Anti-metastatic activity of Acanthopanax senticosus extract and its possible immunological mechanism of action

Journal of Ethnopharmacology

Volumn 93, Issue 2-3, 2004, Pages 247-253

  Yoon, Taek Joon ^a   Yoo, Yung Choon ^b   Lee, Seok Won ^c   Shin, Kwang Soon ^a   Choi, Won Hee ^d   Hwang, Soo Hyun ^a   Ha, Eun Suk ^c   Jo, Sung Kee ^e   Kim, Sung Hoon ^c   Park, Woo Mun ^d  

^a Kyonggi University   (South Korea)

^b Konyang University   (South Korea)

^c Kyung Hee University   (South Korea)

^d Research Team   (South Korea)

^e Korea Atomic Energy Research Institute   (South Korea)

Author keywords

Acanthopanax senticosus; Immunomodulation; Macrophage; NK cell; Tumor metastasis

Indexed keywords

ELEUTHEROCOCCUS SENTICOSUS EXTRACT; GF 100;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER GROWTH; CELL STIMULATION; COLON CANCER; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DOSE RESPONSE; DRUG DOSE REGIMEN; ELEUTHEROCOCCUS SENTICOSUS; FEMALE; IMMUNOSTIMULATION; IN VITRO STUDY; INOCULATION; LUNG METASTASIS; MEDICINAL PLANT; METASTASIS INHIBITION; MOUSE; NONHUMAN; PERITONEUM MACROPHAGE; SPLEEN CELL;

ACANTHOPANAX; ADJUVANTS, IMMUNOLOGIC; ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; CELL LINE, TUMOR; COLONIC NEOPLASMS; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; LUNG NEOPLASMS; MACROPHAGE ACTIVATION; MICE; MICE, INBRED BALB C; NEOPLASM METASTASIS; PHYTOTHERAPY; PLANT BARK; PLANT EXTRACTS; RABBITS; SPECIFIC PATHOGEN-FREE ORGANISMS;

EID: 3242684503     PISSN: 03788741     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jep.2004.03.052     Document Type: Article

References (30)

