A helical conotoxin from Conus imperialis has a novel cysteine framework and defines a new superfamily

Journal of Biological Chemistry

Volumn 287, Issue 18, 2012, Pages 14973-14983

  Ye, Mingyu ^a,h   Khoo, Keith K ^b,c,d   Xu, Shaoqiong ^a   Zhou, Mi ^a   Boonyalai, Nonlawat ^e   Perugini, Matthew A ^f   Shao, Xiaoxia ^a   Chi, Chengwu ^a,g   Galea, Charles A ^b   Wang, Chunguang ^a   Norton, Raymond S ^b  

^a TONGJI UNIVERSITY   (China)

^b MONASH UNIVERSITY   (Australia)

^c WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH   (Australia)

^d UNIVERSITY OF MELBOURNE   (Australia)

^e KASETSART UNIVERSITY   (Thailand)

^f LA TROBE UNIVERSITY   (Australia)

^g INSTITUTE OF BIOCHEMISTRY AND CELL BIOLOGY   (China)

^h Chinese Academy of Sciences   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ACIDIC RESIDUES; BIOLOGICAL TARGETS; CHEMICAL MAPPING; CONE SNAILS; CONOTOXINS; CYSTEINE RESIDUES; DISULFIDE BRIDGE; HELICAL HAIRPINS; ION CHANNEL; ISOLATION AND CHARACTERIZATION; NMR STRUCTURES; PERIPHERAL NERVOUS SYSTEM; SIGNAL PEPTIDE; SOLUTION STRUCTURES;

AMINO ACIDS; COVALENT BONDS; IODINE; MAMMALS; PEPTIDES; TOXIC MATERIALS;

METABOLITES;

COMPLEMENTARY DNA; CONOTOXIN; CYSTEINE; DISULFIDE; SIGNAL PEPTIDE; SNAIL VENOM;

ACIDITY; AMINO ACID SEQUENCE; ARTICLE; CALCIUM BINDING; CENTRAL NERVOUS SYSTEM; CONUS SNAIL; DISULFIDE BOND; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; NUCLEOTIDE SEQUENCE; PERIPHERAL NERVOUS SYSTEM; PRIORITY JOURNAL; PROTEIN FAMILY; PROTEIN FOLDING; TOXIN ANALYSIS; TOXIN STRUCTURE;

AMINO ACID MOTIFS; AMINO ACID SEQUENCE; ANIMALS; CONOTOXINS; CONUS SNAIL; DISULFIDES; MAGNETIC RESONANCE SPECTROSCOPY; MICE; MOLECULAR SEQUENCE DATA; RECOMBINANT PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP;

CONUS IMPERIALIS; GASTROPODA; MUS;

EID: 84860359591     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.334615     Document Type: Article

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