Molecular dynamics simulation of the complex PBP-2x with drug cefuroxime to explore the drug resistance mechanism of streptococcus suis R61

PLoS ONE

Volumn 7, Issue 4, 2012, Pages

  Ge, Yan ^b   Wu, Jiayan ^a   Xia, Yingjie ^c,d   Yang, Ming ^a,d   Xiao, Jingfa ^a   Yu, Jun ^a  

^a Chinese Academy of Sciences   (China)

^b CHINA AGRICULTURAL UNIVERSITY   (China)

^c KUNMING INSTITUTE OF ZOOLOGY   (China)

^d UNIVERSITY OF CHINESE ACADEMY OF SCIENCES   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE; CEFUROXIME; GLUTAMINE; GLYCINE; PENICILLIN BINDING PROTEIN; THREONINE; TYROSINE; ANTIINFECTIVE AGENT;

ARTICLE; BACTERIAL STRAIN; BINDING AFFINITY; CONTROLLED STUDY; DRUG MECHANISM; DRUG PROTEIN BINDING; GENE MUTATION; GENE SEQUENCE; HYDROGEN BOND; HYDROPHILICITY; MOLECULAR DYNAMICS; NONHUMAN; SEQUENCE ALIGNMENT; SIMULATION; STREPTOCOCCUS SUIS; AMINO ACID SEQUENCE; ANTIBIOTIC RESISTANCE; BINDING SITE; CHEMICAL PHENOMENA; DRUG EFFECT; GENETICS; METABOLISM; MOLECULAR GENETICS; MUTATION; PROTEIN BINDING; PROTEIN TERTIARY STRUCTURE; THERMODYNAMICS;

STREPTOCOCCUS SUIS; SUIDAE;

AMINO ACID SEQUENCE; ANTI-BACTERIAL AGENTS; BINDING SITES; CEFUROXIME; DRUG RESISTANCE, BACTERIAL; HYDROGEN BONDING; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; MOLECULAR DYNAMICS SIMULATION; MOLECULAR SEQUENCE DATA; MUTATION; PENICILLIN-BINDING PROTEINS; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; SEQUENCE ALIGNMENT; STREPTOCOCCUS SUIS; THERMODYNAMICS;

EID: 84860386132     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0035941     Document Type: Article

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