Arginine deficiency leads to impaired cofilin dephosphorylation in activated human T lymphocytes

International Immunology

Volumn 24, Issue 5, 2012, Pages 303-313

  Feldmeyer, Nadja ^a,b   Wabnitz, Guido ^b   Leicht, Stefan ^c   Luckner minden, Claudia ^d   Schiller, Martin ^a   Franz, Thomas ^c   Conradi, Roland ^d   Kropf, Pascale ^e   Müller, Ingrid ^e   Ho, Anthony D ^a   Samstag, Yvonne ^b   Munder, Markus ^d  

^a UNIVERSITY HOSPITAL HEIDELBERG   (Germany)

^b UNIVERSITY OF HEIDELBERG   (Germany)

^c EUROPEAN MOLECULAR BIOLOGY LABORATORY   (Germany)

^d UNIVERSITY MEDICAL CENTER MAINZ   (Germany)

^e IMPERIAL COLLEGE LONDON   (United Kingdom)

Author keywords

Cell activation; Immune regulation; T cells

Indexed keywords

ARGININE; COFILIN; CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 2; PHOSPHATIDYLINOSITOL 3 KINASE;

ACTIN POLYMERIZATION; AMINO ACID DEFICIENCY; ARTICLE; CYTOKINE PRODUCTION; HUMAN; HUMAN CELL; IMMUNOLOGICAL SYNAPSE; IMMUNOREGULATION; INFLAMMATION; PRIORITY JOURNAL; PROTEIN DEPHOSPHORYLATION; T LYMPHOCYTE ACTIVATION;

EID: 84860005763     PISSN: 09538178     EISSN: 14602377     Source Type: Journal    
DOI: 10.1093/intimm/dxs004     Document Type: Article

References (37)

