메뉴 건너뛰기




Volumn 707, Issue 2, 1996, Pages 165-179

MK-801 neurotoxicity in male mice: Histologic effects and chronic impairment in spatial learning

Author keywords

Activity; Cingulate cortex; Dizocilipine maleate; MK 801; Mouse; N Methyl D aspartate antagonist; Neuropathology; Neurotoxicity; Sensorimotor; Spatial learning and memory

Indexed keywords

DIZOCILPINE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT;

EID: 0030021834     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/0006-8993(95)01230-3     Document Type: Article
Times cited : (83)

References (60)
  • 1
    • 0025057202 scopus 로고
    • Phencyclidine, dizocilipine, and cerebrocortical neurons
    • Allen, H.L. and Iversen, L.L., Phencyclidine, dizocilipine, and cerebrocortical neurons, Science, 247 (1990) 221.
    • (1990) Science , vol.247 , pp. 221
    • Allen, H.L.1    Iversen, L.L.2
  • 2
    • 0027954255 scopus 로고
    • The nature and time course of neuronal vacuolization induced by the N-methyl-D-aspartate antagonist MK-801
    • Auer, R.N. and Coulter, K.C., The nature and time course of neuronal vacuolization induced by the N-methyl-D-aspartate antagonist MK-801, Acta Neuropathol., 87 (1994) 1-7.
    • (1994) Acta Neuropathol. , vol.87 , pp. 1-7
    • Auer, R.N.1    Coulter, K.C.2
  • 3
    • 0343023395 scopus 로고
    • Cerebrocortical neurotoxicity and chronic memory impairment induced by MK-801 in the mouse
    • Brosnan-Watters, G., Wozniak, D.F., McEwen, M. and Olney, J.W., Cerebrocortical neurotoxicity and chronic memory impairment induced by MK-801 in the mouse, Soc. Neurosci. Abstr., 19 (1993) 1134.
    • (1993) Soc. Neurosci. Abstr. , vol.19 , pp. 1134
    • Brosnan-Watters, G.1    Wozniak, D.F.2    McEwen, M.3    Olney, J.W.4
  • 4
    • 0343023397 scopus 로고
    • High dose MK-801 kills neurons in a single brain region and chronically impairs memory
    • Brosnan-Watters, G., Wozniak, D.F., Nardi, A., Olney, J.W. and Fix, A.S., High dose MK-801 kills neurons in a single brain region and chronically impairs memory, Soc. Neurosci. Abstr., 20 (1994) 1217.
    • (1994) Soc. Neurosci. Abstr. , vol.20 , pp. 1217
    • Brosnan-Watters, G.1    Wozniak, D.F.2    Nardi, A.3    Olney, J.W.4    Fix, A.S.5
  • 6
    • 0028299910 scopus 로고
    • Spatial memory and N-methyl-D-aspartate receptor antagonists APV and MK-801: Memory impairments depend on familarity with the environment, drug dose, and training duration
    • Caramanos, Z. and Shapiro, M.L., Spatial memory and N-methyl-D-aspartate receptor antagonists APV and MK-801: memory impairments depend on familarity with the environment, drug dose, and training duration, Behav. Neurosci., 108 (1994) 30-43.
    • (1994) Behav. Neurosci. , vol.108 , pp. 30-43
    • Caramanos, Z.1    Shapiro, M.L.2
  • 7
    • 0019427553 scopus 로고
    • A modified cupric-silver technique for the impregnation of degenerating neurons and their processes
    • Carlsen, J. and de Olmos, J.S., A modified cupric-silver technique for the impregnation of degenerating neurons and their processes, Brain Res., 208 (1981) 426-431.
    • (1981) Brain Res. , vol.208 , pp. 426-431
    • Carlsen, J.1    De Olmos, J.S.2
  • 8
    • 0027116042 scopus 로고
    • Bench to bedside: The glutamate connection
    • Choi, D.W., Bench to bedside: the glutamate connection, Science, 258 (1992) 241-243.
