Bactericidal activity against meticillin-resistant Staphylococcus aureus of a novel eukaryotic therapeutic recombinant antimicrobial peptide

International Journal of Antimicrobial Agents

Volumn 39, Issue 6, 2012, Pages 496-499

  Li, Qingtian ^a   Huang, Jiewen ^a   Guo, Hongxiong ^b   Guo, Xiaokui ^c   Zhu, Yongzhang ^c   Dong, Ke ^c  

^a SHANGHAI JIAO TONG UNIVERSITY   (China)

^b JIANGSU PROVINCIAL CENTER FOR DISEASE CONTROL AND PREVENTION   (China)

^c SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

Antimicrobial peptide; Bactericidal activity; Eukaryotic expression; Meticillin resistant Staphylococcus aureus

Indexed keywords

BD3 PEPTIDE; CBD PEPTIDE; METICILLIN; POLYPEPTIDE ANTIBIOTIC AGENT; RECOMBINANT PROTEIN; UNCLASSIFIED DRUG; VAX1 PEPTIDE;

BACTERICIDAL ACTIVITY; CELL STRAIN HEK293; CONFERENCE PAPER; CONTROLLED STUDY; DRUG DESIGN; DRUG DETERMINATION; DRUG RESEARCH; DRUG STABILITY; EUKARYOTE; HUMAN; HUMAN CELL; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS INFECTION; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ANTI-BACTERIAL AGENTS; ANTIMICROBIAL CATIONIC PEPTIDES; EUKARYOTIC CELLS; HEK293 CELLS; HUMANS; KIDNEY; METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS; MICROBIAL SENSITIVITY TESTS; RECOMBINANT PROTEINS; TRANSFECTION;

EID: 84860446154     PISSN: 09248579     EISSN: 18727913     Source Type: Journal    
DOI: 10.1016/j.ijantimicag.2012.03.003     Document Type: Conference Paper

References (23)

1. A. Izadpanah, and R.L. Gallo Antimicrobial peptides J Am Acad Dermatol 52 2005 381 390 [quiz 391-2]
2. N. Ostberg, and Y. Kaznessis Protegrin structure-activity relationships: using homology models of synthetic sequences to determine structural characteristics important for activity Peptides 26 2005 197 206 (Pubitemid 40051415)
3. Y.J. Gordon, E.G. Romanowski, and A.M. McDermott A review of antimicrobial peptides and their therapeutic potential as anti-infective drugs Curr Eye Res 30 2005 505 515 (Pubitemid 41113552)
4. Q. Li, Y. Zhou, K. Dong, and X. Guo Potential therapeutic efficacy of a bactericidal-immunomodulatory fusion peptide against methicillin-resistant Staphylococcus aureus skin infection Appl Microbiol Biotechnol 86 2010 305 309
5. L. Huang, J. Wang, Z. Zhong, L. Peng, H. Chen, and Z. Xu Production of bioactive human β-defensin-3 in Escherichia coli by soluble fusion expression Biotechnol Lett 28 2006 627 632
6. H. Ishimoto, H. Mukae, Y. Date, T. Shimbara, M.S. Mondal, and J. Ashitani Identification of hBD-3 in respiratory tract and serum: the increase in pneumonia Eur Respir J 27 2006 253 260 (Pubitemid 43180899)
7. Q.T. Li, Y.Z. Zhu, J.Y. Chu, K. Dong, P. He, and C.Y. Feng Granulocyte-macrophage colony-stimulating factor DNA prime-protein boost strategy to enhance efficacy of a recombinant pertussis DNA vaccine Acta Pharmacol Sin 27 2006 1487 1494 (Pubitemid 44630318)
8. Q. Li, Y. Zhu, J. Chu, Y. Wang, Y. Xu, and Q. Hou Protective immunity against Bordetella pertussis by a recombinant DNA vaccine and the effect of coinjection with a granulocyte-macrophage colony stimulating factor gene Microbiol Immunol 50 2006 929 936 (Pubitemid 44974648)
9. O. Toke Antimicrobial peptides: new candidates in the fight against bacterial infections Biopolymers 80 2005 717 735 (Pubitemid 43266580)
10. H. Fedders, R. Podschun, and M. Leippe The antimicrobial peptide Ci-MAM-A24 is highly active against multidrug-resistant and anaerobic bacteria pathogenic for humans Int J Antimicrob Agents 36 2010 264 266
11. A. Uehara, Y. Fujimoto, K. Fukase, and H. Takada Various human epithelial cells express functional Toll-like receptors, NOD1 and NOD2 to produce anti-microbial peptides, but not proinflammatory cytokines Mol Immunol 44 2007 3100 3111 (Pubitemid 46610510)
12. J.P. Tam, Y.A. Lu, and J.L. Yang Antimicrobial dendrimeric peptides Eur J Biochem 269 2002 923 932 (Pubitemid 34175413)
13. C. Gabay Interleukin-6 and chronic inflammation Arthritis Res Ther 8 Suppl. 2 2006 S3
14. J. Gunther, K. Esch, N. Poschadel, W. Petzl, H. Zerbe, and S. Mitterhuemer Comparative kinetics of Escherichia coli- and Staphylococcus aureus-specific activation of key immune pathways in mammary epithelial cells demonstrates that S. aureus elicits a delayed response dominated by interleukin-6 (IL-6) but not by IL-1A or tumor necrosis factor α Infect Immun 79 2011 695 707
15. F. Sachse, K. Becker, C. von Eiff, D. Metze, and C. Rudack Staphylococcus aureus invades the epithelium in nasal polyposis and induces IL-6 in nasal epithelial cells in vitro Allergy 65 2010 1430 1437
16. S. Someya, M. Kakuta, M. Morita, K. Sumikoshi, W. Cao, and Z. Ge Prediction of carbohydrate-binding proteins from sequences using support vector machines Adv Bioinform 2010 Article ID:289301
17. K.O. Kisich, M.D. Howell, M. Boguniewicz, H.R. Heizer, N.U. Watson, and D.Y. Leung The constitutive capacity of human keratinocytes to kill Staphylococcus aureus is dependent on β-defensin 3 J Invest Dermatol 127 2007 2368 2380 (Pubitemid 47619743)
18. C.I. Chang, and J. Deisenhofer The peptidoglycan recognition proteins LCa and LCx Cell Mol Life Sci 64 2007 1395 1402 (Pubitemid 46889233)
19. B.O. Schroeder, Z. Wu, S. Nuding, S. Groscurth, M. Marcinowski, and J. Beisner Reduction of disulphide bonds unmasks potent antimicrobial activity of human β-defensin 1 Nature 469 2011 419 423
20. L. Liu, Y. Fang, Q. Huang, and J. Wu A rigidity-enhanced antimicrobial activity: a case for linear cationic α-helical peptide HP(2-20) and its four analogues PLoS One 6 2011 e16441
21. D.M. Hoover, Z. Wu, K. Tucker, W. Lu, and J. Lubkowski Antimicrobial characterization of human β-defensin 3 derivatives Antimicrob Agents Chemother 47 2003 2804 2809 (Pubitemid 37040251)
22. J. Harder, J. Bartels, E. Christophers, and J.M. Schroder Isolation and characterization of human β-defensin-3, a novel human inducible peptide antibiotic J Biol Chem 276 2001 5707 5713
23. D. Sawamura, M. Goto, A. Shibaki, M. Akiyama, J.R. McMillan, and Y. Abiko β Defensin-3 engineered epidermis shows highly protective effect for bacterial infection Gene Ther 12 2005 857 861 (Pubitemid 40753978)