Nigella sativa modulates splenocyte proliferation, Th1/Th2 cytokine profile, macrophage function and NK anti-tumor activity

Journal of Ethnopharmacology

Volumn 131, Issue 2, 2010, Pages 268-275

  Majdalawieh, Amin F ^a   Hmaidan, Reem ^a   Carr, Ronald I ^b  

^a AMERICAN UNIVERSITY OF SHARJAH   (United Arab Emirates)

^b DALHOUSIE UNIVERSITY   (Canada)

Author keywords

Anti tumor; Immunomodulation; Inflammation; Macrophages; Nigella sativa; NK cells

Indexed keywords

CYTOKINE; INTERLEUKIN 6; NIGELLA SATIVA EXTRACT; NITRIC OXIDE; THYMIDINE; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; BLACK CUMIN; CELL FUNCTION; CELL PROLIFERATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; ENZYME LINKED IMMUNOSORBENT ASSAY; IMMUNE RESPONSE; MACROPHAGE; MOUSE; NATURAL KILLER CELL; NONHUMAN; PROTEIN SECRETION; SPLEEN CELL; TH1 CELL; TH2 CELL;

ANIMALS; ANTI-INFLAMMATORY AGENTS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; CELL LINE, TUMOR; CELL PROLIFERATION; CYTOKINES; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME-LINKED IMMUNOSORBENT ASSAY; IMMUNOLOGIC FACTORS; INFLAMMATION MEDIATORS; ISOTOPE LABELING; KILLER CELLS, NATURAL; MACROPHAGES; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; NEOPLASMS; NIGELLA; PHYTOTHERAPY; PLANT EXTRACTS; SEEDS; SPLEEN; TH1-TH2 BALANCE;

NIGELLA SATIVA;

EID: 77956282108     PISSN: 03788741     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jep.2010.06.030     Document Type: Article

References (47)

