MT1-MMP-dependent remodeling of cardiac extracellular matrix structure and function following myocardial infarction

American Journal of Pathology

Volumn 180, Issue 5, 2012, Pages 1863-1878

  Koenig, Gerald C ^a   Rowe, R Grant ^b   Day, Sharlene M ^a   Sabeh, Farideh ^b   Atkinson, Jeffrey J ^b   Cooke, Kenneth R ^a   Weiss, Stephen J ^b  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF MICHIGAN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COLLAGEN TYPE 1; COLLAGENASE 3; GELATINASE A; GELATINASE B; MATRIX METALLOPROTEINASE; MELATONIN 1 RECEPTOR; NEUTROPHIL COLLAGENASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL ISOLATION; CELL REGENERATION; CELL STRUCTURE; COLLAGEN DEGRADATION; CONTROLLED STUDY; ECHOCARDIOGRAPHY; ENZYME ACTIVITY; EXPLANT; EXTRACELLULAR MATRIX; FEMALE; FIBROBLAST; HEART FUNCTION; HEART INDEX; HEART INFARCTION; HEART LEFT VENTRICLE EJECTION FRACTION; HEART LEFT VENTRICLE MASS; HEART MUSCLE CELL; HEART OUTPUT; HEART RATE VARIABILITY; HISTOPATHOLOGY; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; NULL ALLELE; PRIORITY JOURNAL; SURVIVAL; SYSTOLIC BLOOD PRESSURE;

ANIMALS; COLLAGEN TYPE I; EXTRACELLULAR MATRIX; FEMALE; FIBROBLASTS; IN SITU HYBRIDIZATION; MATRIX METALLOPROTEINASE 14; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MYOCARDIAL INFARCTION; MYOCARDIAL ISCHEMIA; ORGAN CULTURE TECHNIQUES; VENTRICULAR REMODELING;

EID: 84860255582     PISSN: 00029440     EISSN: 15252191     Source Type: Journal    
DOI: 10.1016/j.ajpath.2012.01.022     Document Type: Article

References (98)

1. T.K. Borg, J.B. Caulfield The collagen matrix of the heart Fed Proc 40 1981 2037 2041
2. K.T. Weber Cardiac interstitium in health and disease: the fibrillar collagen network J Am Coll Cardiol 13 1989 1637 1652
3. B.C. Berk, K. Fujiwara, S. Lehoux ECM remodeling in hypertensive heart disease J Clin Invest 117 2007 568 575
4. G.M. Fomovsky, S. Thomopoulos, J.W. Holmes Contribution of extracellular matrix to the mechanical properties of the heart J Mol Cell Cardiol 48 2010 490 496
5. K.T. Weber, Y. Sun, S.C. Tyagi, J.P. Cleutjens Collagen network of the myocardium: function, structural remodeling and regulatory mechanisms J Mol Cell Cardiol 26 1994 279 292
6. R. Zamilpa, M.L. Lindsey Extracellular matrix turnover and signaling during cardiac remodeling following MI: causes and consequences J Mol Cell Cardiol 48 2010 558 563
7. G.L. Gallagher, C.J. Jackson, S.N. Hunyor Myocardial extracellular matrix remodeling in ischemic heart failure Front Biosci 12 2007 1410 1419
8. M.A. Pfeffer, E. Braunwald Ventricular remodeling after myocardial infarction Experimental observations and clinical implications Circulation 81 1990 1161 1172
9. N.G. Frangogiannis, C.W. Smith, M.L. Entman The inflammatory response in myocardial infarction Cardiovasc Res 53 2002 31 47
10. M. Dobaczewski, C. Gonzalez-Quesada, N.G. Frangogiannis The extracellular matrix as a modulator of the inflammatory and reparative response following myocardial infarction J Mol Cell Cardiol 48 2010 504 511
