PN, et al. (2010) Ag85B-ESAT-6 adjuvanted with IC31 promotes strong and long-lived Mycobacterium tuberculosis specific T cell responses in naive human volunteers. Vaccine 28: 3571-3581.
    • (2010) Vaccine , vol.28 , pp. 3571-3581
    • van Dissel, J.T.1    Arend, S.M.2    Prins, C.3    Bang, P.4    Tingskov, P.N.5
  • 22
    • 65249141684 scopus 로고    scopus 로고
    • Safety and immunogenicity of a new tuberculosis vaccine, MVA85A, in Mycobacterium tuberculosis-infected individuals
    • Sander CR, Pathan AA, Beveridge NE, Poulton I, Minassian A, et al. (2009) Safety and immunogenicity of a new tuberculosis vaccine, MVA85A, in Mycobacterium tuberculosis-infected individuals. Am J Respir Crit Care Med 179: 724-733.
    • (2009) Am J Respir Crit Care Med , vol.179 , pp. 724-733
    • Sander, C.R.1    Pathan, A.A.2    Beveridge, N.E.3    Poulton, I.4    Minassian, A.5
  • 23
    • 0025752316 scopus 로고
    • A localization index for distinction between extracellular and intracellular antigens of Mycobacterium tuberculosis
    • Wiker HG, Harboe M, Nagai S, (1991) A localization index for distinction between extracellular and intracellular antigens of Mycobacterium tuberculosis. J Gen Microbiol 137: 875-884.
    • (1991) J Gen Microbiol , vol.137 , pp. 875-884
    • Wiker, H.G.1    Harboe, M.2    Nagai, S.3
  • 24
    • 43549108562 scopus 로고    scopus 로고
    • Membrane and membrane-associated proteins in Triton X-114 extracts of Mycobacterium bovis BCG identified using a combination of gel-based and gel-free fractionation strategies
    • Malen H, Berven FS, Softeland T, Arntzen MO, D'Santos CS, et al. (2008) Membrane and membrane-associated proteins in Triton X-114 extracts of Mycobacterium bovis BCG identified using a combination of gel-based and gel-free fractionation strategies. Proteomics 8: 1859-1870.
    • (2008) Proteomics , vol.8 , pp. 1859-1870
    • Malen, H.1    Berven, F.S.2    Softeland, T.3    Arntzen, M.O.4    D'Santos, C.S.5
  • 25
    • 0031965470 scopus 로고    scopus 로고
    • MPB70 and MPB83 as indicators of protein localization in mycobacterial cells
    • Harboe M, Wiker HG, Ulvund G, Lund-Pedersen B, Andersen AB, et al. (1998) MPB70 and MPB83 as indicators of protein localization in mycobacterial cells. Infect Immun 66: 289-296.
    • (1998) Infect Immun , vol.66 , pp. 289-296
    • Harboe, M.1    Wiker, H.G.2    Ulvund, G.3    Lund-Pedersen, B.4    Andersen, A.B.5
  • 27
    • 77956820976 scopus 로고    scopus 로고
    • Development of a skin test for bovine tuberculosis for differentiating infected from vaccinated animals
    • Whelan AO, Clifford D, Upadhyay B, Breadon EL, McNair J, et al. (2010) Development of a skin test for bovine tuberculosis for differentiating infected from vaccinated animals. J Clin Microbiol 48: 3176-3181.
    • (2010) J Clin Microbiol , vol.48 , pp. 3176-3181
    • Whelan, A.O.1    Clifford, D.2    Upadhyay, B.3    Breadon, E.L.4    McNair, J.5
  • 28
    • 0027998402 scopus 로고
    • Serodiagnosis of Mycobacterium bovis infection in badgers: development of an indirect ELISA using a 25 kDa antigen
    • Goodger J, Nolan A, Russell WP, Dalley DJ, Thorns CJ, et al. (1994) Serodiagnosis of Mycobacterium bovis infection in badgers: development of an indirect ELISA using a 25 kDa antigen. Vet Rec 135: 82-85.
