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Volumn 20, Issue 1, 2012, Pages 54-62

Adenovirus i-leader truncation bioselected against cancer-associated fibroblasts to overcome tumor stromal barriers

Author keywords

[No Author keywords available]

Indexed keywords

ONCOLYTIC ADENOVIRUS;

EID: 84860395763     PISSN: 15250016     EISSN: 15250024     Source Type: Journal    
DOI: 10.1038/mt.2011.159     Document Type: Article
Times cited : (25)

References (44)
  • 1
    • 33846650370 scopus 로고    scopus 로고
    • Clinical trial results with oncolytic virotherapy: A century of promise, a decade of progress
    • DOI 10.1038/ncponc0736, PII NCPONC0736
    • Liu, TC, Galanis, E and Kirn, D (2007). Clinical trial results with oncolytic virotherapy: a century of promise, a decade of progress. Nat Clin Pract Oncol 4: 101-117. (Pubitemid 46189539)
    • (2007) Nature Clinical Practice Oncology , vol.4 , Issue.2 , pp. 101-117
    • Liu, T.-C.1    Galanis, E.2    Kirn, D.3
  • 2
    • 70349923535 scopus 로고    scopus 로고
    • Anatomical and physical barriers to tumor targeting with oncolytic adenoviruses in vivo
    • Strauss, R and Lieber, A (2009). Anatomical and physical barriers to tumor targeting with oncolytic adenoviruses in vivo. Curr Opin Mol Ther 11: 513-522.
    • (2009) Curr Opin Mol Ther , vol.11 , pp. 513-522
    • Strauss, R.1    Lieber, A.2
  • 3
    • 44349106062 scopus 로고    scopus 로고
    • Translation of targeted oncolytic virotherapeutics from the lab into the clinic, and back again: A high-value iterative loop
    • DOI 10.1038/mt.2008.70, PII MT200870
    • Liu, TC, Hwang, TH, Bell, JC and Kirn, DH (2008). Translation of targeted oncolytic virotherapeutics from the lab into the clinic, and back again: a high-value iterative loop. Mol Ther 16: 1006-1008. (Pubitemid 351737062)
    • (2008) Molecular Therapy , vol.16 , Issue.6 , pp. 1006-1008
    • Liu, T.-C.1    Hwang, T.-H.2    Bell, J.C.3    Kirn, D.H.4
  • 5
    • 28844444157 scopus 로고    scopus 로고
    • Exploring the tumour environment: Cancer-associated fibroblasts as targets in cancer therapy
    • DOI 10.1517/14728222.9.6.1217
    • Micke, P and Ostman, A (2005). Exploring the tumour environment: cancer-associated fibroblasts as targets in cancer therapy. Expert Opin Ther Targets 9: 1217-1233. (Pubitemid 41762875)
    • (2005) Expert Opinion on Therapeutic Targets , vol.9 , Issue.6 , pp. 1217-1233
    • Micke, P.1    Ostman, A.2
  • 6
    • 66849134484 scopus 로고    scopus 로고
    • Tumor associated stromal cells play a critical role on the outcome of the oncolytic efficacy of conditionally replicative adenoviruses
    • Lopez, MV, Viale, DL, Cafferata, EG, Bravo, AI, Carbone, C, Gould, D et al. (2009). Tumor associated stromal cells play a critical role on the outcome of the oncolytic efficacy of conditionally replicative adenoviruses. PLoS ONE 4: e5119.