11. B.I. Jugdutt Ventricular remodeling after infarction and the extracellular collagen matrix: when is enough enough? Circulation 108 2003 1395 1403
12. G. Vilahur, O. Juan-Babot, E. Pena, B. Onate, L. Casani, L. Badimon Molecular and cellular mechanisms involved in cardiac remodeling after acute myocardial infarction J Mol Cell Cardiol 50 2011 522 533
13. R. Mukherjee, T.A. Brinsa, K.B. Dowdy, A.A. Scott, J.M. Baskin, A.M. Deschamps, A.S. Lowry, G.P. Escobar, D.G. Lucas, W.M. Yarbrough, M.R. Zile, F.G. Spinale Myocardial infarct expansion and matrix metalloproteinase inhibition Circulation 107 2003 618 625
14. K.A. Apple, W.M. Yarbrough, R. Mukherjee, A.M. Deschamps, P.G. Escobar, J.T. Mingoia, J.A. Sample, J.W. Hendrick, K.B. Dowdy, J.E. McLean, R.E. Stroud, T.P. O'Neill, F.G. Spinale Selective targeting of matrix metalloproteinase inhibition in post-infarction myocardial remodeling J Cardiovasc Pharmacol 47 2006 228 235
15. F.G. Spinale Myocardial matrix remodeling and the matrix metalloproteinases: influence on cardiac form and function Physiol Rev 87 2007 1285 1342
16. A. Page-McCaw, A.J. Ewald, Z. Werb Matrix metalloproteinases and the regulation of tissue remodelling Nat Rev Mol Cell Biol 8 2007 221 233
17. E.M. Wilson, F.G. Spinale Myocardial remodelling and matrix metalloproteinases in heart failure: turmoil within the interstitium Ann Med 33 2001 623 634
18. A.M. Deschamps, W.M. Yarbrough, C.E. Squires, R.A. Allen, D.M. McClister, K.B. Dowdy, J.E. McLean, J.T. Mingoia, J.A. Sample, R. Mukherjee, F.G. Spinale Trafficking of the membrane type-1 matrix metalloproteinase in ischemia and reperfusion: relation to interstitial membrane type-1 matrix metalloproteinase activity Circulation 111 2005 1166 1174
19. H. Su, F.G. Spinale, L.W. Dobrucki, J. Song, J. Hua, S. Sweterlitsch, D.P. Dione, P. Cavaliere, C. Chow, B.N. Bourke, X.Y. Hu, M. Azure, P. Yalamanchili, R. Liu, E.H. Cheesman, S. Robinson, D.S. Edwards, A.J. Sinusas Noninvasive targeted imaging of matrix metalloproteinase activation in a murine model of postinfarction remodeling Circulation 112 2005 3157 3167
20. C.S. Webb, D.D. Bonnema, S.H. Ahmed, A.H. Leonardi, C.D. McClure, L.L. Clark, R.E. Stroud, W.C. Corn, L. Finklea, M.R. Zile, F.G. Spinale Specific temporal profile of matrix metalloproteinase release occurs in patients after myocardial infarction: relation to left ventricular remodeling Circulation 114 2006 1020 1027
21. L.E. Rohde, A. Ducharme, L.H. Arroyo, M. Aikawa, G.H. Sukhova, A. Lopez-Anaya, K.F. McClure, P.G. Mitchell, P. Libby, R.T. Lee Matrix metalloproteinase inhibition attenuates early left ventricular enlargement after experimental myocardial infarction in mice Circulation 99 1999 3063 3070
22. M.L. Lindsey, J. Gannon, M. Aikawa, F.J. Schoen, E. Rabkin, L. Lopresti-Morrow, J. Crawford, S. Black, P. Libby, P.G. Mitchell, R.T. Lee Selective matrix metalloproteinase inhibition reduces left ventricular remodeling but does not inhibit angiogenesis after myocardial infarction Circulation 105 2002 753 758
