메뉴 건너뛰기




Volumn 13, Issue 7, 2011, Pages 835-847

CD4+ CD25+ regulatory T cells ameliorate Behcet's disease-like symptoms in a mouse model

Author keywords

Behcet's disease; Herpes simplex virus; Mouse model; Regulatory T cells; Systemic inflammation

Indexed keywords

BETA ACTIN; CD4 ANTIGEN; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 17; INTERLEUKIN 2 RECEPTOR ALPHA; INTERLEUKIN 6; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR ALPHA;

EID: 84860390324     PISSN: 14653249     EISSN: 14772566     Source Type: Journal    
DOI: 10.3109/14653249.2011.571245     Document Type: Article
Times cited : (21)

References (66)
  • 1
    • 0018657469 scopus 로고
    • Behcet disease (Behcet syndrome)
    • Shimizu T. Behcet disease (Behcet syndrome). Semin Arthritis Rheum. 1979;8:223-60.
    • (1979) Semin Arthritis Rheum , vol.8 , pp. 223-260
    • Shimizu, T.1
  • 2
    • 0000718206 scopus 로고
    • Ueber rezidivierende aphthoese durch ein Virus verursachte Geschwuere am Mund am Auge und an den Genitalien
    • Behcet H. Ueber rezidivierende, aphthoese durch ein Virus verursachte Geschwuere am Mund, am Auge und an den Genitalien. Dermatol Wochenschr. 1937;105:1152-7.
    • (1937) Dermatol Wochenschr , vol.105 , pp. 1152-1157
    • Behcet, H.1
  • 3
    • 0029924089 scopus 로고    scopus 로고
    • Polymerase chain reaction reveals herpes simplex virus DNA in saliva of patients with Behcet's disease
    • Lee S, Bang D, Cho YH, Lee ES, Sohn S. Polymerase chain reaction reveals herpes simplex virus DNA in saliva of patients with Behcet's disease. Arch Dermatol Res. 1996;288:179-83.
    • (1996) Arch Dermatol Res , vol.288 , pp. 179-183
    • Lee, S.1    Bang, D.2    Cho, Y.H.3    Lee, E.S.4    Sohn, S.5
  • 4
    • 34648866607 scopus 로고
    • Herpes simplex virus detection by polymerase chain reaction in intestinal ulcer of patients with Behcet's disease
    • Lee ES, Lee S, Bang D, Sohn S, Park C, Lee K. Herpes simplex virus detection by polymerase chain reaction in intestinal ulcer of patients with Behcet's disease. J Invest Dermatol. 1993;101:474
    • (1993) J Invest Dermatol , vol.101 , pp. 474
    • Lee, E.S.1    Lee, S.2    Bang, D.3    Sohn, S.4    Park, C.5    Lee, K.6
  • 6
    • 34648873356 scopus 로고    scopus 로고
    • Detection of herpes simplex virus DNA by polymerase chain reaction in genital ulcer of patients with Behcet's disease
    • Lee ES, Lee S, Bang D, Sohn S. Detection of herpes simplex virus DNA by polymerase chain reaction in genital ulcer of patients with Behcet's disease. Revue du Rhumatisme. 1996;63:532
    • (1996) Revue du Rhumatisme , vol.63 , pp. 532
    • Lee, E.S.1    Lee, S.2    Bang, D.3    Sohn, S.4
  • 7
    • 0031593678 scopus 로고    scopus 로고
    • Behçet's disease-like symptoms induced by the Herpes simplex virus in ICR mice
    • Sohn S, Lee ES, Bang D, Lee S. Behçet's disease-like symptoms induced by the Herpes simplex virus in ICR mice. Eur J Dermatol. 1998;8:21-3.
    • (1998) Eur J Dermatol , vol.8 , pp. 21-23
    • Sohn, S.1    Lee, E.S.2    Bang, D.3    Lee, S.4
  • 9
    • 0029150110 scopus 로고
    • Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases
    • Sakaguchi S, Sakaguchi N, Asano M, Itoh M, Toda M. Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. J Immunol. 1995;155:1151-64.
    • (1995) J Immunol , vol.155 , pp. 1151-1164
    • Sakaguchi, S.1    Sakaguchi, N.2    Asano, M.3    Itoh, M.4    Toda, M.5
  • 10
    • 16844365788 scopus 로고    scopus 로고
    • Naturally arising Foxp3-expressing CD25+ CD4+ regulatory T cells in immunological tolerance to self and non-self
    • Sakaguchi S. Naturally arising Foxp3-expressing CD25+ CD4+ regulatory T cells in immunological tolerance to self and non-self. Nat Immunol. 2005;6:345-52.
