The potential role of quorum-sensing peptides in oncology

Medical Hypotheses

Volumn 78, Issue 6, 2012, Pages 814-817

  Wynendaele, E ^a   Pauwels, E ^a   Van de Wiele, C ^b   Burvenich, C ^c   De Spiegeleer, B ^a  

^a GHENT UNIVERSITY   (Belgium)

^b GHENT UNIVERSITY   (Belgium)

^c Faculty Of Veterinary Medicine   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

CATHELICIDIN; CATHEPSIN; CECROPIN; DEFENSIN; INTERLEUKIN 12; LACTOFERRICIN; MAGAININ 2; MATRIX METALLOPROTEINASE; MELITTIN; PROTEIN P53; TUMOR NECROSIS FACTOR ALPHA; UROKINASE; VITRONECTIN RECEPTOR;

ANGIOGENESIS; APOPTOSIS; ARTICLE; CANCER INVASION; CELL ADHESION; CELL COMMUNICATION; CELL DENSITY; CELL MOTILITY; CYTOKINE RELEASE; EUKARYOTE; METASTASIS; MICELLIZATION; NONHUMAN; ONCOLOGY; PROKARYOTE; PSEUDOMONAS AERUGINOSA; QUORUM SENSING; SIGNAL TRANSDUCTION; TUMOR CELL;

HUMANS; MODELS, BIOLOGICAL; NEOPLASMS; PEPTIDES; QUORUM SENSING;

BACTERIA (MICROORGANISMS); EUKARYOTA; PROKARYOTA;

EID: 84860385229     PISSN: 03069877     EISSN: 15322777     Source Type: Journal    
DOI: 10.1016/j.mehy.2012.03.018     Document Type: Article

References (52)