1. Abuharfeil N.M., Maraqa A., Von Kleist S. Augmentation of natural killer cell activity in vitro against tumor cells by wild plants from Jordan. Journal of Ethnopharmacology 2000, 71:55-63.
2. Abuharfeil N.M., Salim M., Von Kleist S. Augmentation of natural killer cell activity in vivo against tumour cells by some wild plants from Jordan. Phytotherapy Research 2001, 15:109-113.
3. Agarwal R., Kharya M.D., Shrivastava R. Antimicrobial and antihelmintic activities of the essential oil of Nigella sativa Linn. Indian Journal of Experimental Biology 1979, 17:1264-1265.
4. Ait Mbarek L., Ait Mouse H., Elabbadi N., Bensalah M., Gamouh A., Aboufatima R., Benharref A., Chait A., Kamal M., Dalal A., Zyad A. Anti-tumor properties of blackseed (Nigella sativa L.) extracts. Brazilian Journal of Medical and Biological Research 2007, 40:839-847.
5. Ali B.H., Blunden G. Pharmacological and toxicological properties of Nigella sativa. Phytotherapy Research 2003, 17:299-305.
6. Al-Naggar T.B., Gómez-Serranillos M.P., Carretero M.E., Villar A.M. Neuropharmacological activity of Nigella sativa L. extracts. Journal of Ethnopharmacology 2003, 88:63-68.
7. Asea A., Stein-Streilein J. Signalling through NK1.1 triggers NK cells to die but induces NK T cells to produce interleukin-4. Immunology 1998, 93:296-305.
8. Awad E.M. In vitro decreases of the fibrinolytic potential of cultured human fibrosarcoma cell line, HT1080, by Nigella sativa oil. Phytomedicine 2005, 12:100-107.
9. Boskabady M.H., Javan H., Sajady M., Rakhshandeh H. The possible prophylactic effect of Nigella sativa seed extract in asthmatic patients. Fundamental and Clinical Pharmacology 2007, 21:559-566.
10. Büyüköztürk S., Gelincik A., Ozşeker F., Genç S., Savran F.O., Kiran B., Yillar G., Erden S., Aydin F., Colakoĝlu B., Dal M., Ozer H., Bilir A. Nigella sativa (black seed) oil does not affect the T-helper 1 and T-helper 2 type cytokine production from splenic mononuclear cells in allergen sensitized mice. Journal of Ethnopharmacology 2005, 100:295-298.
11. Chakravarty N. Inhibition of histamine release from mast cells by nigellone. Annals of Allergy 1993, 70:237-242.
12. Chehl N., Chipitsyna G., Gong Q., Yeo C.J., Arafat H.A. Anti-inflammatory effects of the Nigella sativa seed extract, thymoquinone, in pancreatic cancer cells. HPB (Oxford) 2009, 13-14:1749-1770.
13. Craig W.J. Health-promoting properties of common herbs. American Journal of Clinical Nutrition 1999, 70:491S-499S.
14. Dubick M.A. Historical perspectives on the use of herbal preparations to promote health. Journal of Nutrition 1986, 116:1348-1354.
15. El-Dakhakhny M., Madi N.J., Lembert N., Ammon H.P. Nigella sativa oil, nigellone and derived thymoquinone inhibit synthesis of 5-lipoxygenase products in polymorphonuclear leukocytes from rats. Journal of Ethnopharmacology 2002, 81:161-164.
16. El Gazzar M., El Mezayen R., Nicolls M.R., Marecki J.C., Dreskin S.C. Downregulation of leukotriene biosynthesis by thymoquinone attenuates airway inflammation in a mouse model of allergic asthma. Biochimica et Biophysica Acta 2006, 1760:1088-1095.
17. El-Kadi A., Kandil O., Tabuni A.M. Nigella sativa and cell mediated immunity. Archives of AIDS Research 1989, 1:232-233.
18. Gore C., Custovic A. Can we prevent allergy?. Allergy 2004, 59:151-161.
19. Hajhashemi V., Ghannadi A., Jafarabadi H. Black cumin seed essential oil, as a potent analgesic and antiinflammatory drug. Phytotherapy Research 2004, 18:195-199.
20. Hanafy M.S., Hatem M.E. Studies on the antimicrobial activity of Nigella sativa seed (black cumin). Journal of Ethnopharmacology 1991, 34:275-278.
21. Hirschberg Y., Shackelford A., Mascioli E.A., Babayan V.K., Bistrian B.R., Blackburn G.L. The response to endotoxin in guinea pigs after intravenous black currant seed oil. Lipids 1990, 25:491-496.
22. Houghton P.J., Zarka R., de las Heras B., Hoult J.R. Fixed oil of Nigella sativa and derived thymoquinone inhibit eicosanoid generation in leukocytes and membrane lipid peroxidation. Planta Medica 1995, 61:33-36.
23. Islam S.N., Begum P., Ahsan T., Huque S., Ahsan M. Immunosuppressive and cytotoxic properties of Nigella sativa. Phytotherapy Research 2004, 18:395-398.
