Crystal structures of N-acetylmannosamine kinase provide insights into enzyme activity and inhibition

Journal of Biological Chemistry

Volumn 287, Issue 17, 2012, Pages 13656-13665

  Martinez, Jacobo ^a   Nguyen, Long Duc ^b   Hinderlich, Stephan ^c   Zimmer, Reinhold ^a   Tauberger, Eva ^a   Reutter, Werner ^b   Saenger, Wolfram ^a   Fan, Hua ^b   Moniot, Sébastien ^a,d  

^a FREIE UNIVERSITÄT BERLIN   (Germany)

^b CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^c BEUTH UNIVERSITY OF APPLIED SCIENCES   (Germany)

^d UNIVERSITY OF BAYREUTH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVE CENTER; BIFUNCTIONAL; BIOLOGICAL FUNCTIONS; CELL SURFACES; CELLULAR PROCESS; DIRECT IMPACT; ESSENTIAL COMPONENT; GLYCOCONJUGATES; KEY ENZYMES; SIALIC ACIDS; SIALYLATION; SPECIFIC INHIBITORS; STRUCTURAL BASIS;

BIOCHEMISTRY; BIOSYNTHESIS; CARBOHYDRATES; CARBOXYLIC ACIDS; CELL MEMBRANES; PHOSPHORYLATION;

ENZYMES;

N ACETYLMANNOSAMINE KINASE; PHOSPHOTRANSFERASE; SIALIC ACID; UNCLASSIFIED DRUG; URIDINE DIPHOSPHATE N ACETYLGLUCOSAMINE 2 EPIMERASE;

AMINO ACID SEQUENCE; ARTICLE; BIOLOGICAL FUNCTIONS; CARBOHYDRATE SYNTHESIS; CIRCULAR DICHROISM; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME PURIFICATION; ENZYME SUBSTRATE; HYDROGEN BOND; PRIORITY JOURNAL; STRUCTURE ANALYSIS;

ASPARTIC ACID; BINDING SITES; CELL MEMBRANE; CRYSTALLOGRAPHY, X-RAY; DIMERIZATION; ENZYME INHIBITORS; ESCHERICHIA COLI; GLYCOCONJUGATES; GLYCOPROTEINS; HEXOSAMINES; HUMANS; N-ACETYLNEURAMINIC ACID; PHOSPHORYLATION; PHOSPHOTRANSFERASES (ALCOHOL GROUP ACCEPTOR); PROTEIN FOLDING; PROTEIN STRUCTURE, SECONDARY; RECOMBINANT PROTEINS; ZINC;

EID: 84859997945     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.318170     Document Type: Article

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