Study on the immunomodulation effect of isodon japonicus extract via splenocyte function and NK anti-tumor activity

International Journal of Molecular Sciences

Volumn 13, Issue 4, 2012, Pages 4880-4888

  Hwang, Yu Jin ^a,b   Kim, Jaehyun ^a   Park, Dong Sik ^a   Hwang, Kyung A ^a  

^a National Institute of Animal Science   (South Korea)

^b Sungkyunkwan University   (South Korea)

Author keywords

Cytokine; Isodon japonicus; Natural killer cell; Splenocyte

Indexed keywords

ALCOHOL; GAMMA INTERFERON; IMMUNOMODULATING AGENT; ISODON JAPONICUS EXTRACT; PLANT EXTRACT; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; IMMUNOLOGIC FACTOR;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER INHIBITION; CELL FUNCTION; CELL PROLIFERATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG CYTOTOXICITY; DRUG EFFECT; DRUG EFFICACY; HUMAN; HUMAN CELL; IC 50; IMMUNOMODULATION; IN VITRO STUDY; ISODON; ISODON JAPONICUS; LEUKEMIA CELL; MALE; MOUSE; NATURAL KILLER CELL; NATURAL KILLER CELL MEDIATED CYTOTOXICITY; NONHUMAN; SPLEEN CELL; TUMOR CELL; TUMOR IMMUNITY; ANIMAL; B LYMPHOCYTE; BIOSYNTHESIS; C57BL MOUSE; CYTOLOGY; DRUG EFFECTS; HT 29 CELL LINE; IMMUNOLOGY; KOREAN MEDICINE; LEUKEMIA; MCF 7 CELL LINE; METABOLISM; SPLEEN; T LYMPHOCYTE; TUMOR CELL LINE;

ANIMALS; B-LYMPHOCYTES; CELL LINE, TUMOR; CELL PROLIFERATION; HT29 CELLS; HUMANS; IMMUNOLOGIC FACTORS; IMMUNOMODULATION; INTERFERON-GAMMA; ISODON; KILLER CELLS, NATURAL; LEUKEMIA; MALE; MCF-7 CELLS; MEDICINE, KOREAN TRADITIONAL; MICE; MICE, INBRED C57BL; PLANT EXTRACTS; SPLEEN; T-LYMPHOCYTES; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84860162406     PISSN: None     EISSN: 14220067     Source Type: Journal    
DOI: 10.3390/ijms13044880     Document Type: Article

References (24)

