Zebrafish chemical screening reveals the impairment of dopaminergic neuronal survival by cardiac glycosides

PLoS ONE

Volumn 7, Issue 4, 2012, Pages

  Sun, Yaping ^a   Dong, Zhiqiang ^a   Khodabakhsh, Hadie ^a,b   Chatterjee, Sandip ^a,c   Guo, Su ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b GEORGE WASHINGTON UNIVERSITY SCHOOL OF MEDICINE AND HEALTH SCIENCES   (United States)

^c SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); CARDIAC GLYCOSIDE; NERIIFOLIN; PROTEIN P53; SODIUM POTASSIUM ADENOSINE TRIPHOSPHATASE ALPHA 3 SUBUNIT; UNCLASSIFIED DRUG; ANTIOXIDANT; CARDENOLIDE;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BRAIN REGION; CELL DEATH; CELL SURVIVAL; CHEMICAL ANALYSIS; CONTROLLED STUDY; DOPAMINERGIC NERVE CELL; EMBRYO; ENZYME ACTIVITY; ENZYME INHIBITION; GENE SILENCING; NERVE CELL DIFFERENTIATION; NEUROMODULATION; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; OXIDATIVE STRESS; SCREENING TEST; ZEBRA FISH; ANIMAL; ANIMAL EMBRYO; CHEMISTRY; CYTOLOGY; DRUG ANTAGONISM; DRUG EFFECT; GENETICS; GROWTH, DEVELOPMENT AND AGING; HUMAN; METABOLISM;

DANIO RERIO; MAMMALIA;

ANIMALS; ANTIOXIDANTS; CARDENOLIDES; CARDIAC GLYCOSIDES; CELL SURVIVAL; DOPAMINERGIC NEURONS; EMBRYO, NONMAMMALIAN; HUMANS; OXIDATIVE STRESS; SODIUM-POTASSIUM-EXCHANGING ATPASE; TUMOR SUPPRESSOR PROTEIN P53; ZEBRAFISH;

EID: 84860360034     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0035645     Document Type: Article

References (54)