23. F.J. Villarreal, M. Griffin, J. Omens, W. Dillmann, J. Nguyen, J. Covell Early short-term treatment with doxycycline modulates postinfarction left ventricular remodeling Circulation 108 2003 1487 1492
24. W.M. Yarbrough, R. Mukherjee, G.P. Escobar, J.T. Mingoia, J.A. Sample, J.W. Hendrick, K.B. Dowdy, J.E. McLean, A.S. Lowry, T.P. O'Neill, F.G. Spinale Selective targeting and timing of matrix metalloproteinase inhibition in post-myocardial infarction remodeling Circulation 108 2003 1753 1759
25. E.E. Creemers, J.N. Davis, A.M. Parkhurst, P. Leenders, K.B. Dowdy, E. Hapke, A.M. Hauet, P.G. Escobar, J.P. Cleutjens, J.F. Smits, M.J. Daemen, M.R. Zile, F.G. Spinale Deficiency of TIMP-1 exacerbates LV remodeling after myocardial infarction in mice Am J Physiol Heart Circ Physiol 284 2003 H364 H371
26. H. Tian, M. Cimini, P.W. Fedak, S. Altamentova, S. Fazel, M.L. Huang, R.D. Weisel, R.K. Li TIMP-3 deficiency accelerates cardiac remodeling after myocardial infarction J Mol Cell Cardiol 43 2007 733 743
27. V. Kandalam, R. Basu, T. Abraham, X. Wang, P.D. Soloway, D.M. Jaworski, G.Y. Oudit, Z. Kassiri TIMP2 deficiency accelerates adverse post-myocardial infarction remodeling because of enhanced MT1-MMP activity despite lack of MMP2 activation Circ Res 106 2010 796 808
28. I. Koskivirta, Z. Kassiri, O. Rahkonen, R. Kiviranta, G.Y. Oudit, T.D. McKee, V. Kyto, A. Saraste, E. Jokinen, P.P. Liu, E. Vuorio, R. Khokha Mice with tissue inhibitor of metalloproteinases 4 (Timp4) deletion succumb to induced myocardial infarction but not to cardiac pressure overload J Biol Chem 285 2010 24487 24493
29. J.S. Ikonomidis, J.W. Hendrick, A.M. Parkhurst, A.R. Herron, P.G. Escobar, K.B. Dowdy, R.E. Stroud, E. Hapke, M.R. Zile, F.G. Spinale Accelerated LV remodeling after myocardial infarction in TIMP-1-deficient mice: effects of exogenous MMP inhibition Am J Physiol Heart Circ Physiol 288 2005 H149 H158
30. A. Ducharme, S. Frantz, M. Aikawa, E. Rabkin, M. Lindsey, L.E. Rohde, F.J. Schoen, R.A. Kelly, Z. Werb, P. Libby, R.T. Lee Targeted deletion of matrix metalloproteinase-9 attenuates left ventricular enlargement and collagen accumulation after experimental myocardial infarction J Clin Invest 106 2000 55 62
31. S. Hayashidani, H. Tsutsui, M. Ikeuchi, T. Shiomi, H. Matsusaka, T. Kubota, K. Imanaka-Yoshida, T. Itoh, A. Takeshita Targeted deletion of MMP-2 attenuates early LV rupture and late remodeling after experimental myocardial infarction Am J Physiol Heart Circ Physiol 285 2003 H1229 H1235
32. S. Matsumura, S. Iwanaga, S. Mochizuki, H. Okamoto, S. Ogawa, Y. Okada Targeted deletion or pharmacological inhibition of MMP-2 prevents cardiac rupture after myocardial infarction in mice J Clin Invest 115 2005 599 609
33. S. Heymans, A. Luttun, D. Nuyens, G. Theilmeier, E. Creemers, L. Moons, G.D. Dyspersin, J.P. Cleutjens, M. Shipley, A. Angellilo, M. Levi, O. Nube, A. Baker, E. Keshet, F. Lupu, J.M. Herbert, J.F. Smits, S.D. Shapiro, M. Baes, M. Borgers, D. Collen, M.J. Daemen, P. Carmeliet Inhibition of plasminogen activators or matrix metalloproteinases prevents cardiac rupture but impairs therapeutic angiogenesis and causes cardiac failure Nat Med 5 1999 1135 1142
