High-throughput determination of faropenem in human plasma and urine by on-line solid-phase extraction coupled to high-performance liquid chromatography with UV detection and its application to the pharmacokinetic study

Journal of Pharmaceutical and Biomedical Analysis

Volumn 52, Issue 1, 2010, Pages 114-121

  Xie, Rui ^a,b,c   Wen, Jun ^a,b,c   Wei, Hua ^a,b,c   Fan, Guorong ^a,b,c   Zhang, Dabing ^d  

^a SECOND MILITARY MEDICAL UNIVERSITY   (China)

^b SHANGHAI KEY LABORATORY FOR PHARMACEUTICAL METABOLITE RESEARCH   (China)

^c Shanghai Research Centre for Drug Chinese Materia Medica Metabolism   (China)

^d Jiangsu Hanbon Science and Technology Co Ltd   (China)

Author keywords

Faropenem; HPLC; On line solid phase extraction; Pharmacokinetic study; Self made trap column

Indexed keywords

ACETONITRILE; FROPENEM;

ACCURACY; ADULT; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG BLOOD LEVEL; DRUG DETERMINATION; DRUG DOSE COMPARISON; DRUG EXCRETION; DRUG STRUCTURE; DRUG URINE LEVEL; FEMALE; FLOW RATE; HALF LIFE TIME; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN EXPERIMENT; MALE; MAXIMUM PLASMA CONCENTRATION; MEAN RESIDENCE TIME; NORMAL HUMAN; ONLINE ANALYSIS; PLASMA CONCENTRATION-TIME CURVE; PRIORITY JOURNAL; PROCESS OPTIMIZATION; SENSITIVITY AND SPECIFICITY; SINGLE DRUG DOSE; SOLID PHASE EXTRACTION; TIME TO MAXIMUM PLASMA CONCENTRATION;

ADMINISTRATION, ORAL; ADULT; ANTI-BACTERIAL AGENTS; ASIAN CONTINENTAL ANCESTRY GROUP; AUTOMATION, LABORATORY; BETA-LACTAMS; CALIBRATION; CHINA; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CHROMATOGRAPHY, REVERSE-PHASE; DRUG STABILITY; FEMALE; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; HYDROGEN-ION CONCENTRATION; MALE; ONLINE SYSTEMS; REFERENCE STANDARDS; REPRODUCIBILITY OF RESULTS; SOLID PHASE EXTRACTION; SPECTROPHOTOMETRY, ULTRAVIOLET; YOUNG ADULT;

EID: 74249095139     PISSN: 07317085     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jpba.2009.12.010     Document Type: Article

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