Compound lipophilicity as a descriptor to predict binding affinity (1/ K m) in mammals

Environmental Science and Technology

Volumn 46, Issue 9, 2012, Pages 5168-5174

  Pirovano, Alessandra ^a   Huijbregts, Mark A J ^a   Ragas, Ad M J ^a,b   Hendriks, A Jan ^a  

^a RADBOUD UNIVERSITY NIJMEGEN   (Netherlands)

^b OPEN UNIVERSITY OF THE NETHERLANDS   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOL DEHYDROGENASE; ALDEHYDE DEHYDROGENASE; BINDING AFFINITIES; BIOACCUMULATION MODELS; COMPOUND K; CONFIDENCE INTERVAL; CYTOCHROME P450; DESCRIPTORS; FLAVIN-CONTAINING MONOOXYGENASE; GENERAL PATTERNS; LIPOPHILIC COMPOUNDS; LIPOPHILICITY; METABOLIC RATES; NUCLEOPHILIC ATTACK; REACTION MECHANISM;

ALDEHYDES; BINDING ENERGY; BIOCHEMISTRY; ENZYMES; METABOLISM; WATER SUPPLY SYSTEMS;

MAMMALS;

ALCOHOL DEHYDROGENASE; CYTOCHROME P450; DIMETHYLANILINE MONOOXYGENASE;

BIOACCUMULATION; BIOTRANSFORMATION; CHEMICAL BINDING; ENZYME ACTIVITY; MAMMAL; METABOLITE; PROTEIN; SUBSTRATE;

ARTICLE; BINDING AFFINITY; BIOTRANSFORMATION; CATALYSIS; ENZYME BINDING; ENZYME METABOLISM; HUMAN; LIPOPHILICITY; MAMMAL; NONHUMAN; OXIDATION; PREDICTION;

ALDEHYDE DEHYDROGENASE; ANIMALS; CYTOCHROME P-450 ENZYME SYSTEM; MAMMALS; MODELS, BIOLOGICAL; OXYGENASES; REGRESSION ANALYSIS;

MAMMALIA;

EID: 84860447819     PISSN: 0013936X     EISSN: 15205851     Source Type: Journal    
DOI: 10.1021/es204506g     Document Type: Article

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