-
1
-
-
0035824553
-
Putative ACP phosphodiesterase gene (acpD) encodes an azoreductase
-
Nakanishi, M., Yatome, C., Ishida, N. & Kitade, Y. Putative ACP phosphodiesterase gene (acpD) encodes an azoreductase. J Biol Chem 276, 46394-46399 (2001).
-
(2001)
J Biol Chem
, vol.276
, pp. 46394-46399
-
-
Nakanishi, M.1
Yatome, C.2
Ishida, N.3
Kitade, Y.4
-
2
-
-
35148864753
-
Molecular cloning, characterisation and ligand-bound structure of an azoreductase from Pseudomonas aeruginosa
-
Wang, C. J. et al. Molecular cloning, characterisation and ligand-bound structure of an azoreductase from Pseudomonas aeruginosa. J Mol Biol 373, 1213-1228 (2007).
-
(2007)
J Mol Biol
, vol.373
, pp. 1213-1228
-
-
Wang, C.J.1
-
3
-
-
0028861748
-
Subunit functional studies of NAD(P)H:quinone oxidoreductase with a heterodimer approach
-
Cui, K., Lu, A. Y. & Yang, C. S. Subunit functional studies of NAD(P)H:quinone oxidoreductase with a heterodimer approach. Proc Natl Acad Sci USA 92, 1043-1047 (1995).
-
(1995)
Proc Natl Acad Sci USA
, vol.92
, pp. 1043-1047
-
-
Cui, K.1
Lu, A.Y.2
Yang, C.S.3
-
4
-
-
0015348162
-
The role of intestinal bacteria in themetabolism of salicylazosulfapyridine
-
Peppercorn, M. A. & Goldman, P. The role of intestinal bacteria in themetabolism of salicylazosulfapyridine. J Pharmacol Exp Ther 181, 555-562 (1972).
-
(1972)
J Pharmacol Exp Ther
, vol.181
, pp. 555-562
-
-
Peppercorn, M.A.1
Goldman, P.2
-
5
-
-
79953133983
-
Reaction mechanism of azoreductases suggests convergent evolution with quinone oxidoreductases
-
Ryan, A., Wang, C. J., Laurieri, N., Westwood, I. & Sim, E. Reaction mechanism of azoreductases suggests convergent evolution with quinone oxidoreductases. Protein Cell 1, 780-790 (2010).
-
(2010)
Protein Cell
, vol.1
, pp. 780-790
-
-
Ryan, A.1
Wang, C.J.2
Laurieri, N.3
Westwood, I.4
Sim, E.5
-
6
-
-
72149105881
-
Discovery and evaluation of Escherichia coli nitroreductases that activate the anti-cancer prodrug CB1954
-
Prosser, G. A. et al. Discovery and evaluation of Escherichia coli nitroreductases that activate the anti-cancer prodrug CB1954. Biochemical Pharmacology 79, 678-687 (2010).
-
(2010)
Biochemical Pharmacology
, vol.79
, pp. 678-687
-
-
Prosser, G.A.1
-
7
-
-
33749437211
-
Bioactivation and hepatotoxicity of nitroaromatic drugs
-
DOI 10.2174/138920006778520606
-
Boelsterli, U. A., Ho, H. K., Zhou, S. & Leow, K. Y. Bioactivation and hepatotoxicity of nitroaromatic drugs. Curr Drug Metab 7, 715-727 (2006). (Pubitemid 44509678)
-
(2006)
Current Drug Metabolism
, vol.7
, Issue.7
, pp. 715-727
-
-
Boelsterli, U.A.1
Ho, H.K.2
Zhou, S.3
Leow, K.Y.4
-
8
-
-
33947652039
-
Nitrofurans as novel anti-tuberculosis agents: Identification, development and evaluation
-
DOI 10.2174/156802607780059772
-
Tangallapally, R. P., Yendapally, R., Daniels, A. J. & Lee, R. E. Nitrofurans as Novel Anti-tuberculosis Agents: Identification, Development and Evaluation. Current Topics in Medicinal Chemistry 7, 509-526 (2007). (Pubitemid 46488291)
-
(2007)
Current Topics in Medicinal Chemistry
, vol.7
, Issue.5
