Bioisosteric approach to the discovery of imidazo[1,2-a]pyrazines as potent Aurora kinase inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 1, 2011, Pages 592-598

  Meng, Zhaoyang ^a   Kulkarni, Bheemashankar A ^a   Kerekes, Angela D ^a   Mandal, Amit K ^a   Esposite, Sara J ^a   Belanger, David B ^a   Reddy, Panduranga Adulla ^a   Basso, Andrea D ^a   Tevar, Seema ^a   Gray, Kimberly ^a   Jones, Jennifer ^a   Smith, Elizabeth B ^a   Doll, Ronald J ^a   Siddiqui, M Arshad ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Aurora kinase inhibitors; Bioisosterism; Imidazo 1,2 a pyrazine

Indexed keywords

IMIDAZOPYRAZINE DERIVATIVE;

ARTICLE; DRUG INHIBITION; DRUG STRUCTURE; DRUG SYNTHESIS; SUBSTITUTION REACTION;

ANIMALS; DRUG EVALUATION, PRECLINICAL; IMIDAZOLES; PROTEIN KINASE INHIBITORS; PROTEIN-SERINE-THREONINE KINASES; PYRAZINES; RATS;

EID: 78650517364     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2010.10.008     Document Type: Article

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