SP-8203 shows neuroprotective effects and improves cognitive impairment in ischemic brain injury through NMDA receptor

Pharmacology Biochemistry and Behavior

Volumn 100, Issue 1, 2011, Pages 73-80

  Noh, Su Jin ^a   Lee, Jong Min ^b   Lee, Ki Sung ^b   Hong, Hyun Su ^b   Lee, Chul Kyu ^b   Cho, Il Hwan ^b   Kim, Hye Sun ^a   Suh, Yoo Hun ^a  

^a Seoul National University   (South Korea)

^b Shinpoong Pharmaceutical Co   (South Korea)

Author keywords

Cerebral ischemia; Earth worms; Excitotoxicity; Memory; Neuronal death; NMDA

Indexed keywords

CALCIUM ION; DIZOCILPINE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; NEUROPROTECTIVE AGENT; SP 8203; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN ISCHEMIA; COGNITIVE DEFECT; CONTROLLED STUDY; DRUG RECEPTOR BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; EARTHWORM; EISENIA ANDREI; IN VITRO STUDY; IN VIVO STUDY; LEARNING; MALE; MAZE TEST; MEMORY; MIDDLE CEREBRAL ARTERY OCCLUSION; MOUSE; NERVE CELL NECROSIS; NEUROPROTECTION; NEUROTOXICITY; NEWBORN; NONHUMAN; PRIORITY JOURNAL; SPATIAL LEARNING;

ANIMALS; ANIMALS, NEWBORN; BRAIN INJURIES; BRAIN ISCHEMIA; CELLS, CULTURED; COGNITION DISORDERS; DOSE-RESPONSE RELATIONSHIP, DRUG; MALE; MICE; MICE, INBRED ICR; N-METHYLASPARTATE; NEUROPROTECTIVE AGENTS; QUINAZOLINONES; RATS; RATS, WISTAR; RECEPTORS, N-METHYL-D-ASPARTATE;

EISENIA ANDREI; RATTUS;

EID: 84860416495     PISSN: 00913057     EISSN: 18735177     Source Type: Journal    
DOI: 10.1016/j.pbb.2011.07.018     Document Type: Article

References (41)