    • (2005) Nat Immunol , vol.6 , pp. 345-352
    • Sakaguchi, S.1
  • 11
    • 1242295282 scopus 로고    scopus 로고
    • Naturally-occurring CD4+ CD25+ immunoregulatory T cells: Central players in the arena of peripheral tolerance
    • Piccirillo CA, Shevach EM. Naturally-occurring CD4+ CD25+ immunoregulatory T cells: Central players in the arena of peripheral tolerance. Semin Immunol. 2004;16:81-8.
    • (2004) Semin Immunol , vol.16 , pp. 81-88
    • Piccirillo, C.A.1    Shevach, E.M.2
  • 13
    • 34548680982 scopus 로고    scopus 로고
    • Foxp3+ regulatory T cells: Selfi shness under scrutiny
    • Stephens GL, Shevach EM. Foxp3+ regulatory T cells: Selfi shness under scrutiny. Immunity. 2007;27:417-9.
    • (2007) Immunity , vol.27 , pp. 417-419
    • Stephens, G.L.1    Shevach, E.M.2
  • 14
    • 0035806244 scopus 로고    scopus 로고
    • Ex vivo isolation and characterization of CD4+ CD25+ T cells with regulatory properties from human blood
    • Dieckmann D, Plottner H, Berchtold S, Berger T, Schuler G. Ex vivo isolation and characterization of CD4+ CD25+ T cells with regulatory properties from human blood. J Exp Med. 2001;193:1303-10.
    • (2001) J Exp Med , vol.193 , pp. 1303-1310
    • Dieckmann, D.1    Plottner, H.2    Berchtold, S.3    Berger, T.4    Schuler, G.5
  • 15
    • 0037099719 scopus 로고    scopus 로고
    • Infectious tolerance: Human CD25(+) regulatory T cells convey suppressor activity to conventional CD4(+ ) T helper cells
    • Jonuleit H, Schmitt E, Kakirman H, Stassen M, Knop J, Enk AH. Infectious tolerance: Human CD25(+ ) regulatory T cells convey suppressor activity to conventional CD4(+ ) T helper cells. J Exp Med. 2002;196:255-60.
    • (2002) J Exp Med , vol.196 , pp. 255-260
    • Jonuleit, H.1    Schmitt, E.2    Kakirman, H.3    Stassen, M.4    Knop, J.5    Enk, A.H.6
  • 17
    • 4444300314 scopus 로고    scopus 로고
    • CD4+ CD25+ regulatory T cells in rheumatoid arthritis: Difference in the presence, phenotype, and function between peripheral blood and synovial fluid
    • Amelsfort J, Jacvobs K, Bijlsma J, Lafeber F, Taams L. CD4+ CD25+ regulatory T cells in rheumatoid arthritis: Difference in the presence, phenotype, and function between peripheral blood and synovial fluid. Arthritis Rheum. 2004;50:2775-85.
    • (2004) Arthritis Rheum , vol.50 , pp. 2775-2785
    • Amelsfort, J.1    Jacvobs, K.2    Bijlsma, J.3    Lafeber, F.4    Taams, L.5
  • 18
    • 0037261145 scopus 로고    scopus 로고
    • Isolation and functional characterization of regulatory CD25 bright CD4 T cells from the target organ of patients with rheumatoid arthritis
    • Cao D. Isolation and functional characterization of regulatory CD25 bright CD4 T cells from the target organ of patients with rheumatoid arthritis. Eur J Immunol. 2003;33:215-23.
    • (2003) Eur J Immunol , vol.33 , pp. 215-223
    • Cao, D.1
  • 19
    • 0242403301 scopus 로고    scopus 로고
    • Quantifi cation of regulatory T cells in patients with systemic lupus erythematosus
    • Crispin JC, Martinez A, Varela JA. Quantifi cation of regulatory T cells in patients with systemic lupus erythematosus. J Autoimmun. 2003;21:273-6.