34. H.E. Kim, S.S. Dalal, E. Young, M.J. Legato, M.L. Weisfeldt, J. D'Armiento Disruption of the myocardial extracellular matrix leads to cardiac dysfunction J Clin Invest 106 2000 857 866
35. F. Sabeh, X.Y. Li, T.L. Saunders, R.G. Rowe, S.J. Weiss Secreted versus membrane-anchored collagenases: relative roles in fibroblast-dependent collagenolysis and invasion J Biol Chem 284 2009 23001 23011
36. K. Hotary, E. Allen, A. Punturieri, I. Yana, S.J. Weiss Regulation of cell invasion and morphogenesis in a three-dimensional type I collagen matrix by membrane-type matrix metalloproteinases 1, 2, and 3 J Cell Biol 149 2000 1309 1323
37. F. Sabeh, I. Ota, K. Holmbeck, H. Birkedal-Hansen, P. Soloway, M. Balbin, C. Lopez-Otin, S. Shapiro, M. Inada, S. Krane, E. Allen, D. Chung, S.J. Weiss Tumor cell traffic through the extracellular matrix is controlled by the membrane-anchored collagenase MT1-MMP J Cell Biol 167 2004 769 781
38. X.Y. Li, I. Ota, I. Yana, F. Sabeh, S.J. Weiss Molecular dissection of the structural machinery underlying the tissue-invasive activity of membrane type-1 matrix metalloproteinase Mol Biol Cell 19 2008 3221 3233
39. K. Holmbeck, P. Bianco, J. Caterina, S. Yamada, M. Kromer, S.A. Kuznetsov, M. Mankani, P.G. Robey, A.R. Poole, I. Pidoux, J.M. Ward, H. Birkedal-Hansen MT1-MMP-deficient mice develop dwarfism, osteopenia, arthritis, and connective tissue disease due to inadequate collagen turnover Cell 99 1999 81 92
40. T.H. Chun, F. Sabeh, I. Ota, H. Murphy, K.T. McDonagh, K. Holmbeck, H. Birkedal-Hansen, E.D. Allen, S.J. Weiss MT1-MMP-dependent neovessel formation within the confines of the three-dimensional extracellular matrix J Cell Biol 167 2004 757 767
41. T.H. Chun, K.B. Hotary, F. Sabeh, A.R. Saltiel, E.D. Allen, S.J. Weiss A pericellular collagenase directs the 3-dimensional development of white adipose tissue Cell 125 2006 577 591
42. Z. Zhou, S.S. Apte, R. Soininen, R. Cao, G.Y. Baaklini, R.W. Rauser, J. Wang, Y. Cao, K. Tryggvason Impaired endochondral ossification and angiogenesis in mice deficient in membrane-type matrix metalloproteinase I Proc Natl Acad Sci U S A 97 2000 4052 4057
43. M. Kuzuya, S. Kanda, T. Sasaki, N. Tamaya-Mori, X.W. Cheng, T. Itoh, S. Itohara, A. Iguchi Deficiency of gelatinase a suppresses smooth muscle cell invasion and development of experimental intimal hyperplasia Circulation 108 2003 1375 1381
44. M. Balbin, A. Fueyo, A.M. Tester, A.M. Pendas, A.S. Pitiot, A. Astudillo, C.M. Overall, S.D. Shapiro, C. Lopez-Otin Loss of collagenase-2 confers increased skin tumor susceptibility to male mice Nat Genet 35 2003 252 257
45. Z. Liu, J.M. Shipley, T.H. Vu, X. Zhou, L.A. Diaz, Z. Werb, R.M. Senior Gelatinase B-deficient mice are resistant to experimental bullous pemphigoid J Exp Med 188 1998 475 482
46. M. Inada, Y. Wang, M.H. Byrne, M.U. Rahman, C. Miyaura, C. Lopez-Otin, S.M. Krane Critical roles for collagenase-3 (Mmp13) in development of growth plate cartilage and in endochondral ossification Proc Natl Acad Sci U S A 101 2004 17192 17197
