Intercepting neoplastic progression in lung malignancies via the beta adrenergic (β-AR) pathway: Implications for anti-cancer drug targets

Pharmacological Research

Volumn 66, Issue 1, 2012, Pages 33-40

  Al Wadei, Hussein A N ^a,b   Ullah, Mohammad F ^a   Al Wadei, Mohammed H ^a  

^a UNIVERSITY OF TENNESSEE   (United States)

^b SANA A UNIVERSITY   (Yemen)

Author keywords

Adrenergic receptors pathway; Anti cancer drug; Drug targets; Lung cancer

Indexed keywords

3 ISOPROPYLAMINO 1 (7 METHYL 4 INDANYLOXY) 2 BUTANOL; 4 (3 CHLOROANILINO) 6,7 DIMETHOXYQUINAZOLINE; 4 (METHYLNITROSAMINO) 1 (3 PYRIDYL) 1 BUTANONE; 4 AMINOBUTYRIC ACID; ADENYLATE CYCLASE; ALITRETINOIN; ALPHA TOCOPHEROL; ANTINEOPLASTIC AGENT; ATENOLOL; BETA 1 ADRENERGIC RECEPTOR; BETA ADRENERGIC RECEPTOR; BETA CAROTENE; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; DEXAMETHASONE; EPIDERMAL GROWTH FACTOR RECEPTOR; GLUCOCORTICOID; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; ISOTRETINOIN; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; N [2 (4 BROMOCINNAMYLAMINO)ETHYL] 5 ISOQUINOLINESULFONAMIDE; NICOTINE; PROPRANOLOL; RETINOIC ACID; RETINOID; RETINOL; STAT PROTEIN; UNINDEXED DRUG;

ANTIINFLAMMATORY ACTIVITY; ANTINEOPLASTIC ACTIVITY; CANCER GROWTH; CANCER RADIOTHERAPY; CHEMOPROPHYLAXIS; DRUG EFFICACY; DRUG TARGETING; ENZYME PHOSPHORYLATION; HUMAN; LUNG ADENOCARCINOMA; LUNG CANCER; LUNG CARCINOGENESIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECEPTOR AFFINITY; REVIEW; SIGNAL TRANSDUCTION; SMOKING; UNSPECIFIED SIDE EFFECT; VITAMIN SUPPLEMENTATION;

ADRENERGIC BETA-ANTAGONISTS; ANIMALS; ANTINEOPLASTIC AGENTS; CELL PROLIFERATION; CELL TRANSFORMATION, NEOPLASTIC; GABA AGONISTS; HUMANS; LUNG NEOPLASMS; RECEPTORS, ADRENERGIC, BETA; RISK FACTORS; SIGNAL TRANSDUCTION;

EID: 84860439227     PISSN: 10436618     EISSN: 10961186     Source Type: Journal    
DOI: 10.1016/j.phrs.2012.03.014     Document Type: Review

References (81)

