Honokiol protects brain against global brain ischemia in mice through inhibiting MPTP opening and PARP-1 activity

Chinese Pharmacological Bulletin

Volumn 28, Issue 2, 2012, Pages 218-221

  Yang, Shuang ^a   Liu, Xiao Yan ^a   Hu, Zhen Yu ^a   Chen, Shi Zhong ^a   Wang, Yin Ye ^a  

^a PEKING UNIVERSITY   (China)

Author keywords

ATP; Global brain ischemia; Honokiol; Lactic acid; MPTP; PARP 1

Indexed keywords

HONOKIOL; LACTIC ACID; MITOCHONDRIAL PERMEABILITY TRANSITION PORE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE 1;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANOXIA; ARTICLE; BRAIN HOMOGENATE; BRAIN ISCHEMIA; BREATHING RATE; CELL STRAIN; CELL VIABILITY; DECAPITATION; DRUG EFFICACY; ENERGY CONSUMPTION; FLUOROMETRY; MICROEMULSION; MOUSE; NEUROPROTECTION; NONHUMAN; SPECTROPHOTOMETRY; TREATMENT OUTCOME;

EID: 84860270068     PISSN: 10011978     EISSN: None     Source Type: Journal    
DOI: 10.3969/j.issn.1001-1978.2012.02.016     Document Type: Article

References (14)

1. Ren J W, Yang Q. Protective mechanism of resveratrol on cerebral ischemia/reperfusion injury via ameliorating oxidative stress[J]. Chin Pharmacol Bull,2011,27(4):448-51.
2. Liou K T, Shen Y C, Chen C F, et al. Honokiol protects rat brain from focal cerebral ischemia-reperfusion injury by inhibiting neutrophil infiltration and reactive oxygen species production[J]. Brain Res,2003,992(2):159-66.
3. Hu H, Tang Z Y, Chen S Z, et al. Honokiol ameliorates focal cerebral ischemia and enhances tissue reactive oxygen species scavenging capacity after cerebral ischemia-reperfusion[J]. Chin Pharmacol Toxicol,2006,20(6):455-60. (Pubitemid 46033292)
4. Fukuyama Y, Nakade, Minoshima Y, et al. Neurotrophic activity of honokiol on the cultures of fetal rat cortical neurons[J]. Bioorg Med Chem Lett,2002,12(8):1163-6.
5. Lioua K T, Shenb Y C, Chenb C F, et al. The anti-inflammatory effect of honokiol on neutrophils: mechanisms in the inhibition of reactive oxygen species production[J]. Eur J Pharmacol,2003(1-3),475:19-27.
6. Hu H, Zhang X X, Wang Y Y, et al. Honokiol inhibits arterial thrombosis through endothelial cell protection and stimulation of prostacyclin[J]. Acta Pharmacol Sin,2005,26(9):1063-8. (Pubitemid 41296945)
7. Zhang X, Chen S Z, Wang Y Y. Honokiol up-regulates prostacyclin synthease protein expression and inhibits endothelial cell apoptosis[J]. Eur J Pharmacol,2007,554(1):1-7. (Pubitemid 44820042)
8. Yao C S, Meng X L, Ren B, et al. The protective effect of calcitonin Gene-Related Peptide on the of global brain ischemic tissue[J]. Chin Clin Rehabil,2004,8(16):3056-7. (Pubitemid 39029994)
9. + channel is mediated by inhibiting the mitochondrial permeability transition pore[J]. Neurosci Lett,2006,402(1-2):184-9.
10. Kosenko E, Venediktova N, Kaminsky Y, et al. Preparation and handling of brain mitochondria useful to study uptake and release of calcium[J]. Brain Res Protoc,2001,7(3):248-54. (Pubitemid 32592516)
11. +: application to the high-throughput screening of small molecules as potential inhibitors[J]. Anal Biochem,2004,326(1):78-86.
12. Zhang Z Y. The vasodilative effect of honokiol and its correlated mechanism[J]. Thes Shenyang Pharm Univ,2009:5.
13. +-ATPase Activity and Mitochondrial Functions[J]. Basic Clin Pharmacol Toxicol,2007,101(2):108-16.
14. Kamanaka Y, Kondoc K, Ikeda Y, et al. ADP-ribose polymerase (PARP), on cytotoxicity of PC12 cells and ischemic cerebral damage[J]. Life Sci,2004,76(2):151-62.