Prolonged exposure to insulin induces mitochondrion-derived oxidative stress through increasing mitochondrial cholesterol content in hepatocytes

Endocrinology

Volumn 153, Issue 5, 2012, Pages 2120-2129

  Mei, Shuang ^a   Gu, Haihua ^a   Yang, Xuefeng ^a,b   Guo, Huailan ^a,c   Liu, Zhenqi ^d   Cao, Wenhong ^a,e  

^a University of North Carolina   (United States)

^b HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^c HUBEI UNIVERSITY OF MEDICINE   (China)

^d UNIVERSITY OF VIRGINIA HEALTH SYSTEM   (United States)

^e DUKE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHOLESTEROL; GLUTATHIONE; GLUTATHIONE DISULFIDE; INSULIN; INSULIN GLARGINE; REACTIVE OXYGEN METABOLITE; SIMVASTATIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL CULTURE; CELL ISOLATION; CELL MEMBRANE FLUIDITY; CELL MEMBRANE POTENTIAL; CHOLESTEROL BLOOD LEVEL; CHOLESTEROL SYNTHESIS; CONTROLLED STUDY; DATA ANALYSIS; HUMAN; HUMAN CELL; LIVER CELL; MALE; MEDICAL RECORD; MITOCHONDRION; MOUSE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL;

ANIMALS; CELL LINE; CHOLESTEROL; HEPATOCYTES; HYPOGLYCEMIC AGENTS; INSULIN; INSULIN, LONG-ACTING; MALE; MEMBRANE POTENTIAL, MITOCHONDRIAL; MICE; MITOCHONDRIA; OXIDATIVE STRESS; REACTIVE OXYGEN SPECIES;

EID: 84860330885     PISSN: 00137227     EISSN: 19457170     Source Type: Journal    
DOI: 10.1210/en.2011-2119     Document Type: Article

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