Regulation and pathophysiological implications of UDP-GlcNAc 2-epimerase/ManNAc kinase (GNE) as the key enzyme of sialic acid biosynthesis

Biological Chemistry

Volumn 390, Issue 7, 2009, Pages 591-599

  Reinke, Stefan O ^a   Lehmer, Gerhard ^b   Hinderlich, Stephan ^a   Reutter, Werner ^b  

^a BEUTH UNIVERSITY OF APPLIED SCIENCES   (Germany)

^b CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

Author keywords

CMP Neu5Ac; GlcNProp; H IBM; ManNAc; Sialic acid Neu5Ac; UDP GlcNAc 2 epimerase ManNAc kinase (GNE)

Indexed keywords

CYTIDINE PHOSPHATE; CYTIDINE PHOSPHATE N ACETYLNEURAMINIC ACID; N ACETYLNEURAMINIC ACID; PROTEIN KINASE C; SIALIC ACID; URIDINE DIPHOSPHATE N ACETYLGLUCOSAMINE 2 EPIMERASE;

BIOCHEMISTRY; BIOSYNTHESIS; CONCENTRATION (PARAMETERS); ENZYME PHOSPHORYLATION; ENZYME REGULATION; GENETIC DISORDER; GENETICS; INBORN ERROR OF METABOLISM; INCLUSION BODY MYOPATHY; KNOCKOUT MOUSE; LETHALITY; LIVER; METABOLIC CAPACITY; METABOLISM; MYOPATHY; NEGATIVE FEEDBACK; NONHUMAN; PATHOPHYSIOLOGY; PLACENTA; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INTERACTION; REGNUM; REVIEW; SIALIC ACID URINE LEVEL; VERTEBRATE;

ANIMALS; CARBOHYDRATE EPIMERASES; DISEASE; ENZYME INHIBITORS; HUMANS; N-ACETYLNEURAMINIC ACID; PHOSPHOTRANSFERASES (ALCOHOL GROUP ACCEPTOR);

ANIMALIA; MUS;

EID: 68149131942     PISSN: 14316730     EISSN: 14374315     Source Type: Journal    
DOI: 10.1515/BC.2009.073     Document Type: Review

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