1. World Health Organisation. Cancer 2012, Available from: <>. http://www.who.int/topics/cancer/en/.
2. Alberts B. The challenge of cancer. Science 2011, 331:1491.
3. Kitajima K., Murakami K., Yamasaki E., Domeki Y., Kaji Y., Sugimura K. Performance of FDG-PET/CT for diagnosis of recurrent uterine cervical cancer. Eur Radiol 2008, 18:2040-2047.
4. Clin B., Morlais F., Guittet L., et al. Performance of chest radiograph and CT scan for lung cancer screening in asbestos-exposed workers. Occup Environ Med 2009, 66:529-534.
5. Hoskin D.W., Ramamoorthy A. Studies on anticancer activities of antimicrobial peptides. Biochim Biophys Acta 2008, 1778:357-375.
6. Schally A.V. New approaches to the therapy of various tumors based on peptide analogues. Horm Metab Res 2008, 40:315-322.
7. Bhutia S.K., Maiti T.K. Targeting tumors with peptides from natural sources. Trends Biotechnol 2008, 26:210-217.
8. Aina O.H., Liu R.W., Sutcliffe J.L., Marik J., Pan C.X., Lam K.S. From combinatorial chemistry to cancer-targeting peptides. Mol Pharm 2007, 4:631-651.
9. Van Dorpe S., Verbeken M., Wynendaele E., De Spiegeleer B. Purity profiling of peptide drugs. J Bioanal Biomed 2011, 10.4172/1948-593X.S6-003.
10. Mader J.S., Hoskin D.W. Cationic antimicrobial peptides as novel cytotoxic agents for cancer treatment. Expert Opin Investig Drugs 2006, 15:933-946.
11. Zhang L., Ming L., Yu J. BH3 mimetics to improve cancer therapy: mechanisms and examples. Drug Resist Updat 2007, 10:207-217.
12. Shimura T., Suehiro T., Suzuki H., et al. Peptides derived from a soluble molecule of the human leukocyte antigen (HLA) class I cause apoptosis in gastric cancer cell lines. Dig Dis Sci 2009, 54:63-69.
13. Wu G., Chai J., Suber T.L., et al. Structural basis of IAP recognition by Smac/DIABLO. Nature 2000, 408:1008-1012.
14. Koivunen E., Arap W., Valtanen H. Tumor targeting with a selective gelatinase inhibitor. Nat Biotechnol 1999, 17:768-774.
15. Wu B., Chien Y.E.T., Mol C.D., et al. Structures of the CXCR4 chemokine GPCR with small-molecule and cyclic peptide antagonists. Science 2010, 330:1066-1071.
16. Liu Z., Wang F., Chen X. Integrin alpha(V)beta(3)-targeted cancer therapy. Drug Dev Res 2008, 69:329-339.
17. Reardon D.A., Nabors L.B., Stupp R., Mikkelsen T. Cilengitide: an integrin-targeting arginine-glycine-aspartic acid peptide with promising activity for glioblastoma multiforme. Expert Opin Investig Drugs 2008, 17:1225-1235.
18. Ardini E., Sporchia B., Pollegioni L., et al. Identification of a novel function for 67-kDa laminin receptor: increase in laminin degradation rate and release of motility fragments. Cancer Res 2002, 62:1321-1325.
19. + glioma patients. Cancer Sci 2008, 99:1656-1662.
20. Yamanaka R. Cell-and peptide-based immunotherapeutic approaches for glioma. Trends Mol Med 2008, 14:228-235.
21. Ueda H., Yamazaki M. Induction of tumor necrosis factor-a in solid tumor region by the orally administered synthetic muramyl dipeptide analogue, romurtide. Int Immunopharmacol 2001, 1:97-104.
22. Schorlemmer H.U., Bosslet K., Sedlacek H.H. Ability of the immunomodulating dipeptide bestatin to activate cytotoxic mononuclear phagocytes. Cancer Res 1983, 43:4148-4153.
23. Powers J.P.S., Hancock R.E.W. The relationship between peptide structure and antibacterial activity. Peptides 2003, 24:1681-1691.
24. Kondo E., Seto M., Yoshikawa K., Yoshino T. Highly efficient delivery of p16 antitumor peptide into aggressive leukemia/lymphoma cells using a novel transporter system. Mol Cancer Ther 2004, 3:1623-1630.
25. Kondo E., Tanaka T., Miyake T., et al. Potent synergy of dual antitumor peptides for growth suppression of human glioblastoma cell lines. Mol Cancer Ther 2008, 7:1461-1471.
26. Meyer J.E., Harder J. Antimicrobial peptides in oral cancer. Curr Pharm Des 2007, 12:3119-3130.
27. Parodi P.W. A role for milk proteins and their peptides in cancer prevention. Curr Pharm Des 2007, 13:813-828.
28. De Mejia E.G., Dia V.P. The role of nutraceutical proteins and peptides in apoptosis, angiogenesis, and metastasis of cancer cells. Cancer Metastasis Rev 2010, 29:511-528.