47. J.G. Zhang, S. Ghosh, C.D. Ockleford, M. Galinanes Characterization of an in vitro model for the study of the short and prolonged effects of myocardial ischaemia and reperfusion in man Clin Sci (Lond) 99 2000 443 453
48. L.B. Creemers, D.C. Jansen, A. van Veen-Reurings, T. van den Bos, V. Everts Microassay for the assessment of low levels of hydroxyproline Biotechniques 22 1997 656 658
49. S. Filippov, G.C. Koenig, T.H. Chun, K.B. Hotary, I. Ota, T.H. Bugge, J.D. Roberts, W.P. Fay, H. Birkedal-Hansen, K. Holmbeck, F. Sabeh, E.D. Allen, S.J. Weiss MT1-matrix metalloproteinase directs arterial wall invasion and neointima formation by vascular smooth muscle cells J Exp Med 202 2005 663 671
50. J. Xu, D. Rodriguez, E. Petitclerc, J.J. Kim, M. Hangai, Y.S. Moon, G.E. Davis, P.C. Brooks Proteolytic exposure of a cryptic site within collagen type IV is required for angiogenesis and tumor growth in vivo J Cell Biol 154 2001 1069 1079
51. S.M. Day, M.V. Westfall, E.V. Fomicheva, K. Hoyer, S. Yasuda, N.C. La Cross, L.G. D'Alecy, J.S. Ingwall, J.M. Metzger Histidine button engineered into cardiac troponin I protects the ischemic and failing heart Nat Med 12 2006 181 189
52. S.M. Day, J.L. Reeve, B. Pedersen, D.M. Farris, D.D. Myers, M. Im, T.W. Wakefield, N. Mackman, W.P. Fay Macrovascular thrombosis is driven by tissue factor derived primarily from the blood vessel wall Blood 105 2005 192 198
53. T. Namba, H. Tsutsui, H. Tagawa, M. Takahashi, K. Saito, T. Kozai, M. Usui, K. Imanaka-Yoshida, T. Imaizumi, A. Takeshita Regulation of fibrillar collagen gene expression and protein accumulation in volume-overloaded cardiac hypertrophy Circulation 95 1997 2448 2454
54. A. Nicoletti, D. Heudes, N. Hinglais, M.D. Appay, M. Philippe, C. Sassy-Prigent, J. Bariety, J.B. Michel Left ventricular fibrosis in renovascular hypertensive rats Effect of losartan and spironolactone Hypertension 26 1995 101 111
55. A.D. Bradshaw, C.F. Baicu, T.J. Rentz, A.O. Van Laer, D.D. Bonnema, M.R. Zile Age-dependent alterations in fibrillar collagen content and myocardial diastolic function: role of SPARC in post-synthetic procollagen processing Am J Physiol Heart Circ Physiol 298 2010 H614 H622
56. T. Yano, T. Miura, P. Whittaker, T. Miki, J. Sakamoto, Y. Nakamura, Y. Ichikawa, Y. Ikeda, H. Kobayashi, K. Ohori, K. Shimamoto Macrophage colony-stimulating factor treatment after myocardial infarction attenuates left ventricular dysfunction by accelerating infarct repair J Am Coll Cardiol 47 2006 626 634
57. K.B. Hotary, E.D. Allen, P.C. Brooks, N.S. Datta, M.W. Long, S.J. Weiss Membrane type I matrix metalloproteinase usurps tumor growth control imposed by the three-dimensional extracellular matrix Cell 114 2003 33 45
58. J.J. Atkinson, H.M. Toennies, K. Holmbeck, R.M. Senior Membrane type 1 matrix metalloproteinase is necessary for distal airway epithelial repair and keratinocyte growth factor receptor expression after acute injury Am J Physiol Lung Cell Mol Physiol 293 2007 L600 L610
