Acute liver failure

Current Opinion in Critical Care

Volumn 17, Issue 2, 2011, Pages 160-164

  Larsen, Fin Stolze ^a   Bjerring, Peter Nissen ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

ammonia; brain edema; MODS; plasmapheresis; sepsis; transplantation

Indexed keywords

ADRENALIN; ANTIBIOTIC AGENT; BARBITURIC ACID DERIVATIVE; DOBUTAMINE; DOPAMINE; FRESH FROZEN PLASMA; GLUCOSE; INDOMETACIN; INOTROPIC AGENT; MANNITOL; MIDAZOLAM; NORADRENALIN; PARACETAMOL; PROPOFOL; SEDATIVE AGENT; SODIUM CHLORIDE; TERLIPRESSIN;

ACUTE LIVER FAILURE; ACUTE ON CHRONIC LIVER FAILURE; ALBUMIN DIALYSIS; ANTIBIOTIC PROPHYLAXIS; ARTIFICIAL VENTILATION; BLOOD CLOTTING DISORDER; BRAIN DEATH; BRAIN EDEMA; COLLOID; COMA; CONSCIOUSNESS LEVEL; CONTINUOUS HEMODIAFILTRATION; CRYSTALLOID; DECOMPENSATED LIVER CIRRHOSIS; DRUG INDUCED DISEASE; FILTER; HEPATITIS B; HEPATITIS E; HUMAN; HYPOGLYCEMIA; HYPOTENSION; INDUCED HYPOTHERMIA; INTRACRANIAL HYPERTENSION; INTRACRANIAL PRESSURE MONITORING; JAUNDICE; KIDNEY DYSFUNCTION; LIVER NECROSIS; LIVER REGENERATION; LIVER TRANSPLANTATION; METABOLIC ACIDOSIS; MICROCIRCULATION; MORTALITY; MULTIPLE ORGAN FAILURE; PATHOPHYSIOLOGY; PLASMAPHERESIS; PORTAL HYPERTENSION; PROGNOSIS; RENAL REPLACEMENT THERAPY; REVIEW; SEPSIS; SURVIVAL; TRANSTHORACIC ECHOCARDIOGRAPHY; VASODILATATION;

HUMANS; LIVER FAILURE, ACUTE;

EID: 79953119108     PISSN: 10705295     EISSN: 15317072     Source Type: Journal    
DOI: 10.1097/MCC.0b013e328344b3c6     Document Type: Review

References (17)

1. O'Grady JG, Schalm SW, Williams R. Acute liver failure: redefining the syndromes. Lancet 1993;342:273-275. (Pubitemid 23224421)
2. Trey C, Davidson LS. The management of fulminant hepatic failure. In: Hopper H, Schaffer F, editors. Progress in liver disease. New York: Grune and Stratton; 1970. pp. 282-298.
3. Bernal W, Auzinger G, Dhawan A, Wendon J. Acute liver failure. Lancet 2010;376:190-201. This review gives an excellent, full and indepth review on prognostic markers, cause, pathophysiology and management in ALF.
4. Jalan R. Intracranial hypertension in acute liver failure: pathophysiological basis of rational management. Semin Liver Dis 2003;23:271-282. (Pubitemid 37052452)
5. Bernal W, Donaldson N, Wyncoll D, Wendon J. Blood lactate as an early predictor of outcome in paracetamol-induced acute liver failure: a cohort study. Lancet 2002;359:558-563. (Pubitemid 34178437)
6. Schmidt LE, Larsen FS. Prognostic implications of hyperlactatemia, multiple organ failure, and systemic inflammatory response syndrome in patients with acetaminophen-induced acute liver failure. Crit Care Med 2006;34:337-343. (Pubitemid 43145610)
7. Schmidt LE, Dalhoff K. Serum phosphate is an early predictor of outcome in severe acetaminophen-induced hepatotoxicity. Hepatology 2002;36:659-665. (Pubitemid 34977176)
8. Schmidt LE, Larsen FS. MELD score as a predictor of liver failure and death in patients with acetaminophen-induced liver injury. Hepatology 2007;45:789-796. (Pubitemid 46450630)
9. Clemmesen JO, Gerbes AL, Gülberg V, et al. Hepatic blood flow and splanchnic oxygen consumption in patients with liver failure. Effect of highvolume plasmapheresis. Hepatology 1999;29:347-355. (Pubitemid 29088436)
10. Larsen FS, Schmidt LE, Wendon J, et al. Liver assisting with high-volume plasma exchange in patients with acute liver failure [abstract]. Hepatology 2010;52(Suppl 1):376A.
11. Eefsen M, Dethloff T, Frederiksen HJ, et al. Comparison of terlipressin and noradrenalin on cerebral perfusion, intracranial pressure and cerebral extracellular concentrations of lactate and pyruvate in patients with acute liver failure in need of inotropic support. J Hepatol 2007;47:381-386. (Pubitemid 47189608)
12. Larsen FS, Wendon J. Prevention and management of brain edema in patients with acute liver failure. Liver Transpl 2008;14(Suppl 2):S90-S96.
13. Jalan R, O'Damink SW, Deutz NE, et al. Moderate hypothermia for uncontrolled intracranial hypertension in acute liver failure. Lancet 1999;354:1164-1168. (Pubitemid 29460446)
14. Stravitz RT, Larsen FS. Therapeutic hypothermia for acute liver failure. Crit Care Med 2009;37(7 Suppl): S258-S264. This review gives a full insight to the current knowledge of the effect of using hypothermia in ALF.
15. Schmidt LE, Wang LP, Hansen BA, Larsen FS. Systemic hemodynamic effects of treatment with the molecular adsorbents recirculating system in patients with hyperacute liver failure: a prospective controlled trial. Liver Transpl 2003;9:290-297. (Pubitemid 36322332)
16. Saliba F. The Molecular Adsorbent Recirculating System (MARS) in the intensive care unit: a rescue therapy for patients with hepatic failure. Crit Care 2006;10:118.
17. Chamuleau RA. Future of bioartificial liver support. World J Gastrointest Surg 2009;1:21-25.