, pp. 509-526
-
-
Tangallapally, R.P.1
Yendapally, R.2
Daniels, A.J.3
Lee, R.E.B.4
Lee, R.E.5
-
9
-
-
0031771290
-
Oxygen-insensitive nitroreductases: Analysis of the roles of nfsA and nfsB in development of resistance to 5-nitrofuran derivatives in Escherichia coli
-
Whiteway, J. et al. Oxygen-insensitive nitroreductases: analysis of the roles of nfsA and nfsB in development of resistance to 5-nitrofuran derivatives in Escherichia coli. J Bacteriol 180, 5529-5539 (1998). (Pubitemid 28489842)
-
(1998)
Journal of Bacteriology
, vol.180
, Issue.21
, pp. 5529-5539
-
-
Whiteway, J.1
Koziarz, P.2
Veall, J.3
Sandhu, N.4
Kumar, P.5
Hoecher, B.6
Lambert, I.B.7
-
10
-
-
0033871181
-
Bioactivation of 5-(Aziridin-1-yl)-2,4-dinitrobenzamide (CB 1954) by human NAD(P)H quinone oxidoreductase 2: A novel co-substrate-mediated antitumor prodrug therapy
-
Knox, R. J. et al. Bioactivation of 5-(aziridin-1-yl)-2, 4-dinitrobenzamide (CB 1954) by human NAD(P)H quinone oxidoreductase 2: a novel co-substratemediated antitumor prodrug therapy. Cancer Res 60, 4179-4186 (2000). (Pubitemid 30636602)
-
(2000)
Cancer Research
, vol.60
, Issue.15
, pp. 4179-4186
-
-
Knox, R.J.1
Jenkins, T.C.2
Hobbs, S.M.3
Chen, S.4
Melton, R.G.5
Burke, P.J.6
-
11
-
-
17144417314
-
Structural and mechanistic studies of Escherichia coli nitroreductase with the antibiotic nitrofurazone: Reversed binding orientations in different redox states of the enzyme
-
DOI 10.1074/jbc.M409652200
-
Race, P. R. et al. Structural and mechanistic studies of Escherichia coli nitroreductase with the antibiotic nitrofurazone. Reversed binding orientations in different redox states of the enzyme. J Biol Chem 280, 13256-13264 (2005). (Pubitemid 40517209)
-
(2005)
Journal of Biological Chemistry
, vol.280
, Issue.14
, pp. 13256-13264
-
-
Race, P.R.1
Lovering, A.L.2
Green, R.M.3
Ossor, A.4
White, S.A.5
Searle, P.F.6
Wrighton, C.J.7
Hyde, E.I.8
-
12
-
-
5644244248
-
Mechanism of carcinogenesis induced by a veterinary antimicrobial drug, nitrofurazone, via oxidative DNA damage and cell proliferation
-
DOI 10.1016/j.canlet.2004.05.016, PII S0304383504004070
-
Hiraku, Y. et al. Mechanism of carcinogenesis induced by a veterinary antimicrobial drug, nitrofurazone, via oxidative DNA damage and cell proliferation. Cancer Lett 215, 141-150 (2004). (Pubitemid 39370031)
-
(2004)
Cancer Letters
, vol.215
, Issue.2
, pp. 141-150
-
-
Hiraku, Y.1
Sekine, A.2
Nabeshi, H.3
Midorikawa, K.4
Murata, M.5
Kumagai, Y.6
Kawanishi, S.7
-
13
-
-
77953709007
-
A novel mechanism for azoreduction
-
Ryan, A. et al. A novel mechanism for azoreduction. JMol Biol 400, 24-37 (2010).
-
(2010)
JMol Biol
, vol.400
, pp. 24-37
-
-
Ryan, A.1
-
14
-
-
75149171792
-
Role of Tyrosine 131 in the active site of paAzoR1, an azoreductase with specificity for the inflammatory bowel disease pro-drug balsalazide
-
Wang, C. J. et al. Role of Tyrosine 131 in the active site of paAzoR1, an azoreductase with specificity for the inflammatory bowel disease pro-drug balsalazide. Acta Crystallogr F Struct Biol Cryst Commun 66, 2-7 (2010).