1. A. Jemal, R. Siegel, J. Xu, and E. Ward Cancer statistics, 2010 CA Cancer J Clin 60 2010 277 300
2. J.R. Benson, and S.S. Liau Cancer genetics: a primer for surgeons Surg Clin N Am 88 2008 681 704 (Pubitemid 352040752)
3. R.J. Lefkowitz, B.B. Hoffman, and P. Taylor Neurohumoral transmission: the autonomic and somatic motor nervous systems A. Goodman Gilman, T.W. Rall, A.S. Nies, P. Taylor, The pharmacological basis of therapeutics 8th edn 1990 Pergamon Press New York 84 121
4. H.J. Mersmann Overview of the effects of beta-adrenergic receptor agonists on animal growth including mechanisms of action J Anim Sci 76 1998 160 172 (Pubitemid 128439620)
5. H. Al-Wadei, T. Takahashi, and H.M. Schuller Caffeine stimulates the proliferation of human lung adenocarcinoma cells and small airway epithelial cells via activation of PKA, CREB and ERK1/2 Oncol Rep 15 2006 431 435
6. D. Palm, K. Lang, B. Niggemann, T.L. Drell 4th, K. Masur, and Zaenker The norepinephrine-driven metastasis development of PC-3 human prostate cancer cells in BALB/c nude mice is inhibited by beta-blockers Int J Cancer 118 2006 2744 2749 (Pubitemid 43673352)
7. K. Masur, B. Niggemann, K.S. Zanker, and F. Entschladen Norepinephrine-induced migration of SW 480 colon carcinoma cells is inhibited by beta-blockers Cancer Res 61 2001 2866 2869 (Pubitemid 32691927)
8. V.Y. Shin, W.K.K. Wu, K.M. Chu, M.W. Koo, H.P. Wong, and E.K. Lam Functional role of beta-adrenergic receptors in the mitogenic action of nicotine on gastric cancer cells Toxicol Sci 96 2007 21 29 (Pubitemid 46323205)
9. T.L. Drell, J. Joseph, K. Lang, B. Niggemann, K.S. Zaenker, and F. Entschladen Effects of neurotransmitters on the chemokinesis and chemotaxis of MDA-MB-468 human breast carcinoma cells Breast Cancer Res Treat 80 2003 63 70 (Pubitemid 36851285)
10. A.K. Sood, R. Bhatty, A.A. Kamat, C.N. Landen, L. Han, and P.H. Thaker Stress hormone mediated invasion of ovarian cancer cells Clin Cancer Res 12 2006 369 375 (Pubitemid 43166123)
11. B. Marchetti, P.G. Spinola, G. Pelletier, and F. Labrie A potential role for catecholamines in the development and progression of carcinogen-induced mammary tumors: hormonal control of beta-adrenergic receptors and correlation with tumor growth J Steroid Biochem Mol Biol 38 1991 307 320
12. D.G. Powe, M.J. Voss, H.O. Habashy, K.S. Zanker, A.R. Green, and I.O. Allis Alpha- and beta-adrenergic receptor (AR) protein expression is associated with poor clinical outcome in breast cancer: an immunohistochemical study Breast Cancer Res Treat 130 2011 457 463
13. H.A. Al-Wadei, H.K. Plummer 3rd, M.F. Ullah, B. Unger, J.R. Brody, and H.M. Schuller Social stress promotes and γ-aminobutyric acid inhibits tumor growth in mouse models of non-small cell lung cancer Cancer Prev Res 5 2012 189 196
14. S.L. Parker, T. Tong, S. Bolden, and P.A. Wingo Cancer statistics 1997 CA Cancer J Clin 47 1997 5 23
15. D. Hoffmann, A. Rivenson, S. Murphy, F.L. Chung, S. Amin, and S.S. Hecht Cigarette smoking and adenocarcinoma of lungs: the relevance of nicotine derived-nitrosamines J Smoking Relat Disord 4 1993 165 190
16. S.A. Khuder Effect of cigarette smoking on major histological types of lung cancer: a metaanalysis Lung Cancer 31 2001 139 148 (Pubitemid 32107010)
17. J.M. Ostrowski, A. Kjelsberg, M.G. Caron, and R.J. Lefkowitz Mutagenesis of the β2-adrenergic receptor: how structure elucidates function Annu Rev Pharmacol Toxicol 32 1992 167 183
18. T.W. Rall Drugs used in the treatment of asthma A. Goodman-Gilman, T.W. Rall, A.S. Nies, P. Taylor, The pharmacological basis of therapeutics 1990 Pergamon Press New York 618 637
19. E. Miele The nicotinic stimulation of the cat adrenal medulla Arch Int Pharmacodyn Ther 179 1969 343 351
20. T. Maki, K. Kontula, and M. Harkonn The beta-adrenergic system in man: physiological and pathophysiological response. Regulation of receptor density and functioning Scand J Clin Invest Suppl 201 1990 25 43 (Pubitemid 20271059)
21. D. Hoffmann, M.V. Djordjevich, and I. Hoffmann The changing cigarette Prev Med 26 1997 427 434 (Pubitemid 27314094)