    • (1992) Science , vol.258 , pp. 241-243
    • Choi, D.W.1
  • 10
    • 0027215716 scopus 로고
    • Measurement of an explosive behavior in the mouse induced by MK-801, a PCP analogue
    • Deutsch, S.K. and Hitri, A., Measurement of an explosive behavior in the mouse induced by MK-801, a PCP analogue, Clin. Neuropharmacol., 16 (1993) 251-257.
    • (1993) Clin. Neuropharmacol. , vol.16 , pp. 251-257
    • Deutsch, S.K.1    Hitri, A.2
  • 11
    • 0001765011 scopus 로고
    • The contributions of cingulate cortex to human behavior
    • B.A. Vogt and M. Gabriel (Eds.), Birkhauser, Boston
    • Devinsky, O. and Luciano D., The contributions of cingulate cortex to human behavior. In B.A. Vogt and M. Gabriel (Eds.), The Neurobiology of the Cingulate Cortex and Limbic Thalamus, Birkhauser, Boston, 1993, 557-580.
    • (1993) The Neurobiology of the Cingulate Cortex and Limbic Thalamus , pp. 557-580
    • Devinsky, O.1    Luciano, D.2
  • 12
    • 0020584899 scopus 로고
    • Cholinergic neurons in the rat cerebral cortex demonstrated by immunohistochemical localization of choline acetyltransferase
    • Eckenstein, F. and Thoenen, H., Cholinergic neurons in the rat cerebral cortex demonstrated by immunohistochemical localization of choline acetyltransferase, Neurosci. Lett., 36 (1983) 211-215.
    • (1983) Neurosci. Lett. , vol.36 , pp. 211-215
    • Eckenstein, F.1    Thoenen, H.2
  • 13
    • 0028670367 scopus 로고
    • Competitive and noncompetitive NMDA antagonists induce similar limbic degeneration
    • Ellison, G., Competitive and noncompetitive NMDA antagonists induce similar limbic degeneration, NeuroReport, 5 (1994) 2688-2692.
    • (1994) NeuroReport , vol.5 , pp. 2688-2692
    • Ellison, G.1
  • 14
    • 0028934737 scopus 로고
    • The N-methyl-D-aspartate antagonists phencyclidine, ketamine and dizocilipine as both behavioral and anatomical models of dementias
    • Ellison, G., The N-methyl-D-aspartate antagonists phencyclidine, ketamine and dizocilipine as both behavioral and anatomical models of dementias, Brain Res. Rev., 20 (1994) 250-267.
    • (1994) Brain Res. Rev. , vol.20 , pp. 250-267
    • Ellison, G.1
  • 15
    • 0028325323 scopus 로고
    • Differential effects of the N-methyl-D-aspartate antagonist DL-2-amino-5-phosphonovalerate on acquisition of auditory and contextual cues
    • Fanselow, M.S., Kim, J.J., Yipp, J. and De Oca, B., Differential effects of the N-methyl-D-aspartate antagonist DL-2-amino-5-phosphonovalerate on acquisition of auditory and contextual cues, Behav. Neurosci., 108 (1994) 235-240.
    • (1994) Behav. Neurosci. , vol.108 , pp. 235-240
    • Fanselow, M.S.1    Kim, J.J.2    Yipp, J.3    De Oca, B.4
  • 16
    • 0027521274 scopus 로고
    • Neuronal vacuolization and necrosis induced by the noncompetivive N-methyl-D-aspartate (NMDA) antagonist MK(+)801 (dizocilpine maleate): A light and electron microscopic evaluation of the rat retrosplenial cortex
    • Fix, A.S., Horn, J.W., Wightman, K.A., Johnson, C.A., Long, G.G., Storts, R.W., Farber, N., Wozniak, D.F. and Olney, J.W., Neuronal vacuolization and necrosis induced by the noncompetivive N-methyl-D-aspartate (NMDA) antagonist MK(+)801 (dizocilpine maleate): a light and electron microscopic evaluation of the rat retrosplenial cortex, Exp. Neurol., 123 (1993) 204-215.
