Complete dependence on CD4+ cells in late asthmatic response, but limited contribution of the cells to airway remodeling in sensitized mice

Journal of Pharmacological Sciences

Volumn 116, Issue 4, 2011, Pages 373-383

  Nabe, Takeshi ^a   Morishita, Toyoko ^a   Matsuya, Kouki ^a   Ikedo, Ayumu ^a   Fujii, Masanori ^a   Mizutani, Nobuaki ^b   Yoshino, Shin ^b  

^a KYOTO PHARMACEUTICAL UNIVERSITY   (Japan)

^b KOBE PHARMACEUTICAL UNIVERSITY   (Japan)

Author keywords

Airway remodeling; Fibrosis; Interleukin 5; Late asthmatic response

Indexed keywords

CD4 ANTIBODY; DEXAMETHASONE; INTERLEUKIN 5;

AIRWAY REMODELING; AIRWAY RESISTANCE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTHMA; CD4 LYMPHOCYTE COUNT; CONTROLLED STUDY; CYTOKINE PRODUCTION; LYMPHOCYTE ACTIVATION; MOUSE; NONHUMAN; PATHOGENESIS;

EID: 84860396048     PISSN: 13478613     EISSN: 13478648     Source Type: Journal    
DOI: 10.1254/jphs.11083FP     Document Type: Article

References (41)

