Properties of in situ gelling nasal inserts containing estradiol/methyl β-cyclodextrin

Journal of Drug Delivery Science and Technology

Volumn 14, Issue 4, 2004, Pages 275-284

  Werner, U ^a   Damge C ^b   Maincent, P ^c   Bodmeier, R ^a  

^a FREIE UNIVERSITÄT BERLIN   (Germany)

^b UNIVERSITÉ DE STRASBOURG   (France)

^c UNIVERSITÉ DE LORRAINE   (France)

Author keywords

Controlled drug release; Cyclodextrin polymer interaction; Estradiol; Methyl cyclodextrin; Nasal drug delivery; Nasal inserts

Indexed keywords

ALGINIC ACID; CARRAGEENAN; ESTRADIOL; HYDROXYPROPYLMETHYLCELLULOSE; KELTROL F; KOLLIDON 90F; METHOCEL E5; METHYL BETA CYCLODEXTRIN; POLYMER; POVIDONE; XANTHAN;

ADHESION; ANIMAL EXPERIMENT; AQUEOUS SOLUTION; ARTICLE; BIOAVAILABILITY; COMPLEX FORMATION; CONTROLLED STUDY; DEHYDRATION; DRUG ABSORPTION; DRUG RELEASE; ESTRADIOL BLOOD LEVEL; FREEZE DRYING; MALE; MOISTURE; NONHUMAN; NOSE CAVITY; PARTICLE SIZE; RADIOIMMUNOASSAY; RAT; VISCOSITY; WATER TRANSPORT; WETTABILITY;

EID: 4344576598     PISSN: 11571489     EISSN: None     Source Type: Journal    
DOI: 10.1016/s1773-2247(04)50048-5     Document Type: Article

References (38)

