Nociceptin/orphanin FQ inhibition with SB612111 ameliorates dextran sodium sulfate-induced colitis

European Journal of Pharmacology

Volumn 683, Issue 1-3, 2012, Pages 285-293

  Alt, Carsten ^a   Lam, Jennifer S ^a   Harrison, M Travis ^a   Kershaw, Kathleen M ^a   Samuelsson, Steven ^a   Toll, Lawrence ^a   D'Andrea, Annalisa ^a  

^a SRI INTERNATIONAL   (United States)

Author keywords

Dextran sodium sulfate induced colitis; Inflammatory bowel disease; N OFQ receptor; Nociceptin orphanin FQ

Indexed keywords

7 [4 (2,6 DICHLOROPHENYL) 1 PIPERIDINYLMETHYL] 6,7,8,9 TETRAHYDRO 1 METHYL 5H BENZOCYCLOHEPTEN 5 OL; CELL ADHESION MOLECULE; CXCL1 CHEMOKINE; GAMMA INTERFERON; INTERLEUKIN 1BETA; INTERLEUKIN 6; KERATINOCYTE DERIVED CHEMOKINE; MESSENGER RNA; NOCICEPTIN; NOCICEPTIN RECEPTOR; NOCICEPTIN RECEPTOR ANTAGONIST; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; COLITIS; CONTROLLED STUDY; CYTOKINE PRODUCTION; DIARRHEA; DISEASE SEVERITY; DOWN REGULATION; DRUG EFFICACY; DRUG MECHANISM; DRUG RECEPTOR BINDING; DRUG SAFETY; FEMALE; HISTOPATHOLOGY; MOLECULAR PATHOLOGY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN TARGETING; RECEPTOR BLOCKING; WEIGHT REDUCTION;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; COLITIS; COLON; CYCLOHEPTANES; CYTOKINES; DEXTRAN SULFATE; DIARRHEA; FEMALE; GASTROINTESTINAL HEMORRHAGE; GENE EXPRESSION REGULATION; INTESTINAL MUCOSA; MICE; MICE, INBRED C57BL; MOLECULAR TARGETED THERAPY; OPIOID PEPTIDES; PIPERIDINES; RECEPTORS, OPIOID; RNA, MESSENGER; SIGNAL TRANSDUCTION; WEIGHT LOSS;

EID: 84860443741     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2012.03.014     Document Type: Article

References (45)