    • (2003) J Autoimmun , vol.21 , pp. 273-276
    • Crispin, J.C.1    Martinez, A.2    Varela, J.A.3
  • 20
    • 0035180065 scopus 로고    scopus 로고
    • Immunological tolerance maintained by CD25+ CD4+ regulatory T cells: Their common role in controlling autoimmunity, tumor immunity, and transplantation tolerance
    • Sakaguchi S, Sakaguchi N, Shimizu J. Immunological tolerance maintained by CD25+ CD4+ regulatory T cells: Their common role in controlling autoimmunity, tumor immunity, and transplantation tolerance. Immunol Rev. 2001;182:18-32.
    • (2001) Immunol Rev , vol.182 , pp. 18-32
    • Sakaguchi, S.1    Sakaguchi, N.2    Shimizu, J.3
  • 21
    • 49149117727 scopus 로고    scopus 로고
    • Decreased percentages of regulatory T cells in peripheral blood of patients with Behcet's disease before ocular attack: A possible predictive marker of ocular attack
    • Nanke Y, Kotake S, Goto M, Ujihara H, Matsubara M, Kamatani N. Decreased percentages of regulatory T cells in peripheral blood of patients with Behcet's disease before ocular attack: A possible predictive marker of ocular attack. Mod Rheumatol. 2008;18:354-8.
    • (2008) Mod Rheumatol , vol.18 , pp. 354-358
    • Nanke, Y.1    Kotake, S.2    Goto, M.3    Ujihara, H.4    Matsubara, M.5    Kamatani, N.6
  • 22
    • 34547514211 scopus 로고    scopus 로고
    • IL-6-dependent and -independent pathways in the development of interleukin 17- producing T helper cells
    • Kimura A, Naka T, Kishimoto T. IL-6-dependent and -independent pathways in the development of interleukin 17- producing T helper cells. Proc Natl Acad Sci USA. 2007; 104:12099-104.
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 12099-12104
    • Kimura, A.1    Naka, T.2    Kishimoto, T.3
  • 23
    • 0025232878 scopus 로고
    • In vivo cytokine gene expression in T cell subsets of the autoimmune MRL/Mp-lpr/lpr mouse
    • Murray LJ, Lee R, Martens C. In vivo cytokine gene expression in T cell subsets of the autoimmune MRL/Mp-lpr/lpr mouse. Eur J Immunol. 1990;20:163-70.
    • (1990) Eur J Immunol , vol.20 , pp. 163-170
    • Murray, L.J.1    Lee, R.2    Martens, C.3
  • 25
    • 38349178776 scopus 로고    scopus 로고
    • Interleukin 17-producing T helper cells and interleukin 17 orchestrate autoreactive germinal center development in autoimmune BXD2 mice
    • Hsu HC, Yang P, Wang J, Wu Q, Myers R, Chen J, et al. Interleukin 17-producing T helper cells and interleukin 17 orchestrate autoreactive germinal center development in autoimmune BXD2 mice. Nat Immunol. 2008;9:166-75.
    • (2008) Nat Immunol , vol.9 , pp. 166-175
    • Hsu, H.C.1    Yang, P.2    Wang, J.3    Wu, Q.4    Myers, R.5    Chen, J.6
  • 26
    • 38449102562 scopus 로고    scopus 로고
    • IL-17B and IL-17C are associated with TNF-alpha production and contribute to the exacerbation of infl ammatory arthritis
    • Yamaguchi Y, Fujio K, Shoda H, Okamoto A, Tsuno NH, Takahashi K, et al. IL-17B and IL-17C are associated with TNF-alpha production and contribute to the exacerbation of infl ammatory arthritis. J Immunol. 2007;179:7128-36.
    • (2007) J Immunol , vol.179 , pp. 7128-7136
    • Yamaguchi, Y.1    Fujio, K.2    Shoda, H.3    Okamoto, A.4    Tsuno, N.H.5    Takahashi, K.6
  • 27
    • 0037099733 scopus 로고    scopus 로고
    • Human CD4+ CD25+ regulatory, contact-dependent T cells induce interleukin 10-producing, contact-independent type 1-like regulatory T cells
    • Dieckmann D, Bruett CH, Ploettner H, Lutz MB, Schuler G. Human CD4+ CD25+ regulatory, contact-dependent T cells induce interleukin 10-producing, contact-independent type 1-like regulatory T cells. J Exp Med. 2002;196:247-53.
