Identification of α-enolase as an autoantigen associated with severe asthma

Journal of Allergy and Clinical Immunology

Volumn 118, Issue 2, 2006, Pages 376-381

  Nahm, Dong Ho ^a   Lee, Kwang Hoon ^c   Shin, Jee Young ^a   Ye, Young Min ^a   Kang, Yup ^b   Park, Hae Sim ^a  

^a Department of Allergy and Rheumatology ^*  (South Korea)

^b Ajou University School of Medicine   (South Korea)

^c Yonsei University College of Medicine   (South Korea)

Author keywords

airway epithelial cell; Asthma; autoantibodies; autoantigen

Indexed keywords

ALPHA ENOLASE; AUTOANTIGEN; BIOLOGICAL MARKER; IMMUNOGLOBULIN G; RECOMBINANT PROTEIN;

ADULT; AGE DISTRIBUTION; ANTIGEN DETECTION; ANTIGEN RECOGNITION; ARTICLE; ATOPY; BLOOD SAMPLING; COMPARATIVE STUDY; CONTROLLED STUDY; DISEASE EXACERBATION; DISEASE MARKER; DISEASE SEVERITY; EMERGENCY WARD; FEMALE; FORCED EXPIRATORY VOLUME; HOSPITAL ADMISSION; HUMAN; IMMUNOBLOTTING; MAJOR CLINICAL STUDY; MALE; MASS SPECTROMETRY; MILD PERSISTENT ASTHMA; MODERATE PERSISTENT ASTHMA; PRIORITY JOURNAL; RESPIRATORY EPITHELIUM; SEVERE PERSISTENT ASTHMA; SEX RATIO;

EID: 33746579193     PISSN: 00916749     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jaci.2006.04.002     Document Type: Article

References (33)

