Artesunate in combination with oxacillin protect sepsis model mice challenged with lethal live methicillin-resistant Staphylococcus aureus (MRSA) via its inhibition on proinflammatory cytokines release and enhancement on antibacterial activity of oxacillin

International Immunopharmacology

Volumn 11, Issue 8, 2011, Pages 1065-1073

  Jiang, Weiwei ^a   Li, Bin ^a   Zheng, Xinchuan ^a   Liu, Xin ^a   Cen, Yanyan ^a   Li, Jun ^a   Pan, Xichun ^a   Cao, Hongwei ^a   Zheng, Jiang ^a   Zhou, Hong ^a  

^a THIRD MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Artesunate; MRSA; Oxacillin; PBP2a; Sepsis

Indexed keywords

AMPICILLIN; ARTESUNATE; B7 ANTIGEN; BETA LACTAM; CASPASE RECRUITMENT DOMAIN PROTEIN 15; CD14 ANTIGEN; CD86 ANTIGEN; INTERLEUKIN 6; LEVOFLOXACIN; MESSENGER RNA; OXACILLIN; PENICILLIN BINDING PROTEIN 2A; TOLL LIKE RECEPTOR 2; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBACTERIAL ACTIVITY; ARTICLE; BACTERIAL LOAD; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CYTOKINE RELEASE; CYTOTOXICITY; DOWN REGULATION; DRUG POTENTIATION; FEMALE; INFLAMMATION; MACROPHAGE; MALE; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; MONOTHERAPY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; SEPSIS; UPREGULATION;

EID: 84860389848     PISSN: 15675769     EISSN: 18781705     Source Type: Journal    
DOI: 10.1016/j.intimp.2011.02.028     Document Type: Article

References (35)