29. Strosberg J., Kvols L. Antiproliferative effect of somatostatin analogs in gastroenteropancreatic neuroendocrine tumors. World J Gastroenterol 2010, 16:2963-2970.
30. Appetecchia M., Baldelli R. Somatostatin analogues in the treatment of gastroenteropancreatic neuroendocrine tumours, current aspects and new perspectives. J Exp Clin Cancer Res 2010, 29:1-12.
31. Reubi J.C. Peptide receptors as molecular targets for cancer diagnosis and therapy. Endocr Rev 2003, 24:389-427.
32. BioSeeker Group. Peptides in oncology drug pipeline update, <>; 2011 [accessed 16.08.2011]. http://www.bioseeker.com/market-research-report/peptides-in-oncology-drug-pipeline-update-2011.html.
33. Martin C.A., Hoven A.D., Cook A.M. Therapeutic frontiers: preventing and treating infectious diseases by inhibiting bacterial quorum-sensing. Eur J Clin Microbiol Infect Dis 2008, 27:635-642.
34. Diggle S.P., Crusz S.A., Cámara M. Quorum-sensing. Curr Biol 2007, 17:907-910.
35. Konaklieva M.I., Plotkin B.J. Chemical communication - do we have a quorum?. Mini Rev Med Chem 2006, 6:817-825.
36. Ibrahim M., Guillot A., Wessner F., et al. Control of the transcription of a short gene encoding a cyclic peptide in Streptococcus thermophilus: a new quorum-sensing system. J Bacteriol 2007, 189:8844-8854.
37. Griffith K.L., Grossman A.D. A degenerate tripartite DNA-binding site required for activation of ComA dependent quorum response gene expression in Bacillus subtilis. J Mol Biol 2008, 381:261-275.
38. Pottathil M., Jung A. CSF, a species-specific extracellular signaling peptide for communication among strains of Bacillus subtilis and Bacillus mojavensis. J Bacteriol 2008, 190:4095-4099.
39. Nishiguchi K., Nagata M., Tanokura M., Sonomoto K., Nakayama J. Structure-activity relationship of gelatinase biosynthesis-activating pheromone of Enterococcus faecalis. J Bacteriol 2009, 191:641-650.
40. Ni N., Li M., Wang J., Wang B. Inhibitors and antagonists of bacterial quorum-sensing. Med Res Rev 2009, 29:65-124.
41. Okada M., Sato I., Cho S.J., et al. Structure of the Bacillus subtilis quorum-sensing peptide pheromone ComX. Nat Chem Biol 2005, 1:23-24.
42. Von Bodman S.B., Willey J.M., Diggle S.P. Cell-cell communication in bacteria: united we stand. J Bacteriol 2008, 190:4377-4391.
43. Gitzinger M., Parsons J., Reski R., Fussenegger M. Functional cross-kingdom conservation of mammalian and moss (Physcomitrella patens) transcription, translation and secretion machineries. Plant Biotechnol J 2009, 7:73-86.
44. Williams P. Quorum-sensing, communication and cross-kingdom signaling in the bacterial world. Microbiology 2007, 153:3923-3938.
45. Pritchard D.I. Immune modulation by Pseudomonas aeruginosa quorum-sensing signal molecules. Int J Med Microbiol 2006, 296:111-116.
46. Nakayama J., Tanaka E., Kariyama R., et al. Siamycin attenuates fsr quorum-sensing mediated by a gelatinase biosynthesis-activating pheromone in Enterococcus faecalis. J Bacteriol 2007, 189:1358-1365.
47. De Clercq E. Current lead natural products for the chemotherapy of human immunodeficiency virus (HIV) infection. Med Res Rev 2000, 20:323-349.
48. Belitsky M., Avshalom H., Erental A., et al. The Escherichia coli extracellular death factor EDF induces the endoribonucleolytic activities of the toxins MazF and ChpBK. Mol Cell 2011, 41:625-635.
49. Kolodkin-Gal I., Hazan R., Gaathon A., Carmeli S., Engelberg-Kulka H. A linear pentapeptide is a quorum-sensing factor required for mazEF-mediated cell death in Escherichia coli. Science 2007, 318:652-655.
50. Li L., Hooi D., Chhabra S.R., Pritchard D., Shaw P.E. Bacterial N-acylhomoserinelactone-induced apoptosis in breast carcinoma cells correlated with down-modulation of STAT3. Oncogene 2004, 23:4894-4902.
51. Hickson J., Yamada D.S., Berger J., et al. Societal interactions in ovarian cancer metastasis: a quorum-sensing hypothesis. Clin Exp Metastasis 2009, 26:67-76.
52. Agur Z., Kogan Y., Levi L., Harrison H., Kirnasovsky R., Clarke R.B. Disruption of a quorum-sensing mechanism triggers tumorigenesis: a simple discrete model c corroborated by experiments in mammary cancer stem cells. Biol Direct 2010, 5:1-11.