59. K.B. Hotary, I. Yana, F. Sabeh, X.Y. Li, K. Holmbeck, H. Birkedal-Hansen, E.D. Allen, N. Hiraoka, S.J. Weiss Matrix metalloproteinases (MMPs) regulate fibrin-invasive activity via MT1-MMP-dependent and -independent processes J Exp Med 195 2002 295 308
60. S. Netzel-Arnett, D.J. Mitola, S.S. Yamada, K. Chrysovergis, K. Holmbeck, H. Birkedal-Hansen, T.H. Bugge Collagen dissolution by keratinocytes requires cell surface plasminogen activation and matrix metalloproteinase activity J Biol Chem 277 2002 45154 45161
61. T.H. Chun, M. Inoue, H. Morisaki, I. Yamanaka, Y. Miyamoto, T. Okamura, K. Sato-Kusubata, S.J. Weiss Genetic link between obesity and MMP14-dependent adipogenic collagen turnover Diabetes 59 2010 2484 2494
62. H. Sato, T. Takino, T. Kinoshita, K. Imai, Y. Okada, W.G. Stetler Stevenson, M. Seiki Cell surface binding and activation of gelatinase A induced by expression of membrane-type-1-matrix metalloproteinase (MT1-MMP) FEBS Lett 385 1996 238 240
63. M. Toth, I. Chvyrkova, M.M. Bernardo, S. Hernandez-Barrantes, R. Fridman Pro-MMP-9 activation by the MT1-MMP/MMP-2 axis and MMP-3: role of TIMP-2 and plasma membranes Biochem Biophys Res Commun 308 2003 386 395
64. W. Xiong, R. Knispel, J. MacTaggart, T.C. Greiner, S.J. Weiss, B.T. Baxter Membrane-type 1 matrix metalloproteinase regulates macrophage-dependent elastolytic activity and aneurysm formation in vivo J Biol Chem 284 2009 1765 1771
65. F. Schneider, G.K. Sukhova, M. Aikawa, J. Canner, N. Gerdes, S.M. Tang, G.P. Shi, S.S. Apte, P. Libby Matrix-metalloproteinase-14 deficiency in bone-marrow-derived cells promotes collagen accumulation in mouse atherosclerotic plaques Circulation 117 2008 931 939
66. P. Whittaker, D.R. Boughner, R.A. Kloner Analysis of healing after myocardial infarction using polarized light microscopy Am J Pathol 134 1989 879 893
67. N.E. Sounni, K. Dehne, L. van Kempen, M. Egeblad, N.I. Affara, I. Cuevas, J. Wiesen, S. Junankar, L. Korets, J. Lee, J. Shen, C.J. Morrison, C.M. Overall, S.M. Krane, Z. Werb, N. Boudreau, L.M. Coussens Stromal regulation of vessel stability by MMP14 and TGFbeta Dis Model Mech 3 2010 317 332
68. F.G. Spinale, G.P. Escobar, R. Mukherjee, J.A. Zavadzkas, S.M. Saunders, L.B. Jeffords, A.M. Leone, C. Beck, S. Bouges, R.E. Stroud Cardiac-restricted overexpression of membrane type-1 matrix metalloproteinase in mice: effects on myocardial remodeling with aging Circ Heart Fail 2 2009 351 360
69. F.G. Spinale, R. Mukherjee, J.A. Zavadzkas, C.N. Koval, S. Bouges, R.E. Stroud, L.W. Dobrucki, A.J. Sinusas Cardiac restricted overexpression of membrane type-1 matrix metalloproteinase causes adverse myocardial remodeling following myocardial infarction J Biol Chem 285 2010 30316 30327
70. J.A. Zavadzkas, R. Mukherjee, W.T. Rivers, R.K. Patel, E.C. Meyer, L.E. Black, R.A. McKinney, J.M. Oelsen, R.E. Stroud, F.G. Spinale Direct regulation of membrane type-1 matrix metalloproteinase following myocardial infarction causes changes in survival, cardiac function, and remodeling Am J Physiol Heart Circ Physiol 301 2011 H1656 H1666