1. Wang JE, Dahle MK, McDonald M, Foster SJ, Aasen AO, Thiemermann C. Peptidoglycan and lipoteichoic acid in Gram-positive bacterial sepsis: receptors, signal transduction, biological effects, and synergism. Shock 2003;20:402-14.
2. Shurland S, Zhan M, Bradham DD, Roghmann MC. Comparison of mortality risk associated with bacteremia due to methicillin-resistant and methicillin-susceptible Staphylococcus aureus. Infect Control Hosp Epidemiol 2007;28:273-9. (Pubitemid 46480725)
3. Kopp BJ, Nix DE, Armstrong EP. Clinical and economic analysis of methicillinsusceptible and -resistant Staphylococcus aureus infections. Ann Pharmacother 2004;38:1377-82. (Pubitemid 39100187)
4. Vincent JL, Sun Q, Dubois MJ. Clinical trials of immunomodulatory therapies in severe sepsis and septic shock. Clin Infect Dis 2002;34:1084-93. (Pubitemid 34289681)
5. Harbarth S, Holeckova K, Froidevaux C, Pittet D, Ricou B, Grau GE, et al. Diagnostic value of procalcitonin, interleukin-6, and interleukin-8 in critically ill patients admitted with suspected sepsis. Am J Respir Crit Care Med 2001;164:396-402. (Pubitemid 32778205)
6. Yao YM, Redl H, Bahrami S, Schlag G. The inflammatory basis of trauma/shockassociated multiple organ failure. Inflamm Res 1998;47:201-10. (Pubitemid 28256968)
7. Iwaki D, Mitsuzawa H, Murakami S, Sano H, Konishi M, Akino T, et al. The extracellular toll-like receptor 2 domain directly binds peptidoglycan derived from Staphylococcus aureus. J Biol Chem 2002;277:24315-20. (Pubitemid 34951951)
8. Lien E, Sellati TJ, Yoshimura A, Flo TH, Rawadi G, Finberg RW, et al. Toll-like receptor 2 functions as a pattern recognition receptor for diverse bacterial products. J Biol Chem 1999;274:33419-25. (Pubitemid 129511647)
9. Akira S, Uematsu S, Takeuchi O. Pathogen recognition and innate immunity. Cell 2006;124:783-801. (Pubitemid 43261452)
10. File Jr TM. Clinical implications and treatment of multiresistant Streptococcus pneumoniae pneumonia. Clin Microbiol Infect 2006;12:31-41.
11. Norazah A, Salbiah N, Nurizzat M, Santhana R. Vancomycin treatment failure in a vancomycin susceptible methicillin-resistant Staphylococcus aureus (MRSA) infected patient. Med J Malays 2009;64:166-7.
12. Fuda CCS, Fisher JF, Mobashery S. β-lactam resistance in Staphylococcus aureus: the adaptive resistance of plastic genome. Cell Mol Life Sci 2005;62:2617-33. (Pubitemid 41721234)
13. Wright GD. The antibiotic resistome: the nexus of chemical and genetic diversity. Nat Rev Microbiol 2007;5:175-86. (Pubitemid 46291277)
14. Lim D, Strynadka NC. Structural basis for the β-lactam resistance of PBP2a from methicillin-resistant Staphylococcus aureus. Nat Struct Biol 2002;9:870-6. (Pubitemid 35257789)
15. Li B, Li J, Pan X, Ding G, Cao H, Jiang W, et al. Artesunate protects sepsis model mice challenged with Staphylococcus aureus by decreasing TNF-alpha release via inhibition TLR2 and Nod2 mRNA expressions and transcription factor NF-kappaB activation. Int Immunopharmacol 2010;10:344-50.
16. Li B, Zhang R, Li J, Zhang L, Ding G, Luo P, et al. Antimalarial artesunate protects sepsis model mice against heat-killed Escherichia coli challenge by decreasing TLR4, TLR9 mRNA expressions and transcription factor NF-kappa B activation. Int Immunopharmacol 2008;8:379-89.
17. Wang J, Zhou H, Zheng J, Cheng J, Liu W, Ding G, et al. The antimalarial artemisinin synergizes with antibiotics to protect against lethal live Escherichia coli challenge by decreasing proinflammatory cytokine release. Antimicrob Agents Chemother 2006;50:2420-7. (Pubitemid 43993181)
18. Lebrun I, Cavallaro V, Juliano L, Juliano MA, de Sousa e Silva MC. Effects of 'casoparan', a peptide isolated from casein hydrolysates with mastoparan-like properties. Mediat Inflamm 2004;13:263-8. (Pubitemid 39573534)
19. Actor JK, Hwang SA, Kruzel ML. Lactoferrin as a natural immune modulator. Curr Pharm Des 2009;15:1956-73.
20. Clinical and Laboratory Standards Institute. Performance standards for antimicrobial susceptibility testing: 18th informational supplement, M100-S18. Wayne, PA: Clinical and Laboratory Standards Institute; 2008.
21. Rani Basu L, Mazumdar K, Dutta NK, Karak P, Dastidar SG. Antibacterial property of the antipsychotic agent prochlorperazine, and its synergism with methdilazine. Microbiol Res 2005;160:95-100. (Pubitemid 40199408)
22. DongY, Ding GF, Li B,He SQ, YanW, ZhouH, et al. Clone, expression and identification of penicillin binding protein 2a ofmethicillin-resistant Staphylococcus aureus isolated from patients. Zhonghua Shao Shang Za Zhi 2007;23:100-3.
23. Genfa L, Jiang Z, Hong Z, Yimin Z, Liangxi W, Guo W, et al. The screening and isolation of an effective anti-endotoxin monomer from Radix Paeoniae Rubra using affinity biosensor technology. Int Immunopharmacol 2005;5:1007-17.
24. Thanyani ST, Roberts V, Siko DG, Vrey P, Verschoor JA. A novel application of affinity biosensor technology to detect antibodies to mycolic acid in tuberculosis patients. J Immunol Meth 2008;33:261-72.
25. Mosmann T. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J Immunol Meth 1983;65:55-63. (Pubitemid 14203433)
26. Howard CJ, Hope JC, Stephens SA, Gliddon DR, Brooke GP. Co-stimulation and modulation of the ensuing immune response. Vet Immunol Immunopathol 2002;87: 123-30. (Pubitemid 34665230)
27. Landmann R, Müller B, Zimmerli W. CD14, new aspects of ligand and signal diversity. Microbes Infect 2000;2:295-304. (Pubitemid 30167663)
28. Sieradzki K, Markiewicz Z. Mechanism of vancomycin resistance in methicillin resistant Staphylococcus aureus. Pol J Microbiol 2004;53:207-14. (Pubitemid 40064875)
29. Guignard B, Entenza JM, Moreillon P. Beta-lactams against methicillin-resistant Staphylococcus aureus. Curr Opin Pharmacol 2005;5:479-89. (Pubitemid 41258564)
30. He XL, Liu Z. Protection of artesunate on activation and injury of vascular endothelial cells induced by lipopolysaccharide. Zhongguo Zhong Xi Yi Jie He Za Zhi 2004;24:1110-3.
31. Xu H, He Y, Yang X, Liang L, Zhan Z, Ye Y, et al. Anti-malarial agent artesunate inhibits TNF-{alpha}-induced production of proinflammatory cytokines via inhibition of NF-{kappa}B and PI3 kinase/Akt signal pathway in human rheumatoid arthritis fibroblast-like synoviocytes. Rheumatology 2007;46:920-6. (Pubitemid 47062496)
32. Efferth T, Ramirez T, Gebhart E, Halatsch ME. Combination treatment of glioblastoma multiforme cell lines with the antimalarial artesunate and the epidermal growth factor receptor tyrosine kinase inhibitor OSI-774. Biochem Pharmacol 2004;67:1689-700. (Pubitemid 38479847)
33. Chen HH, Zhou HJ, Wu GD, Lou XE. Inhibitory effects of artesunate on angiogenesis and on expressions of vascular endothelial growth factor and VEGF receptor KDR/ flk-1. Pharmacology 2004;71:1-9.
34. Xu JH, Zhang YP. Contragestational effects of dihydroartemisinin and artesunate. Yao Xue Xue Bao 1996;31:657-61. (Pubitemid 126436284)
35. Archer GL, Bosilevac JM. Signaling antibiotic resistance in staphylococci. Science 2001;291:1915-6. (Pubitemid 32216984)