Human fibroblast growth factor receptor 1-IIIb is a functional fibroblast growth factor receptor expressed in the pancreas and involved in proliferation and movement of pancreatic ductal cells

Pancreas

Volumn 35, Issue 2, 2007, Pages 147-157

  Liu, Zhanbing ^a,d   Ishiwata, Toshiyuki ^b   Zhou, Shaxia ^a   Maier, Susanne ^a   Henne Bruns, Doris ^a   Korc, Murray ^c   Bachem, Max ^a   Kornmann, Marko ^a,e  

^a UNIVERSITY OF ULM   (Germany)

^b NIPPON MEDICAL SCHOOL   (Japan)

^c DARTMOUTH MEDICAL SCHOOL   (United States)

^d PEKING UNIVERSITY FIRST HOSPITAL   (China)

^e Department of General Visceral and Transplantation Surgery ^*  (Germany)

Author keywords

Fibroblast growth factor; Mitogen activated protein kinase; Pancreas; Signaling cascades; Tyrosine kinase receptor

Indexed keywords

FIBROBLAST GROWTH FACTOR 1; FIBROBLAST GROWTH FACTOR 2; FIBROBLAST GROWTH FACTOR 4; FIBROBLAST GROWTH FACTOR RECEPTOR; FIBROBLAST GROWTH FACTOR RECEPTOR 1; FIBROBLAST GROWTH FACTOR RECEPTOR 3B; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; STRESS ACTIVATED PROTEIN KINASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL ADHESION; CELL DIFFERENTIATION; CELL MOTION; GLYCOSYLATION; HUMAN; HUMAN TISSUE; IN SITU HYBRIDIZATION; NONHUMAN; PANCREAS; PANCREAS DUCT; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION;

CELL DIVISION; CELL MOVEMENT; GENETIC VECTORS; GLYCOSYLATION; HUMANS; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; PANCREAS; PANCREATIC DUCTS; PROTEIN KINASES; RECEPTOR, FIBROBLAST GROWTH FACTOR, TYPE 1; RECEPTOR, FIBROBLAST GROWTH FACTOR, TYPE 3;

EID: 34447515431     PISSN: 08853177     EISSN: None     Source Type: Journal    
DOI: 10.1097/mpa.0b013e318053e7e3     Document Type: Article

References (23)

1. Ornitz DM, Itoh N. Fibroblast growth factors. Genome Biol. 2001;2:[REVIEWS3005. Epub 2001 March 9].
2. Kornmann M, Korc M. Fibroblast growth factor receptors and cancer-associated perturbations. In: Lennarz WJ, Lane MD, eds. Encyclopedia of Biological Chemistry. vol 2. Oxford, UK: Elsevier; 2004:112-117.
3. Braun S, auf dem Keller U, Steiling H, et al. Fibroblast growth factors in epithelial repair and cytoprotection. Philos Trans R Soc Lond B Biol Sci. 2004;359:753-757.
4. Itoh N, Ornitz DM. Evolution of the Fgf and Fgfr gene families. Trends Genet. 2004;20:563-569.
5. Werner S, Duan DS, de Vries C, et al. Differential splicing in the extracellular region of fibroblast growth factor receptor 1 generates receptor variants with different ligand-binding specificities. Mol Cell Biol. 1992;12:82-88.
6. Plotnikov AN, Hubbard SR, Schlessinger J, et al. Crystal structures of two FGF-FGFR complexes reveal the determinants of ligand-receptor specificity. Cell. 2000;101:413-424.
7. Duan DS, Werner S, Williams LT. A naturally occurring secreted form of fibroblast growth factor (FGF) receptor 1 binds basic FGF in preference over acidic FGF. J Biol Chem. 1992;267:16076-16080.
8. Kornmann M, Beger HG, Korc M. Role of fibroblast growth factors and their receptors in pancreatic cancer and chronic pancreatitis. Pancreas. 1998;17:169-175.
9. Yan G, Fukabori Y, McBride G, et al. Exon switching and activation of stromal and embryonic fibroblast growth factor (FGF)-FGF receptor genes in prostate epithelial cells accompany stromal independence and malignancy. Mol Cell Biol. 1993;13:4513-4522.
10. Kornmann M, Ishiwata T, Matsuda K, et al. The IIIc isoform of fibroblast growth factor receptor 1 is overexpressed in human pancreatic cancer and enhances tumorigenicity of hamster ductal cells. Gastroenterology. 2002;123:301-313.
11. Ornitz DM, Xu J, Colvin JS, et al. Receptor specificity of the fibroblast growth factor family. J Biol Chem. 1996;271:15292-15297.
12. Beer HD, Vindevoghel L, Gait MJ, et al. Fibroblast growth factor (FGF) receptor 1-IIIb is a naturally occurring functional receptor for FGFs that is preferentially expressed in the skin and the brain. J Biol Chem. 2000;275:16091-16097.
13. Lopez ME, Korc M. A novel type I fibroblast growth factor receptor activates mitogenic signaling in the absence of detectable tyrosine phosphorylation of FRS2. J Biol Chem. 2000;275:15933-15939.
14. Kornmann M, Ishiwata T, Beger HG, et al. Fibroblast growth factor-5 stimulates mitogenic signaling and is overexpressed in human pancreatic cancer: evidence for autocrine and paracrine actions. Oncogene. 1997;15:1417-1424.
15. Ishiwata T, Kornmann M, Beger HG, et al. Enhanced fibroblast growth factor 5 expression in stromal and exocrine elements of the pancreas in chronic pancreatitis. Gut. 1998;43:134-139.
16. Kornmann M, Lopez ME, Beger HG, et al. Expression of the IIIc variant of FGF receptor-1 confers mitogenic responsiveness to heparin and FGF-5 in TAKA-1 pancreatic ductal cells. Int J Pancreatol. 2001;29:85-92.
17. Bange J, Prechtl D, Cheburkin Y, et al. Cancer progression and tumor cell motility are associated with the FGFR4 Arg(388) allele. Cancer Res. 2002;62:840-847.
18. Freeman KW, Welm BE, Gangula RD, et al. Inducible prostate intraepithelial neoplasia with reversible hyperplasia in conditional FGFR1-expressing mice. Cancer Res. 2003;63:8256-8263.
19. Jin C, McKeehan K, Guo W, et al. Cooperation between ectopic FGFR1 and depression of FGFR2 in induction of prostatic intraepithelial neoplasia in the mouse prostate. Cancer Res. 2003;63:8784-8790.
20. Koziczak M, Hynes NE. Cooperation between fibroblast growth factor receptor-4 and ErbB2 in regulation of cyclin D1 translation. J Biol Chem. 2004;279:50004-50011.
21. Partanen J, Schwartz L, Rossant J. Opposite phenotypes of hypomorphic and Y766 phosphorylation site mutations reveal a function for Fgfr1 in anteroposterior patterning of mouse embryos. Genes Dev. 1998;12:2332-2344.
22. Zhang H, Dessimoz J, Beyer TA, et al. Fibroblast growth factor receptor 1-IIIb is dispensable for skin morphogenesis and wound healing. Eur J Cell Biol. 2004;83:3-11.
23. Garfinkel S, Hu X, Prudovsky IA, et al. FGF-1-dependent proliferative and migratory responses are impaired in senescent human umbilical vein endothelial cells and correlate with the inability to signal tyrosine phosphorylation of fibroblast growth factor receptor-1 substrates. J Cell Biol. 1996;134:783-791.