    • (2009) PLoS ONE , vol.4
    • Lopez, M.V.1    Viale, D.L.2    Cafferata, E.G.3    Bravo, A.I.4    Carbone, C.5    Gould, D.6
  • 7
    • 0037457032 scopus 로고    scopus 로고
    • Intratumoral spread of wild-type adenovirus is limited after local injection of human xenograft tumors: Virus persists and spreads systemically at late time points
    • DOI 10.1089/104303403321467199
    • Sauthoff, H, Hu, J, Maca, C, Goldman, M, Heitner, S, Yee, H et al. (2003). Intratumoral spread of wild-type adenovirus is limited after local injection of human xenograft tumors: virus persists and spreads systemically at late time points. Hum Gene Ther 14: 425-433. (Pubitemid 36403535)
    • (2003) Human Gene Therapy , vol.14 , Issue.5 , pp. 425-433
    • Sauthoff, H.1    Hu, J.2    Maca, C.3    Goldman, M.4    Heitner, S.5    Yee, H.6    Pipiya, T.7    Rom, W.N.8    Hay, J.G.9
  • 8
    • 0037444281 scopus 로고    scopus 로고
    • Validation and analysis of a mathematical model of a replication- competent oncolytic virus for cancer treatment: Implications for virus design and delivery
    • Wein, LM, Wu, JT and Kirn, DH (2003). Validation and analysis of a mathematical model of a replication-competent oncolytic virus for cancer treatment: implications for virus design and delivery. Cancer Res 63: 1317-1324. (Pubitemid 36348711)
    • (2003) Cancer Research , vol.63 , Issue.6 , pp. 1317-1324
    • Wein, L.M.1    Wu, J.T.2    Kirn, D.H.3
  • 9
    • 59149087387 scopus 로고    scopus 로고
    • A multiscale mathematical model for oncolytic virotherapy
    • Paiva, LR, Binny, C, Ferreira, SC Jr and Martins, ML (2009). A multiscale mathematical model for oncolytic virotherapy. Cancer Res 69: 1205-1211.
    • (2009) Cancer Res , vol.69 , pp. 1205-1211
    • Paiva, L.R.1    Binny, C.2    Ferreira Jr., S.C.3    Martins, M.L.4
  • 10
    • 0033835016 scopus 로고    scopus 로고
    • A prospective phase II trial of ONYX-015 adenovirus and chemotherapy in recurrent squamous cell carcinoma of the head and neck (the Baylor experience)
    • Lamont, JP, Nemunaitis, J, Kuhn, JA, Landers, SA and McCarty, TM (2000). A prospective phase II trial of ONYX-015 adenovirus and chemotherapy in recurrent squamous cell carcinoma of the head and neck (the Baylor experience). Ann Surg Oncol 7: 588-592.
    • (2000) Ann Surg Oncol , vol.7 , pp. 588-592
    • Lamont, J.P.1    Nemunaitis, J.2    Kuhn, J.A.3    Landers, S.A.4    McCarty, T.M.5
  • 11
    • 34447509647 scopus 로고    scopus 로고
    • Combination of the oncolytic adenovirus ICOVIR-5 with chemotherapy provides enhanced anti-glioma effect in vivo
    • DOI 10.1038/sj.cgt.7701067, PII 7701067
    • Alonso, MM, Gomez-Manzano, C, Jiang, H, Bekele, NB, Piao, Y, Yung, WK et al. (2007). Combination of the oncolytic adenovirus ICOVIR-5 with chemotherapy provides enhanced anti-glioma effect in vivo. Cancer Gene Ther 14: 756-761. (Pubitemid 47080367)
    • (2007) Cancer Gene Therapy , vol.14 , Issue.8 , pp. 756-761
    • Alonso, M.M.1    Gomez-Manzano, C.2    Jiang, H.3    Bekele, N.B.4    Piao, Y.5    Yung, W.K.A.6    Alemany, R.7    Fueyo, J.8
  • 12
    • 77952009437 scopus 로고    scopus 로고
    • Verapamil enhances the antitumoral efficacy of oncolytic adenoviruses
    • Gros, A, Puig, C, Guedan, S, Rojas, JJ, Alemany, R and Cascallo, M (2010). Verapamil enhances the antitumoral efficacy of oncolytic adenoviruses. Mol Ther 18: 903-911.