1. Perrin B., Cartier A., Ghezzo H., Grammer L., Harris K., Chan H., et al. Reassessment of the temporal patterns of bronchial obstruction after exposure to occupational sensitizing agents. J Allergy Clin Immunol. 1991;87:630-639.
2. Booij-Noord H., De Vries K., Sluiter H.J., Orie N.G. Late bronchial obstructive reaction to experimental inhalation of house dust extract. Clin Allergy. 1972;2:43-61.
3. Metzger W.J., Nugent K., Richerson H.B. Site of airflow obstruction during early and late phase asthmatic responses to allergen bronchoprovocation. Chest. 1985;88:369-375. (Pubitemid 15248095)
4. Cockcroft D.W., Ruffin R.E., Dolovich J., Hargreave F.E. Allergen-induced increase in non-allergic bronchial reactivity. Clin Allergy. 1977;7:503-513. (Pubitemid 8215959)
5. Van der Veen M.J., Van Neerven R.J., De Jong E.C., Aalberse R.C., Jansen H.M., Van der Zee J.S. The late asthmatic response is associated with baseline allergen-specific proliferative responsiveness of peripheral T lymphocytes in vitro and serum interleukin-5. Clin Exp Allergy. 1999;29:217-227. (Pubitemid 29084468)
6. Khan L.N., Kon O.M., Macfarlane A.J., Meng Q., Ying S., Barnes N.C., et al. Attenuation of the allergen-induced late asthmatic reaction by cyclosporin A is associated with inhibition of bronchial eosinophils, interleukin-5, granulocyte macrophage colonystimulating factor, and eotaxin. Am J Respir Crit Care Med. 2000;162:1377-1382.
7. Nabe T., Yamashita K., Miura M., Kawai T., Kohno S. Cysteinyl leukotriene-dependent interleukin-5 production leading to eosinophilia during late asthmatic response in guinea-pigs. Clin Exp Allergy. 2002;32:633-640. (Pubitemid 34429586)
8. Meyts I., Vanoirbeek J.A., Hens G., Vanaudenaerde B.M., Verbinnen B., Bullens D.M., et al. T-cell mediated late increase in bronchial tone after allergen provocation in a murine asthma model. Clin Immunol. 2008;128:248-258.
9. Pascual R.M., Peters S.P. Airway remodeling contributes to the progressive loss of lung function in asthma: An overview. J Allergy Clin Immunol. 2005;116:477-486 (Pubitemid 41267113)
10. Sumi Y., Hamid Q. Airway remodeling in asthma. Allergol Int. 2007;56:341-348. (Pubitemid 350306388)
11. Foster P.S., Yang M., Herbert C., Kumar R.K. CD4+ T-lymphocytes regulate airway remodeling and hyper-reactivity in a mouse model of chronic asthma. Lab Invest. 2002;82:455-462. (Pubitemid 34311117)
12. Doherty T.A., Soroosh P., Broide D.H., Croft M. CD4+ cells are required for chronic eosinophilic lung inflammation but not airway remodeling. Am J Physiol Lung Cell Mol Physiol. 2009;296:L229-L235.
13. Nabe T., Zindl C.L., Jung Y.W., Stephens R., Sakamoto A., Kohno S., et al. Induction of a late asthmatic response associated with airway inflammation in mice. Eur J Pharmacol. 2005;521:144-155. (Pubitemid 41427802)
14. Cieslewicz G., Tomkinson A., Adler A., Duez C., Schwarze J., Takeda K., et al. The late, but not early, asthmatic response is dependent on IL-5 and correlates with eosinophil infiltration. J Clin Invest. 1999;104:301-308.
15. Karras J.G., McGraw K., McKay R.A., Cooper S.R., Lerner D., Lu T., et al. Inhibition of antigen-induced eosinophilia and late phase airway hyperresponsiveness by an IL-5 antisense oligonucleotide in mouse models of asthma. J Immunol. 2000;164:5409-5415. (Pubitemid 30305223)
16. Taube C., Duez C., Cui Z.H., Takeda K., Rha Y.H., Park J.W., et al. The role of IL-13 in established allergic airway disease. J Immunol. 2002;169:6482-6489. (Pubitemid 36903499)
17. Edwan J.H., Perry G., Talmadge J.E., Agrawal D.K. Flt-3 ligand reverses late allergic response and airway hyper-responsiveness in a mouse model of allergic inflammation. J Immunol. 2004;172:5016-5023. (Pubitemid 38456428)
18. Mizutani N., Nabe T., Yoshino S. Complement C3a regulates late asthmatic response and airway hyperresponsiveness in mice. J Immunol. 2009;183:4039-4046.
19. Ho W., Furst A. Intratracheal instillation method for mouse lungs. Oncology. 1973;27:385-393.
20. Pennock B.E., Cox C.P., Rogers R.M., Cain W.A., Wells J.H. A noninvasive technique for measurement of changes in specific airway resistance. J Appl Physiol. 1979;46:399-406. (Pubitemid 9158788)
21. Flandre T.D., Leroy P.L., Desmecht D.J. Effect of somatic growth, strain, and sex on double-chamber plethysmographic respiratory function values in healthy mice. J Appl Physiol. 2003;94:1129-1136. (Pubitemid 36232030)
22. Nabe T., Hosokawa F., Matsuya K., Morishita T., Ikedo A., Fujii M., et al. Important role of neutrophils in the late asthmatic response in mice. Life Sci. 2011;88:1127-1135.
23. Pavord I.D., Brightling C.E., Woltmann G., Wardlaw A.J. Non-eosinophilic corticosteroid unresponsive asthma. Lancet. 1999;353:2213-2214. (Pubitemid 29295261)
24. Pavord I.D. Non-eosinophilic asthma and the innate immune response. Thorax. 2007;62:193-194. (Pubitemid 46579793)
25. Luccioli S., Brody D.T., Hasan S., Keane-Myers A., Prussin C., Metcalfe D.D. IgE(+), Kit(-), I-A/I-E(-) myeloid cells are the initial source of Il-4 after antigen challenge in a mouse model of allergic pulmonary inflammation. J Allergy Clin Immunol. 2002;110:117-124. (Pubitemid 36132737)
26. Tanaka H., Komai M., Nagao K., Ishizaki M., Kajiwara D., Takatsu K., et al. Role of interleukin-5 and eosinophils in allergen-induced airway remodeling in mice. Am J Respir Cell Mol Biol. 2004;31:62-68. (Pubitemid 38888040)
27. Lim D.H., Cho J.Y., Song D.J., Lee S.Y., Miller M., Broide D.H. PI3K gamma-deficient mice have reduced levels of allergen-induced eosinophilic inflammation and airway remodeling. Am J Physiol Lung Cell Mol Physiol. 2009;296:L210-L219.
28. Rommel C., Camps M., Ji H. PI3K delta and PI3K gamma: Partners in crime in inflammation in rheumatoid arthritis and beyond? Nat Rev Immunol. 2007;7:191-201.
29. Lee C.G., Kang H.R., Homer R.J., Chupp G., Elias J.A. Transgenic modeling of transforming growth factor-beta(1): Role of apoptosis in fibrosis and alveolar remodeling. Proc Am Thorac Soc. 2006;3:418-423. (Pubitemid 44033356)
30. Lee C.G., Homer R.J., Zhu Z., Lanone S., Wang X., Koteliansky V., et al. Interleukin-13 induces tissue fibrosis by selectively stimulating and activating transforming growth factor beta(1). J Exp Med. 2001;194:809-821. (Pubitemid 32983016)
31. Bates J., Irvin C., Brusasco V., Drazen J., Fredberg J., Loring S., et al. The use and misuse of Penh in animal models of lung disease. Am J Respir Cell Mol Biol. 2004;31:373-374. (Pubitemid 39180309)
32. Lundblad L.K., Irvin C.G., Hantos Z., Sly P., Mitzner W., Bates J.H. Penh is not a measure of airway resistance! Eur Respir J. 2007;30:805. (Pubitemid 351194843)
33. Kumar R.K., Foster P.S. Modeling allergic asthma in mice: Pitfalls and opportunities. Am J Respir Cell Mol Biol. 2002;27:267-272. (Pubitemid 34979284)
34. Wakahara K., Tanaka H., Takahashi G., Tamari M., Nasu R., Toyohara T., et al. Repeated instillations of Dermatophagoides farinae into the airways can induce Th2-dependent airway hyperresponsiveness, eosinophilia and remodeling in mice: Effect of intratracheal treatment of fluticasone propionate. Eur J Pharmacol. 2008;578:87-96. (Pubitemid 350179752)
35. Hirose I., Tanaka H., Takahashi G., Wakahara K., Tamari M., Sakamoto T., et al. Immunomodulatory effects of CpG oligodeoxynucleotides on house dust mite-induced airway inflammation in mice. Int Arch Allergy Immunol. 2008;147:6-16.
36. Kelly E.A., Busse W.W., Jarjour N.N. Increased matrix metalloproteinase-9 in the airway after allergen challenge. Am J Respir Crit Care Med. 2000;162:1157-1161.
37. Simpson J.L., Scott R.J., Boyle M.J., Gibson P.G. Differential proteolytic enzyme activity in eosinophilic and neutrophilic asthma. Am J Respir Crit Care Med. 2005;172:559-565. (Pubitemid 41232966)
38. + invariant NKT cell function and homeostatic survival. J Immunol. 2008;180:5448-5456.
39. McLellan A.D., Kämpgen E. Functions of myeloid and lymphoid dendritic cells. Immunol Lett. 2000;72:101-105. (Pubitemid 30332305)
40. + T cells. Adv Immunol. 2010;105:99-130.
41. Nouri-Aria K.T. Foxp3 expressing regulatory T-cells in allergic disease. Adv Exp Med Biol. 2009;665:180-194.