-
(2010)
Acta Crystallogr F Struct Biol Cryst Commun
, vol.66
, pp. 2-7
-
-
Wang, C.J.1
-
15
-
-
4544232470
-
Crystal structure and functional characterization of yeast YLR011wp, an enzyme with NAD(P)H-FMN and ferric iron reductase activities
-
DOI 10.1074/jbc.M405404200
-
Liger, D. et al. Crystal structure and functional characterization of yeast YLR011wp, an enzyme with NAD(P)H-FMN and ferric iron reductase activities. J. Biol. Chem. 279, 34890-34897 (2004). (Pubitemid 39318124)
-
(2004)
Journal of Biological Chemistry
, vol.279
, Issue.33
, pp. 34890-34897
-
-
Liger, D.1
Graille, M.2
Zhou, C.-Z.3
Leulliot, N.4
Quevillon-Cheruel, S.5
Blondeau, K.6
Janin, J.7
Van Tilbeurgh, H.8
-
16
-
-
41549168117
-
Site-directed mutagenesis of substrate binding sites of azoreductase from Rhodobacter sphaeroides
-
Liu, G. et al. Site-directed mutagenesis of substrate binding sites of azoreductase from Rhodobacter sphaeroides. Biotechnol Lett 30, 869-875 (2008).
-
(2008)
Biotechnol Lett
, vol.30
, pp. 869-875
-
-
Liu, G.1
-
17
-
-
0037192818
-
Structures of nitroreductase in three states. Effects of inhibitor binding and reduction
-
DOI 10.1074/jbc.M111334200
-
Haynes, C. A., Koder, R. L., Miller, A. F. & Rodgers, D. W. Structures of nitroreductase in three states: effects of inhibitor binding and reduction. J Biol Chem 277, 11513-11520 (2002). (Pubitemid 34952921)
-
(2002)
Journal of Biological Chemistry
, vol.277
, Issue.13
, pp. 11513-11520
-
-
Haynes, C.A.1
Koder, R.L.2
Miller, A.-F.3
Rodgers, D.W.4
-
18
-
-
0141790765
-
Studies on the nitroreductase prodrug-activating system. Crystal structures of complexes with the inhibitor dicoumarol and dinitrobenzamide prodrugs and of the enzyme active form
-
DOI 10.1021/jm030843b
-
Johansson, E., Parkinson, G. N., Denny, W. A. & Neidle, S. Studies on the nitroreductase prodrug-activating system. Crystal structures of complexes with the inhibitor dicoumarol and dinitrobenzamide prodrugs and of the enzyme active form. J Med Chem 46, 4009-4020 (2003). (Pubitemid 37122447)
-
(2003)
Journal of Medicinal Chemistry
, vol.46
, Issue.19
, pp. 4009-4020
-
-
Johansson, E.1
Parkinson, G.N.2
Denny, W.A.3
Neidle, S.4
-
19
-
-
17944373776
-
NTP Toxicology and carcinogenesis studies of nitrofurazone (CAS No. 59-87-0)in F344/N Rats and B6C3F1 Mice (Feed Studies)
-
Kari, F. NTP Toxicology and Carcinogenesis Studies of Nitrofurazone (CAS No. 59-87-0) in F344/N Rats and B6C3F1 Mice (Feed Studies). Natl Toxicol Program Tech Rep Ser 337, 1-183 (1988).
-
(1988)
Natl Toxicol Program Tech Rep ser
, vol.337
, pp. 1-183
-
-
Kari, F.1
-
20
-
-
24344493957
-
Crystal structure of quinone reductase 2 in complex with cancer prodrug CB1954
-
DOI 10.1016/j.bbrc.2005.08.081, PII S0006291X05017882
-
Fu, Y., Buryanovskyy, L. & Zhang, Z. Crystal structure of quinone reductase 2 in complex with cancer prodrug CB1954. Biochem Biophys Res Commun 336, 332-338 (2005). (Pubitemid 41253438)
-
(2005)
Biochemical and Biophysical Research Communications
, vol.336
, Issue.1
, pp. 332-338
-
-
Fu, Y.1
Buryanovskyy, L.2
Zhang, Z.3
-
21
-
-
0029068515
-
The three-dimensional structure of NAD(P)H:quinone reductase, a flavoprotein involved in cancer chemoprotection and chemotherapy: Mechanism of the two-electron reduction
-
Li, R., Bianchet, M. A., Talalay, P. & Amzel, L. M. The three-dimensional structure of NAD(P)H:quinone reductase, a flavoprotein involved in cancer chemoprotection and chemotherapy: mechanism of the two-electron reduction. Proc Natl Acad Sci USA 92, 8846-8850 (1995).
