Microsomal oxidative damage promoted by acetaminophen metabolism

Toxicology in Vitro

Volumn 25, Issue 7, 2011, Pages 1310-1313

  Letelier, María Eugenia ^a   López Valladares, Miguel ^a   Peredo Silva, Liliana ^a   Rojas Sepúlveda, Daniel ^a   Aracena, Paula ^a  

^a UNIVERSITY OF CHILE   (Chile)

Author keywords

Acetaminophen; Biotransformation; Microsomes; Oxidative stress; ROS

Indexed keywords

APOCYNIN; CATECHIN; CYTOCHROME P450; GLUTATHIONE TRANSFERASE; OXIDOREDUCTASE; PARACETAMOL; PLUMBAGIN; PROADIFEN; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; THIOL;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DOWN REGULATION; DRUG TRANSFORMATION; ENDOPLASMIC RETICULUM; ENZYME ACTIVITY; ENZYME INHIBITION; LIPID PEROXIDATION; LIVER CELL CULTURE; LIVER CELL DAMAGE; LIVER MICROSOME; LIVER MICROSOME METABOLISM; LIVER TOXICITY; MALE; NONHUMAN; OXIDATIVE STRESS; RAT;

ACETAMINOPHEN; ANALGESICS, NON-NARCOTIC; ANIMALS; ANTIPYRETICS; CATECHIN; CYTOCHROME P-450 ENZYME SYSTEM; DRUG INTERACTIONS; GLUTATHIONE TRANSFERASE; LIPID PEROXIDATION; MALE; MICROSOMES, LIVER; NADP; NAPHTHOQUINONES; OXIDATIVE STRESS; PROADIFEN; RATS; RATS, SPRAGUE-DAWLEY;

RATTUS;

EID: 84860390371     PISSN: 08872333     EISSN: 18793177     Source Type: Journal    
DOI: 10.1016/j.tiv.2011.04.022     Document Type: Article

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