24. Kalus U., Pruss A., Bystron J., Jurecka M., Smekalova A., Lichius J.J., Kiesewetter H. Effect of Nigella sativa (black seed) on subjective feeling in patients with allergic diseases. Phytotherapy Research 2003, 17:1209-1214.
25. Kidd P. Th1/Th2 balance: the hypothesis, its limitations, and implications for health and disease. Alternative Medicine Review 2003, 8:223-246.
26. Mahgoub A.A. Thymoquinone protects against experimental colitis in rats. Toxicology Letters 2003, 143:133-143.
27. Mahmood M.S., Gilani A.H., Khwaja A., Rashid A., Ashfaq M.K. The in vitro effect of aqueous extract of Nigella sativa seeds on nitric oxide production. Phytotherapy Research 2003, 17:921-924.
28. Majdalawieh A.F., Carr R.I. In vitro investigation of the potential immunomodulatory and anticancer activities of black pepper (Piper nigrum) and cardamom (Elettaria cardamomum). Journal of Medicinal Food 2010, 10.1089/jmf.2009.1131.
29. Mansour M., Tornhamre S. Inhibition of 5-lipoxygenase and leukotriene C4 synthase in human blood cells by thymoquinone. Journal of Enzyme Inhibition and Medicinal Chemistry 2004, 19:431-436.
30. Matzinger P. The JAM test. A simple assay for DNA fragmentation and cell death. Journal of Immunological Methods 1991, 145:185-192.
31. Miles E.A., Wallace F.A., Calder P.C. Dietary fish oil reduces intercellular adhesion molecule 1 and scavenger receptor expression on murine macrophages. Atherosclerosis 2000, 152:43-50.
32. Mohamed A., Shoker A., Bendjelloul F., Mare A., Alzrigh M., Benghuzzi H., Desin T. Improvement of experimental allergic encephalomyelitis (EAE) by thymoquinone; an oxidative stress inhibitor. Biomedical Sciences Instrumentation 2003, 39:440-445.
33. Padhye S., Banerjee S., Ahmad A., Mohammad R., Sarkar F.H. From here to eternity - the secret of Pharaohs: Therapeutic potential of black cumin seeds and beyond. Cancer Therapy 2008, 6:495-510.
34. Romagnani S. Regulation of the T cell response. Clinical and Experimental Allergy 2006, 36:1357-1366.
35. Salem M.L. Immunomodulatory and therapeutic properties of the Nigella sativa L. seed. International Immunopharmacology 2005, 5:1749-1770.
36. Salomi N.J., Nair S.C., Jayawardhanan K.K., Varghese C.D., Panikkar K.R. Antitumour principles from Nigella sativa seeds. Cancer Letters 1992, 63:41-46.
37. Salomi M.J., Nair S.C., Panikkar K.R. Inhibitory effects of Nigella sativa and saffron (Crocus sativus) on chemical carcinogenesis in mice. Nutrition and Cancer 1991, 16:67-72.
38. Shabsoug B., Khalil R., Abuharfeil N. Enhancement of natural killer cell activity in vitro against human tumor cells by some plants from Jordan. Journal of Immunotoxicology 2008, 5:279-285.
39. Shafi G., Munshi A., Hasan T.N., Alshatwi A.A., Jyothy A., Lei D.K. Induction of apoptosis in HeLa cells by chloroform fraction of seed extracts of Nigella sativa. Cancer Cell International 2009, 9:29-36.
40. Shoieb A.M., Elgayyar M., Dudrick P.S., Bell J.L., Tithof P.K. In vitro inhibition of growth and induction of apoptosis in cancer cell lines by thymoquinone. International Journal of Oncology 2003, 22:107-113.
41. Steinmann A., Sch?zle M., Agathos M., Breit R. Allergic contact dermatitis from black cumin (Nigella sativa) oil after topical use. Contact Dermatitis 1997, 36:268-269.
42. Swamy S.M., Huat B.T. Intracellular glutathione depletion and reactive oxygen species generation are important in alpha-hederin-induced apoptosis of P388 cells. Molecular and Cellular Biochemistry 2003, 245:127-139.
43. Swamy S.M., Tan B.K. Cytotoxic and immunopotentiating effects of ethanolic extract of Nigella sativa L. seeds. Journal of Ethnopharmacology 2000, 70:1-7.
44. Tapsell L.C., Hemphill I., Cobiac L., Patch C.S., Sullivan D.R., Fenech M., Roodenrys S., Keogh J.B., Clifton P.M., Williams P.G., Fazio V.A., Inge K.E. Health benefits of herbs and spices: the past, the present, the future. Medical Journal of Australia 2006, 185:S4-S24.
45. 3H-thymidine incorporation assay. Veterinary Immunology and Immunopathology 1999, 70:151-159.
46. Wood K.S., Buga G.M., Byrns R.E., Ignarro L.J. Vascular smooth muscle-derived relaxing factor (MDRF) and its close similarity to nitric oxide. Biochemical and Biophysical Research Communications 1990, 170:80-88.
47. Zedlitz S., Kaufmann R., Boehncke W.H. Allergic contact dermatitis from black cumin (Nigella sativa) oil-containing ointment. Contact Dermatitis 2002, 46:188.