    • (2010) Mol Ther , vol.18 , pp. 903-911
    • Gros, A.1    Puig, C.2    Guedan, S.3    Rojas, J.J.4    Alemany, R.5    Cascallo, M.6
  • 13
    • 34249316871 scopus 로고    scopus 로고
    • Relaxin-expressing, fiber chimeric oncolytic adenovirus prolongs survival of tumor-bearing mice
    • DOI 10.1158/0008-5472.CAN-06-4260
    • Ganesh, S, Gonzalez Edick, M, Idamakanti, N, Abramova, M, Vanroey, M, Robinson, M et al. (2007). Relaxin-expressing, fiber chimeric oncolytic adenovirus prolongs survival of tumor-bearing mice. Cancer Res 67: 4399-4407. (Pubitemid 46815089)
    • (2007) Cancer Research , vol.67 , Issue.9 , pp. 4399-4407
    • Ganesh, S.1    Edick, M.G.2    Idamakanti, N.3    Abramova, M.4    VanRoey, M.5    Robinson, M.6    Yun, C.-O.7    Jooss, K.8
  • 14
    • 77955403005 scopus 로고    scopus 로고
    • Hyaluronidase expression by an oncolytic adenovirus enhances its intratumoral spread and suppresses tumor growth
    • Guedan, S, Rojas, JJ, Gros, A, Mercade, E, Cascallo, M and Alemany, R (2010). Hyaluronidase expression by an oncolytic adenovirus enhances its intratumoral spread and suppresses tumor growth. Mol Ther 18: 1275-1283.
    • (2010) Mol Ther , vol.18 , pp. 1275-1283
    • Guedan, S.1    Rojas, J.J.2    Gros, A.3    Mercade, E.4    Cascallo, M.5    Alemany, R.6
  • 15
    • 76349110981 scopus 로고    scopus 로고
    • Current issues and future directions of oncolytic adenoviruses
    • Yamamoto, M and Curiel, DT (2010). Current issues and future directions of oncolytic adenoviruses. Mol Ther 18: 243-250.
    • (2010) Mol Ther , vol.18 , pp. 243-250
    • Yamamoto, M.1    Curiel, D.T.2
  • 16
    • 3042735443 scopus 로고    scopus 로고
    • An E1B-19 kDa gene deletion mutant adenovirus demonstrates tumor necrosis factor-enhanced cancer selectivity and enhanced oncolytic potency
    • DOI 10.1016/j.ymthe.2004.03.017, PII S1525001604001200
    • Liu, TC, Hallden, G, Wang, Y, Brooks, G, Francis, J, Lemoine, N et al. (2004). An E1B-19 kDa gene deletion mutant adenovirus demonstrates tumor necrosis factorenhanced cancer selectivity and enhanced oncolytic potency. Mol Ther 9: 786-803. (Pubitemid 38878125)
    • (2004) Molecular Therapy , vol.9 , Issue.6 , pp. 786-803
    • Liu, T.-C.1    Hallden, G.2    Wang, Y.3    Brooks, G.4    Francis, J.5    Lemoine, N.6    Kirn, D.7
  • 17
    • 0034086730 scopus 로고    scopus 로고
    • Tumor-specific, replication-competent adenovirus vectors overexpressing the adenovirus death protein
    • DOI 10.1128/JVI.74.13.6147-6155.2000
    • Doronin, K, Toth, K, Kuppuswamy, M, Ward, P, Tollefson, AE and Wold, WS (2000). Tumor-specific, replication-competent adenovirus vectors overexpressing the adenovirus death protein. J Virol 74: 6147-6155. (Pubitemid 30412986)
    • (2000) Journal of Virology , vol.74 , Issue.13 , pp. 6147-6155
    • Doronin, K.1    Toth, K.2    Kuppuswamy, M.3    Ward, P.4    Tollefson, A.E.5    Wold, W.S.M.6
  • 18
    • 55349119141 scopus 로고    scopus 로고
    • Bioselection of a gain of function mutation that enhances adenovirus 5 release and improves its antitumoral potency
    • Gros, A, Martiez-Quintanilla, J, Puig, C, Guedan, S, Molleví DG, Alemany, R et al. (2008). Bioselection of a gain of function mutation that enhances adenovirus 5 release and improves its antitumoral potency. Cancer Res 68: 8928-8937.