1. Björklund A, Lindvall O, (1984) Dopamine-containing systems in the CNS. In: Björklund A, Hökfelt T, editors. Handbook of Chemical Neuroanatomy Amsterdam Elsevier pp. 55-122.
2. Goldstein DS, Eisenhofer G, McCarty R, (1998) Catecholamines: bridging basic science with clinical medicine; In: August JT, Anders MW, Murad F, Coyle JT, editors. San Diego, California Academic Press.
3. Chaudhuri KR, Schapira AH, (2009) Non-motor symptoms of Parkinson's disease: dopaminergic pathophysiology and treatment. Lancet Neurol 8: 464-474.
4. Meissner WG, Frasier M, Gasser T, Goetz CG, Lozano A, et al. (2011) Priorities in Parkinson's disease research. Nat Rev Drug Discov 10: 377-393.
5. Smeets WJAJ, Reiner A, (1994) Phylogeny and development of catecholamine systems in the CNS of vertebrates Cambridge, England Cambridge University Press.
6. Guo S, Wilson SW, Cooke S, Chitnis AB, Driever W, et al. (1999) Mutations in the zebrafish unmask shared regulatory pathways controlling the development of catecholaminergic neurons. Dev Biol 208: 473-487.
7. Holzschuh J, Ryu S, Aberger F, Driever W, (2001) Dopamine transporter expression distinguishes dopaminergic neurons from other catecholaminergic neurons in the developing zebrafish embryo. Mech Dev 101: 237-243.
8. Ma PM, (2003) Catecholaminergic systems in the zebrafish IV. Organization and projection pattern of dopaminergic neurons in the diencephalon. J Comp Neurol 460: 13-37.
9. McLean DL, Fetcho JR, (2004) Ontogeny and innervation patterns of dopaminergic, noradrenergic, and serotonergic neurons in larval zebrafish. J Comp Neurol 480: 38-56.
10. Tay TL, Ronneberger O, Ryu S, Nitschke R, Driever W, (2011) Comprehensive catecholaminergic projectome analysis reveals single-neuron integration of zebrafish ascending and descending dopaminergic systems. Nat Commun 2: 171.
11. Rink E, Wullimann MF, (2001) The teleostean (zebrafish) dopaminergic system ascending to the subpallium (striatum) is located in the basal diencephalon (posterior tuberculum). Brain Res 889: 316-330.
12. Rink E, Wullimann MF, (2002) Connections of the ventral telencephalon and tyrosine hydroxylase distribution in the zebrafish brain (Danio rerio) lead to identification of an ascending dopaminergic system in a teleost. Brain Res Bull 57: 385-387.
13. Zon LI, Peterson RT, (2005) In vivo drug discovery in zebrafish. Nat Rev Drug Discovery 4: 35-44.
14. Guo S, (2009) Using zebrafish to assess the impact of drugs on neural development and function. Expert Opin Drug Discov 4: 715-726.
15. Yu PB, Hong CC, Sachidanandan C, Babitt JL, Deng DY, et al. (2008) Dorsomorphin inhibits BMP signals required for embryogenesis and iron metabolism. Nat Chem Biol 4: 33-41.
16. Molina G, Vogt A, Bakan A, Dai W, Queiroz de Oliveira P, et al. (2009) Zebrafish chemical screening reveals an inhibitor of Dusp6 that expands cardiac cell lineages. Nat Chem Biol 5: 680-687.
17. Stern HM, Murphey RD, Shepard JL, Amatruda JF, Straub CT, et al. (2005) Small molecules that delay S phase suppress a zebrafish bmyb mutant. Nat Chem Biol 1: 366-370.
18. North TE, Goessling W, Walkley CR, Lengerke C, Kopani KR, et al. (2007) Prostaglandin E2 regulates vertebrate haematopoietic stem cell homeostasis. Nature 447: 1007-1011.
19. Yeh JR, Munson KM, Elagib KE, Goldfarb AN, Sweetser DA, et al. (2009) Discovering chemical modifiers of oncogene-regulated hematopoietic differentiation. Nat Chem Biol 5: 236-243.
20. Hicken CE, Linbo TL, Baldwin DH, Willis ML, Myers MS, et al. (2011) Sublethal exposure to crude oil during embryonic development alters cardiac morphology and reduces aerobic capacity in adult fish. Proc Natl Acad Sci U S A 108: 7086-7090.
21. North TE, Babu IR, Vedder LM, Lord AM, Wishnok JS, et al. (2010) PGE2-regulated wnt signaling and N-acetylcysteine are synergistically hepatoprotective in zebrafish acetaminophen injury. Proc Natl Acad Sci U S A 107: 17315-17320.
22. Peterson RT, Shaw SY, Peterson TA, Milan DJ, Zhong TP, et al. (2004) Chemical suppression of a genetic mutation in a zebrafish model of aortic coarctation. Nat Biotech 22: 595-599.
23. Kawahara G, Karpf JA, Myers JA, Alexander MS, Guyon JR, et al. (2011) Drug screening in a zebrafish model of Duchenne muscular dystrophy. Proc Natl Acad Sci U S A 108: 5331-5336.
24. Rihel J, Prober DA, Arvanites A, Lam K, Zimmerman S, et al. (2010) Zebrafish behavioral profiling links drugs to biological targets and rest/wake regulation. Science 327: 348-351.
25. Kokel D, Bryan J, Laggner C, White R, Cheung CY, et al. (2010) Rapid behavior-based identification of neuroactive small molecules in the zebrafish. Nat Chem Biol 6: 231-237.
26. Prassas I, Diamandis EP, (2008) Novel therapeutic applications of cardiac glycosides. Nat Rev Drug Discov 7: 926-935.