1. C. Alt, M. Laschinger, and B. Engelhardt Functional expression of the lymphoid chemokines CCL19 (ELC) and CCL 21 (SLC) at the blood-brain barrier suggests their involvement in G-protein-dependent lymphocyte recruitment into the central nervous system during experimental autoimmune encephalomyelitis Eur. J. Immunol. 32 2002 2133 2144
2. J. Arjomand, S. Cole, and C.J. Evans Novel orphanin FQ/nociceptin transcripts are expressed in human immune cells J. Neuroimmunol. 130 2002 100 108
3. F. Baert, M. Noman, S. Vermeire, G. Van Assche, G. D'Haens, A. Carbonez, and P. Rutgeerts Influence of immunogenicity on the long-term efficacy of infliximab in Crohn's disease N. Engl. J. Med. 348 2003 601 608
4. S. Becker, J. Quay, H.S. Koren, and J.S. Haskill Constitutive and stimulated MCP-1, GRO alpha, beta, and gamma expression in human airway epithelium and bronchoalveolar macrophages Am. J. Physiol. 266 1994 L278 L286
5. E.I. Benchimol, C.H. Seow, A.H. Steinhart, and A.M. Griffiths Traditional corticosteroids for induction of remission in Crohn's disease Cochrane Database Syst. Rev. 2008 CD006792
6. E. Bettelli, T. Korn, and V.K. Kuchroo Th17: the third member of the effector T cell trilogy Curr. Opin. Immunol. 19 2007 652 657
7. M. Bosani, S. Ardizzone, and G.B. Porro Biologic targeting in the treatment of inflammatory bowel diseases Biologics 3 2009 77 97
8. Z.L. Brookes, E.N. Stedman, R. Guerrini, B.K. Lawton, G. Calo, and D.G. Lambert Proinflammatory and vasodilator effects of nociceptin/orphanin FQ in the rat mesenteric microcirculation are mediated by histamine Am. J. Physiol. Heart Circ. Physiol. 293 2007 H2977 H2985
9. D. Carvalho, F. Petronilho, F. Vuolo, R.A. Machado, L. Constantino, R. Guerrini, G. Calo, E.C. Gavioli, E.L. Streck, and F. Dal-Pizzol The nociceptin/orphanin FQ-NOP receptor antagonist effects on an animal model of sepsis Intensive Care Med. 34 2008 2284 2290
10. S.P. Commins, L. Borish, and J.W. Steinke Immunologic messenger molecules: cytokines, interferons, and chemokines J. Allergy Clin. Immunol. 125 2010 S53 S72
11. L.A. Dieleman, B.U. Ridwan, G.S. Tennyson, K.W. Beagley, R.P. Bucy, and C.O. Elson Dextran sulfate sodium-induced colitis occurs in severe combined immunodeficient mice Gastroenterology 107 1994 1643 1652
12. G.J. Dockray, R.A. Gregory, H.J. Tracy, and W.Y. Zhu Transport of cholecystokinin-octapeptide-like immunoreactivity toward the gut in afferent vagal fibres in cat and dog J. Physiol. 314 1981 501 511
13. D. Economidou, F. Policani, T. Angellotti, M. Massi, T. Terada, and R. Ciccocioppo Effect of novel NOP receptor ligands on food intake in rats Peptides 27 2006 775 783
14. B. Egger, M. Bajaj-Elliott, T.T. MacDonald, R. Inglin, V.E. Eysselein, and M.W. Buchler Characterisation of acute murine dextran sodium sulphate colitis: cytokine profile and dose dependency Digestion 62 2000 240 248
15. R.J. Farrell, M. Alsahli, Y.T. Jeen, K.R. Falchuk, M.A. Peppercorn, and P. Michetti Intravenous hydrocortisone premedication reduces antibodies to infliximab in Crohn's disease: a randomized controlled trial Gastroenterology 124 2003 917 924
16. B.G. Feagan Maintenance therapy for inflammatory bowel disease Am. J. Gastroenterol. 98 2003 S6 S17
17. C. Fiocchi Inflammatory bowel disease: etiology and pathogenesis Gastroenterology 115 1998 182 205
18. M.E. Fiset, C. Gilbert, P.E. Poubelle, and M. Pouliot Human neutrophils as a source of nociceptin: a novel link between pain and inflammation Biochemistry 42 2003 10498 10505
19. A.R. Gintzler, I.D. Adapa, L. Toll, V.M. Medina, and L. Wang Modulation of enkephalin release by nociceptin (orphanin FQ) Eur. J. Pharmacol. 325 1997 29 34
20. J.S. Hom, I. Goldberg, J. Mathis, Y.X. Pan, A.I. Brooks, J. Ryan-Moro, D.A. Scheinberg, and G.W. Pasternak [(125)I]orphanin FQ/nociceptin binding in Raji cells Synapse 34 1999 187 191
21. N. Iida, and G.R. Grotendorst Cloning and sequencing of a new gro transcript from activated human monocytes: expression in leukocytes and wound tissue Mol. Cell. Biol. 10 1990 5596 5599
22. D.E. Kaminsky, and T.J. Rogers Suppression of CCL2/MCP-1 and CCL5/RANTES expression by nociceptin in human monocytes J. Neuroimmune Pharmacol. 3 2008 75 82
23. M.D. Kappelman, S.L. Rifas-Shiman, C.Q. Porter, D.A. Ollendorf, R.S. Sandler, J.A. Galanko, and J.A. Finkelstein Direct health care costs of Crohn's disease and ulcerative colitis in US children and adults Gastroenterology 135 2008 1907 1913