    • (2008) Cancer Res , vol.68 , pp. 8928-8937
    • Gros, A.1    Martiez-Quintanilla, J.2    Puig, C.3    Guedan, S.4    Molleví, D.G.5    Alemany, R.6
  • 20
    • 32444433144 scopus 로고    scopus 로고
    • Genetic identification of adenovirus type 5 genes that influence viral spread
    • DOI 10.1128/JVI.80.4.2000-2012.2006
    • Subramanian, T, Vijayalingam, S and Chinnadurai, G (2006). Genetic identification of adenovirus type 5 genes that influence viral spread. J Virol 80: 2000-2012. (Pubitemid 43228740)
    • (2006) Journal of Virology , vol.80 , Issue.4 , pp. 2000-2012
    • Subramanian, T.1    Vijayalingam, S.2    Chinnadurai, G.3
  • 22
    • 0035138689 scopus 로고    scopus 로고
    • A conditionally replicative adenovirus with enhanced infectivity shows improved oncolytic potency
    • Suzuki, K, Fueyo, J, Krasnykh, V, Reynolds, PN, Curiel, DT and Alemany, R (2001). A conditionally replicative adenovirus with enhanced infectivity shows improved oncolytic potency. Clin Cancer Res 7: 120-126. (Pubitemid 32110214)
    • (2001) Clinical Cancer Research , vol.7 , Issue.1 , pp. 120-126
    • Suzuki, K.1    Fueyo, J.2    Krasnykh, V.3    Reynolds, P.N.4    Curiel, D.T.5    Alemany, R.6
  • 23
    • 0015061505 scopus 로고
    • Isolation of temperature-sensitive mutants of adenovirus type 5
    • Williams, JF, Gharpure, M, Ustacelebi, S and McDonald, S (1971). Isolation of temperature-sensitive mutants of adenovirus type 5. J Gen Virol 11: 95-101.
    • (1971) J Gen Virol , vol.11 , pp. 95-101
    • Williams, J.F.1    Gharpure, M.2    Ustacelebi, S.3    McDonald, S.4
  • 24
    • 0021739589 scopus 로고
    • Deletion of the gene encoding the adenovirus 5 early region 1B 21,000-molecular-weight polypeptide leads to degradation of viral and host cell DNA
    • Pilder, S, Logan, J and Shenk, T (1984). Deletion of the gene encoding the adenovirus 5 early region 1b 21,000-molecular-weight polypeptide leads to degradation of viral and host cell DNA. J Virol 52: 664-671. (Pubitemid 15200219)
    • (1984) Journal of Virology , vol.52 , Issue.2 , pp. 664-671
    • Pilder, S.1    Logan, J.2    Shenk, T.3
  • 26
    • 77953783397 scopus 로고    scopus 로고
    • Adenovirus release from the infected cell as a key factor for adenovirus oncolysis
    • Gros A, Guedan S (2010). Adenovirus release from the infected cell as a key factor for adenovirus oncolysis. The Open Gene Therapy Journal 3: 24-30.
    • (2010) The Open Gene Therapy Journal , vol.3 , pp. 24-30
    • Gros, A.1    Guedan, S.2
  • 28
    • 0025060288 scopus 로고
    • The adenovirus type 5 i-leader open reading frame functions in cis to reduce the half-life of L1 mRNAs
    • Soloway, PD and Shenk, T (1990). The adenovirus type 5 i-leader open reading frame functions in cis to reduce the half-life of L1 mRNAs. J Virol 64: 551-558. (Pubitemid 20032665)
    • (1990) Journal of Virology , vol.64 , Issue.2 , pp. 551-558
    • Soloway, P.D.1    Shenk, T.2
  • 29
    • 0022646558 scopus 로고
    • Biosynthesis of adenovirus type 2 i-leader protein
    • Symington, JS, Lucher, LA, Brackmann, KH, Virtanen, A, Pettersson, U and Green, M (1986). Biosynthesis of adenovirus type 2 i-leader protein. J Virol 57: 848-856. (Pubitemid 16143965)
    • (1986) Journal of Virology , vol.57 , Issue.3 , pp. 848-856
    • Symington, J.S.1    Lucher, L.A.2    Brackmann, K.H.3
  • 30
    • 0029872241 scopus 로고    scopus 로고
    • The adenovirus death protein (E3-11.6K) is required at very late stages of infection for efficient cell lysis and release of adenovirus from infected cells