    • (2002) J Exp Med , vol.196 , pp. 247-253
    • Dieckmann, D.1    Bruett, C.H.2    Ploettner, H.3    Lutz, M.B.4    Schuler, G.5
  • 28
    • 0031570008 scopus 로고    scopus 로고
    • T cell deletion induced by chronic infection with mouse mammary tumor virus spares a CD25-positive IL-10-producing T cell population with infectious capacity
    • Papiernik M, do Carmo Leite-de-Moraes M, Pontoux C, Joret AM, Rocha B, Penit C, et al. T cell deletion induced by chronic infection with mouse mammary tumor virus spares a CD25-positive, IL-10-producing T cell population with infectious capacity. J Immunol. 1997;158:4642-53.
    • (1997) J Immunol , vol.158 , pp. 4642-4653
    • Papiernik, M.1    Do Carmo Leite-de-Moraes, M.2    Pontoux, C.3    Joret, A.M.4    Rocha, B.5    Penit, C.6
  • 29
    • 0035054606 scopus 로고    scopus 로고
    • Human CD4(+ ) CD25(+ ) thymocytes and peripheral T cells have immune suppressive activity in vitro
    • Stephens LA, Mottet C, Mason D, Powrie F. Human CD4(+ ) CD25(+ ) thymocytes and peripheral T cells have immune suppressive activity in vitro. Eur J Immunol. 2001;31:1247-54.
    • (2001) Eur J Immunol , vol.31 , pp. 1247-1254
    • Stephens, L.A.1    Mottet, C.2    Mason, D.3    Powrie, F.4
  • 30
    • 0027724228 scopus 로고
    • Transforming growth factor-beta-1 knockout mice: A mutation in one cytokine gene causes a dramatic infl ammatory disease
    • Kulkarni AB, Karlsson S. Transforming growth factor-beta-1 knockout mice: A mutation in one cytokine gene causes a dramatic infl ammatory disease. Am J Pathol. 1993;143:3-9.
    • (1993) Am J Pathol , vol.143 , pp. 3-9
    • Kulkarni, A.B.1    Karlsson, S.2
  • 31
    • 0026799402 scopus 로고
    • Targeted disruption of the mouse transforming growth factor-beta 1 gene results in multifocal infl ammatory disease
    • Shull MM, Ormsby I, Kier AB, Pawlowski S, Diebold RJ, Yin M, et al. Targeted disruption of the mouse transforming growth factor-beta 1 gene results in multifocal infl ammatory disease. Nature. 1992;359:693-9.
    • (1992) Nature , vol.359 , pp. 693-699
    • Shull, M.M.1    Ormsby, I.2    Kier, A.B.3    Pawlowski, S.4    Diebold, R.J.5    Yin, M.6
  • 32
    • 0035871662 scopus 로고    scopus 로고
    • Expression of Th2 cytokines decreases the development of and improves Beh ç et's disease-like symptoms induced by herpes simplex virus in mice
    • Sohn S, Lee ES, Kwon HJ, Lee SI, Bang D, Lee S. Expression of Th2 cytokines decreases the development of and improves Beh ç et's disease-like symptoms induced by herpes simplex virus in mice. J Infect Dis. 2001;183:1180-6.
    • (2001) J Infect Dis , vol.183 , pp. 1180-1186
    • Sohn, S.1    Lee, E.S.2    Kwon, H.J.3    Lee, S.I.4    Bang, D.5    Lee, S.6
  • 33
    • 10344258543 scopus 로고    scopus 로고
    • Serum interleukin-2, interleukin-6, tumour necrosis factoralpha and nitric oxide levels in patients with Behcet's disease
    • Akdeniz N, Esrefoglu M, KeleşMS, Karakuzu A, Atasoy M. Serum interleukin-2, interleukin-6, tumour necrosis factoralpha and nitric oxide levels in patients with Behcet's disease. Ann Acad Med Singapore. 2004;33:596-9.
    • (2004) Ann Acad Med Singapore , vol.33 , pp. 596-599
    • Akdeniz, N.1    Esrefoglu, M.2    Keleş, M.S.3    Karakuzu, A.4    Atasoy, M.5
  • 34
    • 2142645808 scopus 로고    scopus 로고
    • TGF-beta induces a regulatory phenotype in CD4+ CD25-T cells through Foxp3 induction and down-regulation of Smad7
    • Fantini MC, Becker C, Monteleone G, Pallone F, Galle PR. TGF-beta induces a regulatory phenotype in CD4+ CD25-T cells through Foxp3 induction and down-regulation of Smad7. J Immunol. 2004;172:5149-53.
