Microglial activation in neuroinflammation: Implications for the etiology of neurodegeneration

Neurodegenerative Diseases

Volumn 10, Issue 1-4, 2012, Pages 100-103

  Kaneko, Yoko S ^a   Nakashima, Akira ^a   Mori, Keiji ^a   Nagatsu, Toshiharu ^a   Nagatsu, Ikuko ^a   Ota, Akira ^a  

^a FUJITA HEALTH UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Apoptosis; Autophagy; Life span; Lipopolysaccharide; Microglia

Indexed keywords

CASPASE 3; CYTOKINE; LIPOPOLYSACCHARIDE; PROTEIN BAX; PROTEIN BCL X;

APOPTOSIS; ARTICLE; AUTOPHAGY; CELL ACTIVATION; CELL DEATH; CELL SHAPE; CELL STRUCTURE; CELL SURVIVAL; CONCENTRATION (PARAMETERS); ENZYME ACTIVATION; INFLAMMATION; LIGHT CHAIN; MICROGLIA; MICROTUBULE; NERVE DEGENERATION; NEUROINFLAMMATION; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; BCL-X PROTEIN; BRAIN; CASPASE 3; CELLS, CULTURED; CYTOKINES; LIPOPOLYSACCHARIDES; MICE; MICROGLIA; SIGNAL TRANSDUCTION;

EID: 84860225063     PISSN: 16602854     EISSN: 16602862     Source Type: Journal    
DOI: 10.1159/000332936     Document Type: Article

References (20)

1. Howell OW, Rundle JL, Garg A, Komada M, Brophy PJ, Reynolds R: Activated microglia mediate axoglial disruption that contributes to axonal injury in multiple sclerosis. J Neuropathol Exp Neurol 2010; 69: 1017-1033.
2. Nagatsu T, Sawada M: Cellular and molecular mechanisms of Parkinson's disease: neurotoxins, causative genes, and inflammatory cytokines. Cell Mol Neurobiol 2006; 26: 781-802.
3. Halliday GM, Stevens CH: Glia: initiators and progressors of pathology in Parkinson's disease. Mov Disord 2011; 26: 6-17.
4. Naert G, Rivest S: The role of microglial cell subsets in Alzheimer's disease. Curr Alzheimer Res 2011; 8: 151-155.
5. Block ML, Hong JS: Microglia and inflammation- mediated neurodegeneration: multiple triggers with a common mechanism. Prog Neurobiol 2005; 76: 77-98.
6. McCarty MF: Down-regulation of microglial activation may represent a practical strategy for combating neurodegenerative disorders. Med Hypotheses 2006; 67: 251-269.
7. Liu B, Wang K, Gao HM, Mandavilli B, Wang JY, Hong JS: Molecular consequences of activated microglia in the brain: overactivation induces apoptosis. J Neurochem 2001; 77: 182-189.
8. Xu Y, Jagannath C, Liu X-D, Sharafkhaneh A, Kolodziejska KE, Eissa NT: Toll-like receptor 4 is a sensor for autophagy associated with innate immunity. Immunity 2007; 27: 135-144.
9. Levine B: Eating oneself and uninvited guests: autophagy-related pathways in cellular defense. Cell 2005; 120: 159-162.
10. Wang J-Y, Yang J-M, Wang J-Y, Tao P-L, Yang SN: Synergistic apoptosis induced by bacterial endotoxin lipopolysaccharide and high glucose in rat microglia. Neurosci Lett 2001; 304: 177-180.
11. Kaneko YS, Mori K, Nakashima A, Sawada M, Nagatsu I, Ota A: Peripheral injection of lipopolysaccharide enhances expression of inflammatory cytokines in murine locus coeruleus: possible role of increased norepinephrine turnover. J Neurochem 2005; 94: 393-404.
12. Kaneko YS, Nakashima A, Mori K, Nagatsu T, Nagatsu I, Ota A: Lipopolysaccharide extends the lifespan of mouse primary-cultured microglia. Brain Res 2009; 1279: 9-20.
13. Cho BP, Song DY, Sugama S, Shin DH, Shimizu Y, Kim SS, Kim YS, Joh TH: Pathological dynamics of activated microglia following medial forebrain bundle transection. Glia 2006; 53: 92-102.
14. Tsujimoto Y: Role of Bcl-2 family proteins in apoptosis: apoptosomes or mitochondria? Genes Cells 1998; 3: 697-707.
15. Islam S, Hassan F, Tumurkhuu G, Ito H, Koide N, Mori I, Yoshida T, Yokochi T: Lipopolysaccharide prevents apoptosis induced by brefeldin A, an endoplasmic reticulum stress agent, in RAW 264.7 cells. Biochem Biophys Res Commun 2006; 340: 589-596.
16. Hara T, Nakamura K, Matsui M, Yamamoto A, Nakahara Y, Suzuki-Migishima R, Yokoyama M, Mishima K, Saito I, Okano H, Mizushima N: Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice. Nature 2006; 441: 885-889.
17. Komatsu M, Waguri S, Chiba T, Murata S, Iwata J, Tanida I, Ueno T, Koike M, Uchiyama Y, Kominami E, Tanaka K: Loss of autophagy in the central nervous system causes neurodegeneration in mice. Nature 2006; 441: 880-884.
18. Mizushima N, Levine B, Cuervo AM, Klionsky DJ: Autophagy fights disease through cellular self-digestion. Nature 2008; 451: 1069-1075.
19. Kabeya Y, Mizushima N, Ueno T, Yamamoto A, Kirisako T, Noda T, Kominami E, Ohsumi Y, Yoshimori T: LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing. EMBO J 2000; 19: 5720-5728.
20. Mizushima N: Autophagy: process and function. Genes Dev 2007; 21: 2861-2873.