Selective method for the determination of cefdinir in human plasma using liquid chromatography electrospray ionization tandam mass spectrometry

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 834, Issue 1-2, 2006, Pages 163-169

  Chen, Zhang jing ^a   Zhang, Jing ^a   Yu, Ji cheng ^a   Cao, Guo ying ^a   Wu, Xiao jie ^a   Shi, Yao guo ^a  

^a FUDAN UNIVERSITY   (China)

Author keywords

Cefdinir; Human plasma; LC; Method validation; MS MS

Indexed keywords

BIOLOGICAL ORGANS; CONDITION MONITORING; IONIZATION; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; ORGANIC ACIDS; PLASMAS; PRECIPITATION (CHEMICAL); PROTEINS;

CEFDINIR; HUMAN PLASMA; LC; METHOD VALIDATION; MS/MS;

BODY FLUIDS;

CEFACLOR; CEFDINIR; FORMIC ACID; METHANOL; TRICHLOROACETIC ACID; WATER;

ADULT; AREA UNDER THE CURVE; ARTICLE; BLOOD SAMPLING; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG DETERMINATION; DRUG ELIMINATION; DRUG HALF LIFE; DRUG STABILITY; ELECTROSPRAY MASS SPECTROMETRY; HUMAN; HUMAN EXPERIMENT; LIQUID CHROMATOGRAPHY; MALE; PRECIPITATION; PRIORITY JOURNAL; SENSITIVITY AND SPECIFICITY; TANDEM MASS SPECTROMETRY; VALIDATION PROCESS;

ANTI-INFECTIVE AGENTS; CALIBRATION; CEPHALOSPORINS; HUMANS; QUALITY CONTROL; REFERENCE STANDARDS; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION;

EID: 33645964984     PISSN: 15700232     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jchromb.2006.02.047     Document Type: Article

References (10)

1. Inamoto Y., Chiba T., Kamimura T., and Takaya T. FK482, a new orally active cephalosporin synthesis and biological properties. J. Antibiot. (Tokyo) 41 (1988) 828
2. Budavari S. The Merck index. 12th ed. [M] (1996), Merck Research Laboratories Division of Merck & Co., Inc., Whitehouse Station, NJ p. 316
3. Physician's desk reference, 57th ed. [M], Montvale NJ: Thomson PDR, 2003, p. 489.
4. Sakane K., Inamoto Y., and Takaya T. A new oral cephem, cefdinir: its structure-activity relationships and biological profile. Jpn. J. Antibiot. 45 (1992) 909
5. Shimada K., and Oka S. Effect of food on bioavailability of cefdinir. Chemotherapy (Tokyo) 37 Suppl. 2 (1989) 246
6. Lepsy C.S., Guttendorf R.J., Kugler A.R., et al. Effects of organic anion, organic cation, and dipeptide transport inhibitors on cefdinir in the isolated perfused rat kidney. Antimicrob. Agents Chemother. 47 (2003) 689
7. Okamoto Y., Itoh K., Namiki Y., et al. Method development for the determination of cefdinir and its related substances by high-performance liquid chromatography. J. Pharm. Biomed. Anal. 14 (1996) 739
8. Richer M., Allard S., Manseau L., et al. Suction-induced blister fluid penetration of cefdinir in healthy volunteers following ascending oral doses. Antimicrob. Agents Chemother. 39 (1995) 1082
9. Hishida A., Ohishi K., Nagashima S., et al. Pharmacokinetic study of an oral cephalosporin, cefdinir, in hemodialysis patients. Antimicrob. Agents Chemother. 42 (1998) 1718
10. Cook P.J., Andrews J.M., Wise R., et al. Distribution of cefdinir, a third generration cephalosporin antibiotic, in serum and pulmonary compartments. J. Antimicrob. Chemother. 37 (1996) 331