PTHrP and breast cancer: More than hypercalcemia and bone metastases

Breast Cancer Research

Volumn 14, Issue 2, 2012, Pages

  Boras Granic, Kata ^a   Wysolmerski, John J ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM; CHEMOKINE RECEPTOR; CYCLIN D; PARATHYROID HORMONE RELATED PROTEIN; PROTEIN KINASE B;

ANGIOGENESIS; APOPTOSIS; ARTICLE; B CELL LYMPHOMA; BONE METASTASIS; BREAST CANCER; BREAST EPITHELIUM; CELL PROLIFERATION; GENETIC ASSOCIATION; GENETIC SUSCEPTIBILITY; HYPERCALCEMIA; NONHUMAN; PRIMARY TUMOR; TUMOR GROWTH; ANIMAL; BREAST TUMOR; CHROMOSOME 12; CHROMOSOME 21; EXPERIMENTAL NEOPLASM; FEMALE; GENE LOCUS; GENETIC PREDISPOSITION; GENETICS; HUMAN; METASTASIS; NOTE; PATHOLOGY; PHYSIOLOGY;

ANIMALS; BREAST NEOPLASMS; CHROMOSOMES, HUMAN, PAIR 12; CHROMOSOMES, HUMAN, PAIR 21; FEMALE; GENETIC LOCI; GENETIC PREDISPOSITION TO DISEASE; HUMANS; MAMMARY NEOPLASMS, EXPERIMENTAL; NEOPLASM METASTASIS; PARATHYROID HORMONE-RELATED PROTEIN;

EID: 84860261092     PISSN: 14655411     EISSN: 1465542X     Source Type: Journal    
DOI: 10.1186/bcr3129     Document Type: Article

References (15)

1. Strewler GJ. The physiology of parathyroid hormone-related protein. N Engl J Med 2000, 342:177-185. 10.1056/NEJM200001203420306, 10639544.
2. Wysolmerski J. Parathyroid hormone-related protein. Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism 2008, 127-133. Washington, DC: American Society for Bone and Mineral Research, Rosen C, 7.
3. Boras-Granic K, VanHouten J, Hiremath M, Wysolmerski J. Parathyroid hormone-related protein is not required for normal ductal or alveolar development in the post-natal mammary gland. PLoS One 2011, 6:e27278. 10.1371/journal.pone.0027278, 3210770, 22087279.
4. VanHouten JN, Dann P, Stewart AF, Watson CJ, Pollak M, Karaplis AC, Wysolmerski JJ. Mammary-specific deletion of parathyroid hormone-related protein preserves bone mass during lactation. J Clin Invest 2003, 112:1429-1436. 228471, 14597768.
5. Akhtari M, Mansuri J, Newman KA, Guise TM, Seth P. Biology of breast cancer bone metastasis. Cancer Biol Ther 2008, 7:3-9. 10.4161/cbt.7.1.5163, 18059174.
6. Shen X, Qian L, Falzon M. PTH-related protein enhances MCF-7 breast cancer cell adhesion, migration, and invasion via an intracrine pathway. Exp Cell Res 2004, 294:420-433. 10.1016/j.yexcr.2003.11.028, 15023531.
7. Luparello C, Sirchia R, Lo Sasso B. Midregion PTHrP regulates Rip1 and caspase expression in MDA-MB231 breast cancer cells. Breast Cancer Res Treat 2008, 111:461-474. 10.1007/s10549-007-9816-0, 18030616.
8. Bundred NJ, Walker RA, Ratcliffe WA, Warwick J, Morrison JM, Ratcliffe JG. Parathyroid hormone related protein and skeletal morbidity in breast cancer. Eur J Cancer 1992, 28:690-692. 10.1016/S0959-8049(05)80127-3, 1591095.
9. Hoey RP, Sanderson C, Iddon J, Brady G, Bundred NJ, Anderson NG. The parathyroid hormone-related protein receptor is expressed in breast cancer bone metastases and promotes autocrine proliferation in breast carcinoma cells. Br J Cancer 2003, 88:567-573. 10.1038/sj.bjc.6600757, 2377170, 12592371.
10. Henderson MA, Danks JA, Slavin JL, Byrnes GB, Choong PF, Spillane JB, Hopper JL, Martin TJ. Parathyroid hormone-related protein localization in breast cancers predict improved prognosis. Cancer Res 2006, 66:2250-2256. 10.1158/0008-5472.CAN-05-2814, 16489028.
11. Ghoussaini M, Fletcher O, Michailidou K, Turnbull C, Schmidt MK, Dicks E, Dennis J, Wang Q, Humphreys MK, Luccarini C, Baynes C, Conroy D, Maranian M, Ahmed S, Driver K, Johnson N, Orr N, Dos Santos Silva I, Waisfisz Q, Meijers-Heijboer H, Uitterlinden AG, Rivadeneira F, , et al. Netherlands Collaborative Group on Hereditary Breast and Ovarian Cancer (HEBON) Genome-wide association analysis identifies three new breast cancer susceptibility loci. Nat Genet 2012, 44:312-318. 10.1038/ng.1049, 22267197, Netherlands Collaborative Group on Hereditary Breast and Ovarian Cancer (HEBON).
12. Li J, Karaplis AC, Huang DC, Siegel PM, Camirand A, Yang XF, Muller WJ, Kremer R. PTHrP drives breast tumor initiation, progression, and metastasis in mice and is a potential therapy target. J Clin Invest 2011, 121:4655-4669. 10.1172/JCI46134, 3225988, 22056386.
13. Fleming NI, Trivett MK, George J, Slavin JL, Murray WK, Moseley JM, Anderson RL, Thomas DM. Parathyroid hormone-related protein protects against mammary tumor emergence and is associated with monocyte infiltration in ductal carcinoma in situ. Cancer Res 2009, 69:7473-7479. 10.1158/0008-5472.CAN-09-0194, 19723659.
14. Lim E, Wu D, Pal B, Bouras T, Asselin-Labat ML, Vaillant F, Yagita H, Lindeman GJ, Smyth GK, Visvader JE. Transcriptome analyses of mouse and human mammary cell subpopulations reveal multiple conserved genes and pathways. Breast Cancer Res 2010, 12:R21. 10.1186/bcr2560, 2879567, 20346151.
15. Prosperi JR, Khramtsov AI, Khramtsova GF, Goss KH. Apc mutation enhances PyMT-induced mammary tumorigenesis. PLoS One 2011, 6:e29339. 10.1371/journal.pone.0029339, 3245255, 22216254.