24. S. Kato, Y. Tsuzuki, R. Hokari, Y. Okada, J. Miyazaki, K. Matsuzaki, A. Iwai, A. Kawaguchi, S. Nagao, K. Itoh, H. Suzuki, T. Nabeshima, and S. Miura Role of nociceptin/orphanin FQ (Noc/oFQ) in murine experimental colitis J. Neuroimmunol. 161 2005 21 28
25. Y. Kobayashi The role of chemokines in neutrophil biology Front. Biosci. 13 2008 2400 2407
26. S. Melgar, L. Karlsson, E. Rehnstrom, A. Karlsson, H. Utkovic, L. Jansson, and E. Michaelsson Validation of murine dextran sulfate sodium-induced colitis using four therapeutic agents for human inflammatory bowel disease Int. Immunopharmacol. 8 2008 836 844
27. J.C. Meunier, C. Mollereau, L. Toll, C. Suaudeau, C. Moisand, P. Alvinerie, J.L. Butour, J.C. Guillemot, P. Ferrara, and B. Monsarrat Isolation and structure of the endogenous agonist of opioid receptor-like ORL1 receptor Nature 377 1995 532 535
28. N.A. Molodecky, I.S. Soon, D.M. Rabi, W.A. Ghali, M. Ferris, G. Chernoff, E.I. Benchimol, R. Panaccione, S. Ghosh, H.W. Barkema, and G.G. Kaplan Increasing incidence and prevalence of the inflammatory bowel diseases with time, based on systematic review Gastroenterology 142 2012 46 54 (e42; quiz e30)
29. J. Peluso, K.S. LaForge, H.W. Matthes, M.J. Kreek, B.L. Kieffer, and C. Gaveriaux-Ruff Distribution of nociceptin/orphanin FQ receptor transcript in human central nervous system and immune cells J. Neuroimmunol. 81 1998 184 192
30. J. Peluso, C. Gaveriaux-Ruff, H.W. Matthes, D. Filliol, and B.L. Kieffer Orphanin FQ/nociceptin binds to functionally coupled ORL1 receptors on human immune cell lines and alters peripheral blood mononuclear cell proliferation Brain Res. Bull. 54 2001 655 660
31. R.K. Reinscheid, H.P. Nothacker, A. Bourson, A. Ardati, R.A. Henningsen, J.R. Bunzow, D.K. Grandy, H. Langen, F.J. Monsma Jr., and O. Civelli Orphanin FQ: a neuropeptide that activates an opioidlike G protein-coupled receptor Science 270 1995 792 794
32. P. Rutgeerts, G. Van Assche, and S. Vermeire Optimizing anti-TNF treatment in inflammatory bowel disease Gastroenterology 126 2004 1593 1610
33. W.J. Sandborn Treatment of ulcerative colitis with oral mesalamine: advances in drug formulation, efficacy expectations and dose response, compliance, and chemoprevention Rev. Gastroenterol. Disord. 6 2006 97 105
34. C.N. Serhan, I.M. Fierro, N. Chiang, and M. Pouliot Cutting edge: nociceptin stimulates neutrophil chemotaxis and recruitment: inhibition by aspirin-triggered-15-epi-lipoxin A4 J. Immunol. 166 2001 3650 3654
35. C.A. Siegel, and B.E. Sands Review article: practical management of inflammatory bowel disease patients taking immunomodulators Aliment. Pharmacol. Ther. 22 2005 1 16
36. W. Strober, I.J. Fuss, and R.S. Blumberg The immunology of mucosal models of inflammation Annu. Rev. Immunol. 20 2002 495 549
37. W. Strober, I. Fuss, and P. Mannon The fundamental basis of inflammatory bowel disease J. Clin. Invest. 117 2007 514 521
38. S. Trombella, R. Vergura, S. Falzarano, R. Guerrini, G. Calo, and S. Spisani Nociceptin/orphanin FQ stimulates human monocyte chemotaxis via NOP receptor activation Peptides 26 2005 1497 1502
39. J.P. Williams, J.P. Thompson, J. McDonald, T.A. Barnes, T. Cote, D.J. Rowbotham, and D.G. Lambert Human peripheral blood mononuclear cells express nociceptin/orphanin FQ, but not mu, delta, or kappa opioid receptors Anesth. Analg. 105 2007 998 1005 (table of contents)
40. J.P. Williams, J.P. Thompson, S.P. Young, S.J. Gold, J. McDonald, D.J. Rowbotham, and D.G. Lambert Nociceptin and urotensin-II concentrations in critically ill patients with sepsis Br. J. Anaesth. 100 2008 810 814
41. S. Wirtz, C. Neufert, B. Weigmann, and M.F. Neurath Chemically induced mouse models of intestinal inflammation Nat. Protoc. 2 2007 541 546
42. R.J. Xavier, and D.K. Podolsky Unravelling the pathogenesis of inflammatory bowel disease Nature 448 2007 427 434
43. Y. Yan, V. Kolachala, G. Dalmasso, H. Nguyen, H. Laroui, S.V. Sitaraman, and D. Merlin Temporal and spatial analysis of clinical and molecular parameters in dextran sodium sulfate induced colitis PLoS One 4 2009 e6073
44. L. Yun, and S. Hanauer Selecting appropriate anti-TNF agents in inflammatory bowel disease Expert Rev. Gastroenterol. Hepatol. 3 2009 235 248
45. P.F. Zaratin, G. Petrone, M. Sbacchi, M. Garnier, C. Fossati, P. Petrillo, S. Ronzoni, G.A. Giardina, and M.A. Scheideler Modification of nociception and morphine tolerance by the selective opiate receptor-like orphan receptor antagonist (-)-cis-1-methyl-7-[[4-(2,6-dichlorophenyl)piperidin-1-yl] methyl]-6,7,8,9-tetrahydro-5H-benzocyclohepten-5-ol (SB-612111) J. Pharmacol. Exp. Ther. 308 2004 454 461