1. MYGIND N., DAHL R. - Anatomy, physiology and function of the nasal cavity in health and disease. - Adv. Drug Del. Rev., 28, 3-12, 1998.
2. ROJANASAKUL Y., WANG L.Y., BHAT M., GLOVER D.D., MALANGA C.J., MA J.K.H. - The transport barrier of epithelia: A comparative study on membrane permeability and charge selectivity in the rabbit. - Pharm. Res., 9 (8), 29-34, 1992.
3. YAMAMOTO A., ISEKI T., OCHI-SUGIYAMA M., OKADA N., FUJITA T., MURANISHI S. - Absorption of water-soluble compounds with different molecular weights and [Asu1.7]-eel calcitonin from various mucosal administration sites. - J. Contr. Rel., 76 (3), 363-374, 2001.
4. MERKUS F.W.H.M., VERHOEF J.C. - Nasal drug delivery: Trends and perspectives. - In: Swarbrick J., Boylan J.C. Eds., Encyclopedia of Pharmaceutical Technology, Vol. 10, Marcel Dekker Inc., New York, 1994, pp. 191-220.
5. BODMEIER R., MAINCENT P. - Zubereitungen mit verlängerter Verweildauer am Applikationsort. - German Patent 197 56 314, 2000.
6. WERNER U. - Ph.D. dissertation, Freie Universtät Berlin, 2003.
7. McINNES F., STEVENS H.N., NOLAN A., GIBSON I., BAILLIE A.J. - Nasal absorption of insulin in sheep from a lyophilized formulation. - AAPSPharmSci 2002, Vol. 4, No. 4, Abstract T3176.
8. SOANE R.J., HINCHCLIFFE M., DAVIS S.S., ILLUM L. - Clearance characteristics of chitosan based formulations in the sheep nasal cavity. - Int. J. Pharm., 217, 183-191, 2001.
9. WANG W. - Instability, stabilization, and formulation of liquid protein pharmaceuticals. - Int. J. Pharm., 185, 129-188, 1999.
10. KUBLIK H., VIDGREN M.T. - Nasal delivery systems and their effect on deposition and absorption. - Adv. Drug Deliv. Rev., 29, 157-177, 1998.
11. VAN DE WEERT M., HENNINK W.E., JISKOOT W. - Protein instability in poly(lactic-co-glycolic acid) microparticles. - Pharm. Res., 17, 1159-1167, 2000.
12. JIANG W., SCHWENDEMAN S.P. - Stabilization and controlled release of bovine serum albumin encapsulated in poly(D,L-lactide) and poly(ethylene glycol) microsphere blends. - Pharm. Res., 18, 878-885, 2001.
13. McINNES F., THAPA P., STEVENS H.N., BAILLIE A.J., WATSON D., NOLAN A., GIBSON I. - Nasal absorption of nicotine in sheep from a lyophilised insert formulation. - AAPS PharmSci 2000, Vol. 2, No. 2, Abstract 626.
14. WERNER U., BODMEIER R. - Effect of polymer molecular weight on in vitro properties of fast disintegrating bioadhesive nasal inserts. - AAPS PharmSci 2002, Vol. 4, No. 4, Abstract T3163.
15. BREWSTER M.E., ESTES K.S., LOFTSSON T., PERCHALSKI R., DERENDORF H., MULLERSMAN G., BODOR N. - Improved delivery through biological membranes. XXXL: Solubilization and stabilization of an estradiol chemical delivery system by modified beta-cyclodextrins. - J. Pharm. Sci., 77 (11), 981-985, 1988.
16. FRIDRIKSDOTTIR H., LOFTSSON T., GUDMUNDSSON J.A., BJARNASON G.J., KJELD M., THORSTEINSSON T. - Design and in vivo testing of 17β-estradiol- HPβCD sublingual tablets. - Pharmazie, 51, 39-42, 1996.
17. OKIMOTO K., OHIKE A., IBUKI R., AOKI O., OHNISHI N., IRIE T., UEKAMA K., RAJEWSKI R.A., STELLA V.J. - Design and evaluation of an osmotic pump tablet (OPT) for chlorpromazine using (SBE)7m-beta-CD. - Pharm. Res., 16 (4), 549-554, 1999.
18. IRIE T., WAKAMATSU K., ARIMA H., ARITOMI H., UEKAMA K. - Enhancing effects of cyclodextrins on nasal absorption of insulin in rats. - Int. J. Pharm., 84 (2), 129-139, 1992.
19. IRIE T., UEKAMA K. - Cyclodextrins in peptide and protein delivery. - Adv. Drug. Deliv. Rev., 36, 101-123, 1999.
20. VERMEHREN C., HANSEN H.S., THOMSEN M.K. - Time dependent effects of two absorption enhancers on the nasal absorption of growth hormone in rabbits. - Int. J. Pharm., 128 (1,2), 239-250, 1996.
21. ASAI K., MORISHITA M., KATSUTA H., HOSODA S., SHINOMIYA K., NORO M., NAGAI T., TAKAYAMA K. - The effects of water-soluble cyclodextrins on the histological integrity of the rat nasal mucosa. - Int. J. Pharm., 246, 25-35, 2002.
22. MARTTIN E., VERHOEF J.C., ROMEIJN S.G., MERKUS F.W.H.M. - Effects of absorption enhancers on rat nasal epithelium in vivo: Release of marker compounds in the nasal cavity. - Pharm. Res., 12 (8), 1151-1157, 1995.
23. KABASAKALIAN P., BRITT E., YUDIS M.D. - Solubility of some steroids in water. - J. Pharm. Sci., 55, 642, 1966.
24. PELISSlER C., DE KERVASDOUE A., CHUONG V.T., MAUDIS E.-L., VALLETEAU DE MOUILLAC F., BREIL M.-H., MONIOT G., ZEITOUN-LEPVRIER G., ROBIN M., RIME B. - Clinical evaluation, dose-finding and acceptability of Aerodiol, the pulsed estrogen therapy for the treatment of climacteric symptoms. - Maturitas, 37, 181-189, 2001.
25. HERMENS W.A.J.J., DEURLOO M.J.M., ROMEYN S.G., VERHOEF J.C., MERKUS F.W.H.M. - Nasal absorption enhancement of 17β-estradiol by dimethyl-β-cyclodextrin in rabbits and rats. - Pharm. Res., 7 (5), 500-503, 1990.
26. NAKAMURA F., OHTA R., MACHIDA Y., NAGAI T. - In vitro and in vivo nasal mucoadhesion of some water-soluble polymers. - Int. J. Pharm., 134, 173-181, 1996.
27. ZARZYCKI P.K, LAMPARCZYK H. - The equilibrium constant of β-cyclodextrin-phenolphtalein complex; influence of temperature and tetrahydrofuran addition. - J. Pharmaceutical and Biomedical Analysis, 18, 165-170, 1998.
28. AKAHANE T., KAWASHIMA S., HIRAO I., SHIMIZU T., MINAKATA A. - Ion selectivities of some extracellular viscous polysaccharides from red algae. - Polymer Journal (Tokyo, Japan), 14 (3), 181-188, 1982.
29. ZHANG W., PICULELL L., NILSSON S., KNUTSEN S.H. - Cation specificity and cation binding to low sulfated carrageenans.- Carbohydrate Polymers, 23, 105-110, 1994.
30. HERCULES Inc. - Genu carrageenan, general description. - Product information, 1997.
31. HARADA A. - Construction of supramolecualr structures from cyclodextrins and polymers. - Carbohydrate Polymers, 34, 183-188, 1997.
32. KAWAGUCHI Y., NISHIYAMA T., OKADA M., KAMACHI M., HARADA A. - Complex formation of poly (ε-caprolactone) with cyclodextrins. - Macromolecules, 33, 4472-4477, 2000.
33. LONOSTRO P., LOPES J.R., NINHAM B.W., BAGLIONI P. - Effect of cations and anions on the formation of polypseudorotaxanes. - J. Phys. Chem. B, 106, 2166-2174, 2002.
34. GIBSON HW., LIU S., GONG C., JI Q., JOSEPH E. - Studies of the formation of poly(ester rotaxane)s from diacid chlorides, diols, and crown ethers and their properties. - Macromolecules, 30 (13), 3711-3727, 1997.
35. GONG C., BALANDA RB., GIBSON H.W. - Supramolecular chemistry with macromolecules: New self-assembly based main chain polypseudorotaxanes and their properties. - Macromolecules, 31, 5278-5289, 1998.
36. BIBBY D.C., DAVIES N.M., TUCKER I.G. - Mechanisms by which cyclodextrins modify drug release from polymeric drug delivery systems. - Int. J. Pharm., 197, 1-11, 2000.
37. SOKOL R.Z., OKUDA H., STANCZYK F.Z., WOLFE G.W., DELANEY J.C., CHAPIN R.E. - Normative reproductive indices for male and female adult Sprague-Dawley rats. - Contraception, 59, 203-207, 1999.
38. SCHIPPER N.G.M., VERHOEF J.C., MERKUS F.W.H.M. - The nasal mucociliary clearance: Relevance to nasal drug delivery. - Pharm. Res., 8 (7), 807-814, 1991.