    • (1993) Exp. Neurol. , vol.123 , pp. 204-215
    • Fix, A.S.1    Horn, J.W.2    Wightman, K.A.3    Johnson, C.A.4    Long, G.G.5    Storts, R.W.6    Farber, N.7    Wozniak, D.F.8    Olney, J.W.9
  • 17
    • 0028104510 scopus 로고
    • Neuronal vacuole formation in the rat posterior cingulate/retrosplenial cortex after treatment with the N-methyl-D-aspartate (NMDA) antagonist MK-801 (dizocilipine maleate)
    • Fix, A.S., Horn, J.W., Truex, L.L, Smith, R.A. and Gomez, E., Neuronal vacuole formation in the rat posterior cingulate/retrosplenial cortex after treatment with the N-methyl-D-aspartate (NMDA) antagonist MK-801 (dizocilipine maleate), Acta Neuropathol., 88 (1994) 511-519.
    • (1994) Acta Neuropathol. , vol.88 , pp. 511-519
    • Fix, A.S.1    Horn, J.W.2    Truex, L.L.3    Smith, R.A.4    Gomez, E.5
  • 18
    • 0028823890 scopus 로고
    • Quantitative analysis of factors influencing neuronal necrosis induced by MK-801 in the rat posterior cingulate/retrosplenial cortex
    • Fix, A.S., Wozniak, D.F., Truex, L.L., McEwen, M., Miller, J.P. and Olney, J.W., Quantitative analysis of factors influencing neuronal necrosis induced by MK-801 in the rat posterior cingulate/retrosplenial cortex, Brain Res., 696 (1995) 194-204.
    • (1995) Brain Res. , vol.696 , pp. 194-204
    • Fix, A.S.1    Wozniak, D.F.2    Truex, L.L.3    McEwen, M.4    Miller, J.P.5    Olney, J.W.6
  • 19
    • 0022413369 scopus 로고
    • The effects of Org 2766 on the performance of sham, neocortical, and hippocampal-lesioned rats in a food search task
    • Hannigan, J.H., Jr. and Isaacson, R.L., The effects of Org 2766 on the performance of sham, neocortical, and hippocampal-lesioned rats in a food search task, Pharmacol. Biochem. Behav., 23 (1985) 1019-1027.
    • (1985) Pharmacol. Biochem. Behav. , vol.23 , pp. 1019-1027
    • Hannigan J.H., Jr.1    Isaacson, R.L.2
  • 20
    • 0027427150 scopus 로고
    • Competitive as well as uncompetitive N-methyl-D-aspartate antagonists affect cortical neuronal morphology and cerebral glucose metabolism
    • Hargreaves, R.J., Rigby, M., Smith, D., Hill, R.G. and Iversen, L.L., Competitive as well as uncompetitive N-methyl-D-aspartate antagonists affect cortical neuronal morphology and cerebral glucose metabolism, Neurochem. Res., 18 (1993) 1263-1269.
    • (1993) Neurochem. Res. , vol.18 , pp. 1263-1269
    • Hargreaves, R.J.1    Rigby, M.2    Smith, D.3    Hill, R.G.4    Iversen, L.L.5
  • 21
    • 0026607117 scopus 로고
    • Hyperactivity, hyper-reactivity, and sensorimotor deficits induced by low doses of the N-methyl-D-aspartate non-competitive channel blocker MK-801
    • Hargreaves, E.L. and Cain, D.P., Hyperactivity, hyper-reactivity, and sensorimotor deficits induced by low doses of the N-methyl-D-aspartate non-competitive channel blocker MK-801, Behav. Brain Res., 4 (1992) 23-33.
    • (1992) Behav. Brain Res. , vol.4 , pp. 23-33
    • Hargreaves, E.L.1    Cain, D.P.2
  • 22
    • 0000942415 scopus 로고
    • D-CPPene (SDZ EAA 494), a competitive NMDA antagonist: Results from animal models and first results in humans
    • Herrling, P., D-CPPene (SDZ EAA 494), a competitive NMDA antagonist: results from animal models and first results in humans, Neuropsychopharmacology, 10 (3S/Part 1) (1994) 591S.
    • (1994) Neuropsychopharmacology , vol.10 , Issue.3 S-PART 1
    • Herrling, P.1
  • 23
    • 0011165099 scopus 로고
    • MK-801-induced neuronal damage in normal rats
    • Horvath, Z. and Buzsaki, G., MK-801-induced neuronal damage in normal rats, Soc. Neurosci. Abstr., 19 (1993) 354.