1. Andreesen R., Scheibenbogen C., Brugger W., Krause S., Meerpohl H.G., Leser H.G., Engler H., Lohr G.W. Adoptive transfer of tumor cytotoxic macrophages generated in vitro from circulating monocytes: a new approach to cancer immunotherapy. Cancer Research. 50:1990;7450-7456
2. Barlozzari T., Leonhardt J., Wiltrout R.H., Herberman R.B., Reynolds C.W. Direct evidence for the role of LGL in the reduction of experimental metastasis. Journal of Immunology. 134:1985;2783-2789
3. Baxevanis C.N., Voutsas I.F., Tsitsilonis O.E., Tsiatas M.L., Gritzapis A.D., Papamichail M. Compromised anti-tumor responses in tumor necrosis factor-alpha knockout mice. European Journal of Immunology. 30:2000;1957-1966
4. Davydov M., Krikorian A.D. Eleutherococcus senticosus (Rupr. & Maxim.) Maxim. (Araliaceae) as an adaptogen: a closer look. Journal of Ethnopharmacology. 72:2000;345-393
5. Deyama T., Nishibe S., Nakazawa Y. Constituents and pharmacological effects of Eucommia and Siberian ginseng. Acta Pharmacologica Sinica. 22:2001;1057-1070
6. Dowling E.A., Redondo D.R., Branch J.D., Jones S., McNabb G., Williams M.H. Effect of Eleutherococcus senticosus on submaximal and maximal exercise performance. Medicine and Science in Sports and Exercise. 28:1996;482-489
7. Dubois M., Gilles K.A., Hamilton J.K., Rebers P.A., Smith F. Colorimetric method for determination of sugars and related substances. Analytical Chemistry. 28:1956;350-356
8. Fidler I.J. Cancer metastasis. British Medical Bulletin. 47:1991;157-177
9. Gaffney B.T., Hugel H.M., Rich P.A. Panax ginseng and Eleutherococcus senticosus may exaggerate an already existing biphasic response to stress via inhibition of enzymes which limit the binding of stress hormones to their receptors. Medical Hypotheses. 56:2001;567-572
10. Habu S., Fukui H., Shimamura K., Kasai M., Nagai Y., Okumura K., Tamaoki N. In vivo effect of anti-asialo GM1. I. Reduction of NK activity and enhancement of transplanted tumor growth in nude mice. Journal of Immunology. 127:1981;34-38
11. Hibasami H., Fujikawa T., Takeda H., Nishibe S., Satoh T., Fujisawa T., Nakashima K. Induction of apoptosis by Acanthopanax senticosus HARMS and its component, sesamin in human stomach cancer KATO III cells. Oncology Reports. 7:2000;1213-1216
12. Jeong H.J., Koo H.N., Myung N.I., Shin M.K., Kim J.W., Kim D.K., Kim K.S., Kim H.M., Lee Y.M. Inhibitory effects of mast cell-mediated allergic reactions by cell cultured Siberian Ginseng. Immunopharmacology and Immunotoxicology. 23:2001;107-117
13. Kang N.S., Park S.Y., Lee K.R., Lee S.M., Lee B.G., Shin D.H., Pyo S. Modulation of macrophage function activity by ethanolic extract of larvae of Holotrichia diomphalia. Journal of Ethnopharmacology. 79:2002;89-94
14. Lasek W., Feleszko W., Golab J., Stoklosa T., Marczak M., Dabrowska A., Malejczyk M., Jakobisiak M. Antitumor effects of the combination immunotherapy with interleukin-12 and tumor necrosis factor alpha in mice. Cancer Immunology Immunotherapy. 45:1997;100-108
15. Liotta L.A., Steeg P.S., Stetler-Stevenson W.G. Cancer metastasis and angiogenesis: an imbalance of positive and negative regulation. Cell. 64:1991;327-336
16. Markovic S.N., Murasko D.M. Role of natural killer and T-cells in interferon induced inhibition of spontaneous metastases of the B16F10L murine melanoma. Cancer Research. 51:1991;1124-1128
17. Ogawa M., Yu W.G., Umehara K., Iwasaki M., Wijesuriya R., Tsujimura T., Kubo T., Fujiwara H., Hamaoka T. Multiple roles of interferon-gamma in the mediation of interleukin 12-induced tumor regression. Cancer Research. 58:1998;2426-2432
18. Ohnishi Y., Fujii H., Hayakawa Y., Sakukawa R., Yamaura T., Sakamoto T., Tsukada K., Fujimaki M., Nunome S., Komatsu Y., Saiki I. Oral administration of a Kampo (Japanese herbal) medicine Juzen-taiho-to inhibits liver metastasis of colon 26-L5 carcinoma cells. Japanese Journal of Cancer Research. 89:1998;206-213
19. Saiki I. A Kampo medicine "Juzen-taiho-to"-prevention of malignant progression and metastasis of tumor cells and the mechanism of action. Biological and Pharmaceutical Bulletin. 23:2000;677-688
20. Saiki I., Saito S., Fujita C., Ishida H., Iida J., Murata J., Hasegawa A., Azuma I. Induction of tumoricidal macrophages and production of cytokines by synthetic muramyl dipeptide analogues. Vaccine. 6:1988;238-244
21. Sakamaki S., Kohgo Y., Nojiri S., Kanisawa Y., Ito Y., Takahashi M., Ueno Y., Hirayama Y., Niitsu Y. Effect of Krestin (PSK) on the induction of IL-2 activated killer cells. Japanese Journal of Clinical Oncology. 22:1992;79-83
22. Schantz S.P., Brown B.W., Lira E., Taylor S.L., Beddingfield N. Evidence for the role of natural immunity in the control of metastatic spread of head and neck cancer. Cancer Immunology Immunotherapy. 25:1987;141-148
23. Schmeda-Hirschmann G., Villasenor-Garcia M.M., Lozoya X., Puebla-Perez A.M. Immunomodulatory activity of Chilean Cyttaria species in mice with L5178Y lymphoma. Journal of Ethnopharmacology. 77:2001;253-257
24. Schmolz M.W., Sacher F., Aicher B. The synthesis of Rantes, G-CSF, IL-4, IL-5, IL-6, IL-12 and IL-13 in human whole-blood cultures is modulated by an extract from Eleutherococcus senticosus L. roots. Phytotherapy Research. 15:2001;268-270
25. Suto T., Fukuda S., Moriya N., Watanabe Y., Sasaki D., Yoshida Y., Sakata Y. Clinical study of biological response modifiers as maintenance therapy for hepatocellular carcinoma. Cancer Chemotherapy and Pharmacology. 33:1994;S145-S148
26. Tanigawa K., Craig R.A., Stoolman L.M., Chang A.E. Effects of tumor necrosis factor-alpha on the in vitro maturation of tumor-reactive effector T cells. Journal of Immunotherapy. 23:2000;528-535
27. Umeyama A., Shoji N., Takei M., Endo K., Arihara S. Ciwujianosides D1 and C1: powerful inhibitors of histamine release induced by anti-immunoglobulin E from rat peritoneal mast cells. Journal of Pharmacological Sciences. 81:1992;661-662
28. Yi J.M., Kim M.S., Seo S.W., Lee K.N., Yook C.S., Kim H.M. Acanthopanax senticosus root inhibits mast cell-dependent anaphylaxis. Clinica Chimica Acta. 312:2001;163-168
29. Yoo Y.C., Saiki I., Sato K., Azuma I. MDP-Lys(L18), a lipophilic derivative of muramyl dipeptide, inhibits the metastasis of haematogenous and non-haematogenous tumours in mice. Vaccine. 12:1994;160-175
30. Yoon T.J., Yoo Y.C., Kang T.B., Baek Y.J., Huh C.S., Song S.K., Lee K.H., Azuma I., Kim J.B. Prophylactic effect of Korean mistletoe (Viscum album coloratum) extract on tumor metastasis is mediated by enhancement of NK cell activity. International Journal of Immunopharmacology. 20:1998;163-172