    • (1994) Vet Rec , vol.135 , pp. 82-85
    • Goodger, J.1    Nolan, A.2    Russell, W.P.3    Dalley, D.J.4    Thorns, C.J.5
  • 29
    • 33750695632 scopus 로고    scopus 로고
    • Mutations in Mycobacterium tuberculosis Rv0444c, the gene encoding anti-SigK, explain high level expression of MPB70 and MPB83 in Mycobacterium bovis
    • Said-Salim B, Mostowy S, Kristof AS, Behr MA, (2006) Mutations in Mycobacterium tuberculosis Rv0444c, the gene encoding anti-SigK, explain high level expression of MPB70 and MPB83 in Mycobacterium bovis. Mol Microbiol 62: 1251-1263.
    • (2006) Mol Microbiol , vol.62 , pp. 1251-1263
    • Said-Salim, B.1    Mostowy, S.2    Kristof, A.S.3    Behr, M.A.4
  • 30
    • 80053450349 scopus 로고    scopus 로고
    • Comparative evaluation of MPT83 (Rv2873) for T helper-1 cell reactivity and identification of HLA-promiscuous peptides in Mycobacterium bovis BCG-vaccinated healthy subjects
    • Mustafa AS, (2011) Comparative evaluation of MPT83 (Rv2873) for T helper-1 cell reactivity and identification of HLA-promiscuous peptides in Mycobacterium bovis BCG-vaccinated healthy subjects. Clin Vaccine Immunol 18: 1752-1759.
    • (2011) Clin Vaccine Immunol , vol.18 , pp. 1752-1759
    • Mustafa, A.S.1
  • 31
    • 7044237201 scopus 로고    scopus 로고
    • RNA encoding the MPT83 antigen induces protective immune responses against Mycobacterium tuberculosis infection
    • Xue T, Stavropoulos E, Yang M, Ragno S, Vordermeier M, et al. (2004) RNA encoding the MPT83 antigen induces protective immune responses against Mycobacterium tuberculosis infection. Infect Immun 72: 6324-6329.
    • (2004) Infect Immun , vol.72 , pp. 6324-6329
    • Xue, T.1    Stavropoulos, E.2    Yang, M.3    Ragno, S.4    Vordermeier, M.5
  • 33
    • 74249085478 scopus 로고    scopus 로고
    • Modulation of pulmonary DC function by vaccine-encoded GM-CSF enhances protective immunity against Mycobacterium tuberculosis infection
    • Nambiar JK, Ryan AA, Kong CU, Britton WJ, Triccas JA, (2010) Modulation of pulmonary DC function by vaccine-encoded GM-CSF enhances protective immunity against Mycobacterium tuberculosis infection. Eur J Immunol 40: 153-161.
    • (2010) Eur J Immunol , vol.40 , pp. 153-161
    • Nambiar, J.K.1    Ryan, A.A.2    Kong, C.U.3    Britton, W.J.4    Triccas, J.A.5
  • 34
    • 0034010994 scopus 로고    scopus 로고
    • The immunogenicity of single and combination DNA vaccines against tuberculosis
    • Morris S, Kelley C, Howard A, Li Z, Collins F, (2000) The immunogenicity of single and combination DNA vaccines against tuberculosis. Vaccine 18: 2155-2163.
    • (2000) Vaccine , vol.18 , pp. 2155-2163
    • Morris, S.1    Kelley, C.2    Howard, A.3    Li, Z.4    Collins, F.5
  • 35
    • 26944496074 scopus 로고    scopus 로고
    • Coadministration of interleukin 2 plasmid DNA with combined DNA vaccines significantly enhances the protective efficacy against Mycobacterium tuberculosis
    • Cai H, Yu DH, Tian X, Zhu YX, (2005) Coadministration of interleukin 2 plasmid DNA with combined DNA vaccines significantly enhances the protective efficacy against Mycobacterium tuberculosis. DNA Cell Biol 24: 605-613.
    • (2005) DNA Cell Biol , vol.24 , pp. 605-613
    • Cai, H.1    Yu, D.H.2    Tian, X.3    Zhu, Y.X.4
  • 36
    • 0036126989 scopus 로고    scopus 로고
    • Vaccination of guinea pigs with DNA encoding the mycobacterial antigen MPB83 influences pulmonary pathology but not hematogenous spread following aerogenic infection with Mycobacterium bovis
    • Chambers MA, Williams A, Hatch G, Gavier-Widen D, Hall G, et al. (2002) Vaccination of guinea pigs with DNA encoding the mycobacterial antigen MPB83 influences pulmonary pathology but not hematogenous spread following aerogenic infection with Mycobacterium bovis. Infect Immun 70: 2159-2165.
