Potential therapeutic efficacy of a bactericidal-immunomodulatory fusion peptide against methicillin-resistant Staphylococcus aureus skin infection

Applied Microbiology and Biotechnology

Volumn 86, Issue 1, 2010, Pages 305-309

  Li, Qingtian ^a   Zhou, Yuhua ^a   Dong, Ke ^a   Guo, Xiaokui ^a  

^a SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

Antimicrobial peptide; Fusion peptide; Human defensin 3; MRSA

Indexed keywords

ANGIOGENESIS; ANTIMICROBIAL PEPTIDE; BACTERICIDAL ACTIVITY; BINDING LECTIN; DEFENSINS; FUSION PEPTIDES; FUSION STRATEGIES; IN-VITRO; METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS; SKIN INFECTION; THERAPEUTIC EFFICACY; TISSUE RECONSTRUCTION;

ENZYME INHIBITION; POLYPEPTIDES; STRATEGIC PLANNING;

PEPTIDES;

BETA DEFENSIN 3; HUMAN BETA DEFENSIN 3 LYSOZYME; HUMAN BETA DEFENSIN 3 MANNOSE BINDING LECTIN; HYBRID PROTEIN; POLYPEPTIDE ANTIBIOTIC AGENT; UNCLASSIFIED DRUG;

ANTIBIOTICS; ANTIMICROBIAL ACTIVITY; BACTERIUM; EFFICIENCY MEASUREMENT; ENZYME; INFECTIVITY; PEPTIDE;

ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BACTERICIDAL ACTIVITY; CONTROLLED STUDY; DRUG EFFICACY; DRUG SYNTHESIS; IN VITRO STUDY; IN VIVO STUDY; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS INFECTION; MOUSE; NONHUMAN; SKIN INFECTION; TISSUE REGENERATION;

AMINO ACID SEQUENCE; ANIMALS; BETA-DEFENSINS; HUMANS; IMMUNOLOGIC FACTORS; MALE; MANNOSE-BINDING LECTIN; METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS; MICE; MICE, INBRED BALB C; MICROBIAL SENSITIVITY TESTS; MOLECULAR SEQUENCE DATA; PEPTIDES; RECOMBINANT FUSION PROTEINS; STAPHYLOCOCCAL SKIN INFECTIONS; TREATMENT OUTCOME; WOUND INFECTION;

METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS;

EID: 77149173760     PISSN: 01757598     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00253-009-2313-0     Document Type: Article

References (18)