    • (2004) J Immunol , vol.172 , pp. 5149-5153
    • Fantini, M.C.1    Becker, C.2    Monteleone, G.3    Pallone, F.4    Galle, P.R.5
  • 36
    • 0344389016 scopus 로고    scopus 로고
    • Interleukin-17 mRNA expression in blood and CSF mononuclear cells is augmented in multiple sclerosis
    • Matusevicius D, Kivisäkk P, He B, Kostulas N, Ozenci V, Fredrikson S, et al. Interleukin-17 mRNA expression in blood and CSF mononuclear cells is augmented in multiple sclerosis. Mult Scler. 1999;5:101-4.
    • (1999) Mult Scler , vol.5 , pp. 101-104
    • Matusevicius, D.1    Kivisäkk, P.2    He, B.3    Kostulas, N.4    Ozenci, V.5    Fredrikson, S.6
  • 37
    • 0033772374 scopus 로고    scopus 로고
    • Elevation of proinfl ammatory cytokine (IL-18, IL-17, IL-12) and Th2 cytokine (IL-4) concentrations in patients with systemic lupus erythematosus
    • Wong CK, Ho CY, Li EK, Lam CW. Elevation of proinfl ammatory cytokine (IL-18, IL-17, IL-12) and Th2 cytokine (IL-4) concentrations in patients with systemic lupus erythematosus. Lupus. 2000;9:589-93.
    • (2000) Lupus , vol.9 , pp. 589-593
    • Wong, C.K.1    Ho, C.Y.2    Li, E.K.3    Lam, C.W.4
  • 38
    • 20844455261 scopus 로고    scopus 로고
    • Comparison of IL-17 production by helper T cells among atopic and nonatopic asthmatics and control subjects
    • Hashimoto T, Akiyama K, Kobayashi N, Mori A. Comparison of IL-17 production by helper T cells among atopic and nonatopic asthmatics and control subjects. Int Arch Allergy Immunol. 2005;137:51-4.
    • (2005) Int Arch Allergy Immunol , vol.137 , pp. 51-54
    • Hashimoto, T.1    Akiyama, K.2    Kobayashi, N.3    Mori, A.4
  • 39
    • 0034080842 scopus 로고    scopus 로고
    • Airway neutrophils and interleukin- 17
    • Lindén A, Hoshino H, Laan M. Airway neutrophils and interleukin- 17. Eur Respir J. 2000;15:973-7.
    • (2000) Eur Respir J , vol.15 , pp. 973-977
    • Lindén, A.1    Hoshino, H.2    Laan, M.3
  • 40
    • 51249084103 scopus 로고    scopus 로고
    • Anti tumour necrosis-alpha therapy increases the number of FOXP3 regulatory T cells in children affected by Crohn's disease
    • Ricciardelli I, Lindley KJ, Londei M, Quaratino S. Anti tumour necrosis-alpha therapy increases the number of FOXP3 regulatory T cells in children affected by Crohn's disease. Immunology. 2008;125:178-83.
    • (2008) Immunology , vol.125 , pp. 178-183
    • Ricciardelli, I.1    Lindley, K.J.2    Londei, M.3    Quaratino, S.4
  • 42
    • 44849125410 scopus 로고    scopus 로고
    • Altered frequency and migration capacity of CD4+ CD25+ regulatory T cells in systemic lupus erythematosus
    • Lee HY, Hong YK, Yun HJ, Kim YM, Kim JR, Yoo WH. Altered frequency and migration capacity of CD4+ CD25+ regulatory T cells in systemic lupus erythematosus. Rheumatology (Oxford). 2008;47:789-94.
    • (2008) Rheumatology (Oxford) , vol.47 , pp. 789-794
    • Lee, H.Y.1    Hong, Y.K.2    Yun, H.J.3    Kim, Y.M.4    Kim, J.R.5    Yoo, W.H.6
  • 44
    • 54449085895 scopus 로고    scopus 로고
    • Downregulation of IL-17 and IL-6 in the central nervous system by glatiramer acetate in experimental autoimmune encephalomyelitis
    • Begum-Haque S, Sharma A, Kasper IR, Foureau DM, Mielcarz DW, Haque A, et al. Downregulation of IL-17 and IL-6 in the central nervous system by glatiramer acetate in experimental autoimmune encephalomyelitis. J Neuroimmunol. 2008;204:58-65.