    • (2002) Infect Immun , vol.70 , pp. 2159-2165
    • Chambers, M.A.1    Williams, A.2    Hatch, G.3    Gavier-Widen, D.4    Hall, G.5
  • 37
    • 79956061128 scopus 로고    scopus 로고
    • In vivo electroporation enhances the immunogenicity of an HIV-1 DNA vaccine candidate in healthy volunteers
    • Vasan S, Hurley A, Schlesinger SJ, Hannaman D, Gardiner DF, et al. (2011) In vivo electroporation enhances the immunogenicity of an HIV-1 DNA vaccine candidate in healthy volunteers. PLoS One 6: e19252.
    • (2011) PLoS One , vol.6
    • Vasan, S.1    Hurley, A.2    Schlesinger, S.J.3    Hannaman, D.4    Gardiner, D.F.5
  • 38
    • 79957781340 scopus 로고    scopus 로고
    • Electroporation delivery of DNA vaccines: prospects for success
    • Sardesai NY, Weiner DB, (2011) Electroporation delivery of DNA vaccines: prospects for success. Curr Opin Immunol 23: 421-429.
    • (2011) Curr Opin Immunol , vol.23 , pp. 421-429
    • Sardesai, N.Y.1    Weiner, D.B.2
  • 39
    • 0035055282 scopus 로고    scopus 로고
    • Protection of mice with a tuberculosis subunit vaccine based on a fusion protein of antigen 85b and esat-6
    • Weinrich Olsen A, van Pinxteren LA, Meng Okkels L, Birk Rasmussen P, Andersen P, (2001) Protection of mice with a tuberculosis subunit vaccine based on a fusion protein of antigen 85b and esat-6. Infect Immun 69: 2773-2778.
    • (2001) Infect Immun , vol.69 , pp. 2773-2778
    • Weinrich Olsen, A.1    van Pinxteren, L.A.2    Meng Okkels, L.3    Birk Rasmussen, P.4    Andersen, P.5
  • 40
    • 67649961505 scopus 로고    scopus 로고
    • Protection and polyfunctional T cells induced by Ag85B-TB10.4/IC31 against Mycobacterium tuberculosis is highly dependent on the antigen dose
    • Aagaard C, Hoang TT, Izzo A, Billeskov R, Troudt J, et al. (2009) Protection and polyfunctional T cells induced by Ag85B-TB10.4/IC31 against Mycobacterium tuberculosis is highly dependent on the antigen dose. PLoS One 4: e5930.
    • (2009) PLoS One , vol.4
    • Aagaard, C.1    Hoang, T.T.2    Izzo, A.3    Billeskov, R.4    Troudt, J.5
  • 41
    • 33845197461 scopus 로고    scopus 로고
    • The risk of disseminated Bacille Calmette-Guerin (BCG) disease in HIV-infected children
    • Hesseling AC, Marais BJ, Gie RP, Schaaf HS, Fine PE, et al. (2007) The risk of disseminated Bacille Calmette-Guerin (BCG) disease in HIV-infected children. Vaccine 25: 14-18.
    • (2007) Vaccine , vol.25 , pp. 14-18
    • Hesseling, A.C.1    Marais, B.J.2    Gie, R.P.3    Schaaf, H.S.4    Fine, P.E.5
  • 42
    • 8144229025 scopus 로고    scopus 로고
    • A polyvalent DNA vaccine expressing an ESAT6-Ag85B fusion protein protects mice against a primary infection with Mycobacterium tuberculosis and boosts BCG-induced protective immunity
    • Derrick SC, Yang AL, Morris SL, (2004) A polyvalent DNA vaccine expressing an ESAT6-Ag85B fusion protein protects mice against a primary infection with Mycobacterium tuberculosis and boosts BCG-induced protective immunity. Vaccine 23: 780-788.
    • (2004) Vaccine , vol.23 , pp. 780-788
    • Derrick, S.C.1    Yang, A.L.2    Morris, S.L.3
  • 43
    • 0035001264 scopus 로고    scopus 로고
    • Priming by DNA immunization augments protective efficacy of Mycobacterium bovis Bacille Calmette-Guerin against tuberculosis
    • Feng CG, Palendira U, Demangel C, Spratt JM, Malin AS, et al. (2001) Priming by DNA immunization augments protective efficacy of Mycobacterium bovis Bacille Calmette-Guerin against tuberculosis. Infect Immun 69: 4174-4176.
