Development and validation of a rapid HPLC method for the determination of cefdinir in beagle dog plasma integrated with an automatic on-line solid-phase extraction following protein precipitation in the 96-well plate format

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 895-896, Issue , 2012, Pages 83-88

  Li, Ji ^a,b   Wang, Li ^a,b,c   Chen, Zhao ^a,b   Xie, Rui ^a,b   Li, You ^a,b,d   Hang, Taijun ^c   Fan, Guorong ^a,b  

^a SECOND MILITARY MEDICAL UNIVERSITY   (China)

^b SHANGHAI KEY LABORATORY FOR PHARMACEUTICAL METABOLITE RESEARCH   (China)

^c CHINA PHARMACEUTICAL UNIVERSITY   (China)

^d SHANGHAI OCEAN UNIVERSITY   (China)

Author keywords

96 Well protein precipitation; Cefdinir; HPLC; On line solid phase extraction; Pharmacokinetic study

Indexed keywords

CEFDINIR; HPLC; ON-LINE SOLID PHASE EXTRACTION; PHARMACOKINETIC STUDIES; PROTEIN PRECIPITATION;

ACETONITRILE; FLOW RATE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; INORGANIC ACIDS; METHANOL; PHARMACOKINETICS;

PHASE SEPARATION;

CEFDINIR; PERCHLORIC ACID; PROTEIN;

ANALYTICAL PARAMETERS; ANIMAL EXPERIMENT; ARTICLE; BLOOD SAMPLING; DOG; DRUG BLOOD LEVEL; DRUG DETERMINATION; DRUG PURIFICATION; DRUG STRUCTURE; FLOW RATE; LIMIT OF DETECTION; LIMIT OF QUANTITATION; LINEAR SYSTEM; NONHUMAN; PRECIPITATION; PRIORITY JOURNAL; SENSITIVITY ANALYSIS; SOLID PHASE EXTRACTION; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY;

ACETONITRILES; ANIMALS; CEPHALOSPORINS; CHEMICAL PRECIPITATION; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DOGS; DRUG STABILITY; LIMIT OF DETECTION; LINEAR MODELS; METHANOL; PERCHLORIC ACID; REPRODUCIBILITY OF RESULTS; SOLID PHASE EXTRACTION;

CANIS FAMILIARIS;

EID: 84860208022     PISSN: 15700232     EISSN: 1873376X     Source Type: Journal    
DOI: 10.1016/j.jchromb.2012.03.018     Document Type: Article

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