1. M.E. Bardgett, R. Boeckman, D. Krochmal, H. Fernando, R. Ahrens, and J.G. Csernansky NMDA receptor blockade and hippocampal neuronal loss impair fear conditioning and position habit reversal in C57Bl/6 mice Brain Res Bull 60 2003 131 142 (Pubitemid 36506460)
2. C. Bischoff, and P.I. Tiedtke Competitive and non-competitive NMDA receptor antagonists in spatial learning tasks Eur J Pharmacol 213 1992 269 273
3. K. Biziere, H. Thompson, and J.T. Coyle Characterization of specific, high-affinity binding sites for L-[3H]glutamic acid in rat brain membranes Brain Res 183 2 1980 421 433 (Pubitemid 10178037)
4. H. Brauner-Osborne, J. Egebjerg, E.O. Nielsen, U. Madsen, and P. Krogsgaard-Larsen Ligands for glutamate receptors: design and therapeutic prospects J Med Chem 43 2000 2609 2645 (Pubitemid 30463912)
5. K. Camera, C.F. Mello, A.P. Ceretta, and M.A. Rubin Systemic administration of polyaminergic agents modulate fear conditioning in rats Psychopharmacology (Berl) 192 4 2007 457 464 (Pubitemid 46870741)
6. D.W. Choi Glutamate neurotoxicity and diseases of the nervous system Neuron 1 1988 623 634
7. D.W. Choi, M. Maulucci-Gedde, and A.R. Kriegstein Glutamate neurotoxicity in cortical cell culture J Neurosci 7 1987 357 368 (Pubitemid 17017465)
8. A.N. Clarkson, H. Liu, L. Pearson, M. Kapoor, J.C. Harrison, and I.A. Sammut Neuroprotective effects of spermine following hypoxic-ischemic-induced brain damage: a mechanistic study FASEB J 18 10 2004 1114 1116 (Pubitemid 39561541)
9. G.L. Collingridge, and T.V. Bliss Memories of NMDA receptors and LTP Trends Neurosci 18 1995 54 56
10. E.L. Conway Brain lesions and delayed water maze learning deficits after intracerebroventricular spermine Brain Res 800 1 1998 10 20 (Pubitemid 28361917)
11. G. Ellison The N-methyl-d-aspartate antagonists phencyclidine, ketamine and dizocilpine as both behavioral and anatomical models of the dementias Brain Res Brain Res Rev 20 1995 250 267
12. J.L. Ellsworth, R. Garcia, J. Yu, and M.S. Kindy Fibroblast growth factor-18 reduced infarct volumes and behavioral deficits after transient occlusion of the middle cerebral artery in rats Stroke 34 6 2003 1507 1512 (Pubitemid 36693526)
13. V.D. Gerasimov, D.P. Artemenko, and O.A. Krishtal Therapeutic time window for the neuroprotective action of MK-801 after decapitation ischemia: hippocampal slice data Brain Res 1017 1-2 2004 92 97 (Pubitemid 38917148)
14. G.M. Gilad, and V.H. Gilad Polyamines can protect against ischemia-induced nerve cell death in gerbil forebrain Exp Neurol 111 3 1991 349 355
15. M.D. Ginsberg Neuroprotection for ischemic stroke: past, present and future Neuropharmacology 55 3 2008 363 389
16. M.P. Goldberg, J.H. Weiss, P.C. Pham, and D.W. Choi N-methyl-d-aspartate receptors mediate hypoxic neuronal injury in cortical culture J Pharmacol Exp Ther 243 1987 784 791 (Pubitemid 18011570)
17. G.M. Gomes, C.F. Mello, M.M. Rosa, G.V. Bochi, J. Ferreira, and S. Barron Polyaminergic agents modulate contextual fear extinction in rats Neurobiol Learn Mem 93 4 2010 589 595
18. S.A. Gutnikov, and D. Gaffan Systemic NMDA receptor antagonist CGP-40116 does not impair memory acquisition but protects against NMDA neurotoxicity in rhesus monkeys J Neurosci 16 1996 4041 4045 (Pubitemid 26176067)
19. X. Han, H. Tomitori, S. Mizuno, K. Higashi, C. Füll, and T. Fukiwake Binding of spermine and ifenprodil to a purified, soluble regulatory domain of the N-methyl-d-aspartate receptor J Neurochem 107 6 2008 1566 1577
20. K. Igarashi, and K. Williams Antagonist properties of polyamines and bis(ethyl)polyamines at N-methyl-d-aspartate receptors J Pharmacol Exp Ther 272 3 1995 1101 1109
21. C.K. Lee, J.S. Shin, B.S. Kim, I.H. Cho, Y.S. Kim, and E.B. Lee Antithrombotic effects by oral administration of novel proteinase fraction from earthworm Eisenia andrei on venous thrombosis model in rats Arch Pharm Res 30 2007 475 480