1. Nathan, C. 2002. Points of control in inflammation. Nature 420:846.
2. Grohmann, U. and Bronte, V. 2010. Control of immune response by amino acid metabolism. Immunol. Rev. 236:243.
3. Bronte, V., Serafini, P., Mazzoni, A., Segal, D. M. and Zanovello, P. 2003. L-arginine metabolism in myeloid cells controls T-lymphocyte functions. Trends Immunol. 24:302.
4. Munder, M. 2009. Arginase: an emerging key player in the mammalian immune system. Br. J. Pharmacol. 158:638.
5. Anthony, R. M., Urban, J. F., Jr, Alem, F., et al. 2006. Memory T(H)2 cells induce alternatively activated macrophages to mediate protection against nematode parasites. Nat. Med. 12:955.
6. Munder, M., Mollinedo, F., Calafat, J. et al. 2005. Arginase I is constitutively expressed in human granulocytes and participates in fungicidal activity. Blood 105:2549.
7. Gabrilovich, D. I. and Nagaraj, S. 2009. Myeloid-derived suppressor cells as regulators of the immune system. Nat. Rev. Immunol. 9:162.
8. Rodriguez, P. C., Zea, A. H., Culotta, K. S., Zabaleta, J., Ochoa, J. B. and Ochoa, A. C. 2002. Regulation of T cell receptor CD3zeta chain expression by L-arginine. J. Biol. Chem. 277:21123.
9. Rodriguez, P. C., Quiceno, D. G. and Ochoa, A. C. 2007. L-arginine availability regulates T-lymphocyte cell-cycle progression. Blood 109:1568.
10. Hinnebusch, A. G. 1994. The eIF-2 alpha kinases: regulators of protein synthesis in starvation and stress. Semin. Cell Biol. 5:417.
11. Munn, D. H., Sharma, M. D., Baban, B. et al. 2005. GCN2 kinase in T cells mediates proliferative arrest and anergy induction in response to indoleamine 2,3-dioxygenase. Immunity 22:633.
12. Oberlies, J., Watzl, C., Giese, T. et al. 2009. Regulation of NK cell function by human granulocyte arginase. J. Immunol. 182:5259.
13. Cobbold, S. P., Adams, E., Farquhar, C. A. et al. 2009. Infectious tolerance via the consumption of essential amino acids and mTOR signaling. Proc. Natl Acad. Sci. USA 106:12055.
14. Condeelis, J. 2001. How is actin polymerization nucleated in vivo? Trends Cell. Biol. 11:288.
15. Eibert, S. M., Lee, K. H., Pipkorn, R. et al. 2004. Cofilin peptide homologs interfere with immunological synapse formation and T cell activation. Proc. Natl Acad. Sci. USA 101:1957.
16. Munder, M., Schneider, H., Luckner, C. et al. 2006. Suppression of T-cell functions by human granulocyte arginase. Blood 108:1627.
17. Munder, M., Choi, B. S., Rogers, M. and Kropf, P. 2009. L-arginine deprivation impairs Leishmania major-specific T-cell responses. Eur. J. Immunol. 39:2161.
18. Klemke, M., Wabnitz, G. H., Funke, F., Funk, B., Kirchgessner, H. and Samstag, Y. 2008. Oxidation of cofilin mediates T cell hyporesponsiveness under oxidative stress conditions. Immunity 29:404.
19. Hoffmann, S., Hosseini, B. H., Hecker, M. et al. 2010. Single cell force spectroscopy of T cells recognizing a myelin-derived peptide on antigen presenting cells. Immunol. Lett. 136:13.
20. Wabnitz, G. H., Lohneis, P., Kirchgessner, H. et al. 2010. Sustained LFA-1 cluster formation in the immune synapse requires the combined activities of L-plastin and calmodulin. Eur. J. Immunol. 40:2437.
21. Sester, U., Wabnitz, G. H., Kirchgessner, H. and Samstag, Y. 2007. Ras/PI3kinase/cofilin-independent activation of human CD45RA+ and CD45RO+ T cells by superagonistic CD28 stimulation. Eur. J. Immunol. 37:2881.
22. Li, X., Wilm, M. and Franz, T. 2005. Silicone/graphite coating for on-target desalting and improved peptide mapping performance of matrix-assisted laser desorption/ionization-mass spectrometry targets in proteomic experiments. Proteomics 5:1460.
23. Samstag, Y., Bader, A. and Meuer, S. C. 1991. A serine phosphatase is involved in CD2-mediated activation of human T lymphocytes and natural killer cells. J. Immunol. 147:788.
24. Lee, K. H., Meuer, S. C. and Samstag, Y. 2000. Cofilin: a missing link between T cell co-stimulation and rearrangement of the actin cytoskeleton. Eur. J. Immunol. 30:892.
25. Samstag, Y., Eibert, S. M., Klemke, M. and Wabnitz, G. H. 2003. Actin cytoskeletal dynamics in T lymphocyte activation and migration. J. Leukoc. Biol. 73:30.
26. Samstag, Y., Eckerskorn, C., Wesselborg, S., Henning, S., Wallich, R. and Meuer, S. C. 1994. Costimulatory signals for human T-cell activation induce nuclear translocation of pp.19/cofilin. Proc. Natl Acad. Sci. USA 91:4494.
27. Burkhardt, J. K., Carrizosa, E. and Shaffer, M. H. 2008. The actin cytoskeleton in T cell activation. Annu. Rev. Immunol. 26:233.
28. Wabnitz, G. H., Nebl, G., Klemke, M., Schroder, A. J. and Samstag, Y. 2006. Phosphatidylinositol 3-kinase functions as a Ras effector in the signaling cascade that regulates dephosphorylation of the actin-remodeling protein cofilin after costimulation of untransformed human T lymphocytes. J. Immunol. 176:1668.
29. Fooksman, D. R., Vardhana, S., Vasiliver-Shamis, G. et al. 2010. Functional anatomy of T cell activation and synapse formation. Annu. Rev. Immunol. 28:79.
30. Kropf, P., Baud, D., Marshall, S. E. et al. 2007. Arginase activity mediates reversible T cell hyporesponsiveness in human pregnancy. Eur. J. Immunol. 37:935.
31. Pesce, J. T., Ramalingam, T. R., Mentink-Kane, M. M. et al. 2009. Arginase-1-expressing macrophages suppress Th2 cytokinedriven inflammation and fibrosis. PLoS Pathog. 5:e1000371.
32. Rodriguez, P. C., Hernandez, C. P., Morrow, K. et al. 2010. L-arginine deprivation regulates cyclin D3 mRNA stability in human T cells by controlling HuR expression. J. Immunol. 185: 5198.
33. Wabnitz, G., Goursot, C., Jahraus, B. et al. 2010. Mitochondrial translocation of oxidized cofilin induces caspase-independent necrotic-like programmed cell death of T cells. Cell Death Dis. 1:e58doi:10.1038/cddis.2010.36.
34. Beemiller, P. and Krummel, M. F. 2010. Mediation of T-cell activation by actin meshworks. Cold Spring Harb. Perspect. Biol. 2:a002444.
35. Wulfing, C., Sjaastad, M. D. and Davis, M. M. 1998. Visualizing the dynamics of T cell activation: intracellular adhesion molecule 1 migrates rapidly to the T cell/B cell interface and acts to sustain calcium levels. Proc. Natl Acad. Sci. USA 95:6302.
36. Carr, E. L., Kelman, A., Wu, G. S. et al. 2010. Glutamine uptake and metabolism are coordinately regulated by ERK/MAPK during T lymphocyte activation. J. Immunol. 185:1037.
37. Sabatini, D. M. 2006. mTOR and cancer: insights into a complex relationship. Nat. Rev. Cancer 6:729.