22. D. Hoffmann, A. Rivenson, F.L. Chung, and S.S. Hecht Nicotine-derived nitrosamines (TSNA) and their relevance in tobacco carcinogenesis Crit Rev Toxicol 21 1991 305 311
23. H.M. Schuller, H.P. Witschi, E. Nylen, P.A. Joshi, E. Correa, and K.L. Becker Pathobiology of lung tumors induced in hamsters by 4-(methylnitrosamino)- 1-(3-pyridyl)-1-butanone and the modulating effect of hyperoxia Cancer Res 50 1990 1960 1965 (Pubitemid 20098851)
24. H.M. Schuller, B. Porter, and A. Riechert β-Adrenergic modulation of NNK-induced lung carcinogenesis in hamsters J Cancer Res Clin Oncol 126 2000 624 630
25. E. Laag, M. Majidi, M. Cekanova, T. Masi, T. Takahashi, and H.M. Schuller NNK activates ERK1/2 and CREB/ATF-1 via β-1-AR and EGFR signaling in human lung adenocarcinoma and small airway epithelial cells Int J Cancer 119 2006 1547 1552 (Pubitemid 44258759)
26. S.T. Mayne, J. Buenconsejo, and D.T. Janerich Previous lung disease and risk of lung cancer among men and women nonsmokers Am J Epidemiol 149 1999 13 20 (Pubitemid 29028857)
27. S.I. Rennard Treatment of stable chronic obstructive pulmonary disease Lancet 364 2004 791 802 (Pubitemid 39165101)
28. S. Kuyucu, S. Unal, N. Kuyucu, and E. Yilgor Additive effects of dexamethasone in nebulized salbutamol or l-epinephrine treated infants with acute bronchiolitis Pediatr Int 46 2004 539 544 (Pubitemid 39423198)
29. R. Yao, Y. Wang, W.J. Lemon, R.A. Lubet, and M. You Budesonide exerts its chemopreventive efficacy during mouse lung tumourigenesis by modulating gene expressions Oncogene 23 2004 7746 7752 (Pubitemid 39424933)
30. I. Rogatsky, A.B. Hittelman, D. Pearce, and M.J. Garabedian Distinct glucocorticoid receptor transcriptional regulatory surfaces mediate the cytotoxic and cytostatic effects of glucocorticoids Mol Cell Biol 19 1999 5036 5049 (Pubitemid 29289542)
31. Z. Wang, and M.J. Garabedian Modulation of glucocorticoid receptor transcriptional activation, phosphorylation, and growth inhibition by p27Kip1 J Biol Chem 278 2003 50897 50901 (Pubitemid 38020320)
32. H.A.N. Al-Wadei, T. Takahasi, and H.M. Schuller PKA-dependent growth stimulation of cells derived from human pulmonary adenocarcinoma and small airway epithelium by dexamethasone Eur J Cancer 41 2005 2745 2753 (Pubitemid 41607568)
33. H.M. Schuller, P.K. Tithof, M. Williams, and H. Plummer 3rd. The tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone is a beta-adrenergic agonist and stimulates DNA synthesis in lung adenocarcinoma via beta-adrenergic receptor-mediated release of arachidonic acid Cancer Res 59 1999 4510 4515 (Pubitemid 29428948)
34. H.A. Adissu, and H.M. Schuller Antagonistic growth regulation of cell lines derived from human lung adenocarcinomas of Clara cell and aveolar type II cell lineage: implications for chemoprevention Int J Oncol 24 2004 1467 1472
35. M.B. Sporn, and N. Suh Chemoprevention: an essential approach to controlling cancer Nat Rev Cancer 2 2002 537 543 (Pubitemid 37328935)
36. Group TA-TB-CCPS The effects of vitamin E and beta-carotene on the incidence of lung cancer and other organs in male smokers N Eng J Med 330 1994 1029 1035
37. G.S. Omenn, G.E. Goodman, M.D. Thornquist, J. Balmes, M.R. Cullen, and A. Glass Effects of a combination of beta carotene and vitamin A on lung cancer and cardiovascular disease N Engl J Med 334 1996 1150 1155 (Pubitemid 26137973)
38. H.A.N. Al-Wadei, and H.M. Schuller Cyclic adenosine monophosphate- dependent cell type-specific modulation of mitogenic signaling by retinoids in normal and neoplastic lung cells Cancer Detect Prev 30 2006 403 411 (Pubitemid 44750408)
39. H.A.N. Al-Wadei, and H.M. Schuller Beta-carotene promotes the development of NNK-induced small airway-derived lung adenocarcinoma Eur J Cancer 45 2009 1257 1264
40. G. Re, P. Badino, C. Girardi, and F. Di Carlo Effects of a β2-agonist clenbuterol on cultured human (CG-5) breast cancer cells Pharmacol Res 26 1992 377 384 (Pubitemid 23036561)
