Future approaches for the therapy of malignant glioma: Targeting genes mediating invasion

Future Oncology

Volumn 8, Issue 4, 2012, Pages 343-346

  Emdad, Luni ^a   Dent, Paul ^a,b   Sarkar, Devanand ^a,b   Fisher, Paul B ^a,b  

^a VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

^b VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

Author keywords

astrocyte elevated gene 1; invasion; malignant glioma

Indexed keywords

ANGIOPOIETIN; GELATINASE A; GELATINASE B; MARIMASTAT; TEMOZOLOMIDE;

ANTINEOPLASTIC ACTIVITY; CANCER INVASION; CANCER SURGERY; GENE TARGETING; GLIOBLASTOMA; HUMAN; IMMUNOHISTOCHEMISTRY; MOLECULAR MECHANICS; MULTIMODALITY CANCER THERAPY; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; REVIEW; SIGNAL TRANSDUCTION;

CELL ADHESION MOLECULES; GLIOMA; HUMANS; MOLECULAR TARGETED THERAPY; NEOPLASM INVASIVENESS;

EID: 84860170766     PISSN: 14796694     EISSN: 17448301     Source Type: Journal    
DOI: 10.2217/fon.12.16     Document Type: Review

References (20)

1. Stupp R, Mason W P, van den Bent MJ et al. Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma. N. Engl. J. Med. 352(10), 987-996 (2005). (Pubitemid 40349501)
2. Bernstein JJ, Woodard CA. Glioblastoma cells do not intravasate into blood vessels. Neurosurgery 36, 124-132 (1995).
3. Liotta LA, Stetler-Stevenson WG. Tumor invasion and metastasis: an imbalance of positive and negative regulation. Cancer Res. 51(Suppl. 18), S5054-S5059 (1991).
4. Alves TR, Lima FR, Kahn SA et al. Glioblastoma cells: a heterogeneous and fatal tumor interacting with the parenchyma. Life Sci. 89(15-16), 532-539 (2011).
5. Gondi CS, Rao JS. Therapeutic potential of siRNA-mediated targeting of urokinase plasminogen activator, its receptor and matrix metalloproteinases. Methods Mol. Biol. 487, 267-281 (2009).
6. Hu B, Guo P, Fang Q et al. Angiopoietin-2 induces human glioma invasion through the activation of matrix metalloprotease-2. Proc. Natl Acad. Sci. USA 100(15), 8904-8909 (2003). (Pubitemid 36899196)
7. Groves MD, Puduvalli VK, Hess KR et al. Phase 2 trial of temozolomide plus the matrix metalloproteinase inhibitor, marimastat, in recurrent and progressive glioblastoma multiforme. J. Clin. Oncol. 20(5), 1383-1388 (2002). (Pubitemid 34177446)
8. Lakka SS, Gondi CS, Dinh DH et al. specific interference of urokinase-type plasminogen activator receptor and matrix metalloproteinase-9 gene expression induced by double-stranded RNA results in decreased invasion, tumor growth, and angiogenesis in gliomas. J. Biol. Chem. 280(23), 21882-21892 (2005). (Pubitemid 40827839)
9. Okada Y, Hurwitz EE, Esposito JM, Brower MA, Nutt CL, Louis DN. Selection pressures of TP53 mutation and microenvironmental location infuence epidermal growth factor receptor gene amplification in human glioblastomas. Cancer Res. 63(2), 413-416 (2003). (Pubitemid 36152501)
10. Joy AM, Beaudry CE, Tran NL et al. Migrating glioma cells activate the PI3-K pathway and display decreased susceptibility to apoptosis. J. Cell. Sci. 116(21), 4409-4417 (2003). (Pubitemid 37369596)
11. Nakada M, Nakada S, Demuth T, Tran NL, Hoelzinger DB, Berens ME. Molecular targets of glioma invasion. Cell. Mol. Life Sci. 64(4), 458-478 (2007).
12. Su ZZ, Kang DC, Chen Y et al. Identification and cloning of human astrocyte genes displaying elevated expression after infection with HIV-1 or exposure to HIV-1 envelope glycoprotein by rapid subtraction hybridization, RaSH. Oncogene 21(22), 3592-3602 (2002). (Pubitemid 34587691)
13. Brown DM, Ruoslahti E. Metadherin, a cell surface protein in breast tumors that mediates lung metastasis. Cancer Cell 5(4), 365-374 (2004). (Pubitemid 38482072)
14. Yoo BK, Emdad L, Lee SG et al. Astrocyte elevated gene-1 (AEG-1): a multifunctional regulator of normal and abnormal physiology. Pharmacol. Ther. 130(1), 1-8 (2011).
15. Emdad L, Sarkar D, Lee SG et al. Astrocyte elevated gene-1: a novel target for human glioma therapy. Mol. Cancer Ther. 9(1), 79-88 (2010).
16. Emdad L, Lee SG, Su ZZ et al. Astrocyte elevated gene-1 (AEG-1) functions as an oncogene and regulates angiogenesis. Proc. Natl Acad. Sci. USA 106(50), 21300-21305 (2009).
17. Liu L, Wu J, Ying Z et al. Astrocyte elevated gene-1 upregulates matrix metalloproteinase-9 and induces human glioma invasion. Cancer Res. 70(9), 3750-3759 (2010).
18. Sarkar D, Park ES, Emdad L, Lee SG, Su ZZ, Fisher PB. Molecular basis of nuclear factor-kB activation by astrocyte elevated gene-1. Cancer Res. 68(5), 1478-1484 (2008). (Pubitemid 351346856)
19. Lee SG, Kim K, Kegelman TP et al. Oncogene AEG-1 promotes glioma-induced neurodegeneration by increasing glutamate excitotoxicity. Cancer Res. 71(20), 6514-6523 (2011).
20. Lyons SA, Chung WJ, Weaver AK, Ogunrinu T, Sontheimer H. Autocrine glutamate signaling promotes glioma cell invasion. Cancer Res. 67(19), 9463-9471 (2007). (Pubitemid 47535936)