Effect of polymer molecular weight and of polymer blends on the properties of rapidly gelling nasal inserts

Drug Development and Industrial Pharmacy

Volumn 38, Issue 6, 2012, Pages 659-669

  Bertram, Ulrike ^a   Bodmeier, Roland ^a  

^a FREIE UNIVERSITÄT BERLIN   (Germany)

Author keywords

Bioadhesion; Carrageenan; Extended drug release; Hydrogels; Inserts; Nasal drug delivery; Polymer blends; Polymer molecular weight; Sodium alginate

Indexed keywords

ALGINIC ACID; CARBOMER; CARRAGEENAN; DIPROPHYLLINE; GELLING AGENT; GENUVISCO CARAGEENAN TYPE TPH-1; OXYMETAZOLINE; POLYMER; PROTANAL LF 20/200; UNCLASSIFIED DRUG; WATER; XANTHAN;

ADHESION; ARTICLE; CONTROLLED RELEASE FORMULATION; DRUG DELIVERY SYSTEM; DRUG RELEASE; FREEZE DRYING; GEL; MOLECULAR WEIGHT; ULTRASOUND; VISCOSITY; WATER TRANSPORT;

ADMINISTRATION, INTRANASAL; ALGINATES; CARRAGEENAN; DELAYED-ACTION PREPARATIONS; DRUG DELIVERY SYSTEMS; GELS; MOLECULAR WEIGHT; NASAL CAVITY; NASAL MUCOSA; POLYMERS; SURFACE PROPERTIES;

EID: 84860374867     PISSN: 03639045     EISSN: 15205762     Source Type: Journal    
DOI: 10.3109/03639045.2011.598536     Document Type: Article

References (23)

1. Langguth P, Bohner V, Heizmann J, Merkle HP, Wolffram S, Amidon GL, et al. (1997). The challenge of proteolytic enzymes in intestinal peptide delivery. J Control Release, 46:39-57. (Pubitemid 27110886)
2. Pauletti GM, Gangwar S, Siahaan TJ, Aube J, Borchardt R.T. (1997). Improvement of oral peptide bioavailability: Peptidomimetics and prodrug strategies. Adv Drug Deliv Rev, 27(2,3):235-256. (Pubitemid 27417875)
3. Taki Y, Sakane T, Nadai T, Sezaki H, Amidon GL, Langguth P et al. (1998). First-pass metabolism of peptide drugs in rat perfused liver. J Pharm Pharmacol, 50:1013-1018. (Pubitemid 28464087)
4. Zhou XH. (1994). Overcoming enzymatic and absorption barriers to non-parenterally administered protein and peptide drugs. J Control Release, 29:239-252.
5. Chien YW. (1995). Biopharmaceutics basis for transmucosal delivery. STP Pharma Sci, 4:257-275.
6. Yamamoto A, Iseki T, Ochi-Sugiyama M, Okada N, Fujita T, Muranishi S. (2001). Absorption of water-soluble compounds with different molecular weights and. J Control Release, 76:363-374.
7. Merkus FWHM, Verhoef JC. (1994). Nasal drug delivery: Trends and Perspectives. In: Swarbrick J, Boyian JC (eds.), Encyclopedia of Pharmaceutical Technology, vol. 10, New York: Marcel Dekker Inc., 191-220.
8. Pontiroli AE, Calderara A, Pozza G. (1989). Intranasal drug delivery. Potential advantages and limitations from a clinical pharmacokinetic perspective. Clin Pharmacokinet, 17: 299-307. (Pubitemid 19273672)
9. Marttin E, Schipper NGM, Verhoef JC, Merkus FWHM. (1998). Nasal mucociliary clearance as a factor for nasal drug delivery. Adv Drug Deliv Rev, 29:13-38. (Pubitemid 28045041)
10. Critchley H, Davis SS, Farraj NF, Illum L. (1994). Nasal absorption of desmopressin in rats and sheep. Effect of a bioadhesive microsphere delivery system. J Pharm Pharmacol, 46:651-656. (Pubitemid 24249353)
11. Lueßen HL, Borchard G, Perard D, Noach ABJ, Verhoef JC, de Boer AG et al. (1996). Bioadhesive excipients in peroral peptide drug delivery. J Control Release, 41:S3.
12. Bodmeier R, Maincent P. (1999). Zubereitungen mit verlängerter Verweildauer am Applikationsort. German Patent DE 197 56 314 A 1.
13. Werner U, Damg? C, Maincent P, Bodmeier R. (2004). Properties of in situ gelling nasal insert containing estradiol/methyl β-cyclodextrin. J Drug Del Sci Tech, 14(4):275-284. (Pubitemid 39159106)
14. Bertram U, Bodmeier R. (2006). Parameters affecting the drug release from in situ gelling nasal inserts. Eur J Pharm Biopharm, 63:310-319. (Pubitemid 43776227)
15. Bertram U, Bernard MC, Haensler J, Maincent P, Bodmeier R. (2010). In situ gelling nasal inserts for influenza vaccine delivery. Drug Dev Ind Pharm, 36:581-593.
16. Zaman M, McAllister M, Martini LG, Lawrence MJ. (1999). The physico-chemical and biological factors influencing bioadhesion. Biopharm Europe, 52-60. (Pubitemid 29456860)
17. Nakamura F, Ohta R, Machida Y, Nagai T. (1996). In vitro and in vivo nasal mucoadhesion of some water-soluble polymers. Int J Pharm, 134:173-181. (Pubitemid 26174999)
18. Chen R-H, Chang J-R, Shyur J-S. (1997). Effects of ultrasonic conditions and storage in acidic solutions on changes in molecular weight and polydispersity of treated chitosan solutions. Carbohyd Res, 299:287-294.
19. Lii C, Chen C-H, Yeh A, Lai VM-F. (1999). Preliminary study on the degradation kinetics of agarose and carrageenans by ultrasound. Food Hydrocolloid, 13:477-481. (Pubitemid 129499919)
20. Dürig T, Fassihi R. (2002). Guar-based monolithic matrix systems: effect of ionizable and non-ionizable substances and excipients on gel dynamics and release kinetics. J Control Release, 80: 45-56. (Pubitemid 34273747)
21. Bertram U, Bodmeier R. (2006). In situ gelling, bioadhesive nasal inserts for extended drug delivery: in vitro characterization of a new nasal dosage form. Eur J Pharm Sci 27:62-71. (Pubitemid 41728256)
22. Werner U, Bodmeier R. (2002). Development of a simple in vitro bioadhesion test for fast disintegrating nasal inserts. Archiv der Pharmazie, 335 (Suppl. 1):124.
23. Lee JW, Park JH, Robinson JR. (2000). Bioadhesive-based dosage forms: the next generation. J Pharm Sci, 89:850-866.