1. Liu, C.; Yu, S.; Zinn, K.; Wang, J.; Zhang, L.; Jia, Y.; Kappes, J.C.; Barnes, S.; Kimberly, R.P.; Grizzle, W.E., et al. Murine mammary carcinoma exosomes promote tumor growth by suppression of NK cell function. J. Immunol. 2006, 176, 1375-1385.
2. Ben-Eliyahu, S.; Page, G.G.; Yirmiya, R.; Shakhar, G. Evidence that stress and surgical interventions promote tumor development by suppressing natural killer cell activity. Int. J. Cancer 1999, 80, 880-888.
3. Hicks, A.M.; Riedlinger, G.; Willingham, M.C.; Alexander-Miller, M.A.; von Kap-Herr, C.; Pettenati, M.J.; Sanders, A.M.; Weir, H.M.; Du, W.; Kim, J., et al. Transferable anticancer innate immunity in spontaneous regression/complete resistance mice. Proc. Natl. Acad. Sci. USA 2006, 103, 7753-7758.
4. Grivennikov, S.I.; Greten, F.R.; Karin, M. Immunity, inflammation, and cancer. Cell 2010, 140, 883-899.
5. O'Leary, J.G.; Goodarzi, M.; Drayton, D.L.; von Andrian, U.H. T cell- and B cell-independent adaptive immunity mediated by natural killer cells. Nat. Immunol. 2006, 7, 507-516.
6. Amirghofran, Z.; Bahmani, M.; Azadmehr, A.; Javidnia, K.; Miri, R. Immunomodulatory activities of various medicinal plant extracts: Effects on human lymphocytes apoptosis. Immunol. Investig. 2009, 38, 181-192.
7. Rubel, R.; Dalla Santa, H.S.; Bonatto, S.J.; Bello, S.; Fernandes, L.C.; di Bernardi, R.; Gern, J.; Santos, C.A.; Soccol, C.R. Medicinal mushroom Ganoderma lucidum (Leyss: Fr) karst. Triggers immunomodulatory effects and reduces nitric oxide synthesis in mice. J. Med. Food 2010, 13, 142-148.
8. Kinghorn, A.D.; Farnsworth, N.R.; Soejarto, D.D.; Cordell, G.A.; Swanson, S.M.; Pezzuto, J.M.; Wan, M.C.; Wall, M.E.; Oberlies, N.; Kroll, D., et al. Novel strategies for the discovery of plant-derived anticancer agents. Pham. Biol. 2003, 41, 53-67.
9. Yoon, T.J.; Yoo, Y.C.; Lee, S.W.; Shin, K.S.; Choi, W.H.; Hwang, S.H.; Ha, E.S.; Jo, S.K.; Kim, S.H.; Park, W.M. Anti-metastatic activity of Acanthopanax senticosus extract and its possible immunological mechanism of action. J. Ethnopharmacol. 2004, 93, 247-253.
10. Majdalawieh, A.F.; Hmaidan, R.; Carr, R.I. Nigella sativa modulates splenocyte proliferation, Th1/Th2 cytokine profile, macrophage function and NK anti-tumor activity. J. Ethnopharmacol. 2010, 131, 268-275.
11. Hwang, K.-A.; Hwang, Y.-J.; Park, D.-S.; Kim, J.; Om, A.-S. In vitro investigation of antioxidant and anti-apoptotic activities of Korean wild edible vegetable extracts and their correlation with apoptotic gene expression in HepG2 cells. Food Chem. 2011, 125, 483-487.
12. Kim, B.W.; Koppula, S.; Kim, I.S.; Lim, H.W.; Hong, S.M.; Han, S.D.; Hwang, B.Y.; Choi, D.K. Anti-neuroinflammatory activity of kamebakaurin from Isodon japonicus via inhibition of c-Jun NH2-terminal kinase and p38 mitogen-activated protein kinase pathway in activated microglial cells. J. Pharmacol. Sci. 2011, 116, 296-308.
13. Suzuki, I.; Kondoh, M.; Nagashima, F.; Fujii, M.; Asakawa, Y.; Watanabe, Y. A Comparison of apoptosis and necrosis induced by ent-kaurene-type diterpenoids in HL-60 cells. Planta Med. 2004, 70, 401-406.
14. Kelly, J.M.; Darcy, P.K.; Markby, J.L.; Godfrey, D.I.; Takeda, K.; Yagita, H.; Smyth, M.J. Induction of tumor-specific T cell memory by NK cell-mediated tumor rejection. Nat. Immunol. 2002, 3, 83-90.
15. Barlozzari, T.; Leonhardt, J.; Wiltrout, R.H.; Herberman, R.B.; Reynolds, C.W. Direct evidence for the role of LGL in the reduction of experimental metastasis. J. Immunol. 1985, 134, 2783-2789.
16. Biron, C.A.; Nguyen, K.B.; Pien, G.C.; Cousens, L.P.; Salazar-Mather, T.P. Natural killer cells in antiviral defense. Annu. Rev. Immunol. 1999, 17, 189-220.
17. Tanigawa, K.; Craig, R.A.; Stoolman, L.M.; Chang, A.E. Effects of tumor necrosis factor-alpha on the in vitro maturation of tumor-reactive effector T cells. J. Immunother. 2000, 23, 528-535.
18. Baxevanis, C.N.; Voutsas, I.F.; Tsitsilonis, O.E.; Tsiatas, M.L.; Gritzapis, A.D.; Papamichail, M.; Compromised anti-tumor responses in tumor necrosis factor-alpha knockout mice. Eur. J. Immunol. 2000, 30, 1957-1966.
19. Gillett, A.; Marta, M.; Jin, T.; Tuncel, J.; Leclerc, P.; Nohra, R.; Lange, S.; Holmdahl, R.; Olsson, T.; Harris, R.A.; Jagodic, M. TNF Production in macrophages is genetically determined and regulates inflammatory disease in rats. J. Immunol. 2010, 185, 442-450.
20. Lasek, W.; Feleszko, W.; Golab, J.; Stoklosa, T.; Marczak, M.; Dabrowska, A.; Malejczyk, M.; Jakobisiak, M. Antitumor effects of the combination immunotherapy with interleukin-12 and tumor necrosis factor alpha in mice. Cancer Immunol. Immunother. 1997, 45, 100-108.
21. Markovic, S.N.; Murasko, D.M. Role of natural killer and T-cells in interferon induced inhibition of spontaneous metastases of the B16F10L murine melanoma. Cancer Res. 1991, 51, 1124-1128.
22. Asea, A.; Stein-Streilein, J. Signalling through NK1.1 triggers NK cells to die but induces NK T cells to produce interleukin-4. Immunology 1998, 93, 296-305.
23. Hansen, M.B.; Nielsen, S.E.; Berg, K. Re-examination and further development of a precise and rapid dye method for measuring cell growth/cell kill. J. Immunol. Methods 1989, 119, 203-210.
24. Matzinger, P. The JAM test. A simple assay for DNA fragmentation and cell death. J. Immunol. Methods 1991, 145, 185-192.