    • (1993) Soc. Neurosci. Abstr. , vol.19 , pp. 354
    • Horvath, Z.1    Buzsaki, G.2
  • 24
    • 0021919290 scopus 로고
    • Immunocytochemical localization of choline acetyltransferase in rat cerebral cortex: A study of cholinergic neurons and synapses
    • Houser, C.R., Crawford, G.D., Salvaterra, P.M. and Vaughn, J.E., Immunocytochemical localization of choline acetyltransferase in rat cerebral cortex: a study of cholinergic neurons and synapses, J. Comp. Neurol., 234 (1985) 17-34.
    • (1985) J. Comp. Neurol. , vol.234 , pp. 17-34
    • Houser, C.R.1    Crawford, G.D.2    Salvaterra, P.M.3    Vaughn, J.E.4
  • 25
    • 0342589155 scopus 로고
    • The posterior cingulate cortex in man: Normal structure and changes in Alzheimer's disease
    • Insausti, R., Moreno, M., Insausti, L., Ochoa, L. and Gonzalo, L.M., The posterior cingulate cortex in man: normal structure and changes in Alzheimer's disease. Soc. Neurosci. Abstr., 19 (1993) 357.
    • (1993) Soc. Neurosci. Abstr. , vol.19 , pp. 357
    • Insausti, R.1    Moreno, M.2    Insausti, L.3    Ochoa, L.4    Gonzalo, L.M.5
  • 27
    • 0027417589 scopus 로고
    • Phencyclidine disrupts long-but not short-term memory within a spatial learning task
    • Kesner, R.P., Dakis, M. and Bolland, B.L., Phencyclidine disrupts long-but not short-term memory within a spatial learning task, Psychopharmacology, 111 (1993) 85-90.
    • (1993) Psychopharmacology , vol.111 , pp. 85-90
    • Kesner, R.P.1    Dakis, M.2    Bolland, B.L.3
  • 28
    • 0028118408 scopus 로고
    • Cholinergic innervation of mouse forebrain structures
    • Kitt, C.A., Hohmann, C., Coyle, J.T. and Price, D.L., Cholinergic innervation of mouse forebrain structures, J. Comp. Neurol., 341 (1994) 117-129.
    • (1994) J. Comp. Neurol. , vol.341 , pp. 117-129
    • Kitt, C.A.1    Hohmann, C.2    Coyle, J.T.3    Price, D.L.4
  • 29
    • 0025754076 scopus 로고
    • Effects of the competitive NMDA antagonist CPP on the performance of a place and cue radial maze task
    • Lyford, G.L. and Jarrard, L.E., Effects of the competitive NMDA antagonist CPP on the performance of a place and cue radial maze task, Psychobiology, 19 (1991) 157-160.
    • (1991) Psychobiology , vol.19 , pp. 157-160
    • Lyford, G.L.1    Jarrard, L.E.2
  • 30
    • 0026076110 scopus 로고
    • Autoradiographic assessment of the effects of N-methyl-D-aspartate receptor antagonists in vivo
    • McCulloch, J. and Iverson, L.L., Autoradiographic assessment of the effects of N-methyl-D-aspartate receptor antagonists in vivo, Neurochem. Res., 16 (1991) 951-963.
    • (1991) Neurochem. Res. , vol.16 , pp. 951-963
    • McCulloch, J.1    Iverson, L.L.2
  • 31
    • 0025824371 scopus 로고
    • Differential involvement of anterior and posterior cingulate cortices in spatial discrimination learning in a T-maze in mice
    • Meunier, M., Jaffard, R. and Destrade, C., Differential involvement of anterior and posterior cingulate cortices in spatial discrimination learning in a T-maze in mice. Behav. Brain Res., 44 (1991) 133-143.
    • (1991) Behav. Brain Res. , vol.44 , pp. 133-143
    • Meunier, M.1    Jaffard, R.2    Destrade, C.3
  • 32
    • 0028131438 scopus 로고
    • Posterior cingulate cortex in Alzheimer's disease
    • Minoshima, S., Foster, N.L. and Kuhl, D.E., Posterior cingulate cortex in Alzheimer's disease, Lancet, 344 (1994) 895.
