Dose-dependent pharmacokinetics of SP-8203 in rats

Biopharmaceutics and Drug Disposition

Volumn 31, Issue 5-6, 2010, Pages 358-361

  Lee, Joo H ^a,b   Choi, Young H ^a,c   Suh, Jung H ^a   Kang, Hee E ^d   Lee, Tae H ^d   Cho, Il H ^d   Lee, Myung G ^a  

^a Seoul National University   (South Korea)

^b Kyung Hee University   (South Korea)

^c Dongguk University   (South Korea)

^d Shinpoong Pharmaceutical Co   (South Korea)

Author keywords

Dose dependent pharmacokinetics; Intravenous and oral administration; Rats; SP 8203

Indexed keywords

NEUROPROTECTIVE AGENT; SP 8203; UNCLASSIFIED DRUG; [N [3 (2,4 DIOXO 1,4 DIHYDRO 2H QUINAZOLIN 3 YL)PROPYL] N [4 [3 (2,4 DIOXO 1,4 DIHYDRO 2H QUINAZOLIN 3 YL)PROPYLAMINOGBUTYL]ACETAMIDE]; QUINAZOLINONE DERIVATIVE; SP-8203;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; BRAIN INFARCTION; CONTROLLED STUDY; DOSE RESPONSE; DRUG ADMINISTRATION ROUTE; DRUG BLOOD LEVEL; DRUG METABOLISM; FECES; GASTROINTESTINAL TRACT; LIVER METABOLISM; MALE; NEUROPROTECTION; NONHUMAN; RAT; ANIMAL; COMPARATIVE STUDY; INTRAVENOUS DRUG ADMINISTRATION; ORAL DRUG ADMINISTRATION; SPRAGUE DAWLEY RAT;

ADMINISTRATION, ORAL; ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; INFUSIONS, INTRAVENOUS; MALE; NEUROPROTECTIVE AGENTS; QUINAZOLINONES; RATS; RATS, SPRAGUE-DAWLEY;

EID: 77955707696     PISSN: 01422782     EISSN: 1099081X     Source Type: Journal    
DOI: 10.1002/bdd.713     Document Type: Article

References (7)

1. Baraka MM. Synthesis of novel 2, 4-(1H, 3H)- quinazolinedione derivatives with analgesic and anti-inflammatory activities. Boll Chim Farm 2001; 140: 90-96.
2. Noji T, Nan-ya K, Mizutani M, et al. KF24345, an adenosine uptake inhibitor, ameliorates the severity and mortality of lethal acute pancreatitis via endogenous adenosine in mice. Eur J Pharmacol 2002; 454: 85-93.
3. Choi YH, Kim SG, Lee MG. Dose-independent pharmacokinetics of metformin in rats: hepatic and gastrointestinal first-pass effects. J Pharm Sci 2006; 95: 2543-2552.
4. Choi YH, Suh JH, Lee JH, Cho IH, Lee CK, Lee MG. LC-UV determination of N-{3-(2, 4-dioxo-1, 4-dihy-dro-2H-quinazolin-3-yl)propyl}-N-[4-{3-(2, 4-dioxo-1, 4-dihydro-2H-quinazolin-3-yl)propyl-amino}butyl]-acetamide (SP-8203) in rat plasma, urine, and gastrointestinal tract. Chromatography 2009; 70: 1435-1439.
5. Gibaldi M, Perrier D. Pharmacokinetics, 2nd edn. Marcel-Dekker: New York, 1982.
6. Chiou WL. Critical evaluation of potential error in pharmacokinetic studies using the linear trapezoidal rule method for the calculation of the area under the plasma level-time curve. J Pharmacokinet Biopharm 1978; 6: 539-546.
7. Davies B, Morris T. Physiological parameters in laboratory animals and humans. Pharm Res 1993; 10: 1093-1095.