Lipid metabolite profiling identifies desmosterol metabolism as a new antiviral target for hepatitis C virus

Journal of the American Chemical Society

Volumn 134, Issue 16, 2012, Pages 6896-6899

  Rodgers, Mary A ^a,c   Villareal, Valerie A ^a   Schaefer, Esperance A ^b   Peng, Lee F ^b   Corey, Kathleen E ^b   Chung, Raymond T ^b   Yang, Priscilla L ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

^c UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GENOMIC RNA; HEPATITIS C VIRUS; INFECTION MODELS; LIPID METABOLISMS; LIPID METABOLITES; LIQUID CHROMATOGRAPHY-MASS SPECTROMETRY; METABOLITE PROFILING; PHARMACOLOGICAL INHIBITION; PROTEIN EXPRESSIONS; SERUM LIPID;

CELL CULTURE; METABOLISM; METABOLITES; RNA; VIRUSES;

PHYSIOLOGY;

1,4 BIS(2 CHLOROBENZYLAMINOMETHYL)CYCLOHEXANE; 7 DEHYDROCHOLESTEROL REDUCTASE; CHOLESTEROL; DESMOSTEROL; GENOMIC RNA; LIPID; OXIDOREDUCTASE; RNA; STEROL; UNCLASSIFIED DRUG; VIRUS PROTEIN;

ANIMAL CELL; ANTIVIRAL ACTIVITY; ARTICLE; CELL CULTURE; CELL LINE; CONTROLLED STUDY; DRUG METABOLISM; DRUG SYNTHESIS; DRUG TARGETING; ENZYME INHIBITION; HEPATITIS C VIRUS; IC 50; LIPID ANALYSIS; LIPID METABOLISM; LIQUID CHROMATOGRAPHY; LIQUID CHROMATOGRAPHY TANDEM MASS SPECTROMETRY; MEDIATOR; NONHUMAN; PROTEIN EXPRESSION; RNA INTERFERENCE; STEADY STATE; TANDEM MASS SPECTROMETRY; VIRUS REPLICATION;

ANTIVIRAL AGENTS; CELLS, CULTURED; DESMOSTEROL; HEPACIVIRUS; HEPATITIS C; HUMANS; LIPID METABOLISM; VIRUS REPLICATION;

EID: 84860334010     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja207391q     Document Type: Article

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