BCAR1 protein plays important roles in carcinogenesis and predicts poor prognosis in non-small-cell lung cancer

PLoS ONE

Volumn 7, Issue 4, 2012, Pages

  Huang, Wei ^a   Deng, Bo ^a   Wang, Ru Wen ^a   Tan, Qun You ^a   He, Yong ^a   Jiang, Yao Guang ^a   Zhou, Jing Hai ^a  

^a THIRD MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CRK ASSOCIATED SUBSTRATE PROTEIN; SYNAPTOPHYSIN; BCAR1 PROTEIN, HUMAN; MITOGEN ACTIVATED PROTEIN KINASE P38;

ADULT; ARTICLE; CANCER CELL CULTURE; CANCER TISSUE; CELL CYCLE; CELL CYCLE ARREST; CELL GROWTH; CELL MIGRATION; CONTROLLED STUDY; FEMALE; FOLLOW UP; GROWTH INHIBITION; HUMAN; HUMAN TISSUE; IMMUNOBLOTTING; LUNG CARCINOGENESIS; LUNG NON SMALL CELL CANCER; MAJOR CLINICAL STUDY; MALE; PREDICTION; PROGNOSIS; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; RNA INTERFERENCE; TISSUE MICROARRAY; WESTERN BLOTTING; AGED; APOPTOSIS; CELL CYCLE CHECKPOINT; CELL DIFFERENTIATION; CELL MOTION; CELL PROLIFERATION; CELL TRANSFORMATION; ENZYMOLOGY; GENE SILENCING; LUNG TUMOR; METABOLISM; MIDDLE AGED; MULTIVARIATE ANALYSIS; PATHOLOGY; PHOSPHORYLATION; REGRESSION ANALYSIS; SURVIVAL; TUMOR CELL LINE;

AGED; APOPTOSIS; CARCINOMA, NON-SMALL-CELL LUNG; CELL CYCLE CHECKPOINTS; CELL DIFFERENTIATION; CELL LINE, TUMOR; CELL MOVEMENT; CELL PROLIFERATION; CELL TRANSFORMATION, NEOPLASTIC; CRK-ASSOCIATED SUBSTRATE PROTEIN; FEMALE; GENE KNOCKDOWN TECHNIQUES; HUMANS; LUNG NEOPLASMS; MALE; MIDDLE AGED; MULTIVARIATE ANALYSIS; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; PROGNOSIS; REGRESSION ANALYSIS; SURVIVAL ANALYSIS;

EID: 84860428609     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0036124     Document Type: Article

References (25)