    • Tollefson, AE, Scaria, A, Hermiston, TW, Ryerse, JS, Wold, LJ and Wold, WS (1996). The adenovirus death protein (E3-11.6K) is required at very late stages of infection for efficient cell lysis and release of adenovirus from infected cells. J Virol 70: 2296-2306. (Pubitemid 26087592)
    • (1996) Journal of Virology , vol.70 , Issue.4 , pp. 2296-2306
    • Tollefson, A.E.1    Scaria, A.2    Hermiston, T.W.3    Ryerse, J.S.4    Wold, L.J.5    Wold, W.S.M.6
  • 32
    • 0034628552 scopus 로고    scopus 로고
    • Deletion of the adenoviral E1b-19kD gene enhances tumor cell killing of a replicating adenoviral vector
    • DOI 10.1089/10430340050015851
    • Sauthoff, H, Heitner, S, Rom, WN and Hay, JG (2000). Deletion of the adenoviral E1b-19kD gene enhances tumor cell killing of a replicating adenoviral vector. Hum Gene Ther 11: 379-388. (Pubitemid 30101948)
    • (2000) Human Gene Therapy , vol.11 , Issue.3 , pp. 379-388
    • Sauthoff, H.1    Heitner, S.2    Rom, W.N.3    Hay, J.G.4
  • 33
    • 0036830143 scopus 로고    scopus 로고
    • Conditionally replicative adenovirus expressing p53 exhibits enhanced oncolytic potency
    • van Beusechem, VW, van den Doel, PB, Grill, J, Pinedo, HM and Gerritsen, WR (2002). Conditionally replicative adenovirus expressing p53 exhibits enhanced oncolytic potency. Cancer Res 62: 6165-6171. (Pubitemid 35244467)
    • (2002) Cancer Research , vol.62 , Issue.21 , pp. 6165-6171
    • Van Beusechem, V.W.1    Van Den Doel, P.B.2    Grill, J.3    Pinedo, H.M.4    Gerritsen, W.R.5
  • 34
    • 0035870287 scopus 로고    scopus 로고
    • Viruses as antitumor weapons: Defining conditions for tumor remission
    • Wodarz, D (2001). Viruses as antitumor weapons: defining conditions for tumor remission. Cancer Res 61: 3501-3507. (Pubitemid 32695047)
    • (2001) Cancer Research , vol.61 , Issue.8 , pp. 3501-3507
    • Wodarz, D.1
  • 35
    • 67149093278 scopus 로고    scopus 로고
    • Oncolytic viruses from the perspective of the immune system
    • Alemany, R and Cascallo, M (2009). Oncolytic viruses from the perspective of the immune system. Future Microbiol 4: 527-536.
    • (2009) Future Microbiol , vol.4 , pp. 527-536
    • Alemany, R.1    Cascallo, M.2
  • 36
    • 10844281217 scopus 로고    scopus 로고
    • ADP-overexpressing adenovirus elicits enhanced cytopathic effect by induction of apoptosis
    • DOI 10.1038/sj.cgt.7700769
    • Yun, CO, Kim, E, Koo, T, Kim, H, Lee, YS and Kim, JH (2005). ADP-overexpressing adenovirus elicits enhanced cytopathic effect by induction of apoptosis. Cancer Gene Ther 12: 61-71. (Pubitemid 39665244)
    • (2005) Cancer Gene Therapy , vol.12 , Issue.1 , pp. 61-71
    • Yun, C.-O.1    Kim, E.2    Koo, T.3    Kim, H.4    Lee, Y.-S.5    Kim, J.-H.6
  • 37
    • 0038759070 scopus 로고    scopus 로고
    • Mutations within the ADP (E3-11.6K) protein alter processing and localization of ADP and the kinetics of cell lysis of adenovirus-infected cells
    • DOI 10.1128/JVI.77.14.7764-7778.2003
    • Tollefson, AE, Scaria, A, Ying, B and Wold, WS (2003). Mutations within the ADP (E3-11.6K) protein alter processing and localization of ADP and the kinetics of cell lysis of adenovirus-infected cells. J Virol 77: 7764-7778. (Pubitemid 36792773)
    • (2003) Journal of Virology , vol.77 , Issue.14 , pp. 7764-7778
    • Tollefson, A.E.1    Scaria, A.2    Ying, B.3    Wold, W.S.M.4
  • 39
    • 68949218981 scopus 로고    scopus 로고
    • Deletion of the E3-6.7K/gp19K region reduces the persistence of wild-type adenovirus in a permissive tumor model in Syrian hamsters
    • Bortolanza, S, Bunuales, M, Alzuguren, P, Lamas, O, Aldabe, R, Prieto, J et al. (2009). Deletion of the E3-6.7K/gp19K region reduces the persistence of wild-type adenovirus in a permissive tumor model in Syrian hamsters. Cancer Gene Ther 16: 703-712.