    • (2001) Infect Immun , vol.69 , pp. 4174-4176
    • Feng, C.G.1    Palendira, U.2    Demangel, C.3    Spratt, J.M.4    Malin, A.S.5
  • 44
    • 80052305941 scopus 로고    scopus 로고
    • The TLR4 Agonist Monophosphoryl Lipid A Augments Innate Host Resistance to Systemic Bacterial Infection
    • Romero CD, Varma TK, Hobbs JB, Reyes A, Driver B, et al. (2011) The TLR4 Agonist Monophosphoryl Lipid A Augments Innate Host Resistance to Systemic Bacterial Infection. Infect Immun.
    • (2011) Infect Immun
    • Romero, C.D.1    Varma, T.K.2    Hobbs, J.B.3    Reyes, A.4    Driver, B.5
  • 45
    • 60549116006 scopus 로고    scopus 로고
    • Adjuvanticity of a synthetic cord factor analogue for subunit Mycobacterium tuberculosis vaccination requires FcRgamma-Syk-Card9-dependent innate immune activation
    • Werninghaus K, Babiak A, Gross O, Holscher C, Dietrich H, et al. (2009) Adjuvanticity of a synthetic cord factor analogue for subunit Mycobacterium tuberculosis vaccination requires FcRgamma-Syk-Card9-dependent innate immune activation. J Exp Med 206: 89-97.
    • (2009) J Exp Med , vol.206 , pp. 89-97
    • Werninghaus, K.1    Babiak, A.2    Gross, O.3    Holscher, C.4    Dietrich, H.5
  • 46
    • 77951932177 scopus 로고    scopus 로고
    • Cutting edge: Mincle is essential for recognition and adjuvanticity of the mycobacterial cord factor and its synthetic analog trehalose-dibehenate
    • Schoenen H, Bodendorfer B, Hitchens K, Manzanero S, Werninghaus K, et al. (2010) Cutting edge: Mincle is essential for recognition and adjuvanticity of the mycobacterial cord factor and its synthetic analog trehalose-dibehenate. J Immunol 184: 2756-2760.
    • (2010) J Immunol , vol.184 , pp. 2756-2760
    • Schoenen, H.1    Bodendorfer, B.2    Hitchens, K.3    Manzanero, S.4    Werninghaus, K.5
  • 47
    • 80052209319 scopus 로고    scopus 로고
    • The vesicle size of DDA:TDB liposomal adjuvants plays a role in the cell-mediated immune response but has no significant effect on antibody production
    • Henriksen-Lacey M, Devitt A, Perrie Y, (2011) The vesicle size of DDA:TDB liposomal adjuvants plays a role in the cell-mediated immune response but has no significant effect on antibody production. J Control Release.
    • (2011) J Control Release
    • Henriksen-Lacey, M.1    Devitt, A.2    Perrie, Y.3
  • 48
    • 46149125264 scopus 로고    scopus 로고
    • Immunological diversity within a family of cutinase-like proteins of Mycobacterium tuberculosis
    • West NP, Wozniak TM, Valenzuela J, Feng CG, Sher A, et al. (2008) Immunological diversity within a family of cutinase-like proteins of Mycobacterium tuberculosis. Vaccine 26: 3853-3859.
    • (2008) Vaccine , vol.26 , pp. 3853-3859
    • West, N.P.1    Wozniak, T.M.2    Valenzuela, J.3    Feng, C.G.4    Sher, A.5
  • 49
    • 74149085193 scopus 로고    scopus 로고
    • Cutinase-like protein-6 of Mycobacterium tuberculosis is recognised in tuberculosis patients and protects mice against pulmonary infection as a single and fusion protein vaccine
    • Shanahan ER, Pinto R, Triccas JA, Britton WJ, West NP, (2010) Cutinase-like protein-6 of Mycobacterium tuberculosis is recognised in tuberculosis patients and protects mice against pulmonary infection as a single and fusion protein vaccine. Vaccine 28: 1341-1346.
    • (2010) Vaccine , vol.28 , pp. 1341-1346
    • Shanahan, E.R.1    Pinto, R.2    Triccas, J.A.3    Britton, W.J.4    West, N.P.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.