-
(1995)
Proc Natl Acad Sci USA
, vol.92
, pp. 8846-8850
-
-
Li, R.1
Bianchet, M.A.2
Talalay, P.3
Amzel, L.M.4
-
23
-
-
0028103275
-
The CCP4 suit-programs for protein crystallography
-
Bailey, S. The CCP4 suit-programs for protein crystallography. Acta Crystallogr D Biol Crystallogr 58, 760-763 (1994).
-
(1994)
Acta Crystallogr D Biol Crystallogr
, vol.58
, pp. 760-763
-
-
Bailey, S.1
-
24
-
-
75649151032
-
Xia2: An expert system for macromolecular crystallography data reduction
-
Winter, G. xia2: an expert system for macromolecular crystallography data reduction. J Appl Crystallogr 43, 186-190 (2010).
-
(2010)
J Appl Crystallogr
, vol.43
, pp. 186-190
-
-
Winter, G.1
-
25
-
-
34447508216
-
Phaser crystallographic software
-
DOI 10.1107/S0021889807021206, PII S0021889807021206
-
McCoy, A. J. et al. Phaser crystallographic software. J Appl Crystallogr 40, 658-674 (2007). (Pubitemid 47080256)
-
(2007)
Journal of Applied Crystallography
, vol.40
, Issue.4
, pp. 658-674
-
-
McCoy, A.J.1
Grosse-Kunstleve, R.W.2
Adams, P.D.3
Winn, M.D.4
Storoni, L.C.5
Read, R.J.6
-
26
-
-
77949535720
-
And development of Coot
-
Emsley, P., Lohkamp, B., Scott, W. G. & Cowtan, K. Features and development of Coot. Acta Crystallogr D Biol Crystallogr 66, 486-501 (2010).
-
(2010)
Acta Crystallogr D Biol Crystallogr
, vol.66
, pp. 486-501
-
-
Emsley, P.1
Lohkamp, B.2
Scott, W.G.3
Features, C.K.4
-
27
-
-
0030924992
-
Refinement of macromolecular structures by the maximum-likelihood method
-
DOI 10.1107/S0907444996012255
-
Murshudov, G. N., Vagin, A. A. & Dodson, E. J. Refinement of macromolecular structures by the maximum-likelihood method. Acta Crystallogr D Biol Crystallogr 53, 240-255 (1997). (Pubitemid 27235885)
-
(1997)
Acta Crystallographica Section D: Biological Crystallography
, vol.53
, Issue.3
, pp. 240-255
-
-
Murshudov, G.N.1
Vagin, A.A.2
Dodson, E.J.3
-
28
-
-
76449098262
-
PHENIX: A comprehensive Python-based system for macromolecular structure solution
-
Adams, P. D. et al. PHENIX: a comprehensive Python-based system for macromolecular structure solution. Acta Crystallogr D Biol Crystallogr 66, 213-221 (2010).
-
(2010)
Acta Crystallogr D Biol Crystallogr
, vol.66
, pp. 213-221
-
-
Adams, P.D.1
-
29
-
-
33646260450
-
Optimal description of a protein structure in terms of multiple groups undergoing TLS motion
-
Painter, J. & Merritt, E. A. Optimal description of a protein structure in terms of multiple groups undergoing TLS motion. Acta Crystallogr D Biol Crystallogr 62, 439-450 (2006).
-
(2006)
Acta Crystallogr D Biol Crystallogr
, vol.62
, pp. 439-450
-
-
Painter, J.1
Merritt, E.A.2
-
30
-
-
74549178560
-
MolProbity: All-atom structure validation for macromolecular crystallography
-
Chen, V. B. et al. MolProbity: all-atom structure validation for macromolecular crystallography. Acta Crystallogr D Biol Crystallogr 66, 12-21 (2010).
-
(2010)
Acta Crystallogr D Biol Crystallogr
, vol.66
, pp. 12-21
-
-
Chen, V.B.1
-
31
-
-
84860147514
-
-
DeLano, W. L., Edn. Version 1. 1 (DeLano Scientific, Palo Alto, ,. CA, , USA; 2008)
-
DeLano, W. L., Edn. Version 1. 1 (DeLano Scientific, Palo Alto, ,. CA, , USA; 2008).
-
-
-
|