    • (2008) J Neuroimmunol , vol.204 , pp. 58-65
    • Begum-Haque, S.1    Sharma, A.2    Kasper, I.R.3    Foureau, D.M.4    Mielcarz, D.W.5    Haque, A.6
  • 45
    • 51449116424 scopus 로고    scopus 로고
    • CD4+ CD25 high T cell numbers are enriched in the peripheral blood of patients with rheumatoid arthritis
    • Han GM, O'Neil-Andersen NJ, Zurier RB, Lawrence DA. CD4+ CD25 high T cell numbers are enriched in the peripheral blood of patients with rheumatoid arthritis. Cell Immunol. 2008;253:92-101.
    • (2008) Cell Immunol , vol.253 , pp. 92-101
    • Han, G.M.1    O'Neil-Andersen, N.J.2    Zurier, R.B.3    Lawrence, D.A.4
  • 46
    • 77957909177 scopus 로고    scopus 로고
    • Regulatory T cells suppress natural killer cells during plasmid DNA vaccination in mice, blunting the CD8+ T cell immune response by the cytokine TGFbeta
    • (page 1-8)
    • Frimpong-Boateng K, van Rooijen N, Geiben-Lynn R. Regulatory T cells suppress natural killer cells during plasmid DNA vaccination in mice, blunting the CD8+ T cell immune response by the cytokine TGFbeta. PLoS One. 2010;5:e12281 (page 1-8).
    • (2010) PLoS One , vol.5
    • Frimpong-Boateng, K.1    Van Rooijen, N.2    Geiben-Lynn, R.3
  • 47
    • 0032729476 scopus 로고    scopus 로고
    • Cross-talk between cells of the innate immune system: NKT cells rapidly activate NK cells
    • Carnaud C, Lee D, Donnars O, Park SH, Beavis A, Koezuka Y, et al. Cross-talk between cells of the innate immune system: NKT cells rapidly activate NK cells. J Immunol. 1999;163:4647-50.
    • (1999) J Immunol , vol.163 , pp. 4647-4650
    • Carnaud, C.1    Lee, D.2    Donnars, O.3    Park, S.H.4    Beavis, A.5    Koezuka, Y.6
  • 48
    • 27144435475 scopus 로고    scopus 로고
    • CD8b right CD56+ T cells are cytotoxic effectors in patients with active Behcet's uveitis
    • Ahn JK, Chung H, Lee DS, Yu YS, Yu HG. CD8b right CD56+ T cells are cytotoxic effectors in patients with active Behcet's uveitis. J Immunol. 2005;175:6133-42.
    • (2005) J Immunol , vol.175 , pp. 6133-6142
    • Ahn, J.K.1    Chung, H.2    Lee, D.S.3    Yu, Y.S.4    Yu, H.G.5
  • 49
    • 4043167237 scopus 로고    scopus 로고
    • Abnormal killer inhibitory receptor expression on natural killer cells in patients with Beh ç et's disease
    • Takeno M, Shimoyama Y, Kashiwakura J, Nagafuchi H, Sakane T, Suzuki N. Abnormal killer inhibitory receptor expression on natural killer cells in patients with Beh ç et's disease. Rheumatol Int. 2004; 24:212-6.
    • (2004) Rheumatol Int , vol.24 , pp. 212-216
    • Takeno, M.1    Shimoyama, Y.2    Kashiwakura, J.3    Nagafuchi, H.4    Sakane, T.5    Suzuki, N.6
  • 50
    • 77954644877 scopus 로고    scopus 로고
    • The role of Qa-2, the functional HLA-G, in a Behcet's disease-like mouse model induced by the herpes simplex virus
    • (page 1-12)
    • Lee M, Choi B, Kwon HJ, Shim J, Park KS, Lee ES, Sohn S. The role of Qa-2, the functional HLA-G, in a Behcet's disease-like mouse model induced by the herpes simplex virus. J Infl amm (Lond). 2010;7:31 (page 1-12).
    • (2010) J Infl amm (Lond) , vol.7 , pp. 31
    • Lee, M.1    Choi, B.2    Kwon, H.J.3    Shim, J.4    Park, K.S.5    Lee, E.S.6    Sohn, S.7
  • 51
    • 33846923124 scopus 로고    scopus 로고
    • IL-2 is essential for TGF-beta to convert naive CD4+ CD25-cells to CD25+ Foxp3+ regulatory T cells and for expansion of these cells
    • Zheng SG, Wang J, Wang P, Gray JD, Horwitz DA. IL-2 is essential for TGF-beta to convert naive CD4+ CD25-cells to CD25+ Foxp3+ regulatory T cells and for expansion of these cells. J Immunol. 2007;178:2018-27.