71. C.A. Souders, S.L. Bowers, T.A. Baudino Cardiac fibroblast: the renaissance cell Circ Res 105 2009 1164 1176
72. P. Camelliti, T.K. Borg, P. Kohl Structural and functional characterisation of cardiac fibroblasts Cardiovasc Res 65 2005 40 51
73. L. Zhou, M.A. Aon, T. Liu, B. O'Rourke Dynamic modulation of Ca2+ sparks by mitochondrial oscillations in isolated guinea pig cardiomyocytes under oxidative stress J Mol Cell Cardiol 51 2011 632 639
74. S.W. van den Borne, V.A. van de Schans, A.E. Strzelecka, H.T. Vervoort-Peters, P.M. Lijnen, J.P. Cleutjens, J.F. Smits, M.J. Daemen, B.J. Janssen, W.M. Blankesteijn Mouse strain determines the outcome of wound healing after myocardial infarction Cardiovasc Res 84 2009 273 282
75. M.G. Sutton, N. Sharpe Left ventricular remodeling after myocardial infarction: pathophysiology and therapy Circulation 101 2000 2981 2988
76. J.P. Cleutjens, J.C. Kandala, E. Guarda, R.V. Guntaka, K.T. Weber Regulation of collagen degradation in the rat myocardium after infarction J Mol Cell Cardiol 27 1995 1281 1292
77. J. Chen, C.H. Tung, J.R. Allport, S. Chen, R. Weissleder, P.L. Huang Near-infrared fluorescent imaging of matrix metalloproteinase activity after myocardial infarction Circulation 111 2005 1800 1805
78. D. Vanhoutte, M. Schellings, Y. Pinto, S. Heymans Relevance of matrix metalloproteinases and their inhibitors after myocardial infarction: a temporal and spatial window Cardiovasc Res 69 2006 604 613
79. M.J. Cox, U.A. Hawkins, B.D. Hoit, S.C. Tyagi Attenuation of oxidative stress and remodeling by cardiac inhibitor of metalloproteinase protein transfer Circulation 109 2004 2123 2128
80. M.K. King, M.L. Coker, A. Goldberg, J.H. McElmurray 3rd, H.R. Gunasinghe, R. Mukherjee, M.R. Zile, T.P. O'Neill, F.G. Spinale Selective matrix metalloproteinase inhibition with developing heart failure: effects on left ventricular function and structure Circ Res 92 2003 177 185
81. T. Itoh, M. Tanioka, H. Yoshida, T. Yoshioka, H. Nishimoto, S. Itohara Reduced angiogenesis and tumor progression in gelatinase A-deficient mice Cancer Res 58 1998 1048 1051
82. A.M. Deschamps, J. Zavadzkas, R.L. Murphy, C.N. Koval, J.E. McLean, L. Jeffords, S.M. Saunders, N.J. Sheats, R.E. Stroud, F.G. Spinale Interruption of endothelin signaling modifies membrane type 1 matrix metalloproteinase activity during ischemia and reperfusion Am J Physiol Heart Circ Physiol 294 2008 H875 H883
83. E.M. Wilson, S.L. Moainie, J.M. Baskin, A.S. Lowry, A.M. Deschamps, R. Mukherjee, T.S. Guy, M.G. St John-Sutton, J.H. Gorman 3rd, L.H. Edmunds Jr., R.C. Gorman, F.G. Spinale Region- and type-specific induction of matrix metalloproteinases in post-myocardial infarction remodeling Circulation 107 2003 2857 2863
84. S.J. Weiss Tissue destruction by neutrophils N Engl J Med 320 1989 365 376
85. O. Tatti, P. Vehvilinen, K. Lehti, J. Keski-Oja MT1-MMP releases latent TGF-beta1 from endothelial cell extracellular matrix via proteolytic processing of LTBP-1 Exp Cell Res 314 2008 2501 2514