    • (1994) Lancet , vol.344 , pp. 895
    • Minoshima, S.1    Foster, N.L.2    Kuhl, D.E.3
  • 33
    • 0025367265 scopus 로고
    • Blocking of acquisition but not expression of conditioned fear-potentiated startle by NMDA antagonists in the amygdala
    • Miserendino, M.J.D., Sananes, C.B., Melia, K.R. and Davis, M., Blocking of acquisition but not expression of conditioned fear-potentiated startle by NMDA antagonists in the amygdala, Nature, 345 (1990) 716-718.
    • (1990) Nature , vol.345 , pp. 716-718
    • Miserendino, M.J.D.1    Sananes, C.B.2    Melia, K.R.3    Davis, M.4
  • 34
    • 0022650213 scopus 로고
    • Selective impairment of learning and blockade of long-term potentiation by an N-methyl-D-aspartate receptor antagonist, AP5
    • Morris, R.G.M., Anderson, E., Lynch, G.S. and Baudry, M., Selective impairment of learning and blockade of long-term potentiation by an N-methyl-D-aspartate receptor antagonist, AP5, Nature, 319 (1986) 774-776.
    • (1986) Nature , vol.319 , pp. 774-776
    • Morris, R.G.M.1    Anderson, E.2    Lynch, G.S.3    Baudry, M.4
  • 35
    • 0018145650 scopus 로고
    • The development of food search behavior by rats; the effects of hippocampal damage and haloperidol
    • Oades, R. and Isaacson, R.L., The development of food search behavior by rats; the effects of hippocampal damage and haloperidol, Behav. Biol., 24 (1978) 327-337.
    • (1978) Behav. Biol. , vol.24 , pp. 327-337
    • Oades, R.1    Isaacson, R.L.2
  • 36
    • 0019390806 scopus 로고
    • Types of memory or attention? Impairments after lesions of the hippocampus and limbic ventral tegmentum
    • Oades, R.D., Types of memory or attention? Impairments after lesions of the hippocampus and limbic ventral tegmentum, Brain Res. Bull., 7 (1981) 221-226.
    • (1981) Brain Res. Bull. , vol.7 , pp. 221-226
    • Oades, R.D.1
  • 37
    • 0027361335 scopus 로고
    • MK-801 impairs recognition memory in rhesus monkeys: Comparison with cholinergic drugs
    • Ogura, H. and Aigner T.G., MK-801 impairs recognition memory in rhesus monkeys: comparison with cholinergic drugs, J. Pharmacol. Exp. Ther., 266 (1993) 60-64.
    • (1993) J. Pharmacol. Exp. Ther. , vol.266 , pp. 60-64
    • Ogura, H.1    Aigner, T.G.2
  • 38
    • 0024356295 scopus 로고
    • Excitoxicity and N-methyl-D-aspartate receptors
    • Olney, J.W., Excitoxicity and N-methyl-D-aspartate receptors, Drug Dev. Res., 17 (1989) 299-319.
    • (1989) Drug Dev. Res. , vol.17 , pp. 299-319
    • Olney, J.W.1
  • 39
    • 0029077403 scopus 로고
    • NMDA receptor hypofunction, excitotoxicity and Alzheimer's disease
    • Olney, J.W., NMDA receptor hypofunction, excitotoxicity and Alzheimer's disease, Neurobiol. Aging, 16 (1995) 459-461.
    • (1995) Neurobiol. Aging , vol.16 , pp. 459-461
    • Olney, J.W.1
  • 40
    • 0002112670 scopus 로고
    • Excitatory transmitter neurotoxicity and Alzheimer's disease
    • E. Giacobini and R. Becker (Eds.), Birkhauser, Boston
    • Olney, J.W. and Farber, N.B., Excitatory transmitter neurotoxicity and Alzheimer's disease. In E. Giacobini and R. Becker (Eds.), Alzheimer Disease: Therapeutic Strategies, Birkhauser, Boston, 1994, pp. 293-298.
    • (1994) Alzheimer Disease: Therapeutic Strategies , pp. 293-298
    • Olney, J.W.1    Farber, N.B.2
  • 41
    • 0028850552 scopus 로고    scopus 로고
    • Glutamate receptor dysfunction and schizophrenia
    • In press
    • Olney, J.W. and Farber, N.B., Glutamate receptor dysfunction and schizophrenia, Arch. Gen. Psychiatry (1995) (In press).