27. McGrail KM, Phillips JM, Sweadner KJ, (1991) Immunofluorescent localization of three Na,K-ATPase isozymes in the rat central nervous system: both neurons and glia can express more than one Na,K-ATPase. J Neurosci 11: 381-391.
28. Rajarao SJ, Canfield VA, Mohideen MA, Yan YL, Postlethwait JH, et al. (2001) The repertoire of Na,K-ATPase alpha and beta subunit genes expressed in the zebrafish, Danio rerio. Genome Res 11: 1211-1220.
29. Thisse C, Thisse B, (2005) High Throughput Expression Analysis of ZF-Models Consortium Clones. ZFIN Direct Data Submission (ZFIN web site, available http://zfin.org. Accessed March 26 2012).
30. de Carvalho Aguiar P, Sweadner KJ, Penniston JT, Zaremba J, Liu L, et al. (2004) Mutations in the Na+/K+-ATPase alpha3 gene ATP1A3 are associated with rapid-onset dystonia parkinsonism. Neuron 43: 169-175.
31. Heo HJ, Lee CY, (2004) Protective effects of quercetin and vitamin C against oxidative stress-induced neurodegeneration. J Agric Food Chem 52: 7514-7517.
32. Bournival J, Quessy P, Martinoli MG, (2009) Protective effects of resveratrol and quercetin against MPP+-induced oxidative stress act by modulating markers of apoptotic death in dopaminergic neurons. Cell Mol Neurobiol 29: 169-180.
33. Giaccia AJ, Kastan MB, (1998) The complexity of p53 modulation: emerging patterns from divergent signals. Genes Dev 12: 2973-2983.
34. Fridman JS, Lowe SW, (2003) Control of apoptosis by p53. Oncogene 22: 9030-9040.
35. Haupt S, Berger M, Goldberg Z, Haupt Y, (2003) Apoptosis- the p53 network. J Cell Sci 116: 4077-4085.
36. Langheinrich U, Hennen E, Stott G, Vacun G, (2002) Zebrafish as a model organism for the identification and characterization of drugs and genes affecting p53 signaling. Curr Biol 12: 2023-2028.
37. Ying QL, Stavridis M, Griffiths D, Li M, Smith A, (2003) Conversion of embryonic stem cells into neuroectodermal precursors in adherent monoculture. Nat Biotechnol 21: 183-186.
38. Miyazaki I, Asanuma M, (2008) Dopaminergic neuron-specific oxidative stress caused by dopamine itself. Acta Med Okayama 62: 141-150.
39. Chiueh CC, Markey SP, Burns R, Johannessen JN, Jacobowitz DM, et al. (1984) Neurochemical and behavioral effect of MPTP in rat, quinea pig and monkey. Psychopharmacol Bull 20: 546-553.
40. Lam CS, Korzh V, Strahle U, (2005) Zebrafish embryos are susceptible to the dopaminergic neurotoxin MPTP. Eur J Neurosci 21: 1758-1762.
41. McKinley ET, Baranowski TC, Blavo DO, Cato C, Doan TN, et al. (2005) Neuroprotection of MPTP-induced toxicity in zebrafish dopaminergic neurons. Brain Res Mol Brain Res 141: 128-137.
42. Sallinen V, Torkko V, Sundvik M, Reenilä I, Khrustalyov D, et al. (2009) MPTP and MPP+ target specific aminergic cell populations in larval zebrafish. J Neurochem 108: 719-731.
43. Bretaud S, Lee S, Guo S, (2004) Sensitivity of zebrafish to environmental toxins implicated in Parkinson's disease. Neurotox Teratol 26: 857-864.
44. Betarbet R, Sherer TB, MacKenzie G, Garcia-Osuna M, Panov AV, et al. (2000) Chronic systemic pesticide exposure reproduces features of Parkinson's disease. Nat Neurosci 3: 1301-1306.
45. Greenamyre JT, Betarbet R, Sherer TB, (2003) The rotenone model of Parkinson's disease: genes, environment and mitochondria. Parkinsonism and related disorders 9: S59-S64.
46. Perier C, Bove J, Vila M, Przedborski S, (2003) The rotenone model of Parkinson's disease. Trends Neurosci 26: 345-346.
47. Speciale SG, (2002) MPTP: insights into parkinsonian degeneration. Neurotoxicol Teratol pp. 607-620.
48. Song YH, Terao T, Shiraishi Y, Nakamura J, (2001) Digitalis intoxication misdiagnosed as depression-revisited. Psychosomatics 42: 369-370.
49. Carney MW, Rapp S, Pearce K, (1985) Digoxin toxicity presenting with psychosis in a patient with chronic phobic anxiety. Clin Neuropharmacol 8: 193-195.
50. Guo S, Brush J, Teraoka H, Goddard A, Wilson SW, et al. (1999) Development of noradrenergic neurons in the zebrafish hindbrain requires BMP, FGF8, and the homeodomain protein Soulless/Phox2a. Neuron 24: 555-566.
51. Krishnan K, Salomonis N, Guo S, (2008) Identification of Spt5 target genes in zebrafish development reveals its dual activity in vivo. PLoS ONE 3: e3621.
52. Halloran MC, Sato-Maeda M, Warren JT, Su F, Lele Z, et al. (2000) Laser-induced gene expression in specific cells of transgneic zebrafish. Development 127: 1953-1960.
53. Hooper M, Hardy K, Handyside A, Hunter S, Monk M, (1987) HPRT-deficient (Lesch-Nyhan) mouse embryos derived from germline colonization by cultured cells. Nature 326: 292-295.
54. Ying QL, Smith AG, (2003) Defined conditions for neural commitment and differentiation. Methods Enzymol 365: 327-341.