Mechanisms underlying the inhibition of the cytochrome P450 system by copper ions

Journal of Applied Toxicology

Volumn 29, Issue 8, 2009, Pages 695-702

  Letelier, M E ^a   Faundez M ^b,c   Jara Sandoval, J ^a   Molina Berrios A ^a   Cortes Troncoso J ^a   Aracena Parks, P ^a   Marin Catalan R ^a  

^a UNIVERSITY OF CHILE   (Chile)

^b PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE   (Chile)

^c Campus San Joaquín ^*  (Chile)

Author keywords

Copper toxicology; Cytochrome P450; Drug metabolism; Oxidative stress; Rat liver microsomes

Indexed keywords

4 NITROANISOLE DEMETHYLASE; ASCORBIC ACID; COPPER ION; CYTOCHROME P450; HYDROXYL RADICAL; SUPEROXIDE; UNSPECIFIC MONOOXYGENASE;

ANIMAL TISSUE; ARTICLE; BINDING SITE; CATALYST; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; DRUG METABOLISM; ENZYME ACTIVITY; ENZYME BINDING; ENZYME INHIBITION; ENZYME MECHANISM; ENZYME REGULATION; ENZYME STRUCTURE; ENZYME SUBSTRATE; LIVER MICROSOME; MALE; NONHUMAN; OXIDATION; PHARMACODYNAMICS; PRIORITY JOURNAL; RAT;

ANIMALS; CHELATING AGENTS; COPPER; CYTOCHROME P-450 ENZYME SYSTEM; ENZYME INHIBITORS; GLUTATHIONE; KINETICS; LIVER; MALE; MICROSOMES, LIVER; OXIDANTS; OXIDOREDUCTASES, O-DEMETHYLATING; PROTEIN BINDING; RATS; RATS, SPRAGUE-DAWLEY; SPECTROPHOTOMETRY;

RATTUS;

EID: 74549135194     PISSN: 0260437X     EISSN: 10991263     Source Type: Journal    
DOI: 10.1002/jat.1460     Document Type: Article

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