    • Arch. Gen. Psychiatry , vol.1995
    • Olney, J.W.1    Farber, N.B.2
  • 42
    • 0024338054 scopus 로고
    • Patholological changes induced in cerebrocortical neurons by phencyclidine and related drugs
    • Olney, J.W., Labruyere, J. and Price, M.T., Patholological changes induced in cerebrocortical neurons by phencyclidine and related drugs, Science, 244 (1989) 1360-1362.
    • (1989) Science , vol.244 , pp. 1360-1362
    • Olney, J.W.1    Labruyere, J.2    Price, M.T.3
  • 44
    • 0343459099 scopus 로고
    • Glutamatergic, GABAergic and cholinergic systems in posterior cingulate cortex: Interactions and possible mechanisms in limbic system disease
    • BA Vogt and M Gabriel (Eds), Birkhauser, Boston
    • Olney, J.W., Sesma, M.A. and Wozniak, D.F., Glutamatergic, GABAergic and cholinergic systems in posterior cingulate cortex: Interactions and possible mechanisms in limbic system disease. In BA Vogt and M Gabriel (Eds), The Neurobiology of the Cingulate Cortex and Limbic Thalamus, Birkhauser, Boston, 1993, pp. 557-580.
    • (1993) The Neurobiology of the Cingulate Cortex and Limbic Thalamus , pp. 557-580
    • Olney, J.W.1    Sesma, M.A.2    Wozniak, D.F.3
  • 45
    • 0025241498 scopus 로고
    • Excitatory amino-acid antagonists and memory: Effect of drugs acting at N-methyl-D-aspartate receptors in learning and memory tasks
    • Parada-Turska, J. and Turski, W.A., Excitatory amino-acid antagonists and memory: effect of drugs acting at N-methyl-D-aspartate receptors in learning and memory tasks, Neuropharmacology, 29 (1990) 1111-1116.
    • (1990) Neuropharmacology , vol.29 , pp. 1111-1116
    • Parada-Turska, J.1    Turski, W.A.2
  • 46
    • 0025940588 scopus 로고
    • N-methyl-D-aspartate antagonists and working memory performance: Comparison with the effects of scopolamine, propranolol, diazepam, and phenylisopropyladenosine
    • Pontecorvo, M.J., Clissold, D.B., White, M.F. and Ferkany, J.W., N-Methyl-D-aspartate antagonists and working memory performance: Comparison with the effects of scopolamine, propranolol, diazepam, and phenylisopropyladenosine, Behav. Neurosci., 105 (1991) 521-535.
    • (1991) Behav. Neurosci. , vol.105 , pp. 521-535
    • Pontecorvo, M.J.1    Clissold, D.B.2    White, M.F.3    Ferkany, J.W.4
  • 47
    • 0024405135 scopus 로고
    • Behavioral effects of MK-801 mimic deficits associated with hippocampal damage
    • Robinson, G.S., Jr., Crooks, G.B. Jr., Shinkman, P.G. and Gallagher, M., Behavioral effects of MK-801 mimic deficits associated with hippocampal damage, Psychobiology, 17 (1989) 156-164.
    • (1989) Psychobiology , vol.17 , pp. 156-164
    • Robinson G.S., Jr.1    Crooks G.B., Jr.2    Shinkman, P.G.3    Gallagher, M.4
  • 48
    • 0025179588 scopus 로고
    • NMDA antagonist MK-801 impairs acquistion but not performance of spatial working and reference memory
    • Shapiro, M.L. and Caramanos, Z., NMDA antagonist MK-801 impairs acquistion but not performance of spatial working and reference memory, Psychobiology, 18 (1990) 231-243.
    • (1990) Psychobiology , vol.18 , pp. 231-243
    • Shapiro, M.L.1    Caramanos, Z.2
  • 49
    • 0026704477 scopus 로고
    • N-methyl-D-aspartate receptor antagonist MK-801 and spatial memory representation: Working memory is impaired in an unfamiliar environment but not in a familiar environment
    • Shapiro, M.L. and O'Connor, C., N-methyl-D-aspartate receptor antagonist MK-801 and spatial memory representation: working memory is impaired in an unfamiliar environment but not in a familiar environment, Behav. Neurosci., 106 (1992) 604-612.