41. S. Yang, R. Guzman, S. Richards, W. Imagawa, K. McCormick, and S. Nandi Growth factor and cyclic nucleotide-induced proliferation of normal and malignant mammary epithelial cells Endocrinology 107 1980 35 41 (Pubitemid 10080385)
42. D.M. Klein, and R.F. Loizzi Enhancement of R3230 AC rat mammary tumor growth and cellular differentiation by dibutyrylic cAMP J Natl Cancer Inst 158 1988 813 818
43. X.E.N. Huang, N. Hamajima, T. Saito, K. Matsuo, M. Mizutani, and H. Iwata Possible association of beta2- and beta3-adrenergic receptor gene polymorphisms with susceptibility to breast cancer Breast Cancer Res 3 2001 264 269 (Pubitemid 32631704)
44. K.S. Madden, M.J. Szpunar, and E.B. Brown β-Adrenergic receptors (β-AR) regulate VEGF and IL-6 production by divergent pathways in high β-AR-expressing breast cancer cell lines Breast Cancer Res Treat 130 2011 747 758
45. V.Y. Shin, H.C. Jin, E.K. Ng, J. Yu, W.K. Leung, and C.H. Cho Nicotine and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone induce cyclooxygenase-2 activity in human gastric cancer cells: involvement of nicotinic acetylcholine receptor (nAChR) and β-adrenergic receptor signaling pathways Toxicol Appl Pharmacol 233 2008 254 261 (Pubitemid 50301023)
46. M. Unakami, M. Hara, S. Fukuchi, and H. Akiyama Cancer of the gastric cardia and the habit of smoking Acta Pathol Jpn 39 1989 420 424 (Pubitemid 19241342)
47. V.Y. Shin, W.K. Wu, K.M. Chu, M.W. Koo, H.P. Wong, and E.R. Lam Functional role of beta-adrenergic receptors in the mitogenic action of nicotine on gastric cancer cells Toxicol Sci 96 2007 21 29 (Pubitemid 46323205)
48. W.K. Wu, H.P. Wong, S.W. Luo, K. Chen, F.Y. Huang, and M.K. Hui 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone from cigarette smoke stimulates colon cancer growth via beta-adrenoceptors Cancer Res 65 2005 5272 5277 (Pubitemid 40827338)
49. P. Thomas, H. Hayashi, R. Zimmer, and R.A. Forse Regulation of cytokine production in carcinoembryonic antigen stimulated Kupffer cells by β-2 adrenergic receptors: implications for hepatic metastasis Cancer Lett 209 2004 251 257 (Pubitemid 38678654)
50. S.K. Lutgendorf, K. DeGeest, C.Y. Sung, J.M. Arevalo, F. Penedo, and J. Lucci 3rd Depression, social support, and beta-adrenergic transcription control in human ovarian cancer Brain Behav Immun 23 2009 176 183
51. P.H. Thaker, S.K. Lutgedorf, and A.K. Sood The neuroendocrine impact of chronic stress on cancer Cell Cycle 6 2007 430 433 (Pubitemid 46393445)
52. H.L. Lung, S.W. Shan, D. Tsang, and K.M. Leung Tumor necrosis factor-α mediates the proliferation of rat C6 glioma cells via β-adrenergic receptors J Neuroimmunol 166 2005 102 112 (Pubitemid 41074661)
53. K.T. McVary, K.E. McKenna, and C. Lee Prostate innervation Prostate Suppl 8 1998 2 13 (Pubitemid 28347989)
54. M.G. Juarranz, L.G. Guijarro, A.M. Bajo, M.J. Carmena, and J.C. Prieto Ontogeny of vasoactive intestinal peptide receptors in rat ventral prostate Gen Pharmacol 5 1994 509 514 (Pubitemid 24173070)
55. M.J. Carmena, C. Clemente, I. Carrero, R.M. Solano, and J.C.G. Prieto Proteins and β-adrenergic stimulation of adenylate cyclase activity in the diabetic rat prostate Prostate 33 1997 46 54 (Pubitemid 27381594)
56. M.E. Cox, P.D. Deeble, S. Lakhani, and S.J. Parsons Acquisition of neuroendocrine characteristics by prostate tumor cells is reversible: implications for prostate cancer progression Cancer Res 59 1999 3821 3830 (Pubitemid 29381892)
57. M.E. Cox, P.D. Deeble, E.A. Bissonette, and S.J. Parsons Activated 3″,5″-cyclic AMP dependent protein kinase is sufficient to induce neuroendocrine like differentiation of the LNCaP prostate tumor cell line J Biol Chem 275 2000 13812 13818 (Pubitemid 30257454)
58. R.B. Penn, T. Frielle, J.R. McCullough, G. Aberg, and J.L. Benovic Comparison of R-, S-, and RS-albuterol interaction with human β1 and β2-adrenergic receptors Clin Rev Allergy Immunol 14 1996 37 45 (Pubitemid 126442501)
59. R. Nagmani, D.S. Pasco, R.D. Salas, and D.R. Feller Evaluation of β-adrenergic receptor subtypes in the human prostate cancer cell line-LNCaP Biochem Pharmacol 65 2003 1489 1494 (Pubitemid 36555836)