    • (2007) J Immunol , vol.178 , pp. 2018-2027
    • Zheng, S.G.1    Wang, J.2    Wang, P.3    Gray, J.D.4    Horwitz, D.A.5
  • 52
    • 34247277666 scopus 로고    scopus 로고
    • Foxp3 in control of the regulatory T cell lineage
    • Zheng Y, Rudensky AY. Foxp3 in control of the regulatory T cell lineage. Nat Immunol. 2007;8:457-62.
    • (2007) Nat Immunol , vol.8 , pp. 457-462
    • Zheng, Y.1    Rudensky, A.Y.2
  • 53
    • 3543097547 scopus 로고    scopus 로고
    • Suppressor T cells in human diseases
    • Baecher-Allan C, Hafler DA. Suppressor T cells in human diseases. J Exp Med. 2004;200:273-6.
    • (2004) J Exp Med , vol.200 , pp. 273-276
    • Baecher-Allan, C.1    Hafler, D.A.2
  • 54
    • 23844478869 scopus 로고    scopus 로고
    • Natural recovery and protection from autoimmune encephalomyelitis: Contribution of CD4+ CD25+ regulatory cells within the central nervous system
    • McGeachy MJ, Stephens LA, Anderton SM. Natural recovery and protection from autoimmune encephalomyelitis: Contribution of CD4+ CD25+ regulatory cells within the central nervous system. J Immunol. 2005;175:3025-32.
    • (2005) J Immunol , vol.175 , pp. 3025-3032
    • McGeachy, M.J.1    Stephens, L.A.2    Anderton, S.M.3
  • 55
    • 1842732224 scopus 로고    scopus 로고
    • Loss of functional suppression by CD4+ CD25+ regulatory T cells in patients with multiple sclerosis
    • Viglietta V, Baecher-Allan C, Weiner HL, Hafler DA. Loss of functional suppression by CD4+ CD25+ regulatory T cells in patients with multiple sclerosis. J Exp Med. 2004;199:971-9.
    • (2004) J Exp Med , vol.199 , pp. 971-979
    • Viglietta, V.1    Baecher-Allan, C.2    Weiner, H.L.3    Hafler, D.A.4
  • 56
    • 0031647622 scopus 로고    scopus 로고
    • Immunologic self-tolerance maintained by CD25+ CD4+ naturally anergic and suppressive T cells: Induction of autoimmune disease by breaking their anergic/suppressive state
    • Takahashi T, Kuniyasu Y, Toda M, Sakaguchi N, Itoh M, Iwata M, et al. Immunologic self-tolerance maintained by CD25+ CD4+ naturally anergic and suppressive T cells: Induction of autoimmune disease by breaking their anergic/suppressive state. Int Immunol. 1998;10:1969-80.
    • (1998) Int Immunol , vol.10 , pp. 1969-1980
    • Takahashi, T.1    Kuniyasu, Y.2    Toda, M.3    Sakaguchi, N.4    Itoh, M.5    Iwata, M.6
  • 57
    • 1042269477 scopus 로고    scopus 로고
    • Interleukin-10 is involved in the sup pression of experimental autoimmune encephalomyelitis by CD25+ CD4+ regulatory T cells
    • Zhang X, Koldzic DN, Izikson L, Reddy J, Nazareno RF, Sakaguchi S, et al. Interleukin-10 is involved in the sup pression of experimental autoimmune encephalomyelitis by CD25+ CD4+ regulatory T cells. Int Immunol. 2004;16:249-56.
    • (2004) Int Immunol , vol.16 , pp. 249-256
    • Zhang, X.1    Koldzic, D.N.2    Izikson, L.3    Reddy, J.4    Nazareno, R.F.5    Sakaguchi, S.6
  • 58
    • 1242290580 scopus 로고    scopus 로고
    • Natural and induced CD4+ CD25+ cells educate CD4+ CD25-cells to develop suppressive activity: The role of IL-2, TGF-beta, and IL-10
    • Zheng SG, Wang JH, Gray JD, Soucier H, Horwitz DA. Natural and induced CD4+ CD25+ cells educate CD4+ CD25-cells to develop suppressive activity: The role of IL-2, TGF-beta, and IL-10. J Immunol. 2004;72:5213-21.