22. J.H. Lee, Y.H. Choi, J.H. Suh, H.E. Kang, T.H. Lee, and I.H. Cho Dose-dependent pharmacokinetics of SP-8203 in rats Biopharm Drug Dispos 31 5-6 2010 358 361
23. S. Maren, G. Aharonov, D.L. Stote, and M.S. Fanselow N-methyl-d-aspartate receptors in the basolateral amygdala are required for both acquisition and expression of conditional fear in rats Behav Neurosci 110 6 1996 1365 1374 (Pubitemid 27009199)
24. H. Nagasawa, and K. Kogure Correlation between cerebral blood flow and histologic changes in a new rat model of middle cerebral artery occlusion Stroke 20 1989 1037 1043 (Pubitemid 19204017)
25. S.J. Noh, S.H. Lee, K.Y. Shin, C.K. Lee, I.H. Cho, and H.S. Kim SP-8203 reduces oxidative stress via SOD activity and behavioral deficit in cerebral ischemia Pharmacol Biochem Behav 98 1 2011 150 154
26. A. Ouagazzal, A. Nieoullon, and M. Amalric Effects of dopamine D1 and D2 receptor blockade on MK-801-induced hyperlocomotion in rats Psychopharmacology (Berl) 111 1993 427 434 (Pubitemid 23205666)
27. C.K. Park, D.G. Nehls, D.I. Graham, G.M. Teasdale, and J. McCulloch The glutamate antagonist MK-801 reduces focal ischemic brain damage in the rat Ann Neurol 24 1988 543 551
28. S.M. Rothman, and J.W. Olney Glutamate and the pathophysiology of hypoxic-ischemic brain damage Ann Neurol 19 1986 105 111 (Pubitemid 16114163)
29. E.E. Schenberg, J.C. Soares, and M.G. Oliveira Effects of pre- or post-training entorhinal cortex AP5 injection on fear conditioning Physiol Behav 86 4 2005 508 515 (Pubitemid 41586247)
30. A. Shimada, E.L. Spangler, E.D. London, and D.K. Ingram Spermidine potentiates dizocilpine-induced impairment of learning performance by rats in a 14-unit T-maze Eur J Pharmacol 263 3 1994 293 300 (Pubitemid 24301308)
31. M.D. Shirhan, S.M. Moochhala, P.Y. Ng, J. Lu, K.C. Ng, and A.L. Teo Spermine reduces infarction and neurological deficit following a rat model of middle cerebral artery occlusion: a magnetic resonance imaging study Neuroscience 124 2 2004 299 304 (Pubitemid 38229650)
32. W.W. Shin, W.F. Fong, S.F. Pang, and P.C. Wong Limited blood-brain barrier transport of polyamines J Neurochem 44 4 1985 1056 1059 (Pubitemid 15105755)
33. R.P. Simon, J.H. Swan, T. Griffiths, and B.S. Meldrum Blockade of N-methyl-d-aspartate receptors may protect against ischemic damage in the brain Science 226 1984 850 852 (Pubitemid 15200682)
34. R.A. Swanson, M.T. Morton, G. Tsao-Wu, R.A. Savalos, C. Davidson, and F.R. Sharp A semiautomated method for measuring brain infarct volume J Cereb Blood Flow Metab 10 1990 290 293 (Pubitemid 20096202)
35. M. Upchurch, and J.M. Wehner Effects of N-methyl-d-aspartate antagonism on spatial learning in mice Psychopharmacology (Berl) 100 1990 209 214 (Pubitemid 20038564)
36. N.A. Velloso, G.D. Dalmolin, G.M. Gomes, M.A. Rubin, P.M. Canas, and R.A. Cunha Spermine improves recognition memory deficit in a rodent model of Huntington's disease Neurobiol Learn Mem 92 4 2009 574 580
37. D.M. Villarreal, V. Do, E. Haddad, and B.E. Derrick NMDA receptor antagonists sustain LTP and spatial memory: active processes mediate LTP decay Nat Neurosci 5 2002 48 52 (Pubitemid 34038782)
38. E.H. Wong, and J.A. Kemp Sites for antagonism on the N-methyl-d-aspartate receptor channel complex Annu Rev Pharmacol Toxicol 31 1991 401 425 (Pubitemid 21903854)
39. D.F. Wozniak, G. Brosnan-Watters, A. Nardi, M. McEwen, T.D. Corso, and J.W. Olney MK-801 neurotoxicity in male mice: histologic effects and chronic impairment in spatial learning Brain Res 707 1996 165 179 (Pubitemid 26057583)
40. F. Yonemori, H. Yamada, T. Yamaguchi, A. Uemura, and A. Tamura Spatial memory disturbance after focal cerebral ischemia in rats J Cereb Blood Flow Metab 16 5 1996 973 980 (Pubitemid 26292065)
41. F. Yonemori, T. Yamaguchi, H. Yamada, and A. Tamura Spatial cognitive performance after chronic focal cerebral ischemia in rats J Cereb Blood Flow Metab 19 5 1999 483 494 (Pubitemid 30159810)