1. Rooney C, Sethi T, (2011) The epithelial cell and lung cancer: the link between chronic obstructive pulmonary disease and lung cancer. Respiration 81: 89-104.
2. Ulahannan SV, Brahmer JR, (2011) Antiangiogenic agents in combination with chemotherapy in patients with advanced non-small cell lung cancer. Cancer Invest 29: 325-337.
3. Huang C, Liu D, Masuya D, Nakashima T, Kameyama K, et al. (2005) Clinical application of biological markers for treatments of resectable non-small-cell lung cancers. Br J Cancer 92: 1231-1239.
4. Reynolds AB, Roesel DJ, Kanner SB, Parsons JT, (1989) Transformation-specific tyrosine phosphorylation of a novel cellular protein in chicken cells expressing oncogenic variants of the avian cellular src gene. Mol Cell Biol 9: 629-638.
5. Kanner SB, Reynolds AB, Parsons JT, (1991) Tyrosine phosphorylation of a 120-kilodalton pp60src substrate upon epidermal growth factor and platelet-derived growth factor receptor stimulation and in polyomavirus middle-T-antigen-transformed cells. Mol Cell Biol 11: 713-720.
6. Tikhmyanova N, Little JL, Golemis EA, (2010) CAS proteins in normal and pathological cell growth control. Cell Mol Life Sci 67: 1025-1048.
7. Brinkman A, der Flier Sv, Kok EM, Dorssers LC, (2000) BCAR1, a human homologue of the adapter protein p130Cas, and antiestrogen resistance in breast cancer cells. J Natl Cancer Inst 92: 112-120.
8. Dorssers LC, Grebenchtchikov N, Brinkman A, Look MP, van BSP, et al. (2004) The prognostic value of BCAR1 in patients with primary breast cancer. Clin Cancer Res 10: 6194-6202.
9. Deng B, Huang W, Tan QY, Fan XQ, Jiang YG, et al. (2011) Breast cancer anti-estrogen resistance protein 1 (BCAR1/p130cas) in pulmonary disease tissue and serum. Mol Diagn Ther 15: 31-40.
10. Cuadrado A, Nebreda AR, (2010) Mechanisms and functions of p38 MAPK signalling. Biochem J 429: 403-417.
11. Ji C, Ren F, Xu M, (2010) Caspase-8 and p38MAPK in DATS-induced apoptosis of human CNE2 cells. Braz J Med Biol Res 43: 821-827.
12. Kim W, Seok KY, Soo KJ, Shin NY, Hanks SK, et al. (2008) The integrin-coupled signaling adaptor p130Cas suppresses Smad3 function in transforming growth factor-beta signaling. Mol Biol Cell 19: 2135-2146.
13. Chodniewicz D, Klemke RL, (2004) Regulation of integrin-mediated cellular responses through assembly of a CAS/Crk scaffold. Biochim Biophys Acta 1692: 63-76.
14. Sakai R, Iwamatsu A, Hirano N, Ogawa S, Tanaka T, et al. (1994) A novel signaling molecule, p130, forms stable complexes in vivo with v-Crk and v-Src in a tyrosine phosphorylation-dependent manner. EMBO J 13: 3748-3756.
15. Honda H, Oda H, Nakamoto T, Honda Z, Sakai R, et al. (1998) Cardiovascular anomaly, impaired actin bundling and resistance to Src-induced transformation in mice lacking p130Cas. Nat Genet 19: 361-365.
16. Defilippi P, Di SP, Cabodi S, (2006) p130Cas: a versatile scaffold in signaling networks. Trends Cell Biol 16: 257-263.
17. Takino T, Tamura M, Miyamori H, Araki M, Matsumoto K, et al. (2003) Tyrosine phosphorylation of the CrkII adaptor protein modulates cell migration. J Cell Sci 116: 3145-3155.
18. Kim W, Kook S, Kim DJ, Teodorof C, Song WK, (2004) The 31-kDa caspase-generated cleavage product of p130cas functions as a transcriptional repressor of E2A in apoptotic cells. J Biol Chem 279: 8333-8342.
19. Wei L, Yang Y, Zhang X, Yu Q, (2002) Anchorage-independent phosphorylation of p130(Cas) protects lung adenocarcinoma cells from anoikis. J Cell Biochem 87: 439-449.
20. Brabek J, Constancio SS, Siesser PF, Shin NY, Pozzi A, et al. (2005) Crk-associated substrate tyrosine phosphorylation sites are critical for invasionand metastasis of SRC-transformed cells. Mol Cancer Res 3: 307-315.
21. Purnell PR, Mack PC, Tepper CG, Evans CP, Green TP, et al. (2009) The Src inhibitor AZD0530 blocks invasion and may act as a radiosensitizer inlung cancer cells. J Thorac Oncol 4: 448-454.
22. Greenberg AK, Basu S, Hu J, Yie TA, Tchou-Wong KM, et al. (2002) Selective p38 activation in human non-small cell lung cancer. Am J Respir Cell Mol Biol 26: 558-564.
23. Matsuda K, Idezawa T, You XJ, Kothari NH, Fan H, et al. (2002) Multiple mitogenic pathways in pancreatic cancer cells are blocked by a truncated epidermal growth factor receptor. Cancer Res 62: 5611-5617.
24. Yu J, Bian D, Mahanivong C, Cheng RK, Zhou W, et al. (2004) p38 Mitogen-activated protein kinase regulation of endothelial cell migration depends on urokinase plasminogen activator expression. J Biol Chem 279: 50446-50454.
25. Wendt MK, Smith JA, Schiemann WP, (2009) p130Cas is required for mammary tumor growth and transforming growth factor-beta-mediated metastasis through regulation of Smad2/3 activity. J Biol Chem 284: 34145-34156.