60. B.M. Psaty, N.L. Smith, D.S. Siscovick, T.D. Koepsell, N.S. Weiss, and S.R. Heckbert Health outcomes associated with antihypertensive therapies used as first-line agents. A systematic review and meta-analysis J Am Med Assoc 277 1997 739 745 (Pubitemid 27106227)
61. E.M. Chavey The importance of beta blockers in the treatment of heart failure Am Fam Physician 62 2000 2453 2462
62. D.G. Powe, M.J. Voss, K.S. Zänker, H.O. Habashy, A.R. Green, and I.O. Ellis Beta-blocker drug therapy reduces secondary cancer formation in breast cancer and improves cancer specific survival Oncotarget 1 2010 628 638
63. T.I. Barron, R.M. Connolly, L. Sharp, K. Bennett, and K. Visvanathan Beta blockers and breast cancer mortality: a population-based study J Clin Oncol 29 2011 2635 2644
64. A. Melhem-Bertrandt, M. Chavez-MacGregor, X. Lei, E.N. Brown, R.T. Lee, and F. Meric-Bernstam Beta-blocker use is associated with improved relapse-free survival in patients with triple-negative breast cancer J Clin Oncol 29 2011 2645 2652
65. M. Franek History and the present of metabotropic GABAB receptor Cesk Fysiol 53 2004 117 124
66. R.W. Chapman, J.A. Hey, C.A. Rizzo, and D.C. Bolser GABAB receptors in the lung Trends Pharmacol Sci 14 1993 26 29
67. H.M. Schuller, H.A.N. Al-Wadei, and M. Majidi Gamma-aminobutyric acid, a potential tumor suppressor for small airway-derived lung adenocarcinoma Carcinogenesis 29 2008 1979 1985
68. A. Gladkevich, J. Korf, V.P. Hakobyan, and K.V. Melkonyan The peripheral GABAergic system as a target in endocrine disorders Auton Neurosci 124 2006 1 8
69. M. Oka, M. Wada, Q. Wu, A. Yamamota, and T. Fujita Functional expression of metabotropic GABAB receptors in primary cultures of astrocyets from rat cerebral cortex Biochem Biophys Res Commun 341 2006 874 881 (Pubitemid 43177570)
70. Y. Osawa, D. Xu, D. Sternberg, J.R. Sonett, J. D'Armiento, and R.A. Panettieri Functional expression of the GABA receptor in human airway smooth muscle Am J Physiol Lung Cell Mol Physiol 291 2006 923 931
71. G.E. Pereira, J.P. Gaudillere, P. Pieri, G. Hilbert, M. Maucourt, and C. Deborde Microclimate influence on mineral and metabolic profiles of grape berries J Agric Food Chem 54 2006 6765 6775 (Pubitemid 44426957)
72. B.J. Shelp, A.W. Bown, and D. Faure Extracellular gamma-aminobutyrate mediates communication between plants and other organisms Plant Physiol 142 2006 1350 1352 (Pubitemid 44956918)
73. F. Shizuka, Y. Kido, T. Nakazawa, H. Kitajima, C. Aizawa, and H. Kayamura Antihypertensive effect of gamma-amino butyric acid enriched soy products in spontaneously hypertensive rats Biofactors 22 2004 165 167
74. H. Kim, P. Hall, M. Smith, M. Kirk, J.K. Prasain, and S. Barnes Chemoprevention by grape seed extract and genistein in carcinogen-induced mammary cancer in rats is diet dependent J Nutr 134 2004 3445S 3452S (Pubitemid 39587588)
75. B.B. Aggarwal, and S. Shishodia Molecular targets of dietary agents for prevention and therapy of cancer Biochem Pharmacol 14 2006 1397 1421
76. M.F. Ullah, U. Shamim, S. Hanif, A.S. Azmi, and S.M. Hadi Cellular DNA breakage by soy isoflavone genistein and its methylated structural analogue biochanin A Mol Nutr Food Res 53 2009 1376 1385
77. M.F. Ullah, and M.W. Khan Food as medicine: potential therapeutic tendencies of plant derived polyphenolic compounds Asian Pac J Cancer Prev 9 2008 187 195
78. M. Ezzati, S.J. Henley, A.D. Lopez, and M.J. Thun Role of smoking in global and regional cancer epidemiology: current patterns and data needs Int J Cancer 116 2005 963 971 (Pubitemid 41209205)
79. H. Vainio, and E. Weiderpass Fruit and vegetables in cancer prevention Nutr Cancer 54 2006 111 142 (Pubitemid 44141342)
80. C.H. Adlercreutz, B.R. Goldin, S.L. Gorbach, K.A. Hockerstedt, S. Watanabe, and E.K. Hamalainen Soybean phytoestrogen intake and cancer risk J Nutr 125 1995 757 770
81. H.M. Schuller Is cancer triggered by altered signaling of nicotinic acetylcholine receptors? Nat Rev Cancer 9 2009 195 205