    • (2004) J Immunol , vol.72 , pp. 5213-5221
    • Zheng, S.G.1    Wang, J.H.2    Gray, J.D.3    Soucier, H.4    Horwitz, D.A.5
  • 59
    • 40449117736 scopus 로고    scopus 로고
    • In vitro expansion improves in vivo regulation by CD4+ CD25+ regulatory T cells
    • Chai JG, Coe D, Chen D, Simpson E, Dyson J, Scott D. In vitro expansion improves in vivo regulation by CD4+ CD25+ regulatory T cells. J Immunol. 2008;180:858-69.
    • (2008) J Immunol , vol.180 , pp. 858-869
    • Chai, J.G.1    Coe, D.2    Chen, D.3    Simpson, E.4    Dyson, J.5    Scott, D.6
  • 60
    • 0024353079 scopus 로고
    • Th1 and Th2 cell: Different patterns of lymphokine secretion lead to different functional properties
    • Mosmann TR, Coffman RL. Th1 and Th2 cell: Different patterns of lymphokine secretion lead to different functional properties. Annu Rev Immunol. 1989;7:145-73.
    • (1989) Annu Rev Immunol , vol.7 , pp. 145-173
    • Mosmann, T.R.1    Coffman, R.L.2
  • 61
    • 34248572345 scopus 로고    scopus 로고
    • TH-17 cells in the circle of immunity and autoimmunity
    • Bettelli E, Oukka M, Kuchroo VK. TH-17 cells in the circle of immunity and autoimmunity. Nat Immunol. 2007;8:345-50.
    • (2007) Nat Immunol , vol.8 , pp. 345-350
    • Bettelli, E.1    Oukka, M.2    Kuchroo, V.K.3
  • 62
    • 33845948381 scopus 로고    scopus 로고
    • IL-6 produced by dendritic cells from lupus-prone mice inhibits CD4+ CD25+ T cell regulatory functions
    • Wan S, Xia C, Morel L. IL-6 produced by dendritic cells from lupus-prone mice inhibits CD4+ CD25+ T cell regulatory functions. J Immunol. 2007;178:271-9.
    • (2007) J Immunol , vol.178 , pp. 271-279
    • Wan, S.1    Xia, C.2    Morel, L.3
  • 64
    • 47749124186 scopus 로고    scopus 로고
    • Foxp3 inhibits ROR{gamma}t-mediated IL-17A mRNA transcription through direct interaction with ROR{gamma}t
    • Ichiyama K, Yoshida H, Wakabayashi Y, Chinen T, Saeki K, Nakaya M, et al. Foxp3 inhibits ROR{gamma}t-mediated IL-17A mRNA transcription through direct interaction with ROR{gamma}t. J Biol Chem. 2008;283:17003-8.
    • (2008) J Biol Chem , vol.283 , pp. 17003-17008
    • Ichiyama, K.1    Yoshida, H.2    Wakabayashi, Y.3    Chinen, T.4    Saeki, K.5    Nakaya, M.6
  • 65
    • 62549106162 scopus 로고    scopus 로고
    • Interleukin-6 small interfering RNA improved the herpes simplex virusinduced systemic infl ammation in vivo mouse model
    • Shim J, Byun HO, Lee YD, Lee ES, Sohn S. Interleukin-6 small interfering RNA improved the herpes simplex virusinduced systemic infl ammation in vivo mouse model. Gene Ther. 2009;16:415-25.
    • (2009) Gene Ther , vol.16 , pp. 415-425
    • Shim, J.1    Byun, H.O.2    Lee, Y.D.3    Lee, E.S.4    Sohn, S.5
  • 66
    • 51249124438 scopus 로고    scopus 로고
    • Tumor necrosis factor alpha interfering RNA decreases herpes simplex virus-induced infl ammation in a mouse model
    • Choi B, Hwang Y, Kwon HJ, Lee ES, Park KS, Bang D, et al. Tumor necrosis factor alpha interfering RNA decreases herpes simplex virus-induced infl ammation in a mouse model. J Dermatol Sci. 2008;52:87-97.
    • (2008) J Dermatol Sci , vol.52 , pp. 87-97
    • Choi, B.1    Hwang, Y.2    Kwon, H.J.3    Lee, E.S.4    Park, K.S.5    Bang, D.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.