    • (2009) Cancer Gene Ther , vol.16 , pp. 703-712
    • Bortolanza, S.1    Bunuales, M.2    Alzuguren, P.3    Lamas, O.4    Aldabe, R.5    Prieto, J.6
  • 40
    • 78049467551 scopus 로고    scopus 로고
    • Minimal RB-responsive E1A promoter modification to attain potency, selectivity, and transgene-arming capacity in oncolytic adenoviruses
    • Rojas, JJ, Guedan, S, Searle, PF, Martinez-Quintanilla, J, Gil-Hoyos, R, Alcayaga-Miranda, F et al. (2010). Minimal RB-responsive E1A promoter modification to attain potency, selectivity, and transgene-arming capacity in oncolytic adenoviruses. Mol Ther 18: 1960-1971.
    • (2010) Mol Ther , vol.18 , pp. 1960-1971
    • Rojas, J.J.1    Guedan, S.2    Searle, P.F.3    Martinez-Quintanilla, J.4    Gil-Hoyos, R.5    Alcayaga-Miranda, F.6
  • 42
    • 0031775399 scopus 로고    scopus 로고
    • An adenovirus vector with genetically modified fibers demonstrates expanded tropism via utilization of a coxsackievirus and adenovirus receptor- independent cell entry mechanism
    • Dmitriev, I, Krasnykh, V, Miller, CR, Wang, M, Kashentseva, E, Mikheeva, G et al. (1998). An adenovirus vector with genetically modified fibers demonstrates expanded tropism via utilization of a coxsackievirus and adenovirus receptor-independent cell entry mechanism. J Virol 72: 9706-9713. (Pubitemid 28520834)
    • (1998) Journal of Virology , vol.72 , Issue.12 , pp. 9706-9713
    • Dmitriev, I.1    Krasnykh, V.2    Miller, C.R.3    Wang, M.4    Kashentseva, E.5    Mikheeva, G.6    Belousova, N.7    Curiel, D.T.8
  • 43
    • 0034830243 scopus 로고    scopus 로고
    • CAR-binding ablation does not change biodistribution and toxicity of adenoviral vectors
    • DOI 10.1038/sj.gt.3301515
    • Alemany, R and Curiel, DT (2001). CAR-binding ablation does not change biodistribution and toxicity of adenoviral vectors. Gene Ther 8: 1347-1353. (Pubitemid 32834304)
    • (2001) Gene Therapy , vol.8 , Issue.17 , pp. 1347-1353
    • Alemany, R.1    Curiel, D.T.2
  • 44
    • 33750607468 scopus 로고    scopus 로고
    • Deletion of VAI and VAII RNA genes in the design of oncolytic adenoviruses
    • DOI 10.1089/hum.2006.17.929
    • Cascallo, M, Gros, A, Bayo, N, Serrano, T, Capella, G and Alemany, R (2006). Deletion of VAI and VAII RNA genes in the design of oncolytic adenoviruses. Hum Gene Ther 17: 929-940. (Pubitemid 46076753)
    • (2006) Human Gene Therapy , vol.17 , Issue.9 , pp. 929-940
    • Cascallo, M.1    Gros, A.2    Bayo, N.3    Serrano, T.4    Capella, G.5    Alemany, R.6


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