Substitutions of amino acids in the pore domain of homomeric α7 nicotinic receptors for analogous residues present in heteromeric receptors modify gating, rectification and binding properties

Journal of Neurochemistry

Volumn 119, Issue 1, 2011, Pages 40-49

  Criado, Manuel ^a   Svobodová, Lucie ^a   Mulet, José ^a   Sala, Francisco ^a   Sala, Salvador ^a  

^a MIGUEL HERNÁNDEZ UNIVERSITY   (Spain)

Author keywords

7 neuronal nicotinic receptor; homomeric; M2 segment

Indexed keywords

ACETYLCHOLINE; BUNGAROTOXIN RECEPTOR; MUTANT PROTEIN; NICOTINIC RECEPTOR; NICOTINIC RECEPTOR ALPHA2; NICOTINIC RECEPTOR ALPHA3; NICOTINIC RECEPTOR ALPHA4; NICOTINIC RECEPTOR BETA2; NICOTINIC RECEPTOR BETA4; RECEPTOR SUBUNIT; SERINE; THREONINE; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; BINDING KINETICS; CONCENTRATION RESPONSE; CONTROLLED STUDY; MEMBRANE CURRENT; MUTATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; RECEPTOR BINDING; RECEPTOR DOWN REGULATION; SEQUENCE ALIGNMENT;

ACETYLCHOLINE; ALGORITHMS; AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMALS; BUNGAROTOXINS; CATTLE; DNA, COMPLEMENTARY; ELECTROPHYSIOLOGICAL PHENOMENA; ION CHANNEL GATING; KINETICS; MEMBRANE POTENTIALS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; OOCYTES; PATCH-CLAMP TECHNIQUES; PROTEIN BINDING; RECEPTOR, MUSCARINIC M2; RECEPTORS, NICOTINIC; XENOPUS LAEVIS;

EID: 84860420001     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/j.1471-4159.2011.07398.x     Document Type: Article

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