86. A.C. Poncelet, H.W. Schnaper, R. Tan, Y. Liu, C.E. Runyan Cell phenotype-specific down-regulation of Smad3 involves decreased gene activation as well as protein degradation J Biol Chem 282 2007 15534 15540
87. G.S. Butler, R.A. Dean, E.M. Tam, C.M. Overall Pharmacoproteomics of a metalloproteinase hydroxamate inhibitor in breast cancer cells: dynamics of membrane type 1 matrix metalloproteinase-mediated membrane protein shedding Mol Cell Biol 28 2008 4896 4914
88. M.L. Lindsey, J. Yoshioka, C. MacGillivray, S. Muangman, J. Gannon, A. Verghese, M. Aikawa, P. Libby, S.M. Krane, R.T. Lee Effect of a cleavage-resistant collagen mutation on left ventricular remodeling Circ Res 93 2003 238 245
89. Y. Itoh, M. Seiki MT1-MMP: a potent modifier of pericellular microenvironment J Cell Physiol 206 2006 1 8
90. H. Sato, T. Takino Coordinate action of membrane-type matrix metalloproteinase-1 (MT1-MMP) and MMP-2 enhances pericellular proteolysis and invasion Cancer Sci 101 2010 843 847
91. M.L. Lindsey, G.P. Escobar, L.W. Dobrucki, D.K. Goshorn, S. Bouges, J.T. Mingoia, D.M. McClister Jr., H. Su, J. Gannon, C. MacGillivray, R.T. Lee, A.J. Sinusas, F.G. Spinale Matrix metalloproteinase-9 gene deletion facilitates angiogenesis after myocardial infarction Am J Physiol Heart Circ Physiol 290 2006 H232 H239
92. R.G. Rowe, S.J. Weiss Navigating ECM barriers at the invasive front: the cancer cell-stroma interface Annu Rev Cell Dev Biol 25 2009 567 595
93. N. Hiraoka, E. Allen, I.J. Apel, M.R. Gyetko, S.J. Weiss Matrix metalloproteinases regulate neovascularization by acting as pericellular fibrinolysins Cell 95 1998 365 377
94. P. Stawowy, C. Margeta, H. Kallisch, N.G. Seidah, M. Chretien, E. Fleck, K. Graf Regulation of matrix metalloproteinase MT1-MMP/MMP-2 in cardiac fibroblasts by TGF-beta1 involves furin-convertase Cardiovasc Res 63 2004 87 97
95. M.P. Hudson, P.W. Armstrong, W. Ruzyllo, J. Brum, L. Cusmano, P. Krzeski, R. Lyon, M. Quinones, P. Theroux, D. Sydlowski, H.E. Kim, M.J. Garcia, W.A. Jaber, W.D. Weaver Effects of selective matrix metalloproteinase inhibitor (PG-116800) to prevent ventricular remodeling after myocardial infarction: results of the PREMIER (Prevention of Myocardial Infarction Early Remodeling) trial J Am Coll Cardiol 48 2006 15 20
96. F.G. Spinale, N.M. Wilbur Matrix metalloproteinase therapy in heart failure Curr Treat Options Cardiovasc Med 11 2009 339 346
97. C.M. Overall, O. Kleifeld Tumour microenvironment - opinion: validating matrix metalloproteinases as drug targets and anti-targets for cancer therapy Nat Rev Cancer 6 2006 227 239
98. L. Devy, L. Huang, L. Naa, N. Yanamandra, H. Pieters, N. Frans, E. Chang, Q. Tao, M. Vanhove, A. Lejeune, R. van Gool, D.J. Sexton, G. Kuang, D. Rank, S. Hogan, C. Pazmany, Y.L. Ma, S. Schoonbroodt, A.E. Nixon, R.C. Ladner, R. Hoet, P. Henderikx, C. Tenhoor, S.A. Rabbani, M.L. Valentino, C.R. Wood, D.T. Dransfield Selective inhibition of matrix metalloproteinase-14 blocks tumor growth, invasion, and angiogenesis Cancer Res 69 2009 1517 1526