    • (1992) Behav. Neurosci. , vol.106 , pp. 604-612
    • Shapiro, M.L.1    O'Connor, C.2
  • 50
    • 0025786634 scopus 로고
    • MK-801 and ketamine induce heat shock protein HSP70 in injured neurons in posterior cingulate and retrosplenial cortex
    • Sharp, F.R., Jasper, P., Hall, J., Noble, L. and Sager, S.M., MK-801 and ketamine induce heat shock protein HSP70 in injured neurons in posterior cingulate and retrosplenial cortex, Ann. Neurol., 30 (1991) 801-809.
    • (1991) Ann. Neurol. , vol.30 , pp. 801-809
    • Sharp, F.R.1    Jasper, P.2    Hall, J.3    Noble, L.4    Sager, S.M.5
  • 53
    • 0002465809 scopus 로고
    • Posterior cingulate cortex and spatial memory: A microlimnology analysis
    • B.A. Vogt and M. Gabriel (Eds.), Birkhauser, Boston
    • Sutherland, R.J. and Hoesing, J.M., Posterior cingulate cortex and spatial memory: a microlimnology analysis. In B.A. Vogt and M. Gabriel (Eds.), The Neurobiology of the Cingulate Cortex and Limbic Thalamus, Birkhauser, Boston, 1993, pp. 461-477.
    • (1993) The Neurobiology of the Cingulate Cortex and Limbic Thalamus , pp. 461-477
    • Sutherland, R.J.1    Hoesing, J.M.2
  • 54
    • 0024323992 scopus 로고
    • The behavioral effects of MK-801: A comparison with antagonists acting non-competitively and competitively at the NMDA receptor
    • Tricklebank, M.D., Singh, L., Oles, R.J., Preston, D. and Iversen, S.D., The behavioral effects of MK-801: a comparison with antagonists acting non-competitively and competitively at the NMDA receptor, Eur. J. Pharmacol., 167 (1989) 1127-1135.
    • (1989) Eur. J. Pharmacol. , vol.167 , pp. 1127-1135
    • Tricklebank, M.D.1    Singh, L.2    Oles, R.J.3    Preston, D.4    Iversen, S.D.5
  • 55
    • 0024412746 scopus 로고
    • Immediate and long-lasting effects of MK-801 on motor activity, spatial navigation in a swimming pool and EEG in the rat
    • Whishaw, I.Q. and Auer, R.L., Immediate and long-lasting effects of MK-801 on motor activity, spatial navigation in a swimming pool and EEG in the rat, Psychopharmacology, 98 (1989) 500-507.
    • (1989) Psychopharmacology , vol.98 , pp. 500-507
    • Whishaw, I.Q.1    Auer, R.L.2
  • 56
  • 58
    • 0000770063 scopus 로고
    • MK-801 induces extensive neuronal necrosis in posterior cingulate/retrosplenial cortices
    • Wozniak, D.F., McEwen, M., Sesma, M.A., Olney, J.W. and Fix, A.S., MK-801 induces extensive neuronal necrosis in posterior cingulate/retrosplenial cortices, Soc. Neurosci. Abstr., 19 (1993) 1770.
    • (1993) Soc. Neurosci. Abstr. , vol.19 , pp. 1770
    • Wozniak, D.F.1    McEwen, M.2    Sesma, M.A.3    Olney, J.W.4    Fix, A.S.5
  • 60
    • 0024404885 scopus 로고
    • Comparison of behavioral effects of nucleus basalis magnocellularis lesions and somatosensory cortex ablation in the rat
    • Wozniak, D.F., Stewart, G.R., Finger, S. and Olney, J.W., Comparison of behavioral effects of nucleus basalis magnocellularis lesions and somatosensory cortex ablation in the rat, Neuroscience, 32 (1989) 686-700.
    • (1989) Neuroscience , vol.32 , pp. 686-700
    • Wozniak, D.F.1    Stewart, G.R.2    Finger, S.3    Olney, J.W.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.