1. P Amparyup H Kondo I Hirono T Aoki A Tassanakajon 2008 Molecular cloning, genomic organization and recombinant expression of a crustin-like antimicrobial peptide from black tiger shrimp Penaeus monodon Mol Immunol 45 1085 1093 10.1016/j.molimm.2007.07.031 1:CAS:528:DC%2BD2sXht1GhsrbI (Pubitemid 350019500)
2. A Biragyn M Coscia K Nagashima M Sanford HA Young P Olkhanud 2008 Murine beta-defensin 2 promotes TLR-4/MyD88-mediated and NF-kappaB-dependent atypical death of APCs via activation of TNFR2 J Leukoc Biol 83 998 1008 10.1189/jlb.1007700 1:CAS:528:DC%2BD1cXkt1agsLg%3D (Pubitemid 351959881)
3. CA Brissette SA Lukehart 2007 Mechanisms of decreased susceptibility to beta-defensins by Treponema denticola Infect Immun 75 2307 2315 10.1128/IAI.01718-06 1:CAS:528:DC%2BD2sXlsV2msrs%3D (Pubitemid 46744319)
4. HL Cash CV Whitham CL Behrendt LV Hooper 2006 Symbiotic bacteria direct expression of an intestinal bactericidal lectin Science 313 1126 1130 10.1126/science.1127119 1:CAS:528:DC%2BD28XotlCgtLc%3D (Pubitemid 44300239)
5. JM Embil JA McLeod AM Al-Barrak GM Thompson FY Aoki EJ Witwicki MF Stranc AM Kabani DR Nicoll LE Nicolle 2001 An outbreak of methicillin-resistant Staphylococcus aureus on a burn unit: potential role of contaminated hydrotherapy equipment Burns 27 681 688 10.1016/S0305-4179(01)00045-6 1:STN:280:DC%2BD3MrltlGgtw%3D%3D (Pubitemid 32910612)
6. AA Galoyan LI Korochkin EJ Rybalkina GV Pavlova IN Saburina EI Zaraiski NA Galoyan TK Davtyan KB Bezirganyan AV Revishchin 2008 Hypothalamic proline-rich polypeptide enhances bone marrow colony-forming cell proliferation and stromal progenitor cell differentiation Cell Transplant 17 1061 1066 10.3727/096368908786991579 1:STN:280:DC%2BD1M7gsVygsA%3D%3D
7. C Guo H Diao Y Lian H Yu H Gao Y Zhang D Lin 2009 Recombinant expression and characterization of an epididymis-specific antimicrobial peptide BIN1b/SPAG11E J Biotechnol 139 33 37 10.1016/j.jbiotec.2008.10.003 1:CAS:528:DC%2BD1cXhsV2ltr3F
8. J Harder R Glaser JM Schroder 2007 The role and potential therapeutical applications of antimicrobial proteins in infectious and inflammatory diseases Endocr Metab Immune Disord Drug Targets 7 75 82 10.2174/187153007780832091 1:CAS:528:DC%2BD2sXmtFGls7s%3D
9. J He R Eckert T Pharm MD Simanian C Hu DK Yarbrough F Qi MH Anderson W Shi 2007 Novel synthetic antimicrobial peptides against Streptococcus mutans Antimicrob Agents Chemother 51 1351 1358 10.1128/AAC.01270-06 1:CAS:528:DC%2BD2sXktlOjtLw%3D (Pubitemid 46586816)
10. MD Howell N Novak T Bieber S Pastore G Girolomoni M Boguniewicz J Streib C Wong RL Gallo DY Leung 2005 Interleukin-10 downregulates anti-microbial peptide expression in atopic dermatitis J Invest Dermatol 125 738 745 10.1111/j.0022-202X.2005.23776.x 1:CAS:528:DC%2BD2MXhtFChu7zO
11. H Jenssen P Hamill RE Hancock 2006 Peptide antimicrobial agents Clin Microbiol Rev 19 491 511 10.1128/CMR.00056-05 1:CAS:528:DC%2BD28XosVaqsrk%3D (Pubitemid 44137212)
12. AR Koczulla R Bals 2003 Antimicrobial peptides: current status and therapeutic potential Drugs 63 389 406 10.2165/00003495-200363040-00005 1:CAS:528:DC%2BD3sXisVKjtbk%3D (Pubitemid 36259526)
13. R Palffy R Gardlik M Behuliak L Kadasi J Turna P Celec 2009 On the physiology and pathophysiology of antimicrobial peptides Mol Med 15 51 59 1:CAS:528:DC%2BD1MXnvF2lsr8%3D
14. LR Plano B Adkins M Woischnik R Ewing CM Collins 2001 Toxin levels in serum correlate with the development of staphylococcal scalded skin syndrome in a murine model Infect Immun 69 5193 5197 10.1128/IAI.69.8.5193-5197.2001 1:CAS:528:DC%2BD3MXlsV2htrw%3D (Pubitemid 32674511)
15. J Schauber RL Gallo 2008 Antimicrobial peptides and the skin immune defense system J Allergy Clin Immunol 122 261 266 10.1016/j.jaci.2008.03.027 1:CAS:528:DC%2BD1cXpsVGgs7k%3D
16. O Simonetti O Cirioni R Ghiselli G Goteri A Scalise F Orlando C Silvestri A Riva V Saba KD Madanahally A Offidani N Balaban G Scalise A Giacometti 2008 RNAIII-inhibiting peptide enhances healing of wounds infected with methicillin-resistant Staphylococcus aureus Antimicrob Agents Chemother 52 2205 2211 10.1128/AAC.01340-07 1:CAS:528:DC%2BD1cXmvVait70%3D (Pubitemid 351758560)
17. OE Sorensen N Borregaard AM Cole 2008 Antimicrobial peptides in innate immune responses Contrib Microbiol 15 61 77 10.1159/000136315 1:CAS:528:DC%2BD1MXltlSgu7Y%3D
18. M Zaiou 2007 Multifunctional antimicrobial peptides: therapeutic targets in several human diseases J Mol Med 85 317 329 10.1007/s00109-006-0143-4 1:CAS:528:DC%2BD2sXjt1KktbY%3D (Pubitemid 46452258)