Parathyroid hormone-related protein is not required for normal ductal or alveolar development in the post-natal mammary gland

PLoS ONE

Volumn 6, Issue 11, 2011, Pages

  Boras Granic, Kata ^a   VanHouten, Joshua ^a   Hiremath, Minoti ^b   Wysolmerski, John ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b BOISE STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PARATHYROID HORMONE RELATED PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BASAL CELL; BLAST CELL; BREAST ALVEOLAR DEVELOPMENT; BREAST DEVELOPMENT; BREAST DUCT; BREAST DUCT DEVELOPMENT; BREAST MILK; CONTROLLED STUDY; EMBRYO; GENE; GROWTH RATE; LACTATION; MOUSE; MYOEPITHELIUM CELL; NONHUMAN; POSTNATAL DEVELOPMENT; PREDICTION; PREGNANCY; PROTEIN DEPLETION; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PTHRP GENE; PUBERTY; SIGNAL TRANSDUCTION; TRANSGENE; TRANSGENIC MOUSE; ANIMAL; FEMALE; GENE EXPRESSION; GROWTH, DEVELOPMENT AND AGING; PHYSIOLOGY; TISSUE DISTRIBUTION; UDDER;

MOUSE MAMMARY TUMOR VIRUS; MUS MUSCULUS;

ANIMALS; FEMALE; GENE EXPRESSION; LACTATION; MAMMARY GLANDS, ANIMAL; MICE; MICE, TRANSGENIC; PARATHYROID HORMONE-RELATED PROTEIN; PREGNANCY; TISSUE DISTRIBUTION;

EID: 80555154322     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0027278     Document Type: Article

References (35)

1. Hennighausen L, Robinson GW, (2001) Signaling pathways in mammary gland development. Dev Cell 1: 467-475.
2. Robinson GW, (2007) Cooperation of signalling pathways in embryonic mammary gland development. Nat Rev Genet 8: 963-972.
3. Sternlicht MD, Kouros-Mehr H, Lu P, Werb Z, (2006) Hormonal and local control of mammary branching morphogenesis. Differentiation 74: 365-381.
4. Cowin P, Wysolmerski J, (2010) Molecular mechanisms guiding embryonic mammary gland development. Cold Spring Harb Perspect Biol 2: a003251.
5. Sternlicht MD, (2006) Key stages in mammary gland development: the cues that regulate ductal branching morphogenesis. Breast Cancer Res 8: 201.
6. Watson CJ, Khaled WT, (2008) Mammary development in the embryo and adult: a journey of morphogenesis and commitment. Development 135: 995-1003.
7. Wysolmerski J, (2008) Parathyroid Hormone-related Protein. In: Rosen C, editors. Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism. 7th ed Washington, DC American Society for Bone and Mineral Research pp. 127-133.
8. Dunbar ME, Dann PR, Robinson GW, Hennighausen L, Zhang JP, et al. (1999) Parathyroid hormone-related protein signaling is necessary for sexual dimorphism during embryonic mammary development. Development 126: 3485-3493.
9. Foley J, Dann P, Hong J, Cosgrove J, Dreyer B, et al. (2001) Parathyroid hormone-related protein maintains mammary epithelial fate and triggers nipple skin differentiation during embryonic breast development. Development 128: 513-525.
10. Wysolmerski JJ, Cormier S, Philbrick WM, Dann P, Zhang JP, et al. (2001) Absence of functional type 1 parathyroid hormone (PTH)/PTH-related protein recpetors in humans is associated with abnormal breast development and tooth impaction. Journal of Clinical Endocrinology and Metabolism 86: 1788-1794.
11. Wysolmerski JJ, Philbrick WM, Dunbar ME, Lanske B, Kronenberg HM, et al. (1998) rescue of the parathyroid hormone-related protein knockout mouse demonstrates that parathyroid hormone-related protein is essential for mammary gland development. Development 125: 1285-1294.
12. VanHouten JN, Dann P, Stewart AF, Watson CJ, Pollak M, et al. (2003) Mammary-specific deletion of parathyroid hormone-related protein preserves bone mass during lactation. J Clin Invest 112: 1429-1436.
13. VanHouten JN, Wysolmerski JJ, (2003) Low estrogen and high parathyroid hormone-related peptide levels contribute to accelerated bone resorption and bone loss in lactating mice. Endocrinology 144: 5521-5529.
14. Dunbar ME, Dann P, Brown CW, Van Houton J, Dreyer B, et al. (2001) Temporally regulated overexpression of parathyroid hormone-related protein in the mammary gland reveals distinct fetal and pubertal phenotypes. J Endocrinol 171: 403-416.
15. Dunbar ME, Young P, Zhang JP, McCaughern-Carucci JF, Lanske B, et al. (1998) Stromal cells are critical targets in the regulation of mammary ductal morphogenesis by parathyroid hormone-related protein (PTHrP). Developmental Biology 203: 75-89.
16. Chen X, Macica CM, Dreyer BE, Hammond VE, Hens JR, et al. (2006) Initial characterization of PTH-related protein gene-driven lacZ expression in the mouse. J Bone Miner Res 21: 113-123.
17. Visvader JE, Smith GH, (2011) Murine mammary epithelial stem cells: discovery, function, and current status. Cold Spring Harb Perspect Biol 3.
18. Thiede MA, Rodan GA, (1988) Expression of a calcium-mobilizing parathyroid hormone-like peptide in lactating mammary tissue. Science 242: 278-280.
19. Wysolmerski JJ, McCaughern-Carucci JF, Daifotis AG, Broadus AE, Philbrick WM, (1995) Overexpression of parathyroid hormone-related protein or parathyroid hormone in transgenic mice impairs branching morphogenesis during mammary gland development. Development 121: 3539-3547.
20. Wagner KU, McAllister K, Ward T, Davis B, Wiseman R, et al. (2001) Spatial and temporal expression of the Cre gene under the control of the MMTV-LTR in different lines of transgenic mice. Transgenic Res 10: 545-553.
21. Soriano P, (1999) Generalized lacZ expression with the ROSA26 Cre reporter strain. Nat Genet 21: 70-71.
22. Dewar R, Fadare O, Gilmore H, Gown AM, (2011) Best practices in diagnostic immunohistochemistry: myoepithelial markers in breast pathology. Arch Pathol Lab Med 135: 422-429.
23. Kouros-Mehr H, Slorach EM, Sternlicht MD, Werb Z, (2006) GATA-3 maintains the differentiation of the luminal cell fate in the mammary gland. Cell 127: 1041-1055.
24. Akhtari M, Mansuri J, Newman KA, Guise TM, Seth P, (2008) Biology of breast cancer bone metastasis. Cancer Biol Ther 7: 3-9.
25. Guise TA, Yin JJ, Taylor SD, Kumagai Y, Dallas M, et al. (1996) Evidence for a causal role of parathyroid hormone-related protein in the pathogenesis of human breast cancer-mediated osteolysis. J Clin Invest 98: 1544-1549.
26. Fleming NI, Trivett MK, George J, Slavin JL, Murray WK, et al. (2009) Parathyroid hormone-related protein protects against mammary tumor emergence and is associated with monocyte infiltration in ductal carcinoma in situ. Cancer Res 69: 7473-7479.
27. Shen X, Qian L, Falzon M, (2004) PTH-related protein enhances MCF-7 breast cancer cell adhesion, migration, and invasion via an intracrine pathway. Exp Cell Res 294: 420-433.
28. Jones C, Mackay A, Grigoriadis A, Cossu A, Reis-Filho JS, et al. (2004) Expression profiling of purified normal human luminal and myoepithelial breast cells: identification of novel prognostic markers for breast cancer. Cancer Res 64: 3037-3045.
29. Kendrick H, Regan JL, Magnay FA, Grigoriadis A, Mitsopoulos C, et al. (2008) Transcriptome analysis of mammary epithelial subpopulations identifies novel determinants of lineage commitment and cell fate. BMC Genomics 9: 591.
30. Wysolmerski JJ, Broadus AE, Zhou J, Fuchs E, Milstone LM, et al. (1994) Overexpression of parathyroid hormone-related protein in the skin of transgenic mice interfers with the hair follicle development. Proceedings National Academy of Science USA 91: 1133-1137.
31. Henderson MA, Danks JA, Slavin JL, Byrnes GB, Choong PF, et al. (2006) Parathyroid hormone-related protein localization in breast cancers predict improved prognosis. Cancer Res 66: 2250-2256.
32. Edwards RC, Ratcliffe WA, Walls J, Morrison JM, Ratcliffe JG, et al. (1995) Parathyroid hormone-related protein (PTHrP) in breast cancer and benign breast tissue. Eur J Cancer 31A: 334-339.
33. Li J, Karaplis A, Siegal P, WJ M, Kremer R, (2008) Knockout of parathyroid hormone-related protein (PTHrP) gene in breast cancer cells inhibits tumor progression and metastatic spread in vivo: modulation of cell proliferation, apoptosis and angiogenesis markers. J Bone Miner Res pp. S1016.
34. Fiaschi-Taesch NM, Stewart AF, (2003) Minireview: parathyroid hormone-related protein as an intracrine factor-trafficking mechanisms and functional consequences. Endocrinology 144: 407-411.
35. Brown EM, MacLeod RJ, (2001) Extracellular calcium sensing and extracellular calcium signaling. Physiol Rev 81: 239-297.