1. Global Initiative for Asthma. Global strategy for asthma management and prevention (2002), National Institutes of Health, Bethesda (MD) NIH publication #02-3659
2. The ENFUMOSA Study Group. The ENFUMOSA cross-sectional European multicentre study of the clinical phenotype of chronic severe asthma. Eur Respir J 22 (2003) 470-477
3. Busse W.W., Banks-Schlegel S., and Wenzel S.E. Pathophysiology of severe asthma. J Allergy Clin Immunuol 106 (2000) 1033-1042
4. Rottem M., and Shoenfeld Y. Asthma as a paradigm for autoimmune disease. Int Arch Allergy Immunol 132 (2003) 210-214
5. Virchow Jr. J.C., Kroegel C., Walker C., and Matthys H. Inflammatory determinants of asthma severity: mediator and cellular changes in bronchoalveolar lavage fluid of patients with severe asthma. J Allergy Clin Immunol 98 (1996) S27-S40
6. Wagner V., Tomšíková A., Šach J., Janková J., and Novácková D. Autoimmune mechanism in diseases of the respiratory tract. Acta Allergol 20 (1965) 1-9
7. Dekker J.W., Nizankowska E., Schmitz-Schumann M., Pile K., Bochenek G., Dyczek A., et al. Aspirin-induced asthma and HLA-DRB1 and HLA-DPB1 genotypes. Clin Exp Allergy 27 (1997) 574-577
8. Kero J., Gissler M., Hemminki E., and Isolauri E. Could Th1 and Th2 diseases coexist? evaluation of asthma incidence in children with coeliac disease, type 1 diabetes, or rheumatoid arthritis: a register study. J Allergy Clin Immunol 108 (2001) 781-783
9. Holgate S.T. Cytokine and anti-cytokine therapy for the treatment of asthma and allergic disease. Cytokine 28 (2004) 152-157
10. Kon O.M., and Kay A.B. Anti-T cell strategies in asthma. Inflamm Res 48 (1999) 516-523
11. Abril A., Calamia K.T., and Cohen M.D. The Churg Strauss syndrome (allergic granulomatous angiitis): review and update. Semin Arthritis Rheum 33 (2003) 106-114
12. Lassalle P., Delneste Y., Gosset P., Gras-Masse H., Wallaert B., and Tonnel A.B. T and B cell immune response to a 55-kDa endothelial cell-derived antigen in severe asthma. Eur J Immunol 23 (1993) 796-803
13. Montefort S., Herbert C.A., Robinson C., and Holgate S.T. The bronchial epithelium as a target for inflammatory attack in asthma. Clin Exp Allergy 22 (1992) 511-520
14. Callerame M.L., Condemi J.J., Bohrod M.G., and Vaughan J.H. Immunologic reactions of bronchial tissue in asthma. N Engl J Med 284 (1971) 459-464
15. Nahm D.H., Lee Y.E., Yim E.J., Park H.S., Yim H., Kang Y., et al. Identification of cytokeratin 18 as a bronchial epithelial autoantigen associated with nonallergic asthma. Am J Respir Crit Care Med 165 (2002) 1536-1539
16. Park H.S. Early and late onset asthmatic responses following lysine-aspirin inhalation in aspirin sensitive asthmatic patients. Clin Exp Allergy 25 (1995) 38-40
17. Turner V.F. Detection of acute HIV infections. N Engl J Med 353 (2005) 631-633
18. Mahe C., Kaleebu P., Ojwiya A., and Whitworth J.A. Human immunodeficiency virus type 1 Western blot: revised diagnostic criteria with fewer indeterminate results for epidemiological studies in Africa. Int J Epidemiol 31 (2002) 985-990
19. Berger T., Rubner P., Schautzer F., Egg R., Ulmer H., Mayringer I., et al. Antimyelin antibodies as a predictor of clinically definite multiple sclerosis after a first demyelinating event. N Engl J Med 349 (2003) 139-145
20. Lee K.H., Chung H.S., Kim H.S., Oh S.H., Ha M.K., Baik J.H., et al. Human α-enolase from endothelial cells as a target antigen of anti-endothelial cell antibody in Behcet's disease. Arthritis Rheum 48 (2003) 2025-2035
21. Perkins D.N., Pappin D.J., Creasy D.M., and Cottrell J.S. Probability-based protein identification by searching sequence database using mass spectrometry data. Electrophoresis 20 (1999) 3551-3567
22. Pancholi V. Multifunctional α-enolase: its role in diseases. Cell Mol Life Sci 58 (2001) 902-920
23. Niimi T., Imaizumi M., Abe T., Haimoto H., and Nagura H. Immunohistochemical characteristics of proliferative and metaplastic lesions in bronchial mucosa. Am J Clin Pathol 88 (1987) 545-551
24. Saulot V., Vittecoq O., Charlionet R., Fardellone P., Lange C., Marvin L., et al. Presence of autoantibodies to the glycolytic enzyme α-enolase in sera from patients with early rheumatoid arthritis. Arthritis Rheum 46 (2002) 1196-1201
25. Sinaii N., Cleary S.D., Ballweg M.L., Nieman L.K., and Stratton P. High rates of autoimmune and endocrine disorders, fibromyalgia, chronic fatigue syndrome and atopic diseases among women with endometriosis: a survey analysis. Hum Reprod 17 (2002) 2715-2724
26. Kraft M., Djukanovic R., Wilson S., Holgate S.T., and Martin R.J. Alveolar tissue inflammation in asthma. Am J Respir Crit Care Med 154 (1996) 1505-1510
27. Saetta M., Di Stefano A., Rosina C., Thiene G., and Fabbri L.M. Quantitative structural analysis of peripheral airways and arteries in sudden fatal asthma. Am Rev Respir Dis 143 (1991) 138-143
28. Wallaert B., Janin A., Lassalle P., Copin M.C., Devisme L., Gosset P., et al. Airway-like inflammation of minor salivary gland in bronchial asthma. Am J Respir Crit Care Med 150 (1994) 802-809
29. Wallaert B., Desreumaux P., Copin M.C., Tillie I., Benard A., Colombel J.F., et al. Immunoreactivity for interleukin 3 and 5 and granulocyte/macrophage colony-stimulating factor of intestinal mucosa in bronchial asthma. J Exp Med 182 (1995) 1897-1904
30. Kalsi J., and Isenberg D. Rheumatoid factor: primary or secondary event in the pathogenesis of RA?. Int Arch Allergy Immunol 102 (1993) 209-215
31. Tan E.M., Feltkamp T.E., Smolen J.S., Butcher B., Dawkins R., Fritzler M.J., et al. Range of antinuclear antibodies in "healthy" individuals. Arthritis Rheum 40 (1997) 1601-1611
32. Arnett F.C., Edworthy S.M., Bloch D.A., Mcshane D.J., Fries J.F., Cooper N.S., et al. The American rheumatism association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum 31 (1987) 315-324
33. Tan E.M., Cohen A.S., Fries J.F., Masi A.T., McShane D.J., Rothfield N.